Accelerated In Vivo Proliferation of Memory Phenotype CD4+ T-cells in Human HIV-1 Infection Irrespective of Viral Chemokine Co-receptor Tropism

PLoS Pathogens

Volumn 9, Issue 4, 2013, Pages

  Zhang, Yan ^a   de Lara, Catherine ^b   Worth, Andrew ^b   Hegedus, Andrea ^a   Laamanen, Karoliina ^a   Beverley, Peter ^b   Macallan, Derek ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; FAS ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LOSS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; KINETICS; MALE; MASS FRAGMENTOGRAPHY; MEMORY CELL; PHENOTYPE; PROTEIN EXPRESSION; VIRAL TROPISM; VIRUS LOAD;

ADULT; ANTIGENS, CD45; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; MALE; RECEPTORS, CCR5; RECEPTORS, CXCR4; VIRAL TROPISM; YOUNG ADULT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876857459     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003310     Document Type: Article

References (42)

1. Douek DC, Roederer M, Koup RA, (2009) Emerging concepts in the immunopathogenesis of AIDS. AnnuRevMed 60:471-84: 471-484.
2. Lane HC, (2010) Pathogenesis of HIV infection: total CD4+ T-cell pool, immune activation, and inflammation. Top HIV Med 18: 2-6.
3. Yates A, Stark J, Klein N, Antia R, Callard R, (2007) Understanding the slow depletion of memory CD4+ T cells in HIV infection. PLoSMed 4: e177.
4. Wallace DL, Zhang Y, Ghattas H, Worth A, Irvine A, et al. (2004) Direct measurement of T cell subset kinetics in vivo in elderly men and women. JImmunol 173: 1787-1794.
5. den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mogling R, et al. (2012) Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36: 288-297.
6. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, et al. (1999) Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Medicine 5: 83-89.
7. Hellerstein MK, Hoh RA, Hanley MB, Cesar D, Lee D, et al. (2003) Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection. Journal of Clinical Investigation 112: 956-966.
8. Ribeiro RM, Mohri H, Ho DD, Perelson AS, (2002) In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted? Proceedings of the National Academy of Sciences of the United States of America 99: 15572-15577.
9. Kaur A, Di MM, Barabasz A, Rosenzweig M, McClure HM, et al. (2008) Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus. Journal of Virology 82: 1084-1093.
10. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, et al. (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373: 123-126.
11. Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, et al. (1997) Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387: 183-188.
12. Embretson J, Zupancic M, Beneke J, Till M, Wolinsky S, et al. (1993) Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution. Proc Natl Acad Sci USA 90: 357-361.
13. De Boer RJ, Mohri H, Ho DD, Perelson AS, (2003) Estimating average cellular turnover from 5-bromo-2′-deoxyuridine (BrdU) measurements. Proc Biol Sci 270: 849-858.
14. Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, et al. (1999) Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 179: 859-870.
15. Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, et al. (2006) Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J Virol 80: 6801-6809.
16. Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, et al. (2012) Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. Cell 151: 253-266.
17. Davenport MP, Zaunders JJ, Hazenberg MD, Schuitemaker H, van Rij RP, (2002) Cell turnover and cell tropism in HIV-1 infection. Trends Microbiol 10: 275-278.
18. Ribeiro RM, Hazenberg MD, Perelson AS, Davenport MP, (2006) Naive and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy. J Virol 80: 802-809.
19. Macallan DC, Asquith B, Irvine A, Wallace D, Worth A, et al. (2003) Measurement and Modeling of Human T cell kinetics. European Journal of Immunology 33: 2316-2326.
20. Macallan DC, Wallace D, Zhang Y, De Lara C, Worth AT, et al. (2004) Rapid turnover of effector-memory CD4(+) T cells in healthy humans. J Exp Med 200: 255-260.
21. Vrisekoop N, den B, I, de Boer AB, Ruiter AF, Ackermans MT, et al. (2008) Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proceedings of the National Academy of Sciences of the United States of America 105: 6115-6120.
22. Koot M, Keet IP, Vos AH, de Goede RE, Roos MT, et al. (1993) Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 118: 681-688.
23. Shankarappa R, Margolick JB, Gange SJ, Rodrigo AG, Upchurch D, et al. (1999) Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J Virol 73: 10489-10502.
24. Hazenberg MD, Otto SA, Hamann D, Roos MT, Schuitemaker H, et al. (2003) Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation. AIDS 17: 1419-1424.
25. Macallan DC, Asquith B, Zhang Y, de Lara CM, Ghattas H, et al. (2009) Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labelled glucose. Nature Protocols 4: 1313-1327.
26. Veazey RS, Mansfield KG, Tham IC, Carville AC, Shvetz DE, et al. (2000) Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection. J Virol 74: 11001-11007.
27. Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, et al. (2004) Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 200: 1299-1314.
28. Catalfamo M, Di Mascio M, Hu Z, Srinivasula S, Thaker V, et al. (2008) HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells. Proc Natl Acad Sci U S A 105: 19851-19856.
29. Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, et al. (2001) Evidence for increased T cell turnover and decreased thymic output in HIV infection. J Immunol 167: 6663-6668.
30. Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, et al. (2008) Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. Journal of Immunology 180: 7907-7918.
31. Macallan DC, Wallace DL, Irvine A, Asquith B, Worth A, et al. (2003) Rapid Turnover of T cells in Acute Infectious Mononucleosis. European Journal of Immunology 33: 2655-2665.
32. Cicin-Sain L, Messaoudi I, Park B, Currier N, Planer S, et al. (2007) Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci U S A 104: 19960-19965.
33. Phillips AN, Lee CA, Elford J, Webster A, Janossy G, et al. (1991) More rapid progression to AIDS in older HIV-infected people: the role of CD4+ T-cell counts. J Acquir Immune Defic Syndr 4: 970-975.
34. De Boer RJ, (2007) Time scales of CD4+ T cell depletion in HIV infection. PLoS Med 4: e193.
35. Berhanu D, Mortari F, De Rosa SC, Roederer M, (2003) Optimized lymphocyte isolation methods for analysis of chemokine receptor expression. Journal of Immunological Methods 279: 199-207.
36. McCune JM, Hanley MB, Cesar D, Halvorsen R, Hoh R, et al. (2000) Factors influencing T-cell turnover in HIV-1-seropositive patients. Journal of Clinical Investigation 105: R1-R8.
37. Heeregrave EJ, Geels MJ, Brenchley JM, Baan E, Ambrozak DR, et al. (2009) Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4+ T cell subsets. Virology 393: 24-32.
38. Llano A, Barretina J, Gutierrez A, Blanco J, Cabrera C, et al. (2001) Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals. J Virol 75: 10319-10325.
39. Brieu N, Portales P, Carles MJ, Corbeau P, (2011) Interleukin-7 induces HIV type 1 R5-to-X4 switch. Blood 117: 2073-2074.
40. Sanchez V, Masia M, Robledano C, Padilla S, Ramos JM, et al. (2010) Performance of genotypic algorithms for predicting HIV-1 tropism measured against the enhanced-sensitivity Trofile coreceptor tropism assay. J Clin Microbiol 48: 4135-4139.
41. Busch R, Neese RA, Awada M, Hayes GM, Hellerstein MK, (2007) Measurement of cell proliferation by heavy water labeling. Nature Protocols 2: 3045-3057.
42. Asquith B, Debacq C, Macallan DC, Willems L, Bangham C, (2002) Lymphocyte kinetics: the interpretation of labelling data. Trends in Immunology 23: 596-601.