-
1
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
L.J. Scherer, and J.J. Rossi Approaches for the sequence-specific knockdown of mRNA Nat Biotechnol 21 2003 1457 1465
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1457-1465
-
-
Scherer, L.J.1
Rossi, J.J.2
-
2
-
-
7944230575
-
Oligonucleotide therapeutics: 25 years agrowing
-
J. Goodchild Oligonucleotide therapeutics: 25 years agrowing Curr Opin Mol Ther 6 2004 120 128
-
(2004)
Curr Opin Mol Ther
, vol.6
, pp. 120-128
-
-
Goodchild, J.1
-
3
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
C.F. Bennett, and E.E. Swayze RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform Annu Rev Pharmacol Toxicol 50 2010 259 293
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
4
-
-
84856389509
-
RNA-based therapeutics: Current progress and future prospects
-
J.C. Burnett, and J.J. Rossi RNA-based therapeutics: current progress and future prospects Chem Biol 19 2012 60 71
-
(2012)
Chem Biol
, vol.19
, pp. 60-71
-
-
Burnett, J.C.1
Rossi, J.J.2
-
5
-
-
84880915038
-
Oligonucleotide conjugates for therapeutic applications
-
J. Winkler Oligonucleotide conjugates for therapeutic applications Ther Deliv 4 2013 791 809
-
(2013)
Ther Deliv
, vol.4
, pp. 791-809
-
-
Winkler, J.1
-
6
-
-
84939802078
-
Oligonucleotide therapies: The past and the present
-
K.E. Lundin, O. Gissberg, and C.I. Smith Oligonucleotide therapies: the past and the present Hum Gene Ther 26 2015 475 485
-
(2015)
Hum Gene Ther
, vol.26
, pp. 475-485
-
-
Lundin, K.E.1
Gissberg, O.2
Smith, C.I.3
-
7
-
-
82755161958
-
Silencing disease genes in the laboratory and the clinic
-
J.K. Watts, and D.R. Corey Silencing disease genes in the laboratory and the clinic J Pathol 226 2012 365 379
-
(2012)
J Pathol
, vol.226
, pp. 365-379
-
-
Watts, J.K.1
Corey, D.R.2
-
8
-
-
84908395519
-
Antisense therapeutics in oncology: Current status
-
A.A. Farooqi, Z.U. Rehman, and J. Muntane Antisense therapeutics in oncology: current status Onco Targets Ther 7 2014 2035 2042
-
(2014)
Onco Targets Ther
, vol.7
, pp. 2035-2042
-
-
Farooqi, A.A.1
Rehman, Z.U.2
Muntane, J.3
-
9
-
-
84921030166
-
Therapeutic potential of siRNA and DNAzymes in cancer
-
H.K. Karnati, R.S. Yalagala, R. Undi, S.R. Pasupuleti, and R.K. Gutti Therapeutic potential of siRNA and DNAzymes in cancer Tumour Biol 35 2014 9505 9521
-
(2014)
Tumour Biol
, vol.35
, pp. 9505-9521
-
-
Karnati, H.K.1
Yalagala, R.S.2
Undi, R.3
Pasupuleti, S.R.4
Gutti, R.K.5
-
10
-
-
0005772676
-
Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide
-
M.L. Stephenson, and P.C. Zamecnik Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide Proc Natl Acad Sci U S A 75 1978 285 288
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 285-288
-
-
Stephenson, M.L.1
Zamecnik, P.C.2
-
11
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
-
P.C. Zamecnik, and M.L. Stephenson Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide Proc Natl Acad Sci U S A 75 1978 280 284
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 280-284
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
12
-
-
77955098945
-
Off-target effects related to the phosphorothioate modification of nucleic acids
-
J. Winkler, M. Stessl, J. Amartey, and C.R. Noe Off-target effects related to the phosphorothioate modification of nucleic acids ChemMedChem 5 2010 1344 1352
-
(2010)
ChemMedChem
, vol.5
, pp. 1344-1352
-
-
Winkler, J.1
Stessl, M.2
Amartey, J.3
Noe, C.R.4
-
13
-
-
0031782392
-
A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
-
B.R. Yacyshyn, M.B. Bowen-Yacyshyn, L. Jewell, J.A. Tami, C.F. Bennett, D.L. Kisner, and et al. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease Gastroenterology 114 1998 1133 1142
-
(1998)
Gastroenterology
, vol.114
, pp. 1133-1142
-
-
Yacyshyn, B.R.1
Bowen-Yacyshyn, M.B.2
Jewell, L.3
Tami, J.A.4
Bennett, C.F.5
Kisner, D.L.6
-
14
-
-
0036288638
-
Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
-
B.R. Yacyshyn, W.Y. Chey, J. Goff, B. Salzberg, R. Baerg, A.L. Buchman, and et al. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease Gut 51 2002 30 36
-
(2002)
Gut
, vol.51
, pp. 30-36
-
-
Yacyshyn, B.R.1
Chey, W.Y.2
Goff, J.3
Salzberg, B.4
Baerg, R.5
Buchman, A.L.6
-
15
-
-
21344472110
-
Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1
-
B.R. Yacyshyn, A. Schievella, K.L. Sewell, and J.A. Tami Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1 Clin Exp Immunol 141 2005 141 147
-
(2005)
Clin Exp Immunol
, vol.141
, pp. 141-147
-
-
Yacyshyn, B.R.1
Schievella, A.2
Sewell, K.L.3
Tami, J.A.4
-
16
-
-
7244252832
-
A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
-
S.J. van Deventer, J.A. Tami, and M.K. Wedel A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis Gut 53 2004 1646 1651
-
(2004)
Gut
, vol.53
, pp. 1646-1651
-
-
Van Deventer, S.J.1
Tami, J.A.2
Wedel, M.K.3
-
17
-
-
33646271377
-
A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
-
S.J. van Deventer, M.K. Wedel, B.F. Baker, S. Xia, E. Chuang, and P.B. Miner Jr. A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis Aliment Pharmacol Ther 23 2006 1415 1425
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1415-1425
-
-
Van Deventer, S.J.1
Wedel, M.K.2
Baker, B.F.3
Xia, S.4
Chuang, E.5
Miner, P.B.6
-
18
-
-
33646232502
-
Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: A randomized, double-blind, active-controlled trial
-
P.B. Miner Jr., M.K. Wedel, S. Xia, and B.F. Baker Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: A randomized, double-blind, active-controlled trial Aliment Pharmacol Ther 23 2006 1403 1413
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1403-1413
-
-
Miner, P.B.1
Wedel, M.K.2
Xia, S.3
Baker, B.F.4
-
19
-
-
84925064199
-
Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease
-
G. Monteleone, M.F. Neurath, S. Ardizzone, S.A. Di, M.C. Fantini, F. Castiglione, and et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease N Engl J Med 372 2015 1104 1113
-
(2015)
N Engl J Med
, vol.372
, pp. 1104-1113
-
-
Monteleone, G.1
Neurath, M.F.2
Ardizzone, S.3
Di, S.A.4
Fantini, M.C.5
Castiglione, F.6
-
20
-
-
42949132127
-
Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
-
G.M. Gauvreau, L.P. Boulet, D.W. Cockcroft, A. Baatjes, J. Cote, F. Deschesnes, and et al. Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses Am J Respir Crit Care Med 177 2008 952 958
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 952-958
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Cockcroft, D.W.3
Baatjes, A.4
Cote, J.5
Deschesnes, F.6
-
21
-
-
79961128164
-
Dose-response effects of TPI ASM8 in asthmatics after allergen
-
G.M. Gauvreau, R. Pageau, R. Seguin, D. Carballo, J. Gauthier, H. D'Anjou, and et al. Dose-response effects of TPI ASM8 in asthmatics after allergen Allergy 66 2011 1242 1248
-
(2011)
Allergy
, vol.66
, pp. 1242-1248
-
-
Gauvreau, G.M.1
Pageau, R.2
Seguin, R.3
Carballo, D.4
Gauthier, J.5
D'Anjou, H.6
-
22
-
-
80054978390
-
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
-
H. Imaoka, H. Campbell, I. Babirad, R.M. Watson, M. Mistry, R. Sehmi, and et al. TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge Clin Exp Allergy 41 2011 1740 1746
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 1740-1746
-
-
Imaoka, H.1
Campbell, H.2
Babirad, I.3
Watson, R.M.4
Mistry, M.5
Sehmi, R.6
-
23
-
-
84941174746
-
Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
-
U. Homburg, H. Renz, W. Timmer, J.M. Hohlfeld, F. Seitz, K. Luer, and et al. Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma J Allergy Clin Immunol 136 2015 797 800
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 797-800
-
-
Homburg, U.1
Renz, H.2
Timmer, W.3
Hohlfeld, J.M.4
Seitz, F.5
Luer, K.6
-
24
-
-
84929774279
-
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
-
N. Krug, J.M. Hohlfeld, A.M. Kirsten, O. Kornmann, K.M. Beeh, D. Kappeler, and et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme N Engl J Med 372 2015 1987 1995
-
(2015)
N Engl J Med
, vol.372
, pp. 1987-1995
-
-
Krug, N.1
Hohlfeld, J.M.2
Kirsten, A.M.3
Kornmann, O.4
Beeh, K.M.5
Kappeler, D.6
-
25
-
-
12144291445
-
Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients
-
R.G. Amado, R.T. Mitsuyasu, J.D. Rosenblatt, F.K. Ngok, A. Bakker, S. Cole, and et al. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients Hum Gene Ther 15 2004 251 262
-
(2004)
Hum Gene Ther
, vol.15
, pp. 251-262
-
-
Amado, R.G.1
Mitsuyasu, R.T.2
Rosenblatt, J.D.3
Ngok, F.K.4
Bakker, A.5
Cole, S.6
-
26
-
-
21144470101
-
Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients
-
J.L. MacPherson, M.P. Boyd, A.J. Arndt, A.V. Todd, G.C. Fanning, J.A. Ely, and et al. Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients J Gene Med 7 2005 552 564
-
(2005)
J Gene Med
, vol.7
, pp. 552-564
-
-
MacPherson, J.L.1
Boyd, M.P.2
Arndt, A.J.3
Todd, A.V.4
Fanning, G.C.5
Ely, J.A.6
-
27
-
-
62049083710
-
Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells
-
R.T. Mitsuyasu, T.C. Merigan, A. Carr, J.A. Zack, M.A. Winters, C. Workman, and et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells Nat Med 15 2009 285 292
-
(2009)
Nat Med
, vol.15
, pp. 285-292
-
-
Mitsuyasu, R.T.1
Merigan, T.C.2
Carr, A.3
Zack, J.A.4
Winters, M.A.5
Workman, C.6
-
28
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
H.L. Janssen, H.W. Reesink, E.J. Lawitz, S. Zeuzem, M. Rodriguez-Torres, K. Patel, and et al. Treatment of HCV infection by targeting microRNA N Engl J Med 368 2013 1685 1694
-
(2013)
N Engl J Med
, vol.368
, pp. 1685-1694
-
-
Janssen, H.L.1
Reesink, H.W.2
Lawitz, E.J.3
Zeuzem, S.4
Rodriguez-Torres, M.5
Patel, K.6
-
29
-
-
0036202668
-
A randomized controlled clinical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS
-
The Vitravene Study Group A randomized controlled clinical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS Am J Ophthalmol 133 2002 467 474
-
(2002)
Am J Ophthalmol
, vol.133
, pp. 467-474
-
-
-
30
-
-
0036211366
-
Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS
-
The Vitravene Study Group Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS Am J Ophthalmol 133 2002 475 483
-
(2002)
Am J Ophthalmol
, vol.133
, pp. 475-483
-
-
-
31
-
-
0036202847
-
Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS
-
The Vitravene Study Group Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS Am J Ophthalmol 133 2002 484 498
-
(2002)
Am J Ophthalmol
, vol.133
, pp. 484-498
-
-
-
32
-
-
38749136602
-
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
-
J. DeVincenzo, J.E. Cehelsky, R. Alvarez, S. Elbashir, J. Harborth, I. Toudjarska, and et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) Antiviral Res 77 2008 225 231
-
(2008)
Antiviral Res
, vol.77
, pp. 225-231
-
-
DeVincenzo, J.1
Cehelsky, J.E.2
Alvarez, R.3
Elbashir, S.4
Harborth, J.5
Toudjarska, I.6
-
33
-
-
77952688315
-
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
-
J. DeVincenzo, R. Lambkin-Williams, T. Wilkinson, J. Cehelsky, S. Nochur, E. Walsh, and et al. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus Proc Natl Acad Sci U S A 107 2010 8800 8805
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8800-8805
-
-
DeVincenzo, J.1
Lambkin-Williams, R.2
Wilkinson, T.3
Cehelsky, J.4
Nochur, S.5
Walsh, E.6
-
34
-
-
79951849229
-
RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
-
M.R. Zamora, M. Budev, M. Rolfe, J. Gottlieb, A. Humar, J. DeVincenzo, and et al. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus Am J Respir Crit Care Med 183 2011 531 538
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 531-538
-
-
Zamora, M.R.1
Budev, M.2
Rolfe, M.3
Gottlieb, J.4
Humar, A.5
DeVincenzo, J.6
-
35
-
-
57449103966
-
Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe
-
R.Z. Yu, R.S. Geary, J.D. Flaim, G.C. Riley, D.L. Tribble, A.A. VanVliet, and et al. Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe Clin Pharmacokinet 48 2009 39 50
-
(2009)
Clin Pharmacokinet
, vol.48
, pp. 39-50
-
-
Yu, R.Z.1
Geary, R.S.2
Flaim, J.D.3
Riley, G.C.4
Tribble, D.L.5
VanVliet, A.A.6
-
36
-
-
33750207033
-
Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
-
J.J. Kastelein, M.K. Wedel, B.F. Baker, J. Su, J.D. Bradley, R.Z. Yu, and et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B Circulation 114 2006 1729 1735
-
(2006)
Circulation
, vol.114
, pp. 1729-1735
-
-
Kastelein, J.J.1
Wedel, M.K.2
Baker, B.F.3
Su, J.4
Bradley, J.D.5
Yu, R.Z.6
-
37
-
-
77949485460
-
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial
-
F.J. Raal, R.D. Santos, D.J. Blom, A.D. Marais, M.J. Charng, W.C. Cromwell, and et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial Lancet 375 2010 998 1006
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
Santos, R.D.2
Blom, D.J.3
Marais, A.D.4
Charng, M.J.5
Cromwell, W.C.6
-
38
-
-
84964804845
-
-
Available at:. Accessed July 15, 2015.
-
Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm337195.htm. Accessed July 15, 2015.
-
-
-
-
39
-
-
84892741671
-
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial
-
K. Fitzgerald, M. Frank-Kamenetsky, S. Shulga-Morskaya, A. Liebow, B.R. Bettencourt, J.E. Sutherland, and et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial Lancet 383 2014 60 68
-
(2014)
Lancet
, vol.383
, pp. 60-68
-
-
Fitzgerald, K.1
Frank-Kamenetsky, M.2
Shulga-Morskaya, S.3
Liebow, A.4
Bettencourt, B.R.5
Sutherland, J.E.6
-
40
-
-
84878637167
-
Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans
-
M.J. Graham, R.G. Lee, T.A. Bell III, W. Fu, A.E. Mullick, V.J. Alexander, and et al. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans Circ Res 112 2013 1479 1490
-
(2013)
Circ Res
, vol.112
, pp. 1479-1490
-
-
Graham, M.J.1
Lee, R.G.2
Bell, T.A.3
Fu, W.4
Mullick, A.E.5
Alexander, V.J.6
-
41
-
-
84864855385
-
Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients
-
Q.D. Nguyen, R.A. Schachar, C.I. Nduaka, M. Sperling, A.S. Basile, K.J. Klamerus, and et al. Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients Eye (Lond) 26 2012 1099 1105
-
(2012)
Eye (Lond)
, vol.26
, pp. 1099-1105
-
-
Nguyen, Q.D.1
Schachar, R.A.2
Nduaka, C.I.3
Sperling, M.4
Basile, A.S.5
Klamerus, K.J.6
-
42
-
-
84865678868
-
Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study)
-
Q.D. Nguyen, R.A. Schachar, C.I. Nduaka, M. Sperling, K.J. Klamerus, K. Chi-Burris, and et al. Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study) Ophthalmology 119 2012 1867 1873
-
(2012)
Ophthalmology
, vol.119
, pp. 1867-1873
-
-
Nguyen, Q.D.1
Schachar, R.A.2
Nduaka, C.I.3
Sperling, M.4
Klamerus, K.J.5
Chi-Burris, K.6
-
43
-
-
84872175978
-
Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)
-
Q.D. Nguyen, R.A. Schachar, C.I. Nduaka, M. Sperling, A.S. Basile, K.J. Klamerus, and et al. Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study) Invest Ophthalmol Vis Sci 53 2012 7666 7674
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 7666-7674
-
-
Nguyen, Q.D.1
Schachar, R.A.2
Nduaka, C.I.3
Sperling, M.4
Basile, A.S.5
Klamerus, K.J.6
-
44
-
-
68449088889
-
Tolerability and safety of GS-101 eye drops, an antisense oligonucleotide to insulin receptor substrate-1: A 'first in man' phase I investigation
-
H. Kain, D. Goldblum, B. Geudelin, E. Thorin, and C. Beglinger Tolerability and safety of GS-101 eye drops, an antisense oligonucleotide to insulin receptor substrate-1: A 'first in man' phase I investigation Br J Clin Pharmacol 68 2009 169 173
-
(2009)
Br J Clin Pharmacol
, vol.68
, pp. 169-173
-
-
Kain, H.1
Goldblum, D.2
Geudelin, B.3
Thorin, E.4
Beglinger, C.5
-
45
-
-
69249216429
-
GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: Interim results of a randomized phase II trial
-
C. Cursiefen, F. Bock, F.K. Horn, F.E. Kruse, B. Seitz, V. Borderie, and et al. GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial Ophthalmology 116 2009 1630 1637
-
(2009)
Ophthalmology
, vol.116
, pp. 1630-1637
-
-
Cursiefen, C.1
Bock, F.2
Horn, F.K.3
Kruse, F.E.4
Seitz, B.5
Borderie, V.6
-
46
-
-
84906936272
-
Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: The I-CAN study
-
C. Cursiefen, E. Viaud, F. Bock, B. Geudelin, A. Ferry, P. Kadlecova, and et al. Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: the I-CAN study Ophthalmology 121 2014 1683 1692
-
(2014)
Ophthalmology
, vol.121
, pp. 1683-1692
-
-
Cursiefen, C.1
Viaud, E.2
Bock, F.3
Geudelin, B.4
Ferry, A.5
Kadlecova, P.6
-
47
-
-
84891834550
-
Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure
-
J. Moreno-Montanes, B. Sadaba, V. Ruz, A. Gomez-Guiu, J. Zarranz, M.V. Gonzalez, and et al. Phase I clinical trial of SYL040012, a small interfering RNA targeting beta-adrenergic receptor 2, for lowering intraocular pressure Mol Ther 22 2014 226 232
-
(2014)
Mol Ther
, vol.22
, pp. 226-232
-
-
Moreno-Montanes, J.1
Sadaba, B.2
Ruz, V.3
Gomez-Guiu, A.4
Zarranz, J.5
Gonzalez, M.V.6
-
48
-
-
84866005644
-
Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds
-
S. Ormonde, C.Y. Chou, L. Goold, C. Petsoglou, R. Al-Taie, T. Sherwin, and et al. Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds J Membr Biol 245 2012 381 388
-
(2012)
J Membr Biol
, vol.245
, pp. 381-388
-
-
Ormonde, S.1
Chou, C.Y.2
Goold, L.3
Petsoglou, C.4
Al-Taie, R.5
Sherwin, T.6
-
49
-
-
84883118140
-
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
-
T. Coelho, D. Adams, A. Silva, P. Lozeron, P.N. Hawkins, T. Mant, and et al. Safety and efficacy of RNAi therapy for transthyretin amyloidosis N Engl J Med 369 2013 819 829
-
(2013)
N Engl J Med
, vol.369
, pp. 819-829
-
-
Coelho, T.1
Adams, D.2
Silva, A.3
Lozeron, P.4
Hawkins, P.N.5
Mant, T.6
-
50
-
-
37549034298
-
Local dystrophin restoration with antisense oligonucleotide PRO051
-
J.C. van Deutekom, A.A. Janson, I.B. Ginjaar, W.S. Frankhuizen, A. Aartsma-Rus, M. Bremmer-Bout, and et al. Local dystrophin restoration with antisense oligonucleotide PRO051 N Engl J Med 357 2007 2677 2686
-
(2007)
N Engl J Med
, vol.357
, pp. 2677-2686
-
-
Van Deutekom, J.C.1
Janson, A.A.2
Ginjaar, I.B.3
Frankhuizen, W.S.4
Aartsma-Rus, A.5
Bremmer-Bout, M.6
-
51
-
-
79955158683
-
Systemic administration of PRO051 in Duchenne's muscular dystrophy
-
N.M. Goemans, M. Tulinius, J.T. van den Akker, B.E. Burm, P.F. Ekhart, N. Heuvelmans, and et al. Systemic administration of PRO051 in Duchenne's muscular dystrophy N Engl J Med 364 2011 1513 1522
-
(2011)
N Engl J Med
, vol.364
, pp. 1513-1522
-
-
Goemans, N.M.1
Tulinius, M.2
Van Den Akker, J.T.3
Burm, B.E.4
Ekhart, P.F.5
Heuvelmans, N.6
-
52
-
-
84907991204
-
Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): An exploratory, randomised, placebo-controlled phase 2 study
-
T. Voit, H. Topaloglu, V. Straub, F. Muntoni, N. Deconinck, G. Campion, and et al. Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): An exploratory, randomised, placebo-controlled phase 2 study Lancet Neurol 13 2014 987 996
-
(2014)
Lancet Neurol
, vol.13
, pp. 987-996
-
-
Voit, T.1
Topaloglu, H.2
Straub, V.3
Muntoni, F.4
Deconinck, N.5
Campion, G.6
-
53
-
-
84925283858
-
CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS
-
V. Limmroth, F. Barkhof, N. Desem, M.P. Diamond, and G. Tachas CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS Neurology 83 2014 1780 1788
-
(2014)
Neurology
, vol.83
, pp. 1780-1788
-
-
Limmroth, V.1
Barkhof, F.2
Desem, N.3
Diamond, M.P.4
Tachas, G.5
-
54
-
-
84920984860
-
Factor XI antisense oligonucleotide for prevention of venous thrombosis
-
H.R. Buller, C. Bethune, S. Bhanot, D. Gailani, B.P. Monia, G.E. Raskob, and et al. Factor XI antisense oligonucleotide for prevention of venous thrombosis N Engl J Med 372 2015 232 240
-
(2015)
N Engl J Med
, vol.372
, pp. 232-240
-
-
Buller, H.R.1
Bethune, C.2
Bhanot, S.3
Gailani, D.4
Monia, B.P.5
Raskob, G.E.6
-
55
-
-
84859439270
-
Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease
-
G. Monteleone, M.C. Fantini, S. Onali, F. Zorzi, G. Sancesario, S. Bernardini, and et al. Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease Mol Ther 20 2012 870 876
-
(2012)
Mol Ther
, vol.20
, pp. 870-876
-
-
Monteleone, G.1
Fantini, M.C.2
Onali, S.3
Zorzi, F.4
Sancesario, G.5
Bernardini, S.6
-
56
-
-
84878568056
-
A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease
-
F. Zorzi, E. Calabrese, I. Monteleone, M. Fantini, S. Onali, L. Biancone, and et al. A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease Aliment Pharmacol Ther 36 2012 850 857
-
(2012)
Aliment Pharmacol Ther
, vol.36
, pp. 850-857
-
-
Zorzi, F.1
Calabrese, E.2
Monteleone, I.3
Fantini, M.4
Onali, S.5
Biancone, L.6
-
57
-
-
77951069859
-
Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia
-
F. Akdim, M.E. Visser, D.L. Tribble, B.F. Baker, E.S. Stroes, R. Yu, and et al. Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia Am J Cardiol 105 2010 1413 1419
-
(2010)
Am J Cardiol
, vol.105
, pp. 1413-1419
-
-
Akdim, F.1
Visser, M.E.2
Tribble, D.L.3
Baker, B.F.4
Stroes, E.S.5
Yu, R.6
-
58
-
-
77950332314
-
Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy
-
F. Akdim, E.S. Stroes, E.J. Sijbrands, D.L. Tribble, M.D. Trip, J.W. Jukema, and et al. Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy J Am Coll Cardiol 55 2010 1611 1618
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1611-1618
-
-
Akdim, F.1
Stroes, E.S.2
Sijbrands, E.J.3
Tribble, D.L.4
Trip, M.D.5
Jukema, J.W.6
-
59
-
-
77951072532
-
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
-
M.E. Visser, F. Akdim, D.L. Tribble, A.J. Nederveen, T.J. Kwoh, J.J. Kastelein, and et al. Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia J Lipid Res 51 2010 1057 1062
-
(2010)
J Lipid Res
, vol.51
, pp. 1057-1062
-
-
Visser, M.E.1
Akdim, F.2
Tribble, D.L.3
Nederveen, A.J.4
Kwoh, T.J.5
Kastelein, J.J.6
-
60
-
-
79959661095
-
Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia
-
F. Akdim, D.L. Tribble, J.D. Flaim, R. Yu, J. Su, R.S. Geary, and et al. Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia Eur Heart J 32 2011 2650 2659
-
(2011)
Eur Heart J
, vol.32
, pp. 2650-2659
-
-
Akdim, F.1
Tribble, D.L.2
Flaim, J.D.3
Yu, R.4
Su, J.5
Geary, R.S.6
-
61
-
-
84869039132
-
Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy
-
M.P. McGowan, J.C. Tardif, R. Ceska, L.J. Burgess, H. Soran, I. Gouni-Berthold, and et al. Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy PLoS One 7 2012 e49006
-
(2012)
PLoS One
, vol.7
, pp. e49006
-
-
McGowan, M.P.1
Tardif, J.C.2
Ceska, R.3
Burgess, L.J.4
Soran, H.5
Gouni-Berthold, I.6
-
62
-
-
84860615159
-
Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: A randomized, double-blind, placebo-controlled trial
-
M.E. Visser, G. Wagener, B.F. Baker, R.S. Geary, J.M. Donovan, U.H. Beuers, and et al. Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: A randomized, double-blind, placebo-controlled trial Eur Heart J 33 2012 1142 1149
-
(2012)
Eur Heart J
, vol.33
, pp. 1142-1149
-
-
Visser, M.E.1
Wagener, G.2
Baker, B.F.3
Geary, R.S.4
Donovan, J.M.5
Beuers, U.H.6
-
63
-
-
84868518061
-
Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: Results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
-
E.A. Stein, R. Dufour, C. Gagne, D. Gaudet, C. East, J.M. Donovan, and et al. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease Circulation 126 2012 2283 2292
-
(2012)
Circulation
, vol.126
, pp. 2283-2292
-
-
Stein, E.A.1
Dufour, R.2
Gagne, C.3
Gaudet, D.4
East, C.5
Donovan, J.M.6
-
64
-
-
84888090979
-
Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: A randomized, double-blind, placebo-controlled trial
-
G.S. Thomas, W.C. Cromwell, S. Ali, W. Chin, J.D. Flaim, and M. Davidson Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: A randomized, double-blind, placebo-controlled trial J Am Coll Cardiol 62 2013 2178 2184
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 2178-2184
-
-
Thomas, G.S.1
Cromwell, W.C.2
Ali, S.3
Chin, W.4
Flaim, J.D.5
Davidson, M.6
-
65
-
-
84906061916
-
Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen
-
Z. Li, M.L. Hard, J.S. Grundy, T. Singh, L.L. von Moltke, and I. Boltje Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen J Cardiovasc Pharmacol 64 2014 164 171
-
(2014)
J Cardiovasc Pharmacol
, vol.64
, pp. 164-171
-
-
Li, Z.1
Hard, M.L.2
Grundy, J.S.3
Singh, T.4
Von Moltke, L.L.5
Boltje, I.6
-
66
-
-
0030987678
-
Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)
-
J.M. Glover, J.M. Leeds, T.G. Mant, D. Amin, D.L. Kisner, J.E. Zuckerman, and et al. Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302) J Pharmacol Exp Ther 282 1997 1173 1180
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1173-1180
-
-
Glover, J.M.1
Leeds, J.M.2
Mant, T.G.3
Amin, D.4
Kisner, D.L.5
Zuckerman, J.E.6
-
67
-
-
0035045185
-
Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease
-
S. Schreiber, S. Nikolaus, H. Malchow, W. Kruis, H. Lochs, A. Raedler, and et al. Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease Gastroenterology 120 2001 1339 1346
-
(2001)
Gastroenterology
, vol.120
, pp. 1339-1346
-
-
Schreiber, S.1
Nikolaus, S.2
Malchow, H.3
Kruis, W.4
Lochs, H.5
Raedler, A.6
-
68
-
-
33846804162
-
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
-
B. Yacyshyn, W.Y. Chey, M.K. Wedel, R.Z. Yu, D. Paul, and E. Chuang A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease Clin Gastroenterol Hepatol 5 2007 215 220
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, pp. 215-220
-
-
Yacyshyn, B.1
Chey, W.Y.2
Wedel, M.K.3
Yu, R.Z.4
Paul, D.5
Chuang, E.6
-
69
-
-
1342331543
-
An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
-
P. Miner, M. Wedel, B. Bane, and J. Bradley An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis Aliment Pharmacol Ther 19 2004 281 286
-
(2004)
Aliment Pharmacol Ther
, vol.19
, pp. 281-286
-
-
Miner, P.1
Wedel, M.2
Bane, B.3
Bradley, J.4
-
70
-
-
0036198566
-
A randomized, placebo controlled trial of an antisense oligodeoxynucleotide to intercellular adhesion molecule-1 in the treatment of severe rheumatoid arthritis
-
W.P. Maksymowych, W.D. Blackburn Jr., J.A. Tami, and W.R. Shanahan Jr. A randomized, placebo controlled trial of an antisense oligodeoxynucleotide to intercellular adhesion molecule-1 in the treatment of severe rheumatoid arthritis J Rheumatol 29 2002 447 453
-
(2002)
J Rheumatol
, vol.29
, pp. 447-453
-
-
Maksymowych, W.P.1
Blackburn, W.D.2
Tami, J.A.3
Shanahan, W.R.4
-
71
-
-
4644290316
-
Phase I and phase II safety and efficacy trial of intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302) for the prevention of acute allograft rejection
-
B.D. Kahan, S. Stepkowski, M. Kilic, S.M. Katz, C.T. Van Buren, M.S. Welsh, and et al. Phase I and phase II safety and efficacy trial of intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302) for the prevention of acute allograft rejection Transplantation 78 2004 858 863
-
(2004)
Transplantation
, vol.78
, pp. 858-863
-
-
Kahan, B.D.1
Stepkowski, S.2
Kilic, M.3
Katz, S.M.4
Van Buren, C.T.5
Welsh, M.S.6
-
72
-
-
77955608799
-
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma
-
D.L. DiGiusto, A. Krishnan, L. Li, H. Li, S. Li, A. Rao, and et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma Sci Transl Med 2 2010 36ra43
-
(2010)
Sci Transl Med
, vol.2
, pp. 36ra43
-
-
DiGiusto, D.L.1
Krishnan, A.2
Li, L.3
Li, H.4
Li, S.5
Rao, A.6
-
73
-
-
84876475656
-
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
-
P. Tebas, D. Stein, G. Binder-Scholl, R. Mukherjee, T. Brady, T. Rebello, and et al. Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV Blood 121 2013 1524 1533
-
(2013)
Blood
, vol.121
, pp. 1524-1533
-
-
Tebas, P.1
Stein, D.2
Binder-Scholl, G.3
Mukherjee, R.4
Brady, T.5
Rebello, T.6
-
74
-
-
0029127845
-
Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects
-
R. Zhang, J. Yan, H.K. Shahinian, G. Amin, Z. Lu, T. Liu, and et al. Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects Clin Pharmacol Ther 58 1995 44 53
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 44-53
-
-
Zhang, R.1
Yan, J.2
Shahinian, H.K.3
Amin, G.4
Lu, Z.5
Liu, T.6
-
75
-
-
0032921468
-
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects
-
D. Sereni, R. Tubiana, C. Lascoux, C. Katlama, O. Taulera, A. Bourque, and et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects J Clin Pharmacol 39 1999 47 54
-
(1999)
J Clin Pharmacol
, vol.39
, pp. 47-54
-
-
Sereni, D.1
Tubiana, R.2
Lascoux, C.3
Katlama, C.4
Taulera, O.5
Bourque, A.6
-
76
-
-
79959466157
-
RNA interference and its potential applications to chronic HBV treatment: Results of a Phase I safety and tolerability study
-
R.G. Gish, C. Satishchandran, M. Young, and C. Pachuk RNA interference and its potential applications to chronic HBV treatment: results of a Phase I safety and tolerability study Antivir Ther 16 2011 547 554
-
(2011)
Antivir Ther
, vol.16
, pp. 547-554
-
-
Gish, R.G.1
Satishchandran, C.2
Young, M.3
Pachuk, C.4
-
77
-
-
11144303404
-
Virological effects of ISIS 14803, an antisense oligonucleotide inhibitor of hepatitis C virus (HCV) internal ribosome entry site (IRES), on HCV IRES in chronic hepatitis C patients and examination of the potential role of primary and secondary HCV resistance in the outcome of treatment
-
M. Soler, J.G. McHutchison, T.J. Kwoh, F.A. Dorr, and J.M. Pawlotsky Virological effects of ISIS 14803, an antisense oligonucleotide inhibitor of hepatitis C virus (HCV) internal ribosome entry site (IRES), on HCV IRES in chronic hepatitis C patients and examination of the potential role of primary and secondary HCV resistance in the outcome of treatment Antivir Ther 9 2004 953 968
-
(2004)
Antivir Ther
, vol.9
, pp. 953-968
-
-
Soler, M.1
McHutchison, J.G.2
Kwoh, T.J.3
Dorr, F.A.4
Pawlotsky, J.M.5
-
78
-
-
28844476544
-
A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients
-
J.G. McHutchison, K. Patel, P. Pockros, L. Nyberg, S. Pianko, R.Z. Yu, and et al. A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients J Hepatol 44 2006 88 96
-
(2006)
J Hepatol
, vol.44
, pp. 88-96
-
-
McHutchison, J.G.1
Patel, K.2
Pockros, P.3
Nyberg, L.4
Pianko, S.5
Yu, R.Z.6
-
79
-
-
58049217312
-
MicroRNA-122 stimulates translation of hepatitis C virus RNA
-
J.I. Henke, D. Goergen, J. Zheng, Y. Song, C.G. Schuttler, C. Fehr, and et al. microRNA-122 stimulates translation of hepatitis C virus RNA EMBO J 27 2008 3300 3310
-
(2008)
EMBO J
, vol.27
, pp. 3300-3310
-
-
Henke, J.I.1
Goergen, D.2
Zheng, J.3
Song, Y.4
Schuttler, C.G.5
Fehr, C.6
-
80
-
-
84964860739
-
-
Available at:. Accessed October 12, 2015.
-
Available at: http://www.accessdata.fda.gov/drugsatfda-docs/nda/98/20961-Vitravene.cfm. Accessed October 12, 2015.
-
-
-
-
81
-
-
0037022910
-
Inflammation and atherosclerosis
-
P. Libby, P.M. Ridker, and A. Maseri Inflammation and atherosclerosis Circulation 105 2002 1135 1143
-
(2002)
Circulation
, vol.105
, pp. 1135-1143
-
-
Libby, P.1
Ridker, P.M.2
Maseri, A.3
-
82
-
-
0037180771
-
Inflammation in atherosclerosis
-
P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
-
(2002)
Nature
, vol.420
, pp. 868-874
-
-
Libby, P.1
-
83
-
-
0035571606
-
Immune mechanisms in atherosclerosis
-
G.K. Hansson Immune mechanisms in atherosclerosis Arterioscler Thromb Vasc Biol 21 2001 1876 1890
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1876-1890
-
-
Hansson, G.K.1
-
84
-
-
84890965863
-
Links between allergy and cardiovascular or hemostatic system
-
D.P. Potaczek Links between allergy and cardiovascular or hemostatic system Int J Cardiol 170 2014 278 285
-
(2014)
Int J Cardiol
, vol.170
, pp. 278-285
-
-
Potaczek, D.P.1
-
85
-
-
84930934403
-
Atherosclerosis: Recent trials, new targets and future directions
-
R. Ladeiras-Lopes, S. Agewall, A. Tawakol, B. Staels, E. Stein, R.J. Mentz, and et al. Atherosclerosis: Recent trials, new targets and future directions Int J Cardiol 192 2015 72 81
-
(2015)
Int J Cardiol
, vol.192
, pp. 72-81
-
-
Ladeiras-Lopes, R.1
Agewall, S.2
Tawakol, A.3
Staels, B.4
Stein, E.5
Mentz, R.J.6
-
87
-
-
84876802101
-
Apolipoprotein B antisense inhibition - Update on mipomersen
-
C. Gebhard, G. Huard, E.A. Kritikou, and J.C. Tardif Apolipoprotein B antisense inhibition - update on mipomersen Curr Pharm Des 19 2013 3132 3142
-
(2013)
Curr Pharm des
, vol.19
, pp. 3132-3142
-
-
Gebhard, C.1
Huard, G.2
Kritikou, E.A.3
Tardif, J.C.4
-
88
-
-
84882927131
-
New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromes
-
A. Sahebkar, and G.F. Watts New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes Clin Ther 35 2013 1082 1098
-
(2013)
Clin Ther
, vol.35
, pp. 1082-1098
-
-
Sahebkar, A.1
Watts, G.F.2
-
89
-
-
84921866616
-
Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: Results of 4 phase III trials
-
R.D. Santos, F.J. Raal, A.L. Catapano, J.L. Witztum, E. Steinhagen-Thiessen, and S. Tsimikas Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials Arterioscler Thromb Vasc Biol 35 2015 689 699
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 689-699
-
-
Santos, R.D.1
Raal, F.J.2
Catapano, A.L.3
Witztum, J.L.4
Steinhagen-Thiessen, E.5
Tsimikas, S.6
-
90
-
-
43749096100
-
Neovascular age-related macular degeneration: Potential therapies
-
A.V. Chappelow, and P.K. Kaiser Neovascular age-related macular degeneration: potential therapies Drugs 68 2008 1029 1036
-
(2008)
Drugs
, vol.68
, pp. 1029-1036
-
-
Chappelow, A.V.1
Kaiser, P.K.2
-
91
-
-
67649622340
-
VEGF inhibitors for the treatment of neovascular age-related macular degeneration
-
M.R. Barakat, and P.K. Kaiser VEGF inhibitors for the treatment of neovascular age-related macular degeneration Expert Opin Investig Drugs 18 2009 637 646
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 637-646
-
-
Barakat, M.R.1
Kaiser, P.K.2
-
92
-
-
84900561447
-
Advances in the management of macular degeneration
-
M. Singer Advances in the management of macular degeneration F1000Prime Rep 6 2014 29
-
(2014)
F1000Prime Rep
, vol.6
, pp. 29
-
-
Singer, M.1
-
93
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease Nat Med 1 1995 27 31
-
(1995)
Nat Med
, vol.1
, pp. 27-31
-
-
Folkman, J.1
-
94
-
-
77953909544
-
RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027
-
P.K. Kaiser, R.C. Symons, S.M. Shah, E.J. Quinlan, H. Tabandeh, D.V. Do, and et al. RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027 Am J Ophthalmol 150 2010 33 39
-
(2010)
Am J Ophthalmol
, vol.150
, pp. 33-39
-
-
Kaiser, P.K.1
Symons, R.C.2
Shah, S.M.3
Quinlan, E.J.4
Tabandeh, H.5
Do, D.V.6
-
95
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
T. Shoshani, A. Faerman, I. Mett, E. Zelin, T. Tenne, S. Gorodin, and et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis Mol Cell Biol 22 2002 2283 2293
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
Faerman, A.2
Mett, I.3
Zelin, E.4
Tenne, T.5
Gorodin, S.6
-
96
-
-
4644334830
-
Inhibition of oxygen-induced retinopathy in RTP801-deficient mice
-
A. Brafman, I. Mett, M. Shafir, H. Gottlieb, G. Damari, S. Gozlan-Kelner, and et al. Inhibition of oxygen-induced retinopathy in RTP801-deficient mice Invest Ophthalmol Vis Sci 45 2004 3796 3805
-
(2004)
Invest Ophthalmol Vis Sci
, vol.45
, pp. 3796-3805
-
-
Brafman, A.1
Mett, I.2
Shafir, M.3
Gottlieb, H.4
Damari, G.5
Gozlan-Kelner, S.6
-
97
-
-
1542344006
-
Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
-
P. Delafontaine, Y.H. Song, and Y. Li Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels Arterioscler Thromb Vasc Biol 24 2004 435 444
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 435-444
-
-
Delafontaine, P.1
Song, Y.H.2
Li, Y.3
-
98
-
-
0034647770
-
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways
-
C. Miele, J.J. Rochford, N. Filippa, S. Giorgetti-Peraldi, and E. Van Obberghen Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways J Biol Chem 275 2000 21695 21702
-
(2000)
J Biol Chem
, vol.275
, pp. 21695-21702
-
-
Miele, C.1
Rochford, J.J.2
Filippa, N.3
Giorgetti-Peraldi, S.4
Van Obberghen, E.5
-
99
-
-
33644669648
-
Downregulation of IRS-1 expression causes inhibition of corneal angiogenesis
-
C. Andrieu-Soler, M. Berdugo, M. Doat, Y. Courtois, D. BenEzra, and F. Behar-Cohen Downregulation of IRS-1 expression causes inhibition of corneal angiogenesis Invest Ophthalmol Vis Sci 46 2005 4072 4078
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 4072-4078
-
-
Andrieu-Soler, C.1
Berdugo, M.2
Doat, M.3
Courtois, Y.4
BenEzra, D.5
Behar-Cohen, F.6
-
100
-
-
65649108417
-
Potent in vivo antiangiogenic effects of GS-101 (5′-TATCCGGAGGGCTCGCCATGCTGCT-3′), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1
-
S. Al-Mahmood, S. Colin, N. Farhat, E. Thorin, C. Steverlynck, and S. Chemtob Potent in vivo antiangiogenic effects of GS-101 (5′-TATCCGGAGGGCTCGCCATGCTGCT-3′), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1 J Pharmacol Exp Ther 329 2009 496 504
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 496-504
-
-
Al-Mahmood, S.1
Colin, S.2
Farhat, N.3
Thorin, E.4
Steverlynck, C.5
Chemtob, S.6
-
101
-
-
84896457296
-
The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3beta-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients
-
S. Colin, B. Darne, A. Kadi, A. Ferry, M. Favier, C. Lesaffre, and et al. The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3beta-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients J Pharmacol Exp Ther 349 2014 107 117
-
(2014)
J Pharmacol Exp Ther
, vol.349
, pp. 107-117
-
-
Colin, S.1
Darne, B.2
Kadi, A.3
Ferry, A.4
Favier, M.5
Lesaffre, C.6
-
102
-
-
84876466100
-
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study
-
T.M. Miller, A. Pestronk, W. David, J. Rothstein, E. Simpson, S.H. Appel, and et al. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study Lancet Neurol 12 2013 435 442
-
(2013)
Lancet Neurol
, vol.12
, pp. 435-442
-
-
Miller, T.M.1
Pestronk, A.2
David, W.3
Rothstein, J.4
Simpson, E.5
Appel, S.H.6
-
103
-
-
76349084709
-
First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
-
S.A. Leachman, R.P. Hickerson, M.E. Schwartz, E.E. Bullough, S.L. Hutcherson, K.M. Boucher, and et al. First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder Mol Ther 18 2010 442 446
-
(2010)
Mol Ther
, vol.18
, pp. 442-446
-
-
Leachman, S.A.1
Hickerson, R.P.2
Schwartz, M.E.3
Bullough, E.E.4
Hutcherson, S.L.5
Boucher, K.M.6
-
104
-
-
0347003516
-
Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense
-
A. Aartsma-Rus, A.A. Janson, W.E. Kaman, M. Bremmer-Bout, G.J. van Ommen, J.T. den Dunnen, and et al. Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense Am J Hum Genet 74 2004 83 92
-
(2004)
Am J Hum Genet
, vol.74
, pp. 83-92
-
-
Aartsma-Rus, A.1
Janson, A.A.2
Kaman, W.E.3
Bremmer-Bout, M.4
Van Ommen, G.J.5
Den Dunnen, J.T.6
-
105
-
-
33746667851
-
Antisense oligonucleotide therapy for neurodegenerative disease
-
R.A. Smith, T.M. Miller, K. Yamanaka, B.P. Monia, T.P. Condon, G. Hung, and et al. Antisense oligonucleotide therapy for neurodegenerative disease J Clin Invest 116 2006 2290 2296
-
(2006)
J Clin Invest
, vol.116
, pp. 2290-2296
-
-
Smith, R.A.1
Miller, T.M.2
Yamanaka, K.3
Monia, B.P.4
Condon, T.P.5
Hung, G.6
-
106
-
-
84874095172
-
SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy
-
L. Winer, D. Srinivasan, S. Chun, D. Lacomis, M. Jaffa, A. Fagan, and et al. SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy JAMA Neurol 70 2013 201 207
-
(2013)
JAMA Neurol
, vol.70
, pp. 201-207
-
-
Winer, L.1
Srinivasan, D.2
Chun, S.3
Lacomis, D.4
Jaffa, M.5
Fagan, A.6
-
107
-
-
0037308205
-
The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
-
T. Brenner, Y. Hamra-Amitay, T. Evron, N. Boneva, S. Seidman, and H. Soreq The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis FASEB J 17 2003 214 222
-
(2003)
FASEB J
, vol.17
, pp. 214-222
-
-
Brenner, T.1
Hamra-Amitay, Y.2
Evron, T.3
Boneva, N.4
Seidman, S.5
Soreq, H.6
-
108
-
-
34547895887
-
Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
-
Z. Argov, D. McKee, S. Agus, S. Brawer, N. Shlomowitz, O.B. Yoseph, and et al. Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase Neurology 69 2007 699 700
-
(2007)
Neurology
, vol.69
, pp. 699-700
-
-
Argov, Z.1
McKee, D.2
Agus, S.3
Brawer, S.4
Shlomowitz, N.5
Yoseph, O.B.6
-
109
-
-
45249084126
-
Antisense treatment for myasthenia gravis: Experience with monarsen
-
J.D. Sussman, Z. Argov, D. McKee, E. Hazum, S. Brawer, and H. Soreq Antisense treatment for myasthenia gravis: experience with monarsen Ann N Y Acad Sci 1132 2008 283 290
-
(2008)
Ann N y Acad Sci
, vol.1132
, pp. 283-290
-
-
Sussman, J.D.1
Argov, Z.2
McKee, D.3
Hazum, E.4
Brawer, S.5
Soreq, H.6
-
110
-
-
84871567801
-
Further developments with antisense treatment for myasthenia gravis
-
J. Sussman, Z. Argov, Y. Wirguin, S. Apolski, V. Milic-Rasic, and H. Soreq Further developments with antisense treatment for myasthenia gravis Ann N Y Acad Sci 1275 2012 13 16
-
(2012)
Ann N y Acad Sci
, vol.1275
, pp. 13-16
-
-
Sussman, J.1
Argov, Z.2
Wirguin, Y.3
Apolski, S.4
Milic-Rasic, V.5
Soreq, H.6
-
111
-
-
84902540444
-
PROS1 mutations associated with protein S deficiency in Polish patients with residual vein obstruction on rivaroxaban therapy
-
E. Wypasek, D.P. Potaczek, M. Alhenc-Gelas, and A. Undas PROS1 mutations associated with protein S deficiency in Polish patients with residual vein obstruction on rivaroxaban therapy Thromb Res 134 2014 199 201
-
(2014)
Thromb Res
, vol.134
, pp. 199-201
-
-
Wypasek, E.1
Potaczek, D.P.2
Alhenc-Gelas, M.3
Undas, A.4
-
112
-
-
84891877806
-
First report of the genetic background of Marfan syndrome in Polish patients
-
E. Wypasek, D.P. Potaczek, R. Stapor, P.J. Coucke, J. De Backer, A.M. De Paepe, and et al. First report of the genetic background of Marfan syndrome in Polish patients Pol Arch Med Wewn 123 2013 646 647
-
(2013)
Pol Arch Med Wewn
, vol.123
, pp. 646-647
-
-
Wypasek, E.1
Potaczek, D.P.2
Stapor, R.3
Coucke, P.J.4
De Backer, J.5
De Paepe, A.M.6
-
113
-
-
84894183623
-
Novel missense mutation C106R in the PROC gene associated with type I protein C deficiency in a young Polish man with high-risk pulmonary embolism
-
E. Wypasek, D.P. Potaczek, M. Alhenc-Gelas, and A. Undas Novel missense mutation C106R in the PROC gene associated with type I protein C deficiency in a young Polish man with high-risk pulmonary embolism Pol Arch Med Wewn 124 2014 75 76
-
(2014)
Pol Arch Med Wewn
, vol.124
, pp. 75-76
-
-
Wypasek, E.1
Potaczek, D.P.2
Alhenc-Gelas, M.3
Undas, A.4
-
115
-
-
0035040363
-
Safety of intracoronary administration of c-myc antisense oligomers after percutaneous transluminal coronary angioplasty (PTCA)
-
F. Roque, G. Mon, J. Belardi, A. Rodriguez, L. Grinfeld, R. Long, and et al. Safety of intracoronary administration of c-myc antisense oligomers after percutaneous transluminal coronary angioplasty (PTCA) Antisense Nucleic Acid Drug Dev 11 2001 99 106
-
(2001)
Antisense Nucleic Acid Drug Dev
, vol.11
, pp. 99-106
-
-
Roque, F.1
Mon, G.2
Belardi, J.3
Rodriguez, A.4
Grinfeld, L.5
Long, R.6
-
116
-
-
0037116555
-
Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: Results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenting (ITALICS) trial
-
M.J. Kutryk, D.P. Foley, M. van den Brand, J.N. Hamburger, W.J. van der Giessen, P.J. deFeyter, and et al. Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenting (ITALICS) trial J Am Coll Cardiol 39 2002 281 287
-
(2002)
J Am Coll Cardiol
, vol.39
, pp. 281-287
-
-
Kutryk, M.J.1
Foley, D.P.2
Van Den Brand, M.3
Hamburger, J.N.4
Van Der Giessen, W.J.5
DeFeyter, P.J.6
-
117
-
-
36348962617
-
First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study
-
N. Kipshidze, P. Iversen, P. Overlie, T. Dunlap, B. Titus, D. Lee, and et al. First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study Cardiovasc Revasc Med 8 2007 230 235
-
(2007)
Cardiovasc Revasc Med
, vol.8
, pp. 230-235
-
-
Kipshidze, N.1
Iversen, P.2
Overlie, P.3
Dunlap, T.4
Titus, B.5
Lee, D.6
-
118
-
-
84964819034
-
-
Available at:. Accessed October 27, 2015.
-
Available at: http://www.ema.europa.eu/docs/en-GB/document-library/Summary-of-opinion-Initial-authorisation/human/002429/WC500136279.pdf. Accessed October 27, 2015.
-
-
-
-
119
-
-
16544382507
-
Antisense inhibition: Oligonucleotides, ribozymes, and siRNAs
-
Y.C. Zhang, M.M. Taylor, W.K. Samson, and M.I. Phillips Antisense inhibition: oligonucleotides, ribozymes, and siRNAs Methods Mol Med 106 2005 11 34
-
(2005)
Methods Mol Med
, vol.106
, pp. 11-34
-
-
Zhang, Y.C.1
Taylor, M.M.2
Samson, W.K.3
Phillips, M.I.4
|