Characterization of recombinant human carboxylesterases: Fluorescein diacetate as a probe substrate for human carboxylesterase 2

Drug Metabolism and Disposition

Volumn 39, Issue 8, 2011, Pages 1329-1333

  Wang, Jie ^a   Williams, Eric T ^b   Bourgea, Joanne ^a   Wong, Y Nancy ^b   Patten, Christopher J ^a  

^a BD Biosciences   (United States)

^b EISAI INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENYL ACETATE; ACETIC ACID DERIVATIVE; BIS(4 NITROPHENYL) PHOSPHATE; CARBOXYLESTERASE 1 B; CARBOXYLESTERASE 1 C; CARBOXYLESTERASE 2; FLUORESCEIN DIACETATE; HYDROLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BACULOVIRUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; HYDROLYSIS; IC 50; INSECT CELL; INTESTINE MICROSOME; LIVER MICROSOME; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CELL LINE; FLUORESCEINS; HUMANS; INSECTS; INTESTINE, SMALL; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; TAMOXIFEN;

HEXAPODA;

EID: 79960581304     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.039628     Document Type: Article

References (13)

1. Battin TJ (1997) Assessment of fluorescein diacetate hydrolysis as a measure of total esterase activity in natural stream sediment biofilms. Sci Total Environ 198:51-60.
2. Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, and Potter PM (1999) Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy. Clin Cancer Res 5:917-924. (Pubitemid 29180845)
3. Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, et al. (2005) Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol 352:165-177. (Pubitemid 41207447)
4. Hosokawa M (2008) Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs. Molecules 13:412-431.
5. Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Watanabe N, Tsukada E, Ohhata Y, Kobayashi K, Satoh T, and Chiba K (2008) Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes. Drug Metab Pharmacokinet 23:73-84.
6. Imai T (2006) Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug Metab Pharmacokinet 21:173-185.
7. Imai T, Taketani M, Shii M, Hosokawa M, and Chiba K (2006) Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine. Drug Metab Dispos 34:1734-1741. (Pubitemid 44427476)
8. Li B, Sedlacek M, Manoharan I, Boopathy R, Duysen EG, Masson P, and Lockridge O (2005) Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem Pharmacol 70:1673-1684. (Pubitemid 41540360)
9. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, and Ferrin TE (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.
10. Quinney SK, Sanghani SP, Davis WI, Hurley TD, Sun Z, Murry DJ, and Bosron WF (2005) Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J Pharmacol Exp Ther 313:1011-1016. (Pubitemid 40727004)
11. Tabata T, Katoh M, Tokudome S, Hosakawa M, Chiba K, Nakajima M, and Yokoi T (2004a) Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5′-deoxy-5-fluorocytidine formation. Drug Metab Dispos 32:762-767. (Pubitemid 38821879)
12. Tabata T, Katoh M, Tokudome S, Nakajima M, and Yokoi T (2004b) Identification of the cytosolic carboxylesterase catalyzing the 5′-deoxy-5-fluorocytidine formation from capecitabine in human liver. Drug Metab Dispos 32:1103-1110. (Pubitemid 39287584)
13. Xu G, Zhang W, Ma MK, and McLeod HL (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res 8:2605-2611. (Pubitemid 34856347)