Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Min, Chan Ki ^a   Cheon, Shinhye ^b   Ha, Na Young ^a   Sohn, Kyung Mok ^b   Kim, Yuri ^a   Aigerim, Abdimadiyeva ^a   Shin, Hyun Mu ^a   Choi, Ji Yeob ^a   Inn, Kyung Soo ^c   Kim, Jin Hwan ^b   Moon, Jae Young ^b   Choi, Myung Sik ^a   Cho, Nam Hyuk ^a,d   Kim, Yeon Sook ^b  

^a Seoul National University College of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR;

ADULT; AGED; COMPARATIVE STUDY; COMPLICATION; CORONAVIRUS INFECTION; FEMALE; HUMAN; IMMUNOLOGY; KINETICS; LEUKOCYTOSIS; LYMPHOCYTOPENIA; MALE; METABOLISM; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MORTALITY; PHYSIOLOGY; PNEUMONIA; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA; VERY ELDERLY; VIROLOGY; VIRUS LOAD; VIRUS SHEDDING;

ADULT; AGED; AGED, 80 AND OVER; CORONAVIRUS INFECTIONS; CYTOKINES; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; KINETICS; LEUKOCYTOSIS; LYMPHOPENIA; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PNEUMONIA; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA; VIRAL LOAD; VIRUS SHEDDING;

EID: 84966331098     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25359     Document Type: Article

References (37)

1. Chan, J. F. et al. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev 28, 465-522, doi: 10.1128/CMR.00102-14 (2015).
2. WHO. Middle East respiratory syndrome coronavirus (MERS-CoV), 'http://www.who.int/emergencies/mers-cov/en/' (2015) (Date of acess:31/03/2016).
3. Azhar, E. I. et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med 370, 2499-2505, doi: 10.1056/NEJMoa1401505 (2014).
4. Drosten, C. et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med 371, 828-835, doi: 10.1056/NEJMoa1405858 (2014).
5. Oboho, I. K. et al. 2014 MERS-CoV outbreak in Jeddah-a link to health care facilities. N Engl J Med 372, 846-854, doi: 10.1056/NEJMoa1408636 (2015).
6. Korea Centers for Disease, C. & Prevention. Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect 6, 269-278, doi: 10.1016/j.phrp.2015.08.006 (2015).
7. Butler, D. South Korean MERS outbreak spotlights lack of research. Nature 522, 139-140, doi: 10.1038/522139a (2015).
8. Assiri, A. et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 13, 752-761, doi: 10.1016/S1473-3099(13)70204-4 (2013).
9. Feikin, D. R. et al. Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014. Emerg Infect Dis 21, 2029-2035, doi: 10.3201/eid2111.150764 (2015).
10. Memish, Z. A., Zumla, A. I., Al-Hakeem, R. F., Al-Rabeeah, A. A. & Stephens, G. M. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 368, 2487-2494, doi: 10.1056/NEJMoa1303729 (2013).
11. Yang, J. S. et al. Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015. Emerg Infect Dis 21, 2084-2087, doi: 10.3201/eid2111.151016 (2015).
12. Omrani, A. S. et al. Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study. Lancet Infect Dis 14, 1090-1095, doi: 10.1016/S1473-3099(14)70920-X (2014).
13. Spanakis, N. et al. Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen. Int J Antimicrob Agents 44, 528-532, doi: 10.1016/j.ijantimicag.2014.07.026 (2014).
14. Corman, V. M. et al. Viral shedding and antibody response in 37 patients with MERS-coronavirus infection. Clin Infect Dis, doi: 10.1093/cid/civ951 (2015).
15. Memish, Z. A. et al. Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infect Dis 210, 1590-1594, doi: 10.1093/infdis/jiu292 (2014).
16. Hung, E. C. et al. Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome. Clin chem 49, 2108-2109, doi: 10.1373/clinchem.2003.025437 (2003).
17. Lau, K. K. et al. Possible central nervous system infection by SARS coronavirus. Emerg Infect Dis 10, 342-344, doi: 10.3201/eid1002.030638 (2004).
18. Rochman, Y., Spolski, R. & Leonard, W. J. New insights into the regulation of T cells by gamma(c) family cytokines. Nature Rev Immunol 9, 480-490, doi: 10.1038/nri2580 (2009).
19. Aloui, C. et al. The signaling role of CD40 ligand in platelet biology and in platelet component transfusion. Int J Mol Sci 15, 22342-22364, doi: 10.3390/ijms151222342 (2014).
20. Jung, K. et al. Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus. Vet J 177, 231-235, doi: 10.1016/j.tvjl.2007.04.018 (2008).
21. Meyerholz, D. K., Lambertz, A. M. & McCray, P. B., Jr. Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome. Am J Pathol 186, 78-86, doi: 10.1016/j.ajpath.2015.09.014 (2016).
22. Park, W. B. et al. Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea. Emerg Infect Dis 21, 2186-2189, doi: 10.3201/eid2112.151421 (2015).
23. Cheng, Y. et al. Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur J Clin Microbiol 24, 44-46, doi: 10.1007/s10096-004-1271-9 (2005).
24. Faure, E. et al. Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? PLos ONE 9, e88716, doi: 10.1371/journal.pone.0088716 (2014).
25. Zhou, J. et al. Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis. J Infect Dis 209, 1331-1342, doi: 10.1093/infdis/jit504 (2014).
26. Chu, H. et al. Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. Virol 454-455, 197-205, doi: 10.1016/j.virol.2014.02.018 (2014).
27. Muro, S. et al. Expression of IL-15 in inflammatory pulmonary diseases. J Allergy Clin Immunol 108, 970-975, doi: 10.1067/mai.2001.119556 (2001).
28. Yadava, K. et al. TSLP promotes influenza-specific CD8 + T-cell responses by augmenting local inflammatory dendritic cell function. Mucosal Immunol 6, 83-92, doi: 10.1038/mi.2012.50 (2013).
29. de Wit, E. et al. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci USA 110, 16598-16603, doi: 10.1073/pnas.1310744110 (2013).
30. Totura, A. L. & Baric, R. S. SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr Opin Virol 2, 264-275, doi: 10.1016/j.coviro.2012.04.004 (2012).
31. Cazac, B. B. & Roes, J. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13, 443-451 (2000).
32. Moldoveanu, B. et al. Inflammatory mechanisms in the lung. J Inflamm Res 2, 1-11 (2009).
33. Gilbert, K. & Fine, M. J. Assessing prognosis and predicting patient outcomes in community-acquired pneumonia. Semin Respir Infect 9, 140-152 (1994).
34. Pas, S. D. et al. First international external quality assessment of molecular diagnostics for Mers-CoV. J Clin Virol 69, 81-85, doi: 10.1016/j.jcv.2015.05.022 (2015).
35. Raj, V. S. et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495, 251-254, doi: 10.1038/nature12005 (2013).
36. Muth, D. et al. Infectious Middle East Respiratory Syndrome Coronavirus Excretion and Serotype Variability Based on Live Virus Isolates from Patients in Saudi Arabia. J Clin Microbiol 53, 2951-2955, doi: 10.1128/JCM.01368-15 (2015).
37. Willis, V. C. et al. Sputum Autoantibodies in Patients With Established Rheumatoid Arthritis and Subjects at Risk of Future Clinically Apparent Disease. Arthritis Rheum-Us 65, 2545-2554, doi: 10.1002/art.38066 (2013).