Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

Biology Open

Volumn 1, Issue 10, 2012, Pages 983-993

  Baumbach, Janina ^a   Levesque, Mitchell P ^b,c   Raff, Jordan W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Centrosome amplification; Centrosome defects; Tumours

Indexed keywords

EID: 84964912874     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20122238     Document Type: Article

References (59)

1. Abramoff, M. D., Magalhães, P. J. and Ram, S. J. (2004). Image processing with Image J. Biophotonics International 11, 36-42.
2. Alkuraya, F. S., Cai, X., Emery, C., Mochida, G. H., Al-Dosari, M. S., Felie, J. M., Hill, R. S., Barry, B. J., Partlow, J. N., Gascon, G. G. et al. (2011). Human mutations in NDE1 cause extreme microcephaly with lissencephaly. Am. J. Hum. Genet. 88, 536-547.
3. Bakircioglu, M., Carvalho, O. P., Khurshid, M., Cox, J. J., Tuysuz, B., Barak, T., Yilmaz, S., Caglayan, O., Dincer, A., Nicholas, A. K. et al. (2011). The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am. J. Hum. Genet. 88, 523-535.
4. Basto, R., Lau, J., Vinogradova, T., Gardiol, A., Woods, C. G., Khodjakov, A. and Raff, J. W. (2006). Flies without centrioles. Cell 125, 1375-1386.
5. Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A. and Raff, J. W. (2008). Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032-1042.
6. Bello, B., Reichert, H. and Hirth, F. (2006). The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development 133, 2639-2648.
7. Benjamini, Y. and Hochberg, Y. (2005). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. A Stat. Soc. 57, 289-300.
8. Betschinger, J., Mechtler, K. and Knoblich, J. A. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124, 1241-1253.
9. Bolstad, B. M., Irizarry, R. A., Astrand, M. and Speed, T. P. (2003). A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193.
10. Bond, J. and Woods, C. G. (2006). Cytoskeletal genes regulating brain size. Curr. Opin. Cell Biol. 18, 95-101.
11. Boveri, T. (2008). Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J. Cell Sci. 121 Suppl 1, 1-84.
12. Carney, T. D., Miller, M. R., Robinson, K. J., Bayraktar, O. A., Osterhout, J. A. and Doe, C. Q. (2012). Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Dev. Biol. 361, 137-146.
13. Castellanos, E., Dominguez, P. and Gonzalez, C. (2008). Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr. Biol. 18, 1209-1214.
14. Caussinus, E. and Gonzalez, C. (2005). Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat. Genet. 37, 1125-1129.
15. Conduit, P. T., Brunk, K., Dobbelaere, J., Dix, C. I., Lucas, E. P. and Raff, J. W. (2010). Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM. Curr. Biol. 20, 2178-2186.
16. Conway, A. E., Lindgren, A., Galic, Z., Pyle, A. D., Wu, H., Zack, J. A., Pelligrini, M., Teitell, M. A. and Clark, A. T. (2009). A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells 27, 18-28.
17. Dennis, G., Jr, Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C. and Lempicki, R. A. (2003). DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3.
18. Doe, C. Q. (2008). Neural stem cells: balancing self-renewal with differentiation. Development 135, 1575-1587.
19. Doxsey, S., Zimmerman, W. and Mikule, K. (2005). Centrosome control of the cell cycle. Trends Cell Biol. 15, 303-311.
20. Ferreiro, I., Joaquin, M., Islam, A., Gomez-Lopez, G., Barragan, M., Lombardía, L., Domínguez, O., Pisano, D. G., Lopez-Bigas, N., Nebreda, A. R. et al. (2010). Whole genome analysis of p38 SAPK-mediated gene expression upon stress. BMC Genomics 11, 144.
21. Ganem, N. J., Godinho, S. A. and Pellman, D. (2009). A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282.
22. Gautier, L., Cope, L., Bolstad, B. M. and Irizarry, R. A. (2004). Affy-analysis of Affymetrix Gene Chip data at the probe level. Bioinformatics 20, 307-315.
23. Gonzalez, C. (2007). Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat. Rev. Genet. 8, 462-472.
24. Gonzalez, C. (2008). Centrosome function during stem cell division: the devil is in the details. Curr. Opin. Cell Biol. 20, 694-698.
25. Han, Z., Yi, P., Li, X. and Olson, E. N. (2006). Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. Development 133, 1175-1182.
26. Hsu, L. C. and White, R. L. (1998). BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. USA 95, 12983-12988.
27. Huang, D.-W., Sherman, B. T. and Lempicki, R. A. (2008). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
28. Janic, A., Mendizabal, L., Llamazares, S., Rossell, D. and Gonzalez, C. (2010). Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 330, 1824-1827.
29. Knoblich, J. A. (2008). Mechanisms of asymmetric stem cell division. Cell 132, 583-597.
30. Knoblich, J. A. (2010). Asymmetric cell division: recent developments and their implications for tumour biology. Nat. Rev. Mol. Cell Biol. 11, 849-860.
31. Lagasse, E. (2008). Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther. 15, 136-142.
32. Lee, C.-Y., Andersen, R. O., Cabernard, C., Manning, L., Tran, K. D., Lanskey, M. J., Bashirullah, A. and Doe, C. Q. (2006a). Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 20, 3464-3474.
33. Lee, C. Y., Wilkinson, B. D., Siegrist, S. E., Wharton, R. P. and Doe, C. Q. (2006b). Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev. Cell 10, 441-449.
34. Lefevre, G. and Jr and Wilkins, M. D. (1966). Cytogenetic studies on the white locus in Drosophila melanogaster. Genetics 53, 175-187.
35. Li, L., Borodyansky, L. and Yang, Y. (2009). Genomic instability en route to and from cancer stem cells. Cell Cycle 8, 1000-1002.
36. Liang, Y., Zhong, Z., Huang, Y., Deng, W., Cao, J., Tsao, G., Liu, Q., Pei, D., Kang, T. and Zeng, Y.-X. (2010). Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. J. Biol. Chem. 285, 4931-4940.
37. Lingle, W. L., Barrett, S. L., Negron, V. C., D'Assoro, A. B., Boeneman, K., Liu, W., Whitehead, C. M., Reynolds, C. and Salisbury, J. L. (2002). Centrosome amplification drives chromosomal instability in breast tumor development. Proc. Natl. Acad. Sci. USA 99, 1978-1983.
38. Livak, K. J. and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25, 402-408.
39. Löffler, H., Bochtler, T., Fritz, B., Tews, B., Ho, A. D., Lukas, J., Bartek, J. and Krämer, A. (2007). DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle 6, 2541-2548.
40. Lucas, E. P. and Raff, J. W. (2007). Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin. J. Cell Biol. 178, 725-732.
41. Marshall, O. J. (2004). PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR. Bioinformatics 20, 2471-2472.
42. Martindill, D. M., Risebro, C. A., Smart, N., Franco-Viseras, M. M., Rosario, C. O., Swallow, C. J., Dennis, J. W. and Riley, P. R. (2007). Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat. Cell Biol. 9, 1131-1141.
43. Mikule, K., Delaval, B., Kaldis, P., Jurcyzk, A., Hergert, P. and Doxsey, S. (2007). Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest. Nat. Cell Biol. 9, 160-170.
44. Peel, N., Stevens, N. R., Basto, R. and Raff, J. W. (2007). Overexpressing centriolereplication proteins in vivo induces centriole overduplication and de novo formation. Curr. Biol. 17, 834-843.
45. Pihan, G. A., Wallace, J., Zhou, Y. and Doxsey, S. J. (2003). Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res. 63, 1398-1404.
46. Ramaswamy, S., Ross, K. N., Lander, E. S. and Golub, T. R. (2003). A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33, 49-54.
47. Rhodes, D. R., Yu, J., Shanker, K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T., Pandey, A. and Chinnaiyan, A. M. (2004). Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc. Natl. Acad. Sci. USA 101, 9309-9314.
48. Rodrigues-Martins, A., Bettencourt-Dias, M., Riparbelli, M., Ferreira, C., Ferreira, I., Callaini, G. and Glover, D. M. (2007). DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly. Curr. Biol. 17, 1465-1472.
49. Rossi, F. and Gonzalez, C. (2011). Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth. EMBO Rep. 13, 157-162.
50. Scott, K. L., Nogueira, C., Heffernan, T. P., van Doorn, R., Dhakal, S., Hanna, J. A., Min, C., Jaskelioff, M., Xiao, Y., Wu, C. J. et al. (2011). Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell 20, 92-103.
51. Smyth, G. K. (2005). Limma: linear models for microarray data. In Bioinformatics And Computational Biology Solutions Using R And Bioconductor (ed. R. Gentleman, V. Carey, S. Dudoit, R. Irizarry and W. Huber), pp. 397-420. New York: Springer.
52. Srsen, V., Gnadt, N., Dammermann, A. and Merdes, A. (2006). Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. J. Cell Biol. 174, 625-630.
53. Takada, S., Kwak, S., Koppetsch, B. S. and Theurkauf, W. E. (2007). grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition. Development 134, 1737-1744.
54. Tritarelli, A., Oricchio, E., Ciciarello, M., Mangiacasale, R., Palena, A., Lavia, P., Soddu, S. and Cundari, E. (2004). p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation. Mol. Biol. Cell 15, 3751-3757.
55. Uetake, Y., Loncarek, J., Nordberg, J. J., English, C. N., La Terra, S., Khodjakov, A. and Sluder, G. (2007). Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells. J. Cell Biol. 176, 173-182.
56. Wang, H., Somers, G. W., Bashirullah, A., Heberlein, U., Yu, F. and Chia, W. (2006). Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 20, 3453-3463.
57. Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P. and Cleveland, D. W. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11, 25-36.
58. V12 and scribbled clones induces tumour growth and invasion. Nature 463, 545-548.
59. Wu, Z. and Irizarry, R. A. (2007). A statistical framework for the analysis of microarray probe-level data. Ann. Appl. Stat. 1, 333-357.