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Volumn 9, Issue 3, 2016, Pages 597-609

Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; TRANSCRIPTION FACTOR GATA 3;

EID: 84964932891     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2015.78     Document Type: Article
Times cited : (24)

References (57)
  • 1
    • 84864345639 scopus 로고    scopus 로고
    • New paradigms in type 2 immunity
    • Pulendran, B. & Artis, D. New paradigms in type 2 immunity. Science 337, 431-435 (2012).
    • (2012) Science , vol.337 , pp. 431-435
    • Pulendran, B.1    Artis, D.2
  • 2
    • 77950350422 scopus 로고    scopus 로고
    • Asthma and allergic inflammation
    • Locksley, R.M. Asthma and allergic inflammation. Cell 140, 777-783 (2010).
    • (2010) Cell , vol.140 , pp. 777-783
    • Locksley, R.M.1
  • 3
    • 0036337768 scopus 로고    scopus 로고
    • IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    • Fallon, P.G. et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17, 7-17 (2002).
    • (2002) Immunity , vol.17 , pp. 7-17
    • Fallon, P.G.1
  • 4
    • 83855163410 scopus 로고    scopus 로고
    • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
    • Liang, H.E., Reinhardt, R.L., Bando, J.K., Sullivan, B.M., Ho, I.C. & Locksley, R.M. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat. Immunol. 13, 58-66 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 58-66
    • Liang, H.E.1    Reinhardt, R.L.2    Bando, J.K.3    Sullivan, B.M.4    Ho, I.C.5    Locksley, R.M.6
  • 5
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grunig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263 (1998).
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grunig, G.1
  • 6
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1
  • 7
    • 0032055579 scopus 로고    scopus 로고
    • A critical role for IL-13 in resistance to intestinal nematode infection
    • Bancroft, A.J., McKenzie, A.N. & Grencis, R.K. A critical role for IL-13 in resistance to intestinal nematode infection. J. Immunol. 160, 3453-3461 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 3453-3461
    • Bancroft, A.J.1    McKenzie, A.N.2    Grencis, R.K.3
  • 8
    • 84886003120 scopus 로고    scopus 로고
    • Role of type 1 natural killer T cells in pulmonary immunity
    • Paget, C. & Trottein, F. Role of type 1 natural killer T cells in pulmonary immunity. Mucosal Immunol. 6, 1054-1067 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 1054-1067
    • Paget, C.1    Trottein, F.2
  • 10
    • 0042090563 scopus 로고    scopus 로고
    • Cutting edge: Invariant Valpha 14 NKTcells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model
    • Lisbonne,M. et al. Cutting edge: invariant Valpha 14 NKTcells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J. Immunol. 171, 1637-1641 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1637-1641
    • Lisbonne, M.1
  • 11
    • 0037911660 scopus 로고    scopus 로고
    • Essential role of NKTcells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    • Akbari, O. et al. Essential role of NKTcells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat. Med. 9, 582-588 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 582-588
    • Akbari, O.1
  • 12
    • 77956219087 scopus 로고    scopus 로고
    • Plasticity of invariant NKTcell regulation of allergic airway disease is dependent on IFN-gamma production
    • Matsuda, H. et al. Plasticity of invariant NKTcell regulation of allergic airway disease is dependent on IFN-gamma production. J. Immunol. 185, 253-262 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 253-262
    • Matsuda, H.1
  • 13
    • 0033588821 scopus 로고    scopus 로고
    • Inhibition of T helper cell type 2 cell differentiation and immunoglobulin e response by ligand-activated Valpha14 natural killer T cells
    • Cui, J. et al. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J. Exp. Med. 190, 783-792 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 783-792
    • Cui, J.1
  • 14
    • 84945482711 scopus 로고    scopus 로고
    • Activation and function of iNKT and MAIT cells
    • Chandra, S. & Kronenberg, M. Activation and function of iNKT and MAIT cells. Adv. Immunol. 127, 145-201 (2015).
    • (2015) Adv. Immunol. , vol.127 , pp. 145-201
    • Chandra, S.1    Kronenberg, M.2
  • 15
    • 78649848463 scopus 로고    scopus 로고
    • Role of NKT cells in allergic asthma
    • Iwamura, C. & Nakayama, T. Role of NKT cells in allergic asthma. Curr. Opin. Immunol. 22, 807-813 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 807-813
    • Iwamura, C.1    Nakayama, T.2
  • 16
    • 77951666611 scopus 로고    scopus 로고
    • Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma
    • Thomas, S.Y., Chyung, Y.H. & Luster, A.D. Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma. J. Allergy Clin. Immunol. 125, 980-984 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.125 , pp. 980-984
    • Thomas, S.Y.1    Chyung, Y.H.2    Luster, A.D.3
  • 17
    • 33644986351 scopus 로고    scopus 로고
    • CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    • Akbari, O. et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N. Engl. J. Med. 354, 1117-1129 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1117-1129
    • Akbari, O.1
  • 18
    • 0141924778 scopus 로고    scopus 로고
    • Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function
    • Stetson, D.B. et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med. 198, 1069-1076 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1069-1076
    • Stetson, D.B.1
  • 19
    • 0037816187 scopus 로고    scopus 로고
    • Mouse v alpha 14i natural killer T cells are resistant to cytokine polarization in vivo
    • Matsuda, J.L. et al. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc. Natl. Acad. Sci. USA 100, 8395-8400 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8395-8400
    • Matsuda, J.L.1
  • 20
    • 34249059942 scopus 로고    scopus 로고
    • Identification of an IL-17-producing NK1. 1(neg) iNKTcell population involved in airway neutrophilia
    • Michel, M.L. et al. Identification of an IL-17-producing NK1.1(neg) iNKTcell population involved in airway neutrophilia. J. Exp. Med. 204, 995-1001 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 995-1001
    • Michel, M.L.1
  • 21
    • 49649123906 scopus 로고    scopus 로고
    • Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1. 1-NKTcell population
    • Coquet, J.M. et al. Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1-NKTcell population. Proc. Natl. Acad. Sci. USA 105, 11287-11292 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 11287-11292
    • Coquet, J.M.1
  • 22
    • 45449103839 scopus 로고    scopus 로고
    • CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system
    • Matsuda, J.L., Mallevaey, T., Scott-Browne, J. & Gapin, L. CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr. Opin. Immunol. 20, 358-368 (2008).
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 358-368
    • Matsuda, J.L.1    Mallevaey, T.2    Scott-Browne, J.3    Gapin, L.4
  • 23
    • 84857488339 scopus 로고    scopus 로고
    • Development and function of invariant natural killer T cells producing T(h)2-and T(h)17-cytokines
    • Watarai, H. et al. Development and function of invariant natural killer T cells producing T(h)2-and T(h)17-cytokines. PLoS Biol. 10, e1001255 (2012).
    • (2012) PLoS Biol. , vol.10 , pp. e1001255
    • Watarai, H.1
  • 24
    • 84886673181 scopus 로고    scopus 로고
    • Steadystate production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
    • Lee, Y.J., Holzapfel, K.L., Zhu, J., Jameson, S.C. & Hogquist, K.A. Steadystate production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat. Immunol. 14, 1146-1154 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1146-1154
    • Lee, Y.J.1    Holzapfel, K.L.2    Zhu, J.3    Jameson, S.C.4    Hogquist, K.A.5
  • 25
    • 84946410024 scopus 로고    scopus 로고
    • The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation
    • Carr, T., Krishnamoorthy, V., Yu, S., Xue, H.H., Kee, B.L. & Verykokakis, M. The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. J. Exp. Med. 212, 793-807 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 793-807
    • Carr, T.1    Krishnamoorthy, V.2    Yu, S.3    Xue, H.H.4    Kee, B.L.5    Verykokakis, M.6
  • 26
    • 0036534537 scopus 로고    scopus 로고
    • A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1. 1(-)CD4(+) CD1d-dependent precursor stage
    • Pellicci, D.G., Hammond, K.J., Uldrich, A.P., Baxter, A.G., Smyth, M.J. & Godfrey, D.I. A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J. Exp. Med. 195, 835-844 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 835-844
    • Pellicci, D.G.1    Hammond, K.J.2    Uldrich, A.P.3    Baxter, A.G.4    Smyth, M.J.5    Godfrey, D.I.6
  • 28
    • 23944464542 scopus 로고    scopus 로고
    • Characterization of the early stages of thymic NKT cell development
    • Benlagha, K., Wei, D.G., Veiga, J., Teyton, L. & Bendelac, A. Characterization of the early stages of thymic NKT cell development. J. Exp. Med. 202, 485-492 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 485-492
    • Benlagha, K.1    Wei, D.G.2    Veiga, J.3    Teyton, L.4    Bendelac, A.5
  • 29
    • 84868333045 scopus 로고    scopus 로고
    • Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion
    • Dickgreber, N. et al. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J. Leukoc. Biol. 92, 999-1009 (2012).
    • (2012) J. Leukoc. Biol. , vol.92 , pp. 999-1009
    • Dickgreber, N.1
  • 30
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price, A.E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA 107, 11489-11494 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11489-11494
    • Price, A.E.1
  • 31
    • 0034877815 scopus 로고    scopus 로고
    • Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    • Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R.M. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303-311 (2001).
    • (2001) Immunity , vol.15 , pp. 303-311
    • Mohrs, M.1    Shinkai, K.2    Mohrs, K.3    Locksley, R.M.4
  • 32
    • 26644448473 scopus 로고    scopus 로고
    • A two-step process for cytokine production revealed by IL-4 dual-reporter mice
    • Mohrs, K., Wakil, A.E., Killeen, N., Locksley, R.M. & Mohrs, M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 23, 419-429 (2005).
    • (2005) Immunity , vol.23 , pp. 419-429
    • Mohrs, K.1    Wakil, A.E.2    Killeen, N.3    Locksley, R.M.4    Mohrs, M.5
  • 33
    • 79952238671 scopus 로고    scopus 로고
    • Particulate allergens potentiate allergic asthma inmice through sustained IgE-mediated mast cell activation
    • Jin,C. et al. Particulate allergens potentiate allergic asthma inmice through sustained IgE-mediated mast cell activation. J. Clin. Invest. 121, 941-955 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 941-955
    • Jin, C.1
  • 34
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W. et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12, 27-37 (2000).
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1
  • 35
    • 33845386442 scopus 로고    scopus 로고
    • Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent Tcell activation and T helper 2 cell-mediated inflammation
    • Oliver, P.M. et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent Tcell activation and T helper 2 cell-mediated inflammation. Immunity 25, 929-940 (2006).
    • (2006) Immunity , vol.25 , pp. 929-940
    • Oliver, P.M.1
  • 36
    • 23844502969 scopus 로고    scopus 로고
    • Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway
    • Yamashita, M. et al. Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J. Biol. Chem. 280, 29409-29419 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 29409-29419
    • Yamashita, M.1
  • 37
    • 0036197639 scopus 로고    scopus 로고
    • Dysregulation of T lymphocyte function in itchy mice: A role for Itch in TH2 differentiation
    • Fang, D. et al. Dysregulation of T lymphocyte function in itchy mice: A role for Itch in TH2 differentiation. Nat. Immunol. 3, 281-287 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 281-287
    • Fang, D.1
  • 38
    • 84887460706 scopus 로고    scopus 로고
    • Itch expression by Treg cells controls Th2 inflammatory responses
    • Jin, H.S., Park, Y., Elly, C. & Liu, Y.C. Itch expression by Treg cells controls Th2 inflammatory responses. J. Clin. Invest. 123, 4923-4934 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 4923-4934
    • Jin, H.S.1    Park, Y.2    Elly, C.3    Liu, Y.C.4
  • 39
    • 84893766480 scopus 로고    scopus 로고
    • Gata3 drives development of RORgammat+ group 3 innate lymphoid cells
    • Serafini, N. et al. Gata3 drives development of RORgammat+ group 3 innate lymphoid cells. J. Exp. Med. 211, 199-208 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 199-208
    • Serafini, N.1
  • 40
    • 11844280961 scopus 로고    scopus 로고
    • Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    • Gessner, A., Mohrs, K. & Mohrs, M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol. 174, 1063-1072 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 1063-1072
    • Gessner, A.1    Mohrs, K.2    Mohrs, M.3
  • 41
    • 0034616398 scopus 로고    scopus 로고
    • Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
    • Loots, G.G. et al. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288, 136-140 (2000).
    • (2000) Science , vol.288 , pp. 136-140
    • Loots, G.G.1
  • 42
    • 0034665338 scopus 로고    scopus 로고
    • Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns
    • Kelly, B.L. & Locksley, R.M. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J. Immunol. 165, 2982-2986 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 2982-2986
    • Kelly, B.L.1    Locksley, R.M.2
  • 43
    • 0029995279 scopus 로고    scopus 로고
    • Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31
    • Dolganov, G. et al. Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood 87, 3316-3326 (1996).
    • (1996) Blood , vol.87 , pp. 3316-3326
    • Dolganov, G.1
  • 44
    • 0035887640 scopus 로고    scopus 로고
    • The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3
    • Kishikawa, H., Sun, J., Choi, A., Miaw, S.C. & Ho, I.C. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J. Immunol. 167, 4414-4420 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4414-4420
    • Kishikawa, H.1    Sun, J.2    Choi, A.3    Miaw, S.C.4    Ho, I.C.5
  • 45
    • 0032531605 scopus 로고    scopus 로고
    • Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
    • Zhang, D.H., Yang, L. & Ray, A. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J. Immunol. 161, 3817-3821 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 3817-3821
    • Zhang, D.H.1    Yang, L.2    Ray, A.3
  • 46
    • 9244263631 scopus 로고    scopus 로고
    • Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    • Zhu, J. et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat. Immunol. 5, 1157-1165 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 1157-1165
    • Zhu, J.1
  • 47
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    • Mjosberg, J. et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012).
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjosberg, J.1
  • 48
    • 84867769688 scopus 로고    scopus 로고
    • The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    • Hoyler, T. et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37, 634-648 (2012).
    • (2012) Immunity , vol.37 , pp. 634-648
    • Hoyler, T.1
  • 49
    • 30744455998 scopus 로고    scopus 로고
    • Regulation of Th2 cytokine expression in NKT cells: Unconventional use of Stat6, GATA-3, and NFAT2
    • Wang, Z.Y., Kusam, S., Munugalavadla, V., Kapur, R., Brutkiewicz, R.R. & Dent, A.L. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J. Immunol. 176, 880-888 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 880-888
    • Wang, Z.Y.1    Kusam, S.2    Munugalavadla, V.3    Kapur, R.4    Brutkiewicz, R.R.5    Dent, A.L.6
  • 50
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng,W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 51
    • 3042598052 scopus 로고    scopus 로고
    • Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
    • Yamashita, M. et al. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279, 26983-26990 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 26983-26990
    • Yamashita, M.1
  • 52
    • 84879311467 scopus 로고    scopus 로고
    • Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells
    • Klein Wolterink, R.G. et al. Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc.Natl. Acad. Sci.USA110, 10240-10245 (2013).
    • (2013) Proc.Natl. Acad. Sci.USA , vol.110 , pp. 10240-10245
    • Klein Wolterink, R.G.1
  • 53
    • 84884905739 scopus 로고    scopus 로고
    • IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction
    • Barlow, J.L. et al. IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. J. Allergy Clin. Immunol. 132, 933-941 (2013).
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 933-941
    • Barlow, J.L.1
  • 54
    • 84886630206 scopus 로고    scopus 로고
    • IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells
    • Saenz, S.A. et al. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J. Exp. Med. 210, 1823-1837 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1823-1837
    • Saenz, S.A.1
  • 55
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren, J. et al. Lebrikizumab treatment in adults with asthma. N. Engl. J. Med. 365, 1088-1098 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1088-1098
    • Corren, J.1
  • 56
    • 33745036694 scopus 로고    scopus 로고
    • Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic noneosinophil cells of the innate immune system
    • Voehringer, D., Reese, T.A., Huang, X., Shinkai, K. & Locksley, R.M. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic noneosinophil cells of the innate immune system. J. Exp. Med. 203, 1435-1446 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1435-1446
    • Voehringer, D.1    Reese, T.A.2    Huang, X.3    Shinkai, K.4    Locksley, R.M.5
  • 57
    • 84886680488 scopus 로고    scopus 로고
    • GATA-3 regulates the self-renewal of long-term hematopoietic stem cells
    • Frelin, C. et al. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nat. Immunol. 14, 1037-1044 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1037-1044
    • Frelin, C.1


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