Effect of Rifampin on the Disposition of Brivaracetam in Human Subjects: Further Insights into Brivaracetam Hydrolysis

Drug Metabolism and Disposition

Volumn 44, Issue 6, 2016, Pages 792-799

  Stockis, Armel ^a   Watanabe, Shikiko ^a   Scheen, André J ^b   Tytgat, Dominique ^a,c   Gerin, Brigitte ^a   Rosa, Maria ^a   Chanteux, Hugues ^a   Nicolas, Jean Marie ^a  

^a University Hospital Center ^*  (Belgium)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; BRIVARACETAM; CYTOCHROME P450 2C19; DRUG METABOLITE; HYDROXYACID; RIFAMPICIN; 2 PYRROLIDONE DERIVATIVE; ANTICONVULSIVE AGENT; TUBERCULOSTATIC AGENT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFECT; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MONOTHERAPY; MORNING DOSAGE; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PLASMA CLEARANCE; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION; ADOLESCENT; DRUG EFFECTS; HYDROLYSIS; HYDROXYLATION; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIBIOTICS, ANTITUBERCULAR; ANTICONVULSANTS; AREA UNDER CURVE; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP2C19; HEALTHY VOLUNTEERS; HUMANS; HYDROLYSIS; HYDROXY ACIDS; HYDROXYLATION; MALE; MIDDLE AGED; PYRROLIDINONES; RIFAMPIN; YOUNG ADULT;

EID: 84965071430     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.069161     Document Type: Article

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