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Volumn 25, Issue , 2016, Pages 53-61

Modulation of transcriptomic signature of the infected host: a new therapeutic strategy for the management of severe viral infections? Example of the flu;La modulation de la signature transcriptomique de l’hôte infecté : une nouvelle stratégie thérapeutique dans les viroses graves ? Exemple de la grippe

Author keywords

Drug repurposing; Flu; Transcriptome; Viral infections

Indexed keywords


EID: 84964757083     PISSN: 16240693     EISSN: 19516959     Source Type: Journal    
DOI: 10.1007/s13546-016-1188-1     Document Type: Article
Times cited : (2)

References (62)
  • 2
    • 36348964753 scopus 로고    scopus 로고
    • Ecological origins of novel human pathogens
    • PID: 18033594
    • Woolhouse M, Gaunt E (2007) Ecological origins of novel human pathogens. Critical reviews in microbiology 33: 231–42
    • (2007) Critical reviews in microbiology , vol.33 , pp. 231-242
    • Woolhouse, M.1    Gaunt, E.2
  • 3
    • 48749123605 scopus 로고    scopus 로고
    • Temporal trends in the discovery of human viruses
    • PID: 18505720
    • Woolhouse ME, Howey R, Gaunt E, et al (2008) Temporal trends in the discovery of human viruses. Proc Biol Sci 275: 2111–5
    • (2008) Proc Biol Sci , vol.275 , pp. 2111-2115
    • Woolhouse, M.E.1    Howey, R.2    Gaunt, E.3
  • 4
    • 35448985443 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
    • COI: 1:CAS:528:DC%2BD2sXhtleltrfL
    • Cheng VC, Lau SK, Woo PC, et al (2007) Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clinical Microbiol Rev 20: 660–94
    • (2007) Clinical Microbiol Rev , vol.20 , pp. 660-694
    • Cheng, V.C.1    Lau, S.K.2    Woo, P.C.3
  • 5
    • 84941413167 scopus 로고    scopus 로고
    • Middle East respiratory syndrome
    • PID: 26049252
    • Zumla A, Hui DS, Perlman S (2015) Middle East respiratory syndrome. Lancet 386: 995–1007
    • (2015) Lancet , vol.386 , pp. 995-1007
    • Zumla, A.1    Hui, D.S.2    Perlman, S.3
  • 6
    • 84884249801 scopus 로고    scopus 로고
    • Addressing the public health burden of respiratory viruses: the battle against respiratory viruses (BRaVe) initiative
    • COI: 1:CAS:528:DC%2BC3sXhsVCgurjM
    • Legand A, Briand S, Shindo N, et al (2013) Addressing the public health burden of respiratory viruses: the battle against respiratory viruses (BRaVe) initiative. Future Virol 8: 953–68
    • (2013) Future Virol , vol.8 , pp. 953-968
    • Legand, A.1    Briand, S.2    Shindo, N.3
  • 7
    • 84938405426 scopus 로고    scopus 로고
    • Communityacquired pneumonia requiring hospitalization among U.S. adults
    • COI: 1:CAS:528:DC%2BC2MXhtlyktLvK, PID: 26172429
    • Jain S, Self WH, Wunderink RG, et al (2015) Communityacquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med 373: 415–27
    • (2015) N Engl J Med , vol.373 , pp. 415-427
    • Jain, S.1    Self, W.H.2    Wunderink, R.G.3
  • 8
    • 79953797311 scopus 로고    scopus 로고
    • Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis
    • PID: 21460286
    • Pavia AT (2011) Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis 52:S284–S9
    • (2011) Clin Infect Dis , vol.52 , pp. S284-S289
    • Pavia, A.T.1
  • 9
    • 84885166179 scopus 로고    scopus 로고
    • Orthomyxoviridae
    • Knipe DM, Howley PM, (eds), Lippincott Williams & Wilkins, Philadelphia, USA
    • Shaw ML, Palese P (2006) Orthomyxoviridae. In: Knipe DM, Howley PM (eds) Fields Virol. Lippincott Williams & Wilkins, Philadelphia, USA, pp 1151–85
    • (2006) Fields Virol , pp. 1151-1185
    • Shaw, M.L.1    Palese, P.2
  • 10
    • 76249107253 scopus 로고    scopus 로고
    • Genome packaging in influenza A virus
    • COI: 1:CAS:528:DC%2BC3cXis1equ70%3D, PID: 19955561
    • Hutchinson EC, von Kirchbach JC, Gog JR, et al (2010) Genome packaging in influenza A virus. J Gen Virol 91: 313–28
    • (2010) J Gen Virol , vol.91 , pp. 313-328
    • Hutchinson, E.1    Kirchbach, J.C.2    Gog, J.R.3
  • 11
    • 67650896045 scopus 로고    scopus 로고
    • Historical perspective — Emergence of influenza A(H1N1) viruses
    • COI: 1:CAS:528:DC%2BD1MXos1Sls7w%3D, PID: 19564632
    • Zimmer SM, Burke DS (2009) Historical perspective — Emergence of influenza A(H1N1) viruses. N Engl J Med 361: 279–85
    • (2009) N Engl J Med , vol.361 , pp. 279-285
    • Zimmer, S.M.1    Burke, D.S.2
  • 12
    • 84964795436 scopus 로고    scopus 로고
    • Bonmarin I, Belchior E, Bergounioux J, et al (2016) Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons. Euro Surveill (in press)
    • Bonmarin I, Belchior E, Bergounioux J, et al (2016) Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons. Euro Surveill (in press)
  • 13
    • 84922058163 scopus 로고    scopus 로고
    • The burden of influenza-associated critical illness hospitalizations
    • PID: 25148596
    • Ortiz JR, Neuzil KM, Shay DK, et al (2014) The burden of influenza-associated critical illness hospitalizations. Crit Care Med 42: 2325–32
    • (2014) Crit Care Med , vol.42 , pp. 2325-2332
    • Ortiz, J.R.1    Neuzil, K.M.2    Shay, D.K.3
  • 14
    • 84950300329 scopus 로고    scopus 로고
    • Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13
    • PID: 26678835
    • Streng A, Prifert C, Weissbrich B, et al (2015) Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13. BMC Infect Dis 15: 573
    • (2015) BMC Infect Dis , vol.15 , pp. 573
    • Streng, A.1    Prifert, C.2    Weissbrich, B.3
  • 15
    • 84939630372 scopus 로고    scopus 로고
    • Pregnancyrelated mortality resulting from influenza in the United States during the 2009–2010 pandemic
    • PID: 26244541
    • Callaghan WM, Creanga AA, Jamieson DJ (2015) Pregnancyrelated mortality resulting from influenza in the United States during the 2009–2010 pandemic. Obstet Gynecol 126: 486–90
    • (2015) Obstet Gynecol , vol.126 , pp. 486-490
    • Callaghan, W.M.1    Creanga, A.A.2    Jamieson, D.J.3
  • 16
    • 84907963544 scopus 로고    scopus 로고
    • Health care professionals’ awareness of, knowledge about and attitude to influenza vaccination
    • PID: 25218193
    • Alshammari TM, AlFehaid LS, AlFraih JK, et al (2014) Health care professionals’ awareness of, knowledge about and attitude to influenza vaccination. Vaccine 32: 5957–61
    • (2014) Vaccine , vol.32 , pp. 5957-5961
    • Alshammari, T.M.1    AlFehaid, L.S.2    AlFraih, J.K.3
  • 17
    • 84885426295 scopus 로고    scopus 로고
    • Hepatitis B and influenza vaccines: important occupational vaccines differently perceived among medical students
    • PID: 24016807
    • Wicker S, Rabenau HF, von Gierke L, et al (2013) Hepatitis B and influenza vaccines: important occupational vaccines differently perceived among medical students. Vaccine 31: 5111–7
    • (2013) Vaccine , vol.31 , pp. 5111-5117
    • Wicker, S.1    Rabenau, H.2    Gierke, L.3
  • 18
    • 84894267498 scopus 로고    scopus 로고
    • High intensive care unit admission rate for 2013–2014 influenza is associated with a low rate of vaccination
    • PID: 24512430
    • Catania J, Que LG, Govert JA, et al (2014) High intensive care unit admission rate for 2013–2014 influenza is associated with a low rate of vaccination. Am J Respir Crit Care Med 189: 485–7
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 485-487
    • Catania, J.1    Que, L.G.2    Govert, J.A.3
  • 19
    • 84941309461 scopus 로고    scopus 로고
    • Midseason estimates of influenza vaccine effectiveness against influenza A(H3N2) hospitalization in the elderly in Quebec, Canada, January 2015
    • PID: 26200655
    • Gilca R, Skowronski DM, Douville-Fradet M, et al (2015) Midseason estimates of influenza vaccine effectiveness against influenza A(H3N2) hospitalization in the elderly in Quebec, Canada, January 2015. PloS One 10:e0132195
    • (2015) PloS One , vol.10 , pp. e0132195
    • Gilca, R.1    Skowronski, D.M.2    Douville-Fradet, M.3
  • 20
    • 84922816239 scopus 로고    scopus 로고
    • Reduced crossprotection against influenza A(H3N2) subgroup 3C.2a and 3C.3a viruses among Finnish healthcare workers vaccinated with 2013/14 seasonal influenza vaccine
    • COI: 1:STN:280:DC%2BC2MrlsFartA%3D%3D, PID: 25677051
    • Haveri A, Ikonen N, Julkunen I, et al (2015) Reduced crossprotection against influenza A(H3N2) subgroup 3C.2a and 3C.3a viruses among Finnish healthcare workers vaccinated with 2013/14 seasonal influenza vaccine. Euro Surveill 20: 21028
    • (2015) Euro Surveill , vol.20 , pp. 21028
    • Haveri, A.1    Ikonen, N.2    Julkunen, I.3
  • 21
    • 53049110527 scopus 로고    scopus 로고
    • Influenza
    • PID: 18679129
    • Beigel JH (2008) Influenza. Crit Care Med 36: 2660–6
    • (2008) Crit Care Med , vol.36 , pp. 2660-2666
    • Beigel, J.H.1
  • 22
    • 25844438380 scopus 로고    scopus 로고
    • Incidence of adamantane resistance among influenza A(H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern
    • COI: 1:CAS:528:DC%2BD2MXhtVGrsrbK, PID: 16198766
    • Bright RA, Medina MJ, Xu X, et al (2005) Incidence of adamantane resistance among influenza A(H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 366: 1175–81
    • (2005) Lancet , vol.366 , pp. 1175-1181
    • Bright, R.A.1    Medina, M.J.2    Xu, X.3
  • 23
    • 33644536465 scopus 로고    scopus 로고
    • Adamantane resistance among influenza A viruses isolated early during the 2005–2006 influenza season in the United States
    • COI: 1:CAS:528:DC%2BD28Xhs1Ckur0%3D, PID: 16456087
    • Bright RA, Shay DK, Shu B, et al (2006) Adamantane resistance among influenza A viruses isolated early during the 2005–2006 influenza season in the United States. JAMA 295: 891–4
    • (2006) JAMA , vol.295 , pp. 891-894
    • Bright, R.A.1    Shay, D.K.2    Shu, B.3
  • 24
    • 33344475829 scopus 로고    scopus 로고
    • Antiviral resistance in influenza viruses-implications for management and pandemic response
    • COI: 1:CAS:528:DC%2BD28XhslOgtrY%3D, PID: 16495389
    • Hayden FG (2006) Antiviral resistance in influenza viruses-implications for management and pandemic response. N Engl J Med 354: 785–8
    • (2006) N Engl J Med , vol.354 , pp. 785-788
    • Hayden, F.G.1
  • 25
    • 0042259159 scopus 로고    scopus 로고
    • Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations
    • COI: 1:CAS:528:DC%2BD3sXmsV2lsrg%3D, PID: 12885681
    • Kaiser L, Wat C, Mills T, et al (2003) Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 163: 1667–72
    • (2003) Arch Intern Med , vol.163 , pp. 1667-1672
    • Kaiser, L.1    Wat, C.2    Mills, T.3
  • 26
    • 0034720503 scopus 로고    scopus 로고
    • Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group
    • COI: 1:CAS:528:DC%2BD3cXkt1Crsb0%3D, PID: 10866439
    • Nicholson KG, Aoki FY, Osterhaus AD, et al (2000) Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group. Lancet 355: 1845–50
    • (2000) Lancet , vol.355 , pp. 1845-1850
    • Nicholson, K.G.1    Aoki, F.Y.2    Osterhaus, A.D.3
  • 27
    • 17744412173 scopus 로고    scopus 로고
    • Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group
    • COI: 1:CAS:528:DC%2BD3cXhs1Grsb4%3D, PID: 10697061
    • Treanor JJ, Hayden FG, Vrooman PS, et al (2000) Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group. JAMA 283: 1016–24
    • (2000) JAMA , vol.283 , pp. 1016-1024
    • Treanor, J.J.1    Hayden, F.G.2    Vrooman, P.S.3
  • 28
    • 0033530264 scopus 로고    scopus 로고
    • Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment
    • COI: 1:CAS:528:DyaK1MXmvVWhtbo%3D, PID: 10517426
    • Hayden FG, Treanor JJ, Fritz RS, et al (1999) Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. JAMA 282: 1240–6
    • (1999) JAMA , vol.282 , pp. 1240-1246
    • Hayden, F.G.1    Treanor, J.J.2    Fritz, R.S.3
  • 29
    • 0030724941 scopus 로고    scopus 로고
    • Effects of the neuraminidase inhibitor zanamavir on otologic manifestations of experimental human influenza
    • COI: 1:CAS:528:DyaK2sXnslOrtrc%3D, PID: 9395349
    • Walker JB, Hussey EK, Treanor JJ, et al (1997) Effects of the neuraminidase inhibitor zanamavir on otologic manifestations of experimental human influenza. J infect Dis 176: 1417–22
    • (1997) J infect Dis , vol.176 , pp. 1417-1422
    • Walker, J.B.1    Hussey, E.K.2    Treanor, J.J.3
  • 30
    • 38949197905 scopus 로고    scopus 로고
    • Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada
    • PID: 18190317
    • McGeer A, Green KA, Plevneshi A, et al (2007) Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada. Clin Infect Dis 45: 1568–75
    • (2007) Clin Infect Dis , vol.45 , pp. 1568-1575
    • McGeer, A.1    Green, K.A.2    Plevneshi, A.3
  • 31
    • 84933279419 scopus 로고    scopus 로고
    • High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients
    • PID: 25952823
    • Welch SC, Lam SW, Neuner EA, et al (2015) High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients. Intensive Care Med 41: 1365–6
    • (2015) Intensive Care Med , vol.41 , pp. 1365-1366
    • Welch, S.C.1    Lam, S.W.2    Neuner, E.A.3
  • 32
    • 25444501243 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for influenza
    • COI: 1:CAS:528:DC%2BD2MXhtVGmtL3L, PID: 16192481
    • Moscona A (2005) Neuraminidase inhibitors for influenza. N Engl J Med 353: 1363–73
    • (2005) N Engl J Med , vol.353 , pp. 1363-1373
    • Moscona, A.1
  • 33
    • 29144528757 scopus 로고    scopus 로고
    • Oseltamivir resistance during treatment of influenza A(H5N1) infection
    • PID: 16371632
    • de Jong MD, Tran TT, Truong HK, et al (2005) Oseltamivir resistance during treatment of influenza A(H5N1) infection. N Engl J Med 353: 2667–72
    • (2005) N Engl J Med , vol.353 , pp. 2667-2672
    • de Jong, M.D.1    Tran, T.T.2    Truong, H.K.3
  • 34
    • 27144468290 scopus 로고    scopus 로고
    • Avian flu: isolation of drug-resistant H5N1 virus
    • COI: 1:CAS:528:DC%2BD2MXhtFaht7fF, PID: 16228009
    • Le QM, Kiso M, Someya K, et al (2005) Avian flu: isolation of drug-resistant H5N1 virus. Nature 437: 1108
    • (2005) Nature , vol.437 , pp. 1108
    • Le, Q.M.1    Kiso, M.2    Someya, K.3
  • 35
    • 37449025042 scopus 로고    scopus 로고
    • Detection of human influenza A(H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors
    • COI: 1:CAS:528:DC%2BD1cXhtlGlsg%3D%3D, PID: 18055253
    • Escuret V, Frobert E, Bouscambert-Duchamp M, et al (2008) Detection of human influenza A(H1N1) and B strains with reduced sensitivity to neuraminidase inhibitors. J Clin Virol 41: 25–8
    • (2008) J Clin Virol , vol.41 , pp. 25-28
    • Escuret, V.1    Frobert, E.2    Bouscambert-Duchamp, M.3
  • 36
    • 84896271829 scopus 로고    scopus 로고
    • Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009–2012
    • Hoang Vu MP, Nguyen CT, Nguyen le KH, et al (2013) Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009–2012. Western Pac Surveill Response J (WPSAR) 4: 25–9
    • (2013) Western Pac Surveill Response J (WPSAR) , vol.4 , pp. 25-29
    • Hoang, V.M.1    Nguyen, C.T.2    le Nguyen, K.H.3
  • 37
    • 84878756846 scopus 로고    scopus 로고
    • Emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic
    • COI: 1:CAS:528:DC%2BC3sXhtFSms7nN, PID: 23675925
    • Dixit R, Khandaker G, Ilgoutz S, et al (2013) Emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic. Infect Disord Drug Targets 13: 34–45
    • (2013) Infect Disord Drug Targets , vol.13 , pp. 34-45
    • Dixit, R.1    Khandaker, G.2    Ilgoutz, S.3
  • 38
    • 84863998558 scopus 로고    scopus 로고
    • The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses
    • COI: 1:CAS:528:DC%2BC38XpvVyjsr8%3D, PID: 22770924
    • Terrier O, Moules V, Carron C, et al (2012) The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses. Virology 432: 204–18
    • (2012) Virology , vol.432 , pp. 204-218
    • Terrier, O.1    Moules, V.2    Carron, C.3
  • 39
    • 84897068062 scopus 로고    scopus 로고
    • Ultrastructural fingerprints of avian influenza A(H7N9) virus in infected human lung cells
    • PID: 24889223
    • Terrier O, Carron C, Cartet G, et al (2014) Ultrastructural fingerprints of avian influenza A(H7N9) virus in infected human lung cells. Virology 456–457: 39–42
    • (2014) Virology , vol.456 , pp. 39-42
    • Terrier, O.1    Carron, C.2    Cartet, G.3
  • 40
    • 72949109523 scopus 로고    scopus 로고
    • Interplay between influenza A virus and the innate immune signaling
    • COI: 1:CAS:528:DC%2BC3cXosFKr, PID: 19782761
    • Ehrhardt C, Seyer R, Hrincius ER, et al (2010) Interplay between influenza A virus and the innate immune signaling. Microbes Infect 12: 81–7
    • (2010) Microbes Infect , vol.12 , pp. 81-87
    • Ehrhardt, C.1    Seyer, R.2    Hrincius, E.R.3
  • 41
    • 84877613064 scopus 로고    scopus 로고
    • Development of cellular signaling pathway inhibitors as new antivirals against influenza
    • COI: 1:CAS:528:DC%2BC3sXotlGntbk%3D, PID: 23603495
    • Planz O (2013) Development of cellular signaling pathway inhibitors as new antivirals against influenza. Antiviral Res 98: 457–68
    • (2013) Antiviral Res , vol.98 , pp. 457-468
    • Planz, O.1
  • 42
    • 84878972538 scopus 로고    scopus 로고
    • Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells
    • PID: 23752648
    • Zhang H, Hale BG, Xu K, et al (2013) Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells. Viruses 5: 1431–46
    • (2013) Viruses , vol.5 , pp. 1431-1446
    • Zhang, H.1    Hale, B.G.2    Xu, K.3
  • 43
    • 55549130267 scopus 로고    scopus 로고
    • Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets
    • COI: 1:CAS:528:DC%2BD1cXhtlKiu7jO, PID: 18684821
    • Cameron CM, Cameron MJ, Bermejo-Martin JF, et al (2008) Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J Virol 82: 11308–17
    • (2008) J Virol , vol.82 , pp. 11308-11317
    • Cameron, C.M.1    Cameron, M.J.2    Bermejo-Martin, J.F.3
  • 44
    • 4143083780 scopus 로고    scopus 로고
    • Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    • COI: 1:CAS:528:DC%2BD2cXntVKhsLc%3D, PID: 15308742
    • Kash JC, Basler CF, Garcia-Sastre A, et al (2004) Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J Virol 78: 9499–511
    • (2004) J Virol , vol.78 , pp. 9499-9511
    • Kash, J.C.1    Basler, C.F.2    Garcia-Sastre, A.3
  • 45
    • 44649151063 scopus 로고    scopus 로고
    • Multifaceted mammalian transcriptome
    • COI: 1:CAS:528:DC%2BD1cXmvV2lsrg%3D, PID: 18468878
    • Carninci P, Yasuda J, Hayashizaki Y (2008) Multifaceted mammalian transcriptome. Curr Opin Cell Biol 20: 274–80
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 274-280
    • Carninci, P.1    Yasuda, J.2    Hayashizaki, Y.3
  • 46
    • 70449953975 scopus 로고    scopus 로고
    • The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs
    • COI: 1:CAS:528:DC%2BD1MXhsVaksL%2FJ, PID: 19920851
    • Jacquier A (2009) The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. Nat Rev Genet 10: 833–44
    • (2009) Nat Rev Genet , vol.10 , pp. 833-844
    • Jacquier, A.1
  • 48
    • 0037022296 scopus 로고    scopus 로고
    • Human macrophage activation programs induced by bacterial pathogens
    • COI: 1:CAS:528:DC%2BD38Xht1Clsbo%3D, PID: 11805289
    • Nau GJ, Richmond JF, Schlesinger A, et al (2002) Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci USA 99: 1503–08
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1503-1508
    • Nau, G.J.1    Richmond, J.F.2    Schlesinger, A.3
  • 49
    • 0141446081 scopus 로고    scopus 로고
    • Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria
    • COI: 1:CAS:528:DC%2BD3sXnslyltb0%3D
    • Feezor RJ, Oberholzer C, Baker HV, et al (2003) Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immunity 71: 5803–13
    • (2003) Infect Immunity , vol.71 , pp. 5803-5813
    • Feezor, R.J.1    Oberholzer, C.2    Baker, H.V.3
  • 50
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • COI: 1:CAS:528:DC%2BD2sXns12mug%3D%3D, PID: 17229949
    • Liu R, Wang X, Chen GY, et al (2007) The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356: 217–26
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 51
    • 67349135237 scopus 로고    scopus 로고
    • Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection
    • COI: 1:CAS:528:DC%2BD1MXntVGktbo%3D, PID: 19375457
    • Kash JC (2009) Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection. Antiviral Res 83: 10–20
    • (2009) Antiviral Res , vol.83 , pp. 10-20
    • Kash, J.C.1
  • 52
    • 24344496912 scopus 로고    scopus 로고
    • Emerging drug targets for antiretroviral therapy
    • COI: 1:CAS:528:DC%2BD2MXhtFeisr7L, PID: 16114975
    • Reeves JD, Piefer AJ (2005) Emerging drug targets for antiretroviral therapy. Drugs 65: 1747–66
    • (2005) Drugs , vol.65 , pp. 1747-1766
    • Reeves, J.D.1    Piefer, A.J.2
  • 53
    • 84883076264 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • COI: 1:CAS:528:DC%2BC3sXhtlyis7fF, PID: 23984731
    • Angus DC, van der Poll T (2013) Severe sepsis and septic shock. N Engl J Med 369: 840–51
    • (2013) N Engl J Med , vol.369 , pp. 840-851
    • Angus, D.1    Poll, T.2
  • 54
  • 55
    • 0036717194 scopus 로고    scopus 로고
    • The druggable genome
    • COI: 1:CAS:528:DC%2BD38XmslamtrY%3D, PID: 12209152
    • Hopkins AL, Groom CR (2002) The druggable genome. Nat Rev Drug Discov 1: 727–30
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 727-730
    • Hopkins, A.L.1    Groom, C.R.2
  • 56
    • 84867338003 scopus 로고    scopus 로고
    • Discovery and preclinical validation of drug indications using compendia of public gene expression data
    • Sirota M, Dudley JT, Kim J, et al (2011) Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Translat Med 3: 96ra77
    • (2011) Sci Translat Med , vol.3 , pp. 96
    • Sirota, M.1    Dudley, J.T.2    Kim, J.3
  • 57
    • 78049302135 scopus 로고    scopus 로고
    • Gene expression signature-based screening identifies new broadly effective influenza a antivirals
    • PID: 20957181
    • Josset L, Textoris J, Loriod B, et al (2010) Gene expression signature-based screening identifies new broadly effective influenza a antivirals. PloS One 5:pii:e13169
    • (2010) PloS One , vol.5 , pp. e13169
    • Josset, L.1    Textoris, J.2    Loriod, B.3
  • 58
    • 79958051552 scopus 로고    scopus 로고
    • Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
    • COI: 1:CAS:528:DC%2BC3MXnslCntr8%3D, PID: 21651802
    • Terrier O, Josset L, Textoris J, et al (2011) Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway. Virol J 8: 285
    • (2011) Virol J , vol.8 , pp. 285
    • Terrier, O.1    Josset, L.2    Textoris, J.3
  • 59
    • 84876269314 scopus 로고    scopus 로고
    • Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a
    • COI: 1:CAS:528:DC%2BC3sXnsV2lurk%3D, PID: 23343627
    • Terrier O, Textoris J, Carron C, et al (2013) Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a. J Gen Virol 94: 985–95
    • (2013) J Gen Virol , vol.94 , pp. 985-995
    • Terrier, O.1    Textoris, J.2    Carron, C.3
  • 60
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: a new tool for biomedical research
    • COI: 1:CAS:528:DC%2BD28XhtlCht7nF, PID: 17186018
    • Lamb J (2007) The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 7: 54–60
    • (2007) Nat Rev Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 61
    • 41149168072 scopus 로고    scopus 로고
    • MegaRibavirin aerosol for the treatment of influenza A virus infections in mice
    • COI: 1:CAS:528:DC%2BD1cXktFClu70%3D, PID: 18281104
    • Gilbert BE, McLeay MT (2008) MegaRibavirin aerosol for the treatment of influenza A virus infections in mice. Antiviral Res 78: 223–9
    • (2008) Antiviral Res , vol.78 , pp. 223-229
    • Gilbert, B.E.1    McLeay, M.T.2
  • 62
    • 0031608212 scopus 로고    scopus 로고
    • Midodrine. A review of its therapeutic use in the management of orthostatic hypotension
    • COI: 1:STN:280:DyaK1c7ivVyluw%3D%3D, PID: 9467688
    • McClellan KJ, Wiseman LR, Wilde MI (1998) Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging 12: 76–86
    • (1998) Drugs Aging , vol.12 , pp. 76-86
    • McClellan, K.J.1    Wiseman, L.R.2    Wilde, M.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.