Biopsychosocial aspects of functional gastrointestinal disorders: How central and environmental processes contribute to the development and expression of functional gastrointestinal disorders

Gastroenterology

Volumn 150, Issue 6, 2016, Pages 1355-1367.e2

  Van Oudenhove, Lukas ^a   Levy, Rona L ^g   Crowell, Michael D ^b   Drossman, Douglas A ^c   Halpert, Albena D ^d   Keefer, Laurie ^e   Lackner, Jeffrey M ^f   Murphy, Tasha B ^g   Naliboff, Bruce D ^h  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b MAYO CLINIC   (United States)

^c Center for Education and Practice of Biopsychosocial Care LLC   (United States)

^d Pentucket Medical Associates   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f STATE UNIVERSITY OF NEW YORK   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adverse Life Events; Anxiety; Depression; Psychological Treatments

Indexed keywords

BIOLOGICAL FACTOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANXIETY DISORDER; AROUSAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN FUNCTION; CLINICAL ASSESSMENT; COGNITIVE BEHAVIORAL THERAPY; CULTURAL FACTOR; DIGESTIVE SYSTEM FUNCTION DISORDER; DISTRESS SYNDROME; EMOTION; ENVIRONMENTAL FACTOR; GASTROINTESTINAL SYMPTOM; HUMAN; HYPNOSIS; HYPOPHYSIS ADRENAL SYSTEM; MOOD DISORDER; MUSCLE RELAXATION; NEUROIMAGING; NEUROPHYSIOLOGY; PARENTAL ATTITUDE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROBLEM SOLVING; PSYCHOLOGICAL ASPECT; SOCIAL BELIEF; SOCIAL SUPPORT; SOMATIZATION; STRUCTURED INTERVIEW; SYMPTOM; WHITE MATTER;

EID: 84964776895     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.02.027     Document Type: Article

References (110)

1. G. Bode, H. Brenner, G. Adler, and D. Rothenbacher Recurrent abdominal pain in children: evidence from a population-based study that social and familial factors play a major role but not Helicobacter pylori infection J Psychosom Res 54 2003 417 421
2. R.L. Levy, W.E. Whitehead, M.R. Von Korff, and et al. Intergenerational transmission of gastrointestinal illness behavior Am J Gastroenterol 95 2000 451 456
3. L.S. Walker, J. Garber, and J.W. Greene Somatization symptoms in pediatric abdominal pain patients: Relation to chronicity of abdominal pain and parent somatization J Abnorm Child Psychol 19 1991 379 394
4. L.S. Walker, J. Garber, and J.W. Greene Somatic complaints in pediatric patients: a prospective study of the role of negative life events, child social and academic competence, and parental somatic symptoms J Consult Clin Psychol 62 1994 1213 1221
5. R.L. Levy, K.R. Jones, W.E. Whitehead, and et al. Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology Gastroenterology 121 2001 799 804
6. R.L. Levy, W.E. Whitehead, L.S. Walker, and et al. Increased somatic complaints and health-care utilization in children: effects of parent IBS status and parent response to gastrointestinal symptoms Am J Gastroenterol 99 2004 2442 2451
7. L.S. Walker, S.E. Williams, C.A. Smith, and et al. Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain Pain 122 2006 43 52
8. R.L. Levy, S. Langer, L. Walker, and et al. Twelve month follow-up of cognitive behavioral therapy for children with functional abdominal pain JAMA Pediatr 167 2013 178 184
9. R.L. Levy, S.L. Langer, J.M. Romano, and et al. Cognitive mediators of treatment outcomes in pediatric functional abdominal pain Clin J Pain 30 2014 1033 1043
10. S. Seino, S. Watanabe, N. Ito, and et al. Enhanced auditory brainstem response and parental bonding style in children with gastrointestinal symptoms PLoS One 7 2012 e32913
11. J.V. Campo, J. Bridge, A. Lucas, and et al. Physical and emotional health of mothers of youth with functional abdominal pain Arch Pediatr Adolesc Med 161 2007 131 137
12. S.L. Langer, J.M. Romano, R.L. Levy, and et al. Catastrophizing and parental response to child symptom complaints Child Health Care 38 2009 169 184
13. K. Bradford, W. Shih, E.J. Videlock, and et al. Association between early adverse life events and irritable bowel syndrome Clin Gastroenterol Hepatol 10 2012 385 390
14. D.A. Drossman Abuse, trauma, and GI illness: is there a link? Am J Gastroenterol 106 2011 14 25
15. N. Galli The influence of cultural heritage on the health status of Puerto Ricans J Sch Health 45 1975 10 16
16. E.M. Quigley, A.D. Sperber, and D.A. Drossman WGO - Rome foundation joint symposium summary: IBS - the global perspective J Clin Gastroenterol 45 2011 i ii
17. C.D. Murray, J. Flynn, L. Ratcliffe, and et al. Effect of acute physical and psychological stress on gut autonomic innervation in iritable bowel syndrome Gastroenterology 127 2004 1695 1703
18. A. Bitton, P.L. Dobkin, M.D. Edwardes, and et al. Predicting relapse in Crohn's disease: a biopsychosocial model Gut 57 2008 1386 1392
19. J.M. Lackner, and M.B. Gurtman Pain catastrophizing and interpersonal problems: a circumplex analysis of the communal coping model Pain 110 2004 597 604
20. A.D. Sperber, D.A. Drossman, and E. Quigley The global perspective on irritable bowel syndrome: a Rome Foundation-World Gastroenterology Organization symposium Am J Gastroenterol 107 2012 1602 1609
21. D.A. Drossman, Z. Li, J. Leserman, and et al. Effects of coping on health outcome among female patients with gastrointestinal disorders Psychosom Med 62 2000 309 317
22. E.J. Bennett, C.C. Tennant, C. Piesse, and et al. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome Gut 43 1998 256 261
23. J.M. Lackner, G.D. Gudleski, R. Firth, and et al. Negative aspects of close relationships are more strongly associated than supportive personal relationships with illness burden of irritable bowel syndrome J Psychosom Res 74 2013 493 500
24. E. Jakobsson Ung, G. Ringstrom, H. Sjovall, and et al. How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study Eur J Gastroenterol Hepatol 25 2013 1478 1483
25. J.M. Lackner, A.M. Brasel, B.M. Quigley, and et al. The ties that bind: perceived social support, stress, and IBS in severely affected patients Neurogastroenterol Motil 22 2010 893 900
26. L.A. Conboy, E. Macklin, J. Kelley, and et al. Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship Soc Sci Med 70 2010 479 484
27. G. Addolorato, A. Mirijello, C. D'Angelo, and et al. State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting Int J Clin Pract 62 2008 1063 1069
28. M. Bouchoucha, M. Hejnar, G. Devroede, and et al. Anxiety and depression as markers of multiplicity of sites of functional gastrointestinal disorders: a gender issue? Clin Res Hepatol Gastroenterol 37 2013 422 430
29. L. Van Oudenhove, J. Vandenberghe, R. Vos, and et al. Factors associated with co-morbid irritable bowel syndrome and chronic fatigue-like symptoms in functional dypepsia Neurogastroenterol Motil 23 2011 524-e202
30. V. Miller, L. Hopkins, and P.J. Whorwell Suicidal ideation in patients with irritable bowel syndrome Clin Gastroenterol Hepatol 2 2004 1064 1068
31. J.M. Lackner, and M.B. Gurtman Patterns of interpersonal problems in irritable bowel syndrome patients: a circumplex analysis J Psychosom Res 58 2005 523 532
32. Z.J. Lipowski Somatization: the concept and its clinical application Am J Psychiatry 145 1988 1358 1368
33. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013 American Psychiatric Association Washington, DC
34. J.E. Dimsdale, F. Creed, J. Escobar, and et al. Somatic symptom disorder: an important change in DSM J Psychosom Res 75 2013 223 228
35. V. Duddu, M.K. Isaac, and S.K. Chaturvedi Somatization, somatosensory amplification, attribution styles and illness behaviour: a review Int Rev Psychiatry 18 2006 25 33
36. L. Van Oudenhove, J. Vandenberghe, B. Geeraerts, and et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors, or somatization? Gut 57 2008 1666 1673
37. L. Van Oudenhove, J. Vandenberghe, R. Vos, and et al. Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia Psychosom Med 73 2011 648 655
38. V. Agosti, F.M. Quitkin, J.W. Stewart, and et al. Somatization as a predictor of medication discontinuation due to adverse events Int Clin Psychopharmacol 17 2002 311 314
39. W.E. Whitehead, O.S. Palsson, R.R. Levy, and et al. Comorbidity in irritable bowel syndrome Am J Gastroenterol 102 2007 2767 2776
40. J.M. Lackner, C.X. Ma, L. Keefer, and et al. Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome Clin Gastroenterol Hepatol 11 2013 1147 1157
41. J. Chilcot, and R. Moss-Morris Changes in illness-related cognitions rather than distress mediate improvements in irritable bowel syndrome (IBS) symptoms and disability following a brief cognitive behavioural therapy intervention Behav Res Ther 51 2013 690 695
42. E.A. Mayer, and K. Tillisch The brain-gut axis in abdominal pain syndromes Annu Rev Med 62 2011 381 396
43. S.D. Dorn, O.S. Palsson, S.I.M. Thiwan, and et al. Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity Gut 56 2007 1202 1209
44. B. Dickhaus, E.A. Mayer, N. Firooz, and et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress Am J Gastroenterol 98 2003 135 143
45. S. Elsenbruch, C. Rosenberger, P. Enck, and et al. Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study Gut 59 2010 489 495
46. L. Van Oudenhove, and Q. Aziz The role of psychosocial factors and psychiatric disorders in functional dyspepsia Nat Rev Gastroenterol Hepatol 10 2013 158 167
47. K. Tillisch, E.A. Mayer, and J.S. Labus Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome Gastroenterology 140 2011 91 100
48. L. Van Oudenhove, J. Labus, P. Dupont, and et al. Altered brain network connectivity associated with increased perceptual response to aversive gastric distension and its expectation in functional dyspepsia Neurogastroenterol Motil 22 2010 20 21
49. S.M. Berman, B.D. Naliboff, B. Suyenobu, and et al. Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome J Neurosci 28 2008 349 359
50. J.S. Labus, E.A. Mayer, J. Jarcho, and et al. Acute tryptophan depletion alters the effective connectivity of emotional arousal circuitry during visceral stimuli in healthy women Gut 60 2011 1196 1203
51. E.A. Mayer, S. Berman, B. Suyenobu, and et al. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis Pain 115 2005 398 409
52. D.A. Seminowicz, J.S. Labus, J.A. Bueller, and et al. Regional gray matter density changes in brains of patients with irritable bowel syndrome Gastroenterology 139 2010 48 57.e2
53. U. Blankstein, J. Chen, N.E. Diamant, and et al. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors Gastroenterology 138 2010 1783 1789
54. F. Zeng, W. Qin, Y. Yang, and et al. Regional brain structural abnormality in meal-related functional dyspepsia patients: a voxel-based morphometry study PLoS One 8 2013 e68383
55. J.Y. Hong, L.A. Kilpatrick, J. Labus, and et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain J Neurosci 33 2013 11994 12002
56. F. Zeng, W. Qin, F. Liang, and et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity Gastroenterology 141 2011 499 506
57. M.I. Liu, F.R. Liang, F. Zeng, and et al. Cortical-limbic regions modulate depression and anxiety factors in functional dyspepsia: a PET-CT study Ann Nucl Med 26 2012 35 40
58. H. Ly, J. Ceccarini, N. Weltens, and et al. Increased cerebral cannabinoid-1 receptor availability is a stable feature of functional dyspepsia: a [18F] ML-9470 PET study Psychother Psychosom 84 2015 149 158
59. P. Liu, F. Zeng, G. Zhou, and et al. Alterations of the default mode network in functional dyspepsia patients: a resting-state fMRI study Neurogastroenterol Motil 25 2013 e382 e388
60. J. Nan, J. Liu, G. Li, and et al. Whole-brain functional connectivity identification of functional dyspepsia PLoS One 8 2013 e65870
61. B.M. Ellingson, E. Mayer, R.J. Harris, and et al. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome Pain 154 2013 1528 1541
62. J.Y. Chen, U. Blankstein, N.E. Diamant, and et al. White matter abnormalities in irritable bowel syndrome and relation to individual factors Brain Res 1392 2011 121 131
63. G. Zhou, W. Qin, F. Zeng, and et al. White-matter microstructural changes in functional dyspepsia: a diffusion tensor imagine study Am J Gastroenterol 108 2013 260 269
64. E.A. Mayer The neurobiology of stress and gastrointestinal disease Gut 47 2000 861 869
65. Y. Tache, and B. Bonaz Corticotropin-releasing factor receptors and stress-related alterations of gut motor function J Clin Invest 117 2007 33 40
66. B. Geeraerts, J. Vandenberghe, L. Van Oudenhove, and et al. Influence of experimientally induced anxiety on gastric sensorimotor function in man Gastroenterology 129 2005 1437 1444
67. S. Fukudo, T. Nomura, and M. Hongo Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome Gut 42 1998 845 849
68. H. Tornblom, L. Van Oudenhove, R. Sadik, and et al. Colonic transit time and IBS symptoms: what's the link? Am J Gastroenterol 107 2012 754 760
69. M. Kanazawa, O.S. Palsson, S.I.M. Thiwan, and et al. Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits Am J Gastroenterol 103 2008 2550 2561
70. J. Matricon, M. Meleine, A. Gelot, and et al. Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome Aliment Pharmacol Ther 36 2012 1009 1031
71. D. O'Malley, E.M.M. Quigley, T.G. Dinan, and et al. Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome? Brain Behav Immun 25 2011 1333 1341
72. T.G. Dinan, E.M. Quigley, S.M. Ahmed, and et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 130 2006 304 311
73. T. Liebregts, B. Adam, C. Bredack, and et al. Immune activation in patients with irritable bowel syndrome Gastroenterology 132 2007 913 920
74. S. Kindt, L. Van Oudenhove, D. Broekaert, and et al. Immune dysfunction in patients with functional gastrointestinal disorders Neurogastroenterol Motil 21 2009 389 398
75. T. Piche, M.C. Saint-Paul, R. Dainese, and et al. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome Gut 57 2008 468 473
76. R. Spiller, and K. Garsed Postinfectious irritable bowel syndrome Gastroenterology 136 2009 1979 1988
77. T. Vanuytsel, S. van Wanrooy, H. Vanheel, and et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism Gut 63 2014 1293 1299
78. N. Mazurak, N. Seredyuk, H. Sauer, and et al. Heart rate variability in the irritable bowel syndrome: a review of the literature Neurogastroenterol Motil 24 2012 206 216
79. Q. Liu, E.M. Wang, X.J. Yan, and et al. Automatic functioning in irritable bowel syndrome as measured by heart rate variability: a meta-analysis J Dig Dis 14 2013 638 646
80. L.M. Tak, H. Riese, G.H. de Bock, and et al. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders Biol Psychol 82 2009 101 110
81. L.M. Tak, A.J. Cleare, J. Ormel, and et al. Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders Biol Psychol 87 2011 183 194
82. M.M. Heitkemper, K.C. Cain, W. Deechakawan, and et al. Anticipation of public speaking and sleep and the hypothalamic-pituitary-adrenal axis in women with irritable bowel syndrome Neurogastroenterol Motil 24 2012 626 631
83. L. Chang, S. Sundaresh, J. Elliott, and et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome Neurogastroenterol Motil 21 2009 149 159
84. K.A. Suarez-Hitz, B. Otto, M. Bidlingmaier, and et al. Altered psychobiological responsiveness in women with irritable bowel syndrome Psychosom Med 74 2012 221 231
85. P.J. Kennedy, J.F. Cryan, E.M. Quigley, and et al. A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome Psychol Med 44 2014 3123 3134
86. J.F. Cryan, and T.G. Dinan Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour Nat Rev Neurosci 13 2012 701 712
87. C. Tana, Y. Umesaki, A. Imaoka, and et al. Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome Neurogastroenterol Motil 22 2010 512 519 e114-e115
88. G. Clarke, J.F. Cryan, T.G. Dinan, and et al. Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria Aliment Pharmacol Ther 35 2012 403 413
89. J. Jalanka-Tuovinen, A. Salonen, J. Nikkila, and et al. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms PLoS One 6 2011 e23035
90. K. Tillisch, J. Labus, L. Kilpatrick, and et al. Consumption of fermented milk product with probiotic modulates brain activity Gastroenterology 144 2013 1394 1401 1401.e1-1401.e4
91. R.L. Levy, S.L. Langer, L.S. Walker, and et al. Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms Am J Gastroenterol 105 2010 946 956
92. T.J. D'Zurilla, and A.M. Nezu Problem-solving therapies 2001 Guilford Press New York
93. A.M. Nezu, and G.F. Ronan Life stress, current problems, problem solving, and depressive symptoms: an integrative model J Consult Clin Psychol 53 1985 693 697
94. L. Keefer, and E.B. Blanchard The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study Behav Res Ther 39 2001 801 811
95. L.A. Rokicki, K.A. Holroyd, C.R. France, and et al. Change mechanisms associated with combined relaxation/EMG biofeedback training for chronic tension headache Appl Psychophysiol Biofeedback 22 1997 21 41
96. R. Fried Respiration in stress and stress control: toward a theory of stress as a hypoxic phenomenon P.M. Lehrer, R.L. Woolfolk, Principles and practice of stress management 2nd ed. 1993 Guilford New York 301 333
97. S.A. Gaylord, O.S. Palsson, E.L. Garland, and et al. Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial Am J Gastroenterol 106 2011 1678 1688
98. J.M. Lackner, J. Jaccard, and C. Baum Multidomain patient-reported outcomes of irritable bowel syndrome: exploring person-centered perspectives to better understand symptom severity scores Value Health 16 2013 97 103
99. P.J. Whorwell, A. Prior, and E.B. Faragher Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome Lancet 324 1984 1232 1233
100. M.G. Craske, K.B. Wolitzky-Taylor, J. Labus, and et al. A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations Behav Res Ther 49 2011 413 421
101. B. Ljotsson, H. Hesser, E. Andersson, and et al. Mechanisms of change in an exposure-based treatment for irritable bowel syndrome J Consult Clin Psychol 81 2013 1113 1126
102. A.C. Ford, N.J. Talley, P.S. Schoenfeld, and et al. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis Gut 58 2009 367 378
103. J.M. Lackner, S. Morley, C. Mesmer, and et al. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis J Consult Clin Psychol 72 2004 1100 1113
104. B. Ljótsson, E. Hedman, E. Andersson, and et al. Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: a randomized trial Am J Gastroenterol 106 2011 1481 1491
105. M. Grover, and M. Camilleri Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases J Gastroenterol 48 2013 177 181
106. R. Dekel, D.A. Drossman, and A.D. Sperber The use of psychotropic drugs in irritable bowel syndrome Expert Opin Investig Drugs 22 2013 329 339
107. D.A. Drossman Beyond tricyclics: new ideas for treating patients with painful and refractory functional gastrointestinal symptoms Am J Gastroenterol 104 2009 2897 2902
108. F. Creed The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome Gastroenterol 124 2003 303 317
109. D.A. Drossman, M. Camilleri, E.A. Mayer, and et al. AGA technical review on irritable bowel syndrome Gastroenterology 123 2002 2108 2131
110. B.D. Naliboff, and J.L. Rhudy Anxiety in functional pain disorders E.A. Mayer, M.C. Bushnell, Functional pain syndromes: presentation and pathophysiology 2009 IASP Press Seattle 185 215