Induction of STAT1 Phosphorylation at Serine 727 and Expression of Proinflammatory Cytokines by Porcine Reproductive and Respiratory Syndrome Virus

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Yu, Ying ^a,b   Wang, Rong ^b   Nan, Yuchen ^b   Zhang, Linsheng ^a   Zhang, Yanjin ^b  

^a NORTHWEST A F UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 8; METHYLTRANSFERASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTRUCTURAL PROTEIN 12; SERINE; STAT1 PROTEIN; TYROSINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTERIVIRUS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS STRAIN;

ANIMALS; CELL LINE; CYTOKINES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; MACROPHAGES, ALVEOLAR; METHYLTRANSFERASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SERINE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SWINE; VIRAL PROTEINS;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 84876551933     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061967     Document Type: Article

References (39)

1. Neumann EJ, Kliebenstein JB, Johnson CD, Mabry JW, Bush EJ, et al. (2005) Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc 227: 385-392.
2. An TQ, Tian ZJ, Leng CL, Peng JM, Tong GZ, (2011) Highly pathogenic porcine reproductive and respiratory syndrome virus, Asia. Emerg Infect Dis 17: 1782-1784.
3. Tian K, Yu X, Zhao T, Feng Y, Cao Z, et al. (2007) Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2: e526.
4. Faaberg KS, Balasuriya UB, Brinton MA, Gorbalenya AE, Leung FC-C, et al. (2011) Family Arteriviridae. In: King AMQ, editor. Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses. London: Elsevier Academic Press.
5. Snijder EJ, Meulenberg JJ, (1998) The molecular biology of arteriviruses. J Gen Virol 79 (Pt 5): 961-979.
6. den Boon JA, Faaberg KS, Meulenberg JJ, Wassenaar AL, Plagemann PG, et al. (1995) Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases. J Virol 69: 4500-4505.
7. Wu WH, Fang Y, Farwell R, Steffen-Bien M, Rowland RR, et al. (2001) A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology 287: 183-191.
8. Meulenberg JJ, Petersen-den Besten A, De Kluyver EP, Moormann RJ, Schaaper WM, et al. (1995) Characterization of proteins encoded by ORFs 2 to 7 of Lelystad virus. Virology 206: 155-163.
9. Bautista EM, Meulenberg JJ, Choi CS, Molitor TW, (1996) Structural polypeptides of the American (VR-2332) strain of porcine reproductive and respiratory syndrome virus. Arch Virol 141: 1357-1365.
10. Firth AE, Zevenhoven-Dobbe JC, Wills NM, Go YY, Balasuriya UB, et al. (2011) Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. J Gen Virol 92: 1097-1106.
11. Kim HS, Kwang J, Yoon IJ, Joo HS, Frey ML, (1993) Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line. Archives of Virology 133: 477-483.
12. Rossow KD, Collins JE, Goyal SM, Nelson EA, Christopher Hennings J, et al. (1995) Pathogenesis of porcine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Vet Pathol 32: 361-373.
13. Van Reeth K, Labarque G, Nauwynck H, Pensaert M, (1999) Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res Vet Sci 67: 47-52.
14. van Reeth K, Nauwynck H, (2000) Proinflammatory cytokines and viral respiratory disease in pigs. Vet Res 31: 187-213.
15. Miguel JC, Chen J, Van Alstine WG, Johnson RW, (2010) Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 135: 314-319.
16. Gomez-Laguna J, Salguero FJ, Barranco I, Pallares FJ, Rodriguez-Gomez IM, et al. (2010) Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus. J Comp Pathol 142: 51-60.
17. Lunney JK, Fritz ER, Reecy JM, Kuhar D, Prucnal E, et al. (2010) Interleukin-8, interleukin-1beta, and interferon-gamma levels are linked to PRRS virus clearance. Viral Immunol 23: 127-134.
18. Durbin JE, Hackenmiller R, Simon MC, Levy DE, (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450.
19. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, et al. (1996) Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84: 431-442.
20. Wen Z, Zhong Z, Darnell JE Jr, (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
21. Kovarik P, Stoiber D, Eyers PA, Menghini R, Neininger A, et al. (1999) Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc Natl Acad Sci U S A 96: 13956-13961.
22. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, et al. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364: 229-233.
23. Darnell JE Jr, Kerr IM, Stark GR, (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421.
24. Hevia H, Varela-Rey M, Corrales FJ, Berasain C, Martinez-Chantar ML, et al. (2004) 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes. Hepatology 39: 1088-1098.
25. Mowen KA, Tang J, Zhu W, Schurter BT, Shuai K, et al. (2001) Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 104: 731-741.
26. Patel D, Nan Y, Shen M, Ritthipichai K, Zhu X, et al. (2010) Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J Virol 84: 11045-11055.
27. Ramsauer K, Sadzak I, Porras A, Pilz A, Nebreda AR, et al. (2002) p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc Natl Acad Sci U S A 99: 12859-12864.
28. Kunkel SL, Standiford T, Kasahara K, Strieter RM, (1991) Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp Lung Res 17: 17-23.
29. Stawowczyk M, Van Scoy S, Kumar KP, Reich NC, (2011) The interferon stimulated gene 54 promotes apoptosis. J Biol Chem 286: 7257-7266.
30. Moreno B, Fernandez-Diez B, Di Penta A, Villoslada P, (2010) Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis. Mult Scler 16: 1102-1108.
31. Patel D, Stein DA, Zhang YJ, (2009) Morpholino oligomer-mediated protection of porcine pulmonary alveolar macrophages from arterivirus-induced cell death. Antivir Ther 14: 899-909.
32. Opriessnig T, Patel D, Wang R, Halbur PG, Meng XJ, et al. (2011) Inhibition of porcine reproductive and respiratory syndrome virus infection in piglets by a peptide-conjugated morpholino oligomer. Antiviral Res 91: 36-42.
33. Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, et al. (2003) IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett 86: 123-129.
34. Hou J, Wang L, Quan R, Fu Y, Zhang H, et al. (2012) Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus. Virol J 9: 165.
35. Song S, Bi J, Wang D, Fang L, Zhang L, et al. (2013) Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-kappaB and p38 MAPK pathways in porcine alveolar macrophages. Dev Comp Immunol 39: 265-272.
36. Lusso P, (2000) Chemokines and viruses: the dearest enemies. Virology 273: 228-240.
37. Patel D, Opriessnig T, Stein DA, Halbur PG, Meng XJ, et al. (2008) Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication. Antiviral Res 77: 95-107.
38. Nan Y, Wang R, Shen M, Faaberg KS, Samal SK, et al. (2012) Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate. Virology 432: 261-270.
39. Zhang YJ, Wang KY, Stein DA, Patel D, Watkins R, et al. (2007) Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. Antiviral Res 73: 12-23.