Infectious middle east respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia

Journal of Clinical Microbiology

Volumn 53, Issue 9, 2015, Pages 2951-2955

  Muth, Doreen ^a,b   Corman, Victor M ^a,b   Meyer, Benjamin ^a   Assiri, Abdullah ^c   Al Masri, Malak ^c   Farah, Mohamed ^d   Steinhagen, Katja ^e   Lattwein, Erik ^e   Al Tawfiq, Jaffar A ^f,g   Albarrak, Ali ^c   Müller, Marcel A ^a   Drosten, Christian ^a,b   Memishc, Ziad A ^h  

^a UNIVERSITY OF BONN   (Germany)

^b German Centre for Infection Research (DZIF)   (Germany)

^c MINISTRY OF HEALTH   (Saudi Arabia)

^d Prince Sultan Military Medical City   (Saudi Arabia)

^e Institute of Experimental Immunology   (Germany)

^f DHAHRAN HEALTH CENTER   (Saudi Arabia)

^g INDIANA UNIVERSITY   (United States)

^h ALFAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; VIRUS RNA;

ADULT; AGED; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CACO 2 CELL LINE; CLINICAL ARTICLE; CORONAVIRUS INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFECTION SENSITIVITY; LUNG ASPIRATION; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTYPE; SEROTYPE VARIABILITY; SPUTUM ANALYSIS; TRACHEAL ASPIRATION PROCEDURE; VERO B4 CELL LINE; VERO CELL LINE; VIRUS EXCRETION; VIRUS ISOLATION; VIRUS LOAD; VIRUS SHEDDING; VIRUS TITRATION; VIRUS VIRULENCE; ANIMAL; CACO-2 CELL LINE; CHLOROCEBUS AETHIOPS; CLASSIFICATION; COMPARATIVE STUDY; CORONAVIRUS INFECTIONS; ISOLATION AND PURIFICATION; MIDDLE AGED; SAUDI ARABIA; VERY ELDERLY; VIROLOGY; VIRUS CULTURE; YOUNG ADULT;

CORONAVIRUS;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CACO-2 CELLS; CERCOPITHECUS AETHIOPS; CORONAVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; SAUDI ARABIA; SEROGROUP; VERO CELLS; VIRUS CULTIVATION; YOUNG ADULT;

EID: 84940027267     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01368-15     Document Type: Article

References (16)

1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367:1814-1820. http://dx.doi.org/10.1056/NEJMoa1211721.
2. European Centre for Disease Prevention and Control. 2015. Severe respiratory diseases associated with Middle East respiratory syndrome coronavirus (MERS-CoV), 15th update. European Centre for Disease Prevention and Control, Stockholm, Sweden.
3. Mackay IM, Arden KE. 2015. Middle East respiratory syndrome: an emerging coronavirus infection tracked by the crowd. Virus Res 202:60-88. http://dx.doi.org/10.1016/j.virusres.2015.01.021.
4. Drosten C, Muth D, Corman V, Hussain R, Al Masri M, HajOmar W, Landt O, Assiri A, Eckerle I, Al Shangiti A, Al-Tawfiq JA, Albarrak A, Zumla A, Rambaut A, Memish Z. 2015. An observational, laboratorybased study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014. Clin Infect Dis 60:369-377. http://dx.doi.org/10.1093/cid/ciu812.
5. Memish ZA, Al-Tawfiq JA, Makhdoom HQ, Assiri A, Alhakeem RF, Albarrak A, Alsubaie S, Al-Rabeeah AA, Hajomar WH, Hussain R, Kheyami AM, Almutairi A, Azhar EI, Drosten C, Watson SJ, Kellam P, Cotten M, Zumla A. 2014. Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infect Dis 210:1590-1594. http://dx.doi.org/10.1093/infdis/jiu292.
6. Poissy J, Goffard A, Parmentier-Decrucq E, Favory R, Kauv M, Kipnis E, Mathieu D, Guery B. 2014. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases. J Clin Virol 61:275-278. http://dx.doi.org/10.1016/j.jcv.2014.07.002.
7. Meyer B, Drosten C, Muller MA. 2014. Serological assays for emerging coronaviruses: challenges and pitfalls. Virus Res 194:175-183. http://dx/doi.org/10.1016/j.virusres.2014.03.018.
8. Raj VS, Farag EA, Reusken CB, Lamers MM, Pas SD, Voermans J, Smits SL, Osterhaus AD, Al-Mawlawi N, Al-Romaihi HE, AlHajri MM, El-Sayed AM, Mohran KA, Ghobashy H, Alhajri F, Al-Thani M, Al-Marri SA, El-Maghraby MM, Koopmans MP, Haagmans BL. 2014. Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014. Emerg Infect Dis 20:1339-1342.
9. Muller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, Sieberg A, Aldabbagh S, Bosch BJ, Lattwein E, Alhakeem RF, Assiri AM, Albarrak AM, Al-Shangiti AM, Al-Tawfiq JA, Wikramaratna P, Alrabeeah AA, Drosten C, Memish ZA. 2015. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis 15:559-564. http://dx/doi.org/10.1016/S1473-3099(15)70090-3.
10. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, van Boheemen S, Gopal R, Ballhause M, Bestebroer TM, Muth D, Muller MA, Drexler JF, Zambon M, Osterhaus AD, Fouchier RM, Drosten C. 2012. Detection of a novel human coronavirus by real-time reversetranscription polymerase chain reaction. Euro Surveill 17(39):pii=20285. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20285.
11. Buchholz U, Muller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, Bonin F, Drosten C, Schweiger B, Wolff T, Muth D, Meyer B, Buda S, Krause G, Schaade L, Haas W. 2013. Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012. Euro Surveill 18(8):pii=20406. http://www/eurosurveillance.org/ViewArticle.aspx?ArticleId=20406.
12. Raj VS, Mou H, Smits SL, Dekkers DH, Muller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL. 2013. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495:251-254. http://dx.doi.org/10.1038/nature12005.
13. Cotten M, Watson SJ, Zumla AI, Makhdoom HQ, Palser AL, Ong SH, Al Rabeeah AA, Alhakeem RF, Assiri A, Al-Tawfiq JA, Albarrak A, Barry M, Shibl A, Alrabiah FA, Hajjar S, Balkhy HH, Flemban H, Rambaut A, Kellam P, Memish ZA. 2014. Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. mBio 5(1):e01062-13.
14. de Wit E, Rasmussen AL, Falzarano D, Bushmaker T, Feldmann F, Brining DL, Fischer ER, Martellaro C, Okumura A, Chang J, Scott D, Benecke AG, Katze MG, Feldmann H, Munster VJ. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A 110:16598-16603. http://dx.doi.org/10.1073/pnas.1310744110.
15. Chan KH, Yan MK, To KK, Lau SK, Woo PC, Cheng VC, Li WS, Chan JF, Tse H, Yuen KY. 2013. Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates. J Med Virol 85:874-879. http://dx.doi.org/10.1002/jmv.23538.
16. Couch RB, Atmar RL, Franco LM, Quarles JM, Wells J, Arden N, Nino D, Belmont JW. 2013. Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase. J Infect Dis 207:974-981. http://dx.doi.org/10.1093/infdis/jis935.