Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice

Thrombosis and Haemostasis

Volumn 115, Issue 5, 2016, Pages 969-978

  Niki, Masaru ^a   Nayak, Manasa K ^a   Jin, Hong ^a,e   Bhasin, Neha ^a   Plow, Edward F ^b   Pandolfi, Pier Paolo ^c   Rothman, Paul B ^d   Chauhan, Anil K ^a   Lentz, Steven R ^a  

^a UNIVERSITY OF IOWA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Fibrinogen; Haemostasis; Integrin; Platelets; Thrombin; Thrombosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA3 INTEGRIN; DOWN STREAM OF TYROSINE KINASE; FIBRINOGEN; INTEGRIN; PADGEM PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DOK1 PROTEIN, HUMAN; DOK1 PROTEIN, MOUSE; FIBRINOGEN RECEPTOR; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN; RNA BINDING PROTEIN;

ARTICLE; BLEEDING TIME; BLOOD CLOT RETRACTION; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE AGGREGATION; THROMBOSIS; 129 MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DEFICIENCY; GENETICS; HEMOSTASIS; KNOCKOUT MOUSE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION;

ANIMALS; BLEEDING TIME; CAROTID ARTERY THROMBOSIS; CLOT RETRACTION; DNA-BINDING PROTEINS; FIBRINOGEN; HEMOSTASIS; HUMANS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; P-SELECTIN; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 84964840303     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-05-0373     Document Type: Article

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