Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation

Journal of Biological Chemistry

Volumn 291, Issue 17, 2016, Pages 9025-9041

  Habisov, Sabrina ^a,b,c   Huber, Jessica ^c   Ichimura, Yoshinobu ^d   Akutsu, Masato ^b,c   Rogova, Natalia ^c   Loehr, Frank ^c   McEwan, David G ^b,e   Johansen, Terje ^f   Dikic, Ivan ^b,c   Doetsch, Volker ^c   Komatsu, Masaaki ^d   Rogov, Vladimir V ^c   Kirkin, Vladimir ^a  

^a MERCK KGAA   (Germany)

^b GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d NIIGATA UNIVERSITY   (Japan)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHEMICAL ACTIVATION; TRANSCRIPTION;

ACID RECEPTORS; C TERMINUS; CELL STRESS; LIGHT CHAIN; PROTEIN SUBSTRATE; UBIQUITIN; UBIQUITIN-LIKE; UBIQUITIN-LIKE PROTEINS;

ENZYMES;

4 AMINOBUTYRIC ACID RECEPTOR ASSOCIATED PROTEIN; CELL PROTEIN; LIGHT CHAIN 3 PROTEIN; UBIQUITIN FOLD MODIFIER 1 ACTIVATING ENZYME 5; UBIQUITIN LIKE PROTEIN; UNCLASSIFIED DRUG; GABARAP PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBA5 PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; UFC1 PROTEIN, HUMAN; UFM1 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; UFMYLATION; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; HEK293 CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84964814473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.715474     Document Type: Article

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