Zinc oxide influences intestinal integrity, the expressions of genes associated with inflammation and TLR4-myeloid differentiation factor 88 signaling pathways in weanling pigs

Innate Immunity

Volumn 20, Issue 5, 2014, Pages 478-486

  Hu, Cai Hong ^a   Song, Ze He ^a   Xiao, Kan ^a   Song, Juan ^a   Jiao, Le Fei ^a   Ke, Ya Lu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Intestinal integrity; myeloid differentiation factor 88; nucleotide binding oligomerization domain protein; Toll like receptor 4; weanling pig; zinc oxide

Indexed keywords

ADAPTOR PROTEIN; AMINE OXIDASE (COPPER CONTAINING); CASPASE 3; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CHEMOKINE; CYTOKINE; ENDOTOXIN; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR INTERACTING SERINE THREONINE PROTEIN KINASE 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ZINC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; GENE EXPRESSION; IMMUNOREGULATION; INFLAMMATION; INTESTINE; INTESTINE INJURY; INTESTINE VILLUS; JEJUNUM MUCOSA; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SWINE; ANIMAL; BIOSYNTHESIS; DIET; DRUG EFFECTS; EATING; GENETICS; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PIG;

ANIMALS; CHEMOKINES; CYTOKINES; DIET; DOWN-REGULATION; EATING; GENE EXPRESSION; INFLAMMATION; INTESTINAL MUCOSA; INTESTINES; MYELOID DIFFERENTIATION FACTOR 88; RNA, MESSENGER; SUS SCROFA; SWINE; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; ZINC OXIDE;

EID: 84902585640     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425913499947     Document Type: Article

References (41)

1. Kim JC, Hansen CF, Mullana BP, et al. Nutrition and pathology of weaner pigs: nutritional strategies to support barrier function in the gastrointestinal tract. Anim Feed Sci Technol. 2012 ; 173: 3-16
2. Smith F, Clark JE, Overman BL, et al. Early weaning stress impairs development of mucosal barrier function in the porcine intestine. Am J Physiol Gastrointest Liver Physiol. 2010 ; 298: G352 - G363
3. Wijtten PJA, Meulen J, Verstegen MWA. Intestinal barrier function and absorption in pigs after weaning: a review. Br J Nutr. 2011 ; 105: 967-981
4. Hu CH, Xiao K, Luan ZS, et al. Early weaning increases intestinal permeability, alters expression of cytokine and tight junction protein, and activates mitogen-activated protein kinases in pigs. J Anim Sci. 2013 ; 91: 1094-1101
5. van Beers-Schreurs HMG, Vellenga L, Wensing TH, et al. The pathogenesis of the post-weaning syndrome in weaned piglets, a review. Veterinary Quarterly. 1992 ; 14: 29-34
6. Li Q, Liu Y, Che Z. Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs. Innate Immun. 2012 ; 18: 804-814
7. McCracken BA, Spurlock ME, Roos MA, et al. Weaning anorexia may contribute to local inflammation in the piglet small intestine. J Nutr. 1999 ; 129: 613-619
8. Pié S, Lallès JP, Blazy F, et al. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr. 2004 ; 134: 641-647
9. Hu CH, Song J, Li YL, et al. Diosmectite-ZnO composite improves intestinal barrier function, modulates expression of proinflammatory cytokines and tight junction protein in early weaned pigs. Br J Nutr. :
10. Hu CH, Xiao K, Song J, et al. Effects of ZnO supported on zeolite on growth performance, intestinal microflora and permeability, and cytokines expression of weaned pigs. Anim Feed Sci Tech. 2013 ; 181: 65-71
11. Hu CH, Song J, You ZT, et al. Zinc oxide-montmorillonite hybrid influences diarrhea, intestinal mucosal integrity and digestive enzyme activity in weaned pigs. Biol Trace Elem Res. 2012 ; 149: 190-196
12. Roselli M, Finamore A, Garaguso I, et al. Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli. J Nutr. 2003 ; 133: 4077-4082
13. Hu CH, Gu LY, Luan ZS, et al. Effects of montmorillonite-zinc oxide hybrid on performance, diarrhea, intestinal permeability and morphology of weanling pigs. Anim Feed Sci Tech. 2012 ; 177: 108-115
14. Sargeant HR, McDowall KJ, Miller HM, et al. Dietary zinc oxide affects the expression of genes associated with inflammation: transcriptome analysis. Vet Immunol Immunop. 2010 ; 137: 120-129
15. Magalhaes JG, Tattoli I, Girardin SE. The intestinal epithelial barrier: How to distinguish between the microbial flora and pathogens. Semin Immunol. 2007 ; 19: 106-115
16. Nutrient requirements of swine. 10 th ed. Washington, DC: National Academic Press, 1998. Washington, DC: National Academic Press ; 1998 :
17. Hagman R, Kindahl H, Lagerstedt AS. Pyometra in bitches induces elevated plasma endotoxin and prostaglandin f2α metabolite levels. Acta Vet Scand. 2006 ; 47: 55-68
18. Liu Y, Chen F, Odle J, et al. Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. J Nutr. 2012 ; 142: 2017-2024
19. Chen Y, Chen DW, Tian G, et al. Dietary arginine supplementation alleviates immune challenge induced by Salmonella enterica serovar Choleraesuis bacterin potentially through the Toll-like receptor 4-myeloid differentiation factor 88 signalling pathway in weaned piglets. Br J Nutr. 2012 ; 108: 1069-1076
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2-ΔΔCt method. Methods. 2001 ; 25: 402-408
21. Institute Inc. SAS/STAT user's guide, Version 8.1. Cary, NC: SAS Institute ; 2000 :
22. Barnett KL, Kornegay ET, Risley CR, et al. Characterization of creep feed consumption and its subsequent effects on immune response, scouring index and performance of weanling pigs. J Anim Sci. 1989 ; 67: 2698-2708
23. Wolvekamp MCJ, de Bruin RWF. Diamine oxidase: an overview of historical, biochemical and functional aspects. Digest Dis. 1994 ; 12: 2-14
24. Vazquez E, Gil A, Garcia-Olivares E, et al. Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice. Cytokine. 2000 ; 12: 1267-1270
25. Manzano M, Abadia-Molina AC, Garcia-Olivares E, et al. Absolute counts and distribution of lymphocyte subsets in small intestine of BALB/c mice change during weaning. J Nutr. 2002 ; 132: 2757-2762
26. Mengheri E, Ciapponi L, Vignolini F, et al. Cytokine gene expression in intestine of rat during the postnatal developmental period: increased IL-1 expression at weaning. Life Sci. 1996 ; 59: 1227-1236
27. Al-Sadi R, Boivin M, Ma T. Mechanism of cytokine modulation of epithelial tight junction barrier. Front Biosci. 2009 ; 14: 2765-2778
28. Youakim A, Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol. 1999 ; 276: G1279 - G1288
29. Ma TY, Boivin MA, Ye D, et al. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol. 2005 ; 288: G422 - G430
30. Sargeant HR, Miller HM, Shaw MA. Inflammatory response of porcine epithelial IPEC J2 cells to enterotoxigenic E. coli infection is modulated by zinc supplementation. Mol Immunol. 2011 ; 48: 2113-2121
31. Moeser AJ, Ryan KA, Knighot PK, et al. Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol. 2007 ; 293: G413 - G421
32. Zhu HL, Liu YL, Xie XL, et al. Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge. Innate Immun. 2013 ; 19: 242-252
33. Ou DY, Li DF, Cao YH, et al. Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs. J Nutr Biochem. 2007 ; 18: 820-826
34. Chen F, Liu Y, Zhu H, et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. Innate Immun. :
35. Laird MHW, Rhee SH, Perkins DJ, et al. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukocyte Biol. 2009 ; 85: 966-977
36. Juul-Madse HR, Jensen KH, Nielsen J, et al. Ontogeny and characterization of blood leukocyte subsets and serum proteins in piglets before and after weaning. Vet Immunol Immunop. 2010 ; 133: 95-108
37. Castillo M, Martín-Orúe SM, Nofrarías M, et al. Changes in caecal microbiota and mucosal morphology of weaned pigs. Vet Microbiol. 2007 ; 124: 239-247
38. Su Y, Yao W, Perez-Gutierrez ON, et al. 16S ribosomal RNA-based methods to monitor changes in the hindgut bacterial community of piglets after oral administration of Lactobacillus sobrius S1. Anaerobe. 2008 ; 14: 78-86
39. David JC, Grongnet JF, Lalles JP. Weaning affects the expression of heat shock proteins in different regions of the gastrointestinal tract of piglets. J Nutr. 2002 ; 132: 2551-2561
40. Klosterhalfen B, Töns C, Hauptmann S, et al. Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(dl-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. Biochem Pharmacol. 1996 ; 52: 1201-1210
41. Van Molle W, Van Roy M, Van Bogaert T, et al. Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy. Cancer Res. 2007 ; 67: 7301-7307