GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral e Protein

Cell Chemical Biology

Volumn 23, Issue 4, 2016, Pages 443-452

  Clark, Margaret J ^a   Miduturu, Chandra ^a,b   Schmidt, Aaron G ^a   Zhu, Xuling ^a   Pitts, Jared D ^a   Wang, Jinhua ^a,b   Potisopon, Supanee ^a   Zhang, Jianming ^a,b   Wojciechowski, Amy ^a,b   Hann Chu, Justin Jang ^a   Gray, Nathanael S ^a,b   Yang, Priscilla L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ABELSON KINASE INHIBITOR; ANTIVIRUS AGENT; E PROTEIN; GLYCOPROTEIN E; GNF 2; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN; E-GLYCOPROTEIN, DENGUE VIRUS TYPE 1; E-GLYCOPROTEIN, DENGUE VIRUS TYPE 2; E-GLYCOPROTEIN, DENGUE VIRUS TYPE 3; GLYCOPROTEIN E, DENGUE VIRUS TYPE 4; GNF-2 COMPOUND; PROTEIN KINASE INHIBITOR; VIRUS ENVELOPE PROTEIN;

ALLOSTERISM; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; IC50; IC90; MOUSE; NONHUMAN; PROTEIN CONFORMATION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; VIRION; VIRUS ENTRY; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; NIH 3T3 CELL LINE;

ANIMALS; ANTIVIRAL AGENTS; DENGUE VIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NIH 3T3 CELLS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL ENVELOPE PROTEINS;

EID: 84965074941     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.03.010     Document Type: Article

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