메뉴 건너뛰기




Volumn 100, Issue 3, 2016, Pages 460-468

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs

Author keywords

Breast carcinoma; FOXP3; MRNA expression; Notch; STAT3; Tregs

Indexed keywords

CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; HORMONE RECEPTOR; JAGGED1; MESSENGER RNA; METHOTREXATE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH4 RECEPTOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; NOTCH2 RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN JAGGED 1;

EID: 84965029825     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2016.04.006     Document Type: Article
Times cited : (16)

References (48)
  • 1
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N., et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Sciences 2011, 333:1154-1157.
    • (2011) Sciences , vol.333 , pp. 1154-1157
    • Agrawal, N.1
  • 2
    • 84905186948 scopus 로고    scopus 로고
    • Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients
    • Ali H.R., et al. Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients. Ann. Oncol. 2014, 25:1536-1543.
    • (2014) Ann. Oncol. , vol.25 , pp. 1536-1543
    • Ali, H.R.1
  • 3
    • 10744222828 scopus 로고    scopus 로고
    • Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
    • Anastasi E., et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J. Immunol. 2003, 171:4504-4511.
    • (2003) J. Immunol. , vol.171 , pp. 4504-4511
    • Anastasi, E.1
  • 4
    • 79551649114 scopus 로고    scopus 로고
    • Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
    • Badve S., et al. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod. Pathol. 2011, 24:157-167.
    • (2011) Mod. Pathol. , vol.24 , pp. 157-167
    • Badve, S.1
  • 5
    • 79958058411 scopus 로고    scopus 로고
    • Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription
    • Barbarulo A., et al. Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription. J. Immunol. 2011, 186:6199-6206.
    • (2011) J. Immunol. , vol.186 , pp. 6199-6206
    • Barbarulo, A.1
  • 6
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates G.J., et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J. Clin. Oncol. 2006, 24:5373-5380.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5373-5380
    • Bates, G.J.1
  • 7
    • 0034812349 scopus 로고    scopus 로고
    • A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA- > AAUGAA) leads to the IPEX syndrome
    • Bennett C.L., et al. A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA- > AAUGAA) leads to the IPEX syndrome. Immunogenetics 2001, 53:435-439.
    • (2001) Immunogenetics , vol.53 , pp. 435-439
    • Bennett, C.L.1
  • 8
    • 52949134150 scopus 로고    scopus 로고
    • Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    • Bouras T., et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008, 3:429-441.
    • (2008) Cell Stem Cell , vol.3 , pp. 429-441
    • Bouras, T.1
  • 9
    • 66849140730 scopus 로고    scopus 로고
    • Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer
    • Cheang M.C., et al. Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J. Natl. Cancer Inst. 2009, 101:736-750.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 736-750
    • Cheang, M.C.1
  • 10
    • 84939423024 scopus 로고    scopus 로고
    • Tailoring therapies-improving the management of early breast cancer: St Gallen international expert consensus on the primary therapy of early breast cancer 2015
    • Coates A.S., et al. Tailoring therapies-improving the management of early breast cancer: St Gallen international expert consensus on the primary therapy of early breast cancer 2015. Ann. Oncol. 2015, 26:1533-1546.
    • (2015) Ann. Oncol. , vol.26 , pp. 1533-1546
    • Coates, A.S.1
  • 11
    • 84959528065 scopus 로고    scopus 로고
    • Immunoregulatory forkhead Box protein p3-positive lymphocytes are associated with overall survival in patients with pancreatic neuroendocrine tumors
    • de Reuver P.R., et al. Immunoregulatory forkhead Box protein p3-positive lymphocytes are associated with overall survival in patients with pancreatic neuroendocrine tumors. J. Am. Coll. Surg. 2016, 222:281-287.
    • (2016) J. Am. Coll. Surg. , vol.222 , pp. 281-287
    • de Reuver, P.R.1
  • 13
    • 84925496959 scopus 로고    scopus 로고
    • The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis
    • Engels C.C., et al. The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis. Breast Cancer Res. Treat. 2015, 149:587-596.
    • (2015) Breast Cancer Res. Treat. , vol.149 , pp. 587-596
    • Engels, C.C.1
  • 14
    • 77952316663 scopus 로고    scopus 로고
    • NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
    • Fu Y.P., et al. NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations. Mol. Cancer 2010, 9:113.
    • (2010) Mol. Cancer , vol.9 , pp. 113
    • Fu, Y.P.1
  • 15
    • 84879901369 scopus 로고    scopus 로고
    • Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles
    • Gazinska P., et al. Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles. Mod. Pathol. 2013, 26:955-966.
    • (2013) Mod. Pathol. , vol.26 , pp. 955-966
    • Gazinska, P.1
  • 16
    • 78951481235 scopus 로고    scopus 로고
    • Role of notch and its oncogenic signaling crosstalk in breast cancer
    • Guo S., et al. Role of notch and its oncogenic signaling crosstalk in breast cancer. Biochim. Biophys. Acta 2011, 1815:197-213.
    • (2011) Biochim. Biophys. Acta , vol.1815 , pp. 197-213
    • Guo, S.1
  • 17
    • 78149287242 scopus 로고    scopus 로고
    • American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    • Hammond M.E., et al. American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Oncol Pract. 2010, 6:195-197.
    • (2010) J Oncol Pract. , vol.6 , pp. 195-197
    • Hammond, M.E.1
  • 18
    • 84904295424 scopus 로고    scopus 로고
    • Regulatory T-cell infiltration in tongue squamous cell carcinoma
    • Hanakawa H., et al. Regulatory T-cell infiltration in tongue squamous cell carcinoma. Acta Otolaryngol. 2014, 134:859-864.
    • (2014) Acta Otolaryngol. , vol.134 , pp. 859-864
    • Hanakawa, H.1
  • 19
    • 84945198502 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of FOXP3+ tumor infiltrating lymphocytes in patients with breast cancer: a meta-analysis
    • Jiang D., et al. Clinicopathological and prognostic significance of FOXP3+ tumor infiltrating lymphocytes in patients with breast cancer: a meta-analysis. BMC Cancer 2015, 15:727.
    • (2015) BMC Cancer , vol.15 , pp. 727
    • Jiang, D.1
  • 20
    • 2942709503 scopus 로고    scopus 로고
    • Hes binding to STAT3 mediates crosstalk between notch and JAK-STAT signalling
    • Kamakura S., et al. Hes binding to STAT3 mediates crosstalk between notch and JAK-STAT signalling. Nat. Cell Biol. 2004, 6:547-554.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 547-554
    • Kamakura, S.1
  • 21
    • 84878756332 scopus 로고    scopus 로고
    • FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast
    • Lal A., et al. FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast. Breast Cancer Res. Treat. 2013, 139:381-390.
    • (2013) Breast Cancer Res. Treat. , vol.139 , pp. 381-390
    • Lal, A.1
  • 22
    • 84871445958 scopus 로고    scopus 로고
    • Prognostic impact of FOXP3 expression in triple-negative breast cancer
    • Lee S., et al. Prognostic impact of FOXP3 expression in triple-negative breast cancer. Acta Oncol. 2013, 52:73-81.
    • (2013) Acta Oncol. , vol.52 , pp. 73-81
    • Lee, S.1
  • 23
    • 85027940310 scopus 로고    scopus 로고
    • CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes
    • Liu F., et al. CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res. Treat. 2011, 130:645-655.
    • (2011) Breast Cancer Res. Treat. , vol.130 , pp. 645-655
    • Liu, F.1
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 84944883024 scopus 로고    scopus 로고
    • Promises and paradoxes of regulatory T cells in inflammatory bowel disease
    • Lord J.D. Promises and paradoxes of regulatory T cells in inflammatory bowel disease. World J. Gastroenterol. 2015, 21:11236-11245.
    • (2015) World J. Gastroenterol. , vol.21 , pp. 11236-11245
    • Lord, J.D.1
  • 26
    • 79954815112 scopus 로고    scopus 로고
    • An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer
    • Mahmoud S.M., et al. An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer. Breast Cancer Res. Treat. 2011, 127:99-108.
    • (2011) Breast Cancer Res. Treat. , vol.127 , pp. 99-108
    • Mahmoud, S.M.1
  • 27
    • 77954952444 scopus 로고    scopus 로고
    • Human FOXP3 and cancer
    • Martin F., et al. Human FOXP3 and cancer. Oncogene 2010, 29:4121-4129.
    • (2010) Oncogene , vol.29 , pp. 4121-4129
    • Martin, F.1
  • 28
    • 33750310901 scopus 로고    scopus 로고
    • REporting recommendations for tumor MARKer prognostic studies (REMARK)
    • McShane L.M., et al. REporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res. Treat. 2006, 100:229-235.
    • (2006) Breast Cancer Res. Treat. , vol.100 , pp. 229-235
    • McShane, L.M.1
  • 29
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'Shea J.J., et al. JAKs and STATs in immunity, immunodeficiency, and cancer. N. Engl. J. Med. 2013, 368:161-170.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 161-170
    • O'Shea, J.J.1
  • 30
    • 58049180417 scopus 로고    scopus 로고
    • Notch signaling regulates the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms
    • Ou-Yang H.F., et al. Notch signaling regulates the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms. Mol. Cell. Biochem. 2009, 320:109-114.
    • (2009) Mol. Cell. Biochem. , vol.320 , pp. 109-114
    • Ou-Yang, H.F.1
  • 31
    • 14244269366 scopus 로고    scopus 로고
    • The possible correlation of notch-1 and notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    • Parr C., et al. The possible correlation of notch-1 and notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med. 2004, 14:779-786.
    • (2004) Int J Mol Med. , vol.14 , pp. 779-786
    • Parr, C.1
  • 32
    • 79551643709 scopus 로고    scopus 로고
    • Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma
    • Peiro G., et al. Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. Mod. Pathol. 2011, 24:201-208.
    • (2011) Mod. Pathol. , vol.24 , pp. 201-208
    • Peiro, G.1
  • 33
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou C.M., et al. Molecular portraits of human breast tumours. Nature 2000, 406:747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 34
    • 84921973696 scopus 로고    scopus 로고
    • A new tumor suppressor role for the notch pathway in bladder cancer
    • Rampias T., et al. A new tumor suppressor role for the notch pathway in bladder cancer. Nat. Med. 2014, 20:1199-1205.
    • (2014) Nat. Med. , vol.20 , pp. 1199-1205
    • Rampias, T.1
  • 35
    • 79955479783 scopus 로고    scopus 로고
    • The dual role of the X-linked FoxP3 gene in human cancers
    • Redpath M., et al. The dual role of the X-linked FoxP3 gene in human cancers. Mol Oncol. 2011, 5:156-163.
    • (2011) Mol Oncol. , vol.5 , pp. 156-163
    • Redpath, M.1
  • 36
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M., et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005, 65:8530-8537.
    • (2005) Cancer Res. , vol.65 , pp. 8530-8537
    • Reedijk, M.1
  • 37
    • 52949153986 scopus 로고    scopus 로고
    • Using notches to track mammary epithelial cell homeostasis
    • Robinson G.W. Using notches to track mammary epithelial cell homeostasis. Cell Stem Cell 2008, 3:359-360.
    • (2008) Cell Stem Cell , vol.3 , pp. 359-360
    • Robinson, G.W.1
  • 38
    • 84954400636 scopus 로고    scopus 로고
    • Cancer statistics, 2016
    • Siegel R.L., et al. Cancer statistics, 2016. CA Cancer J Clin. 2016, 66:7-30.
    • (2016) CA Cancer J Clin. , vol.66 , pp. 7-30
    • Siegel, R.L.1
  • 39
    • 84860760469 scopus 로고    scopus 로고
    • Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
    • Sonnenblick A., et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin Transl Oncol. 2012, 14:232-236.
    • (2012) Clin Transl Oncol. , vol.14 , pp. 232-236
    • Sonnenblick, A.1
  • 40
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, notch, and hedgehog pathways
    • Takebe N., et al. Targeting cancer stem cells by inhibiting Wnt, notch, and hedgehog pathways. Nat Rev Clin Oncol. 2011, 8:97-106.
    • (2011) Nat Rev Clin Oncol. , vol.8 , pp. 97-106
    • Takebe, N.1
  • 41
    • 80055092549 scopus 로고    scopus 로고
    • Loss-of-function mutations in notch receptors in cutaneous and lung squamous cell carcinoma
    • Wang N.J., et al. Loss-of-function mutations in notch receptors in cutaneous and lung squamous cell carcinoma. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:17761-17766.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 17761-17766
    • Wang, N.J.1
  • 42
    • 84955608746 scopus 로고    scopus 로고
    • Development and function of Foxp3(+) regulatory T cells
    • Wang Y.M., et al. Development and function of Foxp3(+) regulatory T cells. Nephrology (Carlton) 2016, 21:81-85.
    • (2016) Nephrology (Carlton) , vol.21 , pp. 81-85
    • Wang, Y.M.1
  • 43
    • 84890254448 scopus 로고    scopus 로고
    • Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update
    • Wolff A.C., et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J. Clin. Oncol. 2013, 31:3997-4013.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3997-4013
    • Wolff, A.C.1
  • 44
    • 80051754747 scopus 로고    scopus 로고
    • Notch-1 and notch-4 receptors as prognostic markers in breast cancer
    • Yao K., et al. Notch-1 and notch-4 receptors as prognostic markers in breast cancer. Int. J. Surg. Pathol. 2011, 19:607-613.
    • (2011) Int. J. Surg. Pathol. , vol.19 , pp. 607-613
    • Yao, K.1
  • 45
    • 80054849069 scopus 로고    scopus 로고
    • Clinicopathological significance of altered notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma
    • Yoon H.A., et al. Clinicopathological significance of altered notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma. World J. Gastroenterol. 2011, 17:4023-4030.
    • (2011) World J. Gastroenterol. , vol.17 , pp. 4023-4030
    • Yoon, H.A.1
  • 46
    • 84906326797 scopus 로고    scopus 로고
    • Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients
    • Zahran A.M., et al. Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients. Int. J. Clin. Oncol. 2014, 19:753-760.
    • (2014) Int. J. Clin. Oncol. , vol.19 , pp. 753-760
    • Zahran, A.M.1
  • 47
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4 + CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn E., et al. IL-2 regulates FOXP3 expression in human CD4 + CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006, 108:1571-1579.
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1
  • 48
    • 34250863911 scopus 로고    scopus 로고
    • FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    • Zuo T., et al. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 2007, 129:1275-1286.
    • (2007) Cell , vol.129 , pp. 1275-1286
    • Zuo, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.