High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography

Nano Letters

Volumn 16, Issue 4, 2016, Pages 2198-2204

  Hu, Junqiang ^a   Gondarenko, Alexander A ^a   Dang, Alex P ^a   Bashour, Keenan T ^a   O'Connor, Roddy S ^c   Lee, Sunwoo ^a   Liapis, Anastasia ^d   Ghassemi, Saba ^c   Milone, Michael C ^c   Sheetz, Michael P ^b   Dustin, Michael L ^e   Kam, Lance C ^a   Hone, James C ^a  

^a Department of Earth and Environmental Sciences   (United States)

^b University of Pennsylvania ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

High throughput screening; interleukin 2; Lck; long term expansion; nanotechnology; T cell

Indexed keywords

CELLS; CYTOLOGY; IMAGE RECONSTRUCTION; NANOTECHNOLOGY; PHYSIOLOGY; T-CELLS;

CYTOKINE PRODUCTION; FULLY COMPATIBLE; HIGH THROUGHPUT SCREENING; HIGH-RESOLUTION IMAGING; INTERLEUKIN-2; LONG-TERM EFFECTS; NUMBER OF FACTORS; T CELL ACTIVATION;

THROUGHPUT;

IL2 PROTEIN, HUMAN; INTERLEUKIN 2;

ANIMAL; CELL CULTURE TECHNIQUE; CYTOLOGY; DEVICES; HUMAN; LYMPHOCYTE ACTIVATION; METABOLISM; NANOTECHNOLOGY; PROCEDURES; T LYMPHOCYTE;

ANIMALS; CELL CULTURE TECHNIQUES; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; NANOTECHNOLOGY; T-LYMPHOCYTES;

EID: 84966344967     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/acs.nanolett.5b04364     Document Type: Article

References (43)

1. Chen, C. S. Geometric Control of Cell Life and Death Science 1997, 276, 1425-1428 10.1126/science.276.5317.1425
2. Juliano, R. L.; Haskill, S. Signal transduction from the extracellular matrix J. Cell Biol. 1993, 120, 577-585 10.1083/jcb.120.3.577
3. Flemming, R. G.; Murphy, C. J.; Abrams, G. A.; Goodman, S. L.; Nealey, P. F. Effects of synthetic micro-and nano-structured surfaces on cell behavior Biomaterials 1999, 20, 573-588 10.1016/S0142-9612(98)00209-9
4. Bettinger, C. J.; Langer, R.; Borenstein, J. T. Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function Angew. Chem., Int. Ed. 2009, 48, 5406-5415 10.1002/anie.200805179
5. Anselme, K. et al. The interaction of cells and bacteria with surfaces structured at the nanometre scale Acta Biomater. 2010, 6, 3824-3846 10.1016/j.actbio.2010.04.001
6. Tibbitt, M. W.; Anseth, K. S. Hydrogels as extracellular matrix mimics for 3D cell culture Biotechnol. Bioeng. 2009, 103, 655-663 10.1002/bit.22361
7. Freed, L. E. et al. Biodegradable Polymer Scaffolds for Tissue Engineering Bio/Technology 1994, 12, 689-693 10.1038/nbt0794-689
8. Lee, J.; Cuddihy, M. J.; Kotov, N. A. Three-Dimensional Cell Culture Matrices: State of the Art Tissue Eng., Part B 2008, 14, 61-86 10.1089/teb.2007.0150
9. Yim, E. et al. Nanopattern-induced changes in morphology and motility of smooth muscle cells Biomaterials 2005, 26, 5405-5413 10.1016/j.biomaterials.2005.01.058
10. Yim, E. K. F.; Pang, S. W.; Leong, K. W. Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage Exp. Cell Res. 2007, 313, 1820-1829 10.1016/j.yexcr.2007.02.031
11. Singhvi, R. et al. Engineering cell shape and function Science 1994, 264, 696-698 10.1126/science.8171320
12. Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology Cell 1997, 91, 439-442 10.1016/S0092-8674(00)80429-8
13. von der Mark, K.; Park, J.; Bauer, S.; Schmuki, P. Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix Cell Tissue Res. 2010, 339, 131-153 10.1007/s00441-009-0896-5
14. Shen, K.; Milone, M. C.; Dustin, M. L.; Kam, L. C. Nanoengineering of Immune Cell Function. In MRS Proceedings 2009, 1209, 1209-YY03 (Cambridge Univ Press).
15. Dalby, M. J. et al. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder Nat. Mater. 2007, 6, 997-1003 10.1038/nmat2013
16. Reynolds, P. M.; Pedersen, R. H.; Riehle, M. O.; Gadegaard, N. A Dual Gradient Assay for the Parametric Analysis of Cell-Surface Interactions Small 2012, 8, 2541-2547 10.1002/smll.201200235
17. Majstoravich, S. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology Blood 2004, 104, 1396-1403 10.1182/blood-2004-02-0437
18. Unadkat, H. V. et al. An algorithm-based topographical biomaterials library to instruct cell fate Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 16565-16570 10.1073/pnas.1109861108
19. Markert, L. D. et al. Identification of Distinct Topographical Surface Microstructures Favoring Either Undifferentiated Expansion or Differentiation of Murine Embryonic Stem Cells Stem Cells Dev. 2009, 18, 1331-1342 10.1089/scd.2009.0114
20. Moe, A. A. K. et al. Microarray with Micro- and Nano-topographies Enables Identification of the Optimal Topography for Directing the Differentiation of Primary Murine Neural Progenitor Cells Small 2012, 8, 3050-3061 10.1002/smll.201200490
21. Sunkara, V.; Cho, Y.-K. Investigation on the Mechanism of Aminosilane-Mediated Bonding of Thermoplastics and Poly(dimethylsiloxane) ACS Appl. Mater. Interfaces 2012, 4, 6537-6544 10.1021/am3015923
22. Smith-Garvin, J. E.; Koretzky, G. A.; Jordan, M. S. T Cell Activation Annu. Rev. Immunol. 2009, 27, 591-619 10.1146/annurev.immunol.021908.132706
23. Bashour, K. T. et al. CD28 and CD3 have complementary roles in T-cell traction forces Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 2241-2246 10.1073/pnas.1315606111
24. Bashour, K. T. et al. Cross Talk between CD3 and CD28 Is Spatially Modulated by Protein Lateral Mobility Mol. Cell. Biol. 2014, 34, 955-964 10.1128/MCB.00842-13
25. Deeg, J. et al. T Cell Activation is Determined by the Number of Presented Antigens Nano Lett. 2013, 13, 5619-5626 10.1021/nl403266t
26. Biggs, M. J. P.; Richards, R. G.; Dalby, M. J. Nanotopographical modification: a regulator of cellular function through focal adhesions Nanomedicine 2010, 6, 619-633 10.1016/j.nano.2010.01.009
27. Choudhuri, K. et al. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse Nature 2014, 507, 118-123 10.1038/nature12951
28. Dustin, M. L.; Depoil, D. New insights into the T cell synapse from single molecule techniques Nat. Rev. Immunol. 2011, 11, 672-684 10.1038/nri3066
29. Maus, M. V. et al. Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB Nat. Biotechnol. 2002, 20, 143-148 10.1038/nbt0202-143
30. Levine, B. L. et al. Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells J. Immunol. 1997, 159, 5921-5930
31. O'Connor, R. S. et al. Substrate Rigidity Regulates Human T Cell Activation and Proliferation J. Immunol. 2012, 189, 1330-1339 10.4049/jimmunol.1102757
32. Yu, L. et al. Flow-through functionalized PDMS microfluidic channels with dextran derivative for ELISAs Lab Chip 2009, 9, 1243 10.1039/b816018j
33. Shen, K.; Thomas, V. K.; Dustin, M. L.; Kam, L. C. Micropatterning of costimulatory ligands enhances CD4+ T cell function Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 7791-7796 10.1073/pnas.0710295105
34. Dong, H.; Zhu, G.; Tamada, K.; Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion Nat. Med. 1999, 5, 1365-1369 10.1038/70932
35. Trickett, A.; Kwan, Y. L. T cell stimulation and expansion using anti-CD3/CD28 beads J. Immunol. Methods 2003, 275, 251-255 10.1016/S0022-1759(03)00010-3
36. Bunnell, S. C.; Kapoor, V.; Trible, R. P.; Zhang, W.; Samelson, L. E. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT Immunity 2001, 14, 315-329 10.1016/S1074-7613(01)00112-1
37. Kumari, S.; Dustin, M. L. Immunology: Dendritic Cells Pull the T Cell's Strings Curr. Biol. 2015, 25, R413-R415 10.1016/j.cub.2015.03.040
38. Babich, A. et al. F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation J. Cell Biol. 2012, 197, 775-787 10.1083/jcb.201201018
39. Weiss, A.; Littman, D. R. Signal Transduction by Lymphocyte Antigen Receptors Cell 1994, 76, 263-274 10.1016/0092-8674(94)90334-4
40. Palacios, E. H.; Weiss, A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation Oncogene 2004, 23, 7990-8000 10.1038/sj.onc.1208074
41. Nika, K. et al. Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction Immunity 2010, 32, 766-777 10.1016/j.immuni.2010.05.011
42. Rubb, M. R. et al. Jasplakinolide, a Cytotoxic Natural Product, Induces Actin Polymerization and Competitively Inhibits the Binding of Phalloidin to F-actin J. Biol. Chem. 1994, 269, 14869-14871
43. Straight, A. F. et al. Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor Science 2003, 299, 1743-1747 10.1126/science.1081412