Developmental expression of STATs, nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning

International Immunopharmacology

Volumn 36, Issue , 2016, Pages 199-204

  Yi, Hongbo ^a   Jiang, Denghu ^a   Zhang, Lin ^a   Xiong, Haitao ^a   Han, Feifei ^a   Wang, Yizhen ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Inflammation; Jejunum; Nuclear factor B; Piglet; STATs; Weaning

Indexed keywords

ARGINASE 1; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 22; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN KINASE B; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ARGINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; JEJUNUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WEANING; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PIG;

ANIMALS; ARGINASE; CELL LINE; CYTOKINES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INFLAMMATION; INTESTINAL MUCOSA; JEJUNUM; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; SWINE; WEANING;

EID: 84965010157     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2016.04.032     Document Type: Article

References (36)

1. S.B. Bradfute, K.S. Stuthman, A.C. Shurtleff, and S. Bavari A STAT-1 knockout mouse model for Machupo virus pathogenesis Virol. J. 8 2011 300
2. Y. Yu, R. Wang, Y.C. Nan, L.S. Zhang, and Y.J. Zhang Induction of STAT1 phosphorylation at serine 727 and expression of proinflammatory cytokines by porcine reproductive and respiratory syndrome virus PLoS ONE 8 4 2013 e61967
3. S. Mahalingam, and B.A. Lidbury Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-kappa B) complexes by anti body-dependent enhancement of macrophage infection by Ross River virus Proc. Natl. Acad. Sci. U. S. A. 99 2002 13819 13824
4. H. Yu, D. Pardoll, and R. Jove STATs in cancer inflammation and immunity: a leading role for STAT3 Nat. Rev. Cancer 9 2009 798 809
5. J.X. Xu, C.C. Xu, X.L. Chen, X. Cai, S.F. Yang, Y.S. Sheng, and et al. Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets Nutrition 30 2014 584 589
6. S. Amatya, D. Rastogi, and A. Bhutada Weaning of nasal CPAP in preterm infants: who, when and how? a systematic review of the literature World J. Pediatr. 11 2015 7 13
7. X.H. Gu, D.F. Li, and R.P. She Effect of weaning on small intestinal structure and function in the piglet Arch. Anim. Nutr. Arch. Tierernahr. 56 2002 275 286
8. A.J. Moeser, C. Vander Klok, K.A. Ryan, J.G. Wooten, D. Little, V.L. Cook, and et al. Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 (G173-G81)
9. F. Smith, J.E. Clark, B.L. Overman, C.C. Tozel, J.H. Huang, J.E.F. Rivier, and et al. Early weaning stress impairs development of mucosal barrier function in the porcine intestine Am. J. Physiol. Gastrointest. Liver Physiol. 298 2010 (G352-G63)
10. H. Wang, C. Zhang, G.Y. Wu, Y.L. Sun, B. Wang, B.B. He, and et al. Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of wean ling piglets J. Nutr. 145 2015 25 31
11. C.H. Hu, Z.H. Song, K. Xiao, J. Song, L.F. Jiao, and Y.L. Ke Zinc oxide influences intestinal integrity, the expressions of genes associated with inflammation and TLR4-myeloid differentiation factor 88 signaling pathways in weanling pigs Innate Immun. Lond. 20 2014 478 486
12. B.A. McCracken, M.E. Spurlock, M.A. Roos, F.A. Zuckermann, and H.R. Gaskins Weaning anorexia may contribute to local inflammation in the piglet small intestine J. Nutr. 129 1999 613 619
13. J.P. Lalles, P. Bosi, H. Smidt, and C.R. Stokes Weaning - a challenge to gut physiologists Livest. Sci. 108 2007 82 93
14. C.H. Hu, K. Xiao, Z.S. Luan, and J. Song Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs J. Anim. Sci. 91 2013 1094 1101
15. J. Yin, M.M. Wu, H. Xiao, W.K. Ren, J.L. Duan, G. Yang, and et al. Development of an antioxidant system after early weaning in piglets J. Anim. Sci. 92 2014 612 619
16. Y. Gao, F. Han, X. Huang, Y. Rong, H. Yi, and Y. Wang Changes in gut microbial populations, intestinal morphology, expression of tight junction proteins, and cytokine production between two pig breeds after challenge with Escherichia coli K88: a comparative study J. Anim. Sci. 91 2013 5614 5625
17. H.Y.C. Yi, H. Zhang, D. Song, D. Jiang, H. Du, and Y. Wang Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets Int. Immunopharmacol. 28 2015 61 69
18. M. Iimura, R.L. Gallo, K. Hase, Y. Miyamoto, L. Eckmann, and M.F. Kagnoff Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens J. Immunol. 174 2005 4901 4907
19. X. Zhong, X.H. Zhang, X.M. Li, Y.M. Zhou, W. Li, X.X. Huang, and et al. Intestinal growth and morphology is associated with the increase in heat shock protein 70 expression in weaning piglets through supplementation with glutamine J. Anim. Sci. 89 2011 3634 3642
20. H.L. Wright, R.J. Moots, R.C. Bucknall, and S.W. Edwards Neutrophil function in inflammation and inflammatory diseases Rheumatology 49 2010 1618 1631
21. H.W. Zhang, X. Xia, F.F. Han, Q. Jiang, Y.L. Rong, D.G. Song, and et al. Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis Mol. Pharm. 12 2015 1648 1661
22. A. O'Loughlin, D.J. Lynn, M. Mcgee, S. Doyle, M. McCabe, and B. Earley Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology BMC Genomics 13 2012 250
23. B.L. McLamb, A.J. Gibson, E.L. Overman, C. Stahl, and A.J. Moeser Early weaning stress in pigs impairs innate mucosal immune responses to enterotoxigenic E. coli challenge and exacerbates intestinal injury and clinical disease PLoS One 8 2013 e59838
24. P. Ondrackova, P. Alexa, J. Matiasovic, J. Volf, and M. Faldyna Interaction of porcine neutrophils with different strains of enterotoxigenic Escherichia coli Vet. Microbiol. 160 2012 108 116
25. S. Pie, J.P. Lalles, F. Blazy, J. Laffitte, B. Seve, and I.P. Oswald Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets J. Nutr. 134 2004 641 647
26. F. Fuchs, J. Damm, R. Gerstberger, J. Roth, and C. Rummel Activation of the inflammatory transcription factor nuclear factor interleukin-6 during inflammatory and psychological stress in the brain J. Neuroinflammation 10 2013 140
27. M. Niehof, K. Streetz, T. Rakemann, S.C. Bischoff, M.P. Manns, F. Horn, and et al. Interleukin-6-induced tethering of STAT3 to the LAP/C/EBP beta promoter suggests a new mechanism of transcriptional regulation by STAT3 J. Biol. Chem. 276 2001 9016 9027
28. C. Cappello, A. Zwergal, S. Kanclerski, S.C. Haas, J.D. Kandemir, R. Huber, and et al. C/EBP beta enhances NF-kappa B-associated signalling by reducing the level of I kappa B-alpha Cell. Signal. 21 2009 1918 1924
29. G. Pickert, C. Neufert, M. Leppkes, Y. Zheng, N. Wittkopf, M. Warntjen, and et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing J. Exp. Med. 206 2009 1465 1472
30. X.B. Liu, Y.S. Lee, C.R. Yu, and C.E. Egwuagu Loss of STAT3 in CD4(+) T cells prevents development of experimental autoimmune diseases J. Immunol. 180 2008 6070 6076
31. J. Raymond, S. Bradfute, and M. Bray Filovirus infection of STAT-1 knockout mice J. Infect. Dis. 204 Suppl. 3 2011 S986 S990
32. J.J. Lee, D. Kim, K.H. Pyo, M.K. Kim, H.J. Kim, J.Y. Chai, and et al. STAT6 expression and IL-13 production in association with goblet cell hyperplasia and worm expulsion of Gymnophalloides seoi from C57BL/6 mice Korean J. Parasitol. 51 2013 589 594
33. J.L. Martinez Antibiotics and antibiotic resistance genes in natural environments Science 321 2008 365 367
34. N. Van Panhuys, M. Camberis, M. Yamada, T. Tegoshi, N. Arizono, and G. Le Gros Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6 Parasitology 140 2013 833 843
35. E.M. Einterz, and M.E. Bates Early-childhood feeding practices in Northern Cameroon Trans. R. Soc. Trop. Med. Hyg. 88 1994 575 576
36. W.C. Hung, and L.Y. Chuang Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha Br. J. Cancer 80 1999 705 710