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Volumn 8, Issue 4, 2016, Pages 1708-1718

The antitumor activity study of ginsenosides and metabolites in lung cancer cell

Author keywords

Antitumor activity; Ginsenosides; Lung cancer cell; PPD; PPT

Indexed keywords

CISPLATIN; GINSENOSIDE; GINSENOSIDE RG 3; GINSENOSIDE RH 2; PROTOPANAXADIOL; PROTOPANAXATRIOL; UNCLASSIFIED DRUG;

EID: 84964843593     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (46)

References (42)
  • 1
    • 84865039191 scopus 로고    scopus 로고
    • Ginsenosides as anticancer agents: In vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action
    • Nag SA, Qin JJ, Wan W, Wang MH, Wang H and Zhang R. Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front Pharmacol 2012; 3: 25
    • (2012) Front Pharmacol , vol.3 , pp. 25
    • Nag, S.A.1    Qin, J.J.2    Wan, W.3    Wang, M.H.4    Wang, H.5    Zhang, R.6
  • 2
    • 58049101796 scopus 로고    scopus 로고
    • Management of smallcell lung cancer: Incremental changes but hope for the future
    • Hann CL and Rudin CM. Management of smallcell lung cancer: incremental changes but hope for the future. Oncology (Williston Park) 2008; 22: 1486-1492
    • (2008) Oncology (Williston Park) , vol.22 , pp. 1486-1492
    • Hann, C.L.1    Rudin, C.M.2
  • 4
    • 33947582831 scopus 로고    scopus 로고
    • A review of first-line treatment for small-cell lung cancer
    • Murray N and Turrisi AT. A review of first-line treatment for small-cell lung cancer. J Thorac Oncol 2006; 1: 270-278
    • (2006) J Thorac Oncol , vol.1 , pp. 270-278
    • Murray, N.1    Turrisi, A.T.2
  • 6
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009; 55: 1-99
    • (2009) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 7
    • 0037137560 scopus 로고    scopus 로고
    • Herbal remedies
    • De Smet PA. Herbal remedies. N Engl J Med 2002; 347: 2046-2056
    • (2002) N Engl J Med , vol.347 , pp. 2046-2056
    • De Smet, P.A.1
  • 8
    • 77955663174 scopus 로고    scopus 로고
    • American ginseng: Potential structure-function relationship in cancer chemoprevention
    • Qi LW, Wang CZ and Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol 2010; 80: 947-954
    • (2010) Biochem Pharmacol , vol.80 , pp. 947-954
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 11
    • 34247365969 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer
    • Xu TM, Xin Y, Cui MH, Jang X and Gu LP. Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin Med J (Engl) 2007; 120: 584-588
    • (2007) Chin Med J (Engl) , vol.120 , pp. 584-588
    • Xu, T.M.1    Xin, Y.2    Cui, M.H.3    Jang, X.4    Gu, L.P.5
  • 12
    • 33644618424 scopus 로고    scopus 로고
    • Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma
    • Zhang Q, Kang X, and Zhao W. Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma. Biochem Biophys Res Commun 2006; 342: 824-828
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 824-828
    • Zhang, Q.1    Kang, X.2    Zhao, W.3
  • 14
    • 53549093298 scopus 로고    scopus 로고
    • Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells
    • Chen J, Peng H, Ou-Yang X and He X. Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells. Melanoma Res 2008; 18: 322-329
    • (2008) Melanoma Res , vol.18 , pp. 322-329
    • Chen, J.1    Peng, H.2    Ou-Yang, X.3    He, X.4
  • 16
    • 0035653529 scopus 로고    scopus 로고
    • Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds
    • Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 2001; Suppl 16: S28-S37
    • (2001) J Korean Med Sci , vol.16 , pp. S28-S37
    • Shibata, S.1
  • 17
    • 84866729793 scopus 로고    scopus 로고
    • Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages
    • Bi WY, Fu BD, Shen HQ, Wei Q, Zhang C, Song Z, Qin QQ, Li HP, Lv S, Wu SC, Yi PF and Wei XB. Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. Inflammation 2012; 35: 1659-1668
    • (2012) Inflammation , vol.35 , pp. 1659-1668
    • Bi, W.Y.1    Fu, B.D.2    Shen, H.Q.3    Wei, Q.4    Zhang, C.5    Song, Z.6    Qin, Q.Q.7    Li, H.P.8    Lv, S.9    Wu, S.C.10    Yi, P.F.11    Wei, X.B.12
  • 19
    • 77955575222 scopus 로고    scopus 로고
    • Ginseng on hyperglycemia: Effects and mechanisms
    • Luo JZ and Luo L. Ginseng on hyperglycemia: effects and mechanisms. Evid Based Complement Alternat Med 2009; 6: 423-427
    • (2009) Evid Based Complement Alternat Med , vol.6 , pp. 423-427
    • Luo, J.Z.1    Luo, L.2
  • 20
    • 79952380142 scopus 로고    scopus 로고
    • Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128
    • Wu N, Wu GC, Hu R, Li M and Feng H. Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128. Acta Pharmacol Sin 2011; 32: 345-353
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 345-353
    • Wu, N.1    Wu, G.C.2    Hu, R.3    Li, M.4    Feng, H.5
  • 21
    • 78651445610 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
    • Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS and Du W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett 2011; 301: 185-192
    • (2011) Cancer Lett , vol.301 , pp. 185-192
    • Li, B.1    Zhao, J.2    Wang, C.Z.3    Searle, J.4    He, T.C.5    Yuan, C.S.6    Du, W.7
  • 22
    • 80052064898 scopus 로고    scopus 로고
    • 20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells
    • Zhu GY, Li YW, Tse AK, Hau DK, Leung CH, Yu ZL and Fong WF. 20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells. Eur J Pharmacol 2011; 668: 88-98
    • (2011) Eur J Pharmacol , vol.668 , pp. 88-98
    • Zhu, G.Y.1    Li, Y.W.2    Tse, A.K.3    Hau, D.K.4    Leung, C.H.5    Yu, Z.L.6    Fong, W.F.7
  • 23
    • 45349085085 scopus 로고    scopus 로고
    • Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides
    • Wang W, Rayburn ER, Hao M, Zhao Y, Hill DL, Zhang R and Wang H. Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate 2008; 68: 809-819
    • (2008) Prostate , vol.68 , pp. 809-819
    • Wang, W.1    Rayburn, E.R.2    Hao, M.3    Zhao, Y.4    Hill, D.L.5    Zhang, R.6    Wang, H.7
  • 24
    • 77953827001 scopus 로고    scopus 로고
    • The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/ MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy
    • Li MQ, Hou XF, Shao J, Tang CL, and Li DJ. The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/ MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. Biol Reprod 2010; 82: 968-979
    • (2010) Biol Reprod , vol.82 , pp. 968-979
    • Li, M.Q.1    Hou, X.F.2    Shao, J.3    Tang, C.L.4    Li, D.J.5
  • 27
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009; 55: 1-99
    • (2009) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 29
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • Attele AS, Wu JA and Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999; 58: 1685-1693
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 30
    • 0034508151 scopus 로고    scopus 로고
    • Efficacy and safety of ginseng
    • Kitts DD and Hu C. Efficacy and safety of ginseng. Pub Health Nut 2000; 3: 473-485
    • (2000) Pub Health Nut , vol.3 , pp. 473-485
    • Kitts, D.D.1    Hu, C.2
  • 31
    • 84878382574 scopus 로고    scopus 로고
    • Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells
    • Jung JS, Ahn JH, Le TK, Kim DH and Kim HS. Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells. Neurochem Int 2013; 63: 80-86
    • (2013) Neurochem Int , vol.63 , pp. 80-86
    • Jung, J.S.1    Ahn, J.H.2    Le, T.K.3    Kim, D.H.4    Kim, H.S.5
  • 32
    • 28844468779 scopus 로고    scopus 로고
    • Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogenactivated protein kinase signaling pathways in human astroglioma cells
    • Jung SH, Woo MS, Kim SY, Kim WK, Hyun JW, Kim EJ, Kim DH and Kim HS. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogenactivated protein kinase signaling pathways in human astroglioma cells. Int J Cancer 2006; 118: 490-497
    • (2006) Int J Cancer , vol.118 , pp. 490-497
    • Jung, S.H.1    Woo, M.S.2    Kim, S.Y.3    Kim, W.K.4    Hyun, J.W.5    Kim, E.J.6    Kim, D.H.7    Kim, H.S.8
  • 34
    • 0023136916 scopus 로고
    • Small bowel metastases from primary carcinoma of the lung
    • McNeill PM, Wagman LD and Neifeld JP. Small bowel metastases from primary carcinoma of the lung. Cancer 1987; 59:1486-1489
    • (1987) Cancer , vol.59 , pp. 1486-1489
    • McNeill, P.M.1    Wagman, L.D.2    Neifeld, J.P.3
  • 35
    • 0032695271 scopus 로고    scopus 로고
    • Small bowel metastases in non-small cell lung cancer
    • Stenbygaard LE and Sorensen JB. Small bowel metastases in non-small cell lung cancer. Lung Cancer 1999; 26: 95-101
    • (1999) Lung Cancer , vol.26 , pp. 95-101
    • Stenbygaard, L.E.1    Sorensen, J.B.2
  • 36
    • 84907204565 scopus 로고    scopus 로고
    • Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelialmesenchymal transition in ovarian cancer cells
    • Liu T, Zhao L, Zhang Y, Chen W, Liu D, Hou H, Ding L and Li X. Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelialmesenchymal transition in ovarian cancer cells. PLoS One 2014; 9: e103887
    • (2014) Plos One , vol.9
    • Liu, T.1    Zhao, L.2    Zhang, Y.3    Chen, W.4    Liu, D.5    Hou, H.6    Ding, L.7    Li, X.8
  • 37
    • 84907289379 scopus 로고    scopus 로고
    • Synergistic antitumor effect of ginsenoside Rg3 and cisplatin in cisplatinresistant bladder tumor cell line
    • Lee YJ, Lee S, Ho JN, Byun SS, Hong SK, Lee SE and Lee E. Synergistic antitumor effect of ginsenoside Rg3 and cisplatin in cisplatinresistant bladder tumor cell line. Oncol Rep 2014; 32: 1803-1808
    • (2014) Oncol Rep , vol.32 , pp. 1803-1808
    • Lee, Y.J.1    Lee, S.2    Ho, J.N.3    Byun, S.S.4    Hong, S.K.5    Lee, S.E.6    Lee, E.7
  • 38
    • 84907293011 scopus 로고    scopus 로고
    • Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κBdependent MMP-9 expression
    • Li L, Wang Y, Qi B, Yuan D, Dong S, Guo D, Zhang C and Yu M. Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κBdependent MMP-9 expression. Oncol Rep 2014; 32: 1779-1786
    • (2014) Oncol Rep , vol.32 , pp. 1779-1786
    • Li, L.1    Wang, Y.2    Qi, B.3    Yuan, D.4    Dong, S.5    Guo, D.6    Zhang, C.7    Yu, M.8
  • 39
    • 84924220374 scopus 로고    scopus 로고
    • Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factors
    • Shi Q, Li J, Feng Z, Zhao L, Luo L, You Z, Li D, Xia J, Zuo G and Chen D. Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: recruiting histone deacetylase and inhibiting activator protein 1 transcription factors. Mol Med Rep 2014; 10: 1779-1785
    • (2014) Mol Med Rep , vol.10 , pp. 1779-1785
    • Shi, Q.1    Li, J.2    Feng, Z.3    Zhao, L.4    Luo, L.5    You, Z.6    Li, D.7    Xia, J.8    Zuo, G.9    Chen, D.10
  • 40
    • 0037296911 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats
    • Xu QF, Fang XL and Chen DF. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 2003; 84: 187-192
    • (2003) J Ethnopharmacol , vol.84 , pp. 187-192
    • Xu, Q.F.1    Fang, X.L.2    Chen, D.F.3
  • 41
    • 70349451559 scopus 로고    scopus 로고
    • Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/ mass spectrometric method
    • Joo KM, Lee JH, Jeon HY, Park CW, Hong DK, Jeong HJ, Lee SJ, Lee SY and Lim KM. Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/ mass spectrometric method. J Pharm Biomed Anal 2010; 51: 278-283
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 278-283
    • Joo, K.M.1    Lee, J.H.2    Jeon, H.Y.3    Park, C.W.4    Hong, D.K.5    Jeong, H.J.6    Lee, S.J.7    Lee, S.Y.8    Lim, K.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.