Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15

Journal of Biological Chemistry

Volumn 283, Issue 6, 2008, Pages 3655-3664

  Bhardwaj, Kanchan ^a   Palaninathan, Satheesh ^a   Alcantara, Joanna Maria Ortiz ^a   Yi, Lillian Li ^a   Guarino, Linda ^a   Sacchettini, James C ^a   Kao, C Cheng ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; FLOW INTERACTIONS; MONOMERS; PLANTS (BOTANY); RNA;

ACTIVE SITE RESIDUES; ACTIVE SITES; AFFINITY PURIFICATIONS; ALANINE SUBSTITUTIONS; BINDING RESIDUES; CORONAVIRUS; ENDONUCLEASE ACTIVITIES; ENDORIBONUCLEASE; HEXAMER; INACTIVE MUTANTS; NONSTRUCTURAL PROTEINS; REVERSIBLE CROSSLINKING; RNA BINDINGS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROMES;

NUCLEIC ACIDS;

ALANINE; CYTIDINE PHOSPHATE; LEUCINE; NONSTRUCTURAL PROTEIN 15; PROLINE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RIBONUCLEASE; SERINE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE; VIRUS PROTEIN; NONSTRUCTURAL PROTEIN 15, SARS CORONOVIRUS; RNA DIRECTED RNA POLYMERASE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA BINDING; SARS CORONAVIRUS; AMINO ACID SEQUENCE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

SARS CORONAVIRUS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINES; RNA REPLICASE; SARS VIRUS; SERINE; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 41249083050     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708375200     Document Type: Article

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