Applications of high-throughput genomics to antiviral research: Evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection

Antiviral Research

Volumn 83, Issue 1, 2009, Pages 10-20

  Kash, John C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

1918 Influenza virus; Ebola virus; Filovirus; Host response evasion; Influenza; Interferon

Indexed keywords

INTERFERON;

CYTOKINE RELEASE; DRUG RESEARCH; DRUG RESPONSE; FILOVIRUS; FUNCTIONAL GENOMICS; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; INFLUENZA; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; INNATE IMMUNITY; MICROARRAY ANALYSIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; RNA VIRUS INFECTION; VIRUS HEMORRHAGIC FEVER; VIRUS PNEUMONIA; VIRUS VIRULENCE;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; EBOLAVIRUS; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; RNA VIRUS INFECTIONS;

ANIMALIA; EBOLA VIRUS; MARBURGVIRUS; ORTHOMYXOVIRIDAE; RNA VIRUSES;

EID: 67349135237     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.04.004     Document Type: Review

References (99)

1. Anon. Influenza A virus subtype H5N1 infection in humans. Commun. Dis. Rep. Wkly 7 (1997) 441
2. Anon. Isolation of avian influenza A(H5N1) viruses from humans-Hong Kong, May-December 1997. Morb. Mortal. Wkly. Rep. 46 (1997) 1204-1207
3. Abdel-Ghafar A.N., Chotpitayasunondh T., Gao Z., Hayden F.G., Nguyen D.H., de Jong M.D., Naghdaliyev A., Peiris J.S., Shindo N., Soeroso S., and Uyeki T.M. Update on avian influenza A (H5N1) virus infection in humans. N. Engl. J. Med. 358 (2008) 261-273
4. Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., and Paludan S.R. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J. Immunol. 180 (2008) 2474-2485
5. Ank N., West H., and Paludan S.R. IFN-lambda: novel antiviral cytokines. J. Interferon Cytokine Res. 26 (2006) 373-379
6. Baas T., Roberts A., Teal T.H., Vogel L., Chen J., Tumpey T.M., Katze M.G., and Subbarao K. Genomic analysis reveals age-dependent innate immune responses to severe acute respiratory syndrome coronavirus. J. Virol. 82 (2008) 9465-9476
7. Balachandran S., and Barber G.N. PKR in innate immunity, cancer, and viral oncolysis. Methods Mol. Biol. 383 (2007) 277-301
8. Basler C.F., Mikulasova A., Martinez-Sobrido L., Paragas J., Muhlberger E., Bray M., Klenk H.D., Palese P., and Garcia-Sastre A. The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J. Virol. 77 (2003) 7945-7956
9. Basler C.F., Reid A.H., Dybing J.K., Janczewski T.A., Fanning T.G., Zheng H., Salvatore M., Perdue M.L., Swayne D.E., Garcia-Sastre A., Palese P., and Taubenberger J.K. Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 2746-2751
10. Basler C.F., Wang X., Muhlberger E., Volchkov V., Paragas J., Klenk H.D., Garcia-Sastre A., and Palese P. The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 12289-12294
11. Borden E.C., Sen G.C., Uze G., Silverman R.H., Ransohoff R.M., Foster G.R., and Stark G.R. Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6 (2007) 975-990
12. Bray M. The role of the type I interferon response in the resistance of mice to filovirus infection. J. Gen. Virol. 82 (2001) 1365-1373
13. Cameron C.M., Cameron M.J., Bermejo-Martin J.F., Ran L., Xu L., Turner P.V., Ran R., Danesh A., Fang Y., Chan P.K., Mytle N., Sullivan T.J., Collins T.L., Johnson M.G., Medina J.C., Rowe T., and Kelvin D.J. Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J. Virol. 82 (2008) 11308-11317
14. Cameron M.J., Ran L., Xu L., Danesh A., Bermejo-Martin J.F., Cameron C.M., Muller M.P., Gold W.L., Richardson S.E., Poutanen S.M., Willey B.M., DeVries M.E., Fang Y., Seneviratne C., Bosinger S.E., Persad D., Wilkinson P., Greller L.D., Somogyi R., Humar A., Keshavjee S., Louie M., Loeb M.B., Brunton J., McGeer A.J., and Kelvin D.J. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J. Virol. 81 (2007) 8692-8706
15. Cao W., Manicassamy S., Tang H., Kasturi S.P., Pirani A., Murthy N., and Pulendran B. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat. Immunol. 9 (2008) 1157-1164
16. Claas E.C., Osterhaus A.D., van Beek R., De Jong J.C., Rimmelzwaan G.F., Senne D.A., Krauss S., Shortridge K.F., and Webster R.G. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351 (1998) 472-477
17. Crapo J.D., Barry B.E., Gehr P., Bachofen M., and Weibel E.R. Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. Dis. 126 (1982) 332-337
18. de Lang A., Baas T., Teal T., Leijten L.M., Rain B., Osterhaus A.D., Haagmans B.L., and Katze M.G. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog. 3 (2007) e112
19. de Veer M.J., Holko M., Frevel M., Walker E., Der S., Paranjape J.M., Silverman R.H., and Williams B.R. Functional classification of interferon-stimulated genes identified using microarrays. J. Leukoc. Biol. 69 (2001) 912-920
20. de Wit E., and Fouchier R.A. Emerging influenza. J. Clin. Virol. 41 (2008) 1-6
21. Enterlein S., Warfield K.L., Swenson D.L., Stein D.A., Smith J.L., Gamble C.S., Kroeker A.D., Iversen P.L., Bavari S., and Muhlberger E. VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice. Antimicrob. Agents Chemother. 50 (2006) 984-993
22. Fink J., Gu F., Ling L., Tolfvenstam T., Olfat F., Chin K.C., Aw P., George J., Kuznetsov V.A., Schreiber M., Vasudevan S.G., and Hibberd M.L. Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl. Trop. Dis. 1 (2007) e86
23. Fornek J.L., Korth M.J., and Katze M.G. Use of functional genomics to understand influenza-host interactions. Adv. Virus Res. 70 (2007) 81-100
24. Fredericksen B.L., Smith M., Katze M.G., Shi P.Y., and Gale Jr. M. The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway. J. Virol. 78 (2004) 7737-7747
25. Gao P., Watanabe S., Ito T., Goto H., Wells K., McGregor M., Cooley A.J., and Kawaoka Y. Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J. Virol. 73 (1999) 3184-3189
26. Garcia-Sastre A. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279 (2001) 375-384
27. Garcia-Sastre A. Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses. Curr. Top. Microbiol. Immunol. 283 (2004) 249-280
28. Garcia-Sastre A. Antiviral response in pandemic influenza viruses. Emerg. Infect. Dis. 12 (2006) 44-47
29. Garcia-Sastre A., and Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 312 (2006) 879-882
30. Geiss G.K., Bumgarner R.E., An M.C., Agy M.B., van't Wout A.B., Hammersmark E., Carter V.S., Upchurch D., Mullins J.I., and Katze M.G. Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266 (2000) 8-16
31. Geiss G.K., Salvatore M., Tumpey T.M., Carter V.S., Wang X., Basler C.F., Taubenberger J.K., Bumgarner R.E., Palese P., Katze M.G., and Garcia-Sastre A. Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 10736-10741
32. Gonzalez J.P., Pourrut X., and Leroy E. Ebolavirus and other filoviruses. Curr. Top. Microbiol. Immunol. 315 (2007) 363-387
33. Groseth A., Stroher U., Theriault S., and Feldmann H. Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States. Virus Res. 87 (2002) 155-163
34. Gubareva L.V., McCullers J.A., Bethell R.C., and Webster R.G. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J. Infect. Dis. 178 (1998) 1592-1596
35. Hale B.G., Randall R.E., Ortin J., and Jackson D. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol. 89 (2008) 2359-2376
36. Hao L., Sakurai A., Watanabe T., Sorensen E., Nidom C.A., Newton M.A., Ahlquist P., and Kawaoka Y. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454 (2008) 890-893
37. Harcourt B.H., Sanchez A., and Offermann M.K. Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells. J. Virol. 73 (1999) 3491-3496
38. Hartman A.L., Bird B.H., Towner J.S., Antoniadou Z.A., Zaki S.R., and Nichol S.T. Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus. J. Virol. 82 (2008) 2699-2704
39. Hartman A.L., Dover J.E., Towner J.S., and Nichol S.T. Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication. J. Virol. 80 (2006) 6430-6440
40. Hartman A.L., Ling L., Nichol S.T., and Hibberd M.L. Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein. J. Virol. 82 (2008) 5348-5358
41. Hoenen T., Groseth A., Falzarano D., and Feldmann H. Ebola virus: unravelling pathogenesis to combat a deadly disease. Trends Mol. Med. 12 (2006) 206-215
42. Hutchinson K.L., Villinger F., Miranda M.E., Ksiazek T.G., Peters C.J., and Rollin P.E. Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype). J. Med. Virol. 65 (2001) 561-566
43. Ishikawa H., and Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455 (2008) 674-678
44. Jahrling P.B., Geisbert T.W., Jaax N.K., Hanes M.A., Ksiazek T.G., and Peters C.J. Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic. Arch. Virol. Suppl. 11 (1996) 115-134
45. Jenner R.G., and Young R.A. Insights into host responses against pathogens from transcriptional profiling. Nat. Rev. Microbiol. 3 (2005) 281-294
46. Kash J.C., Basler C.F., Garcia-Sastre A., Carter V., Billharz R., Swayne D.E., Przygodzki R.M., Taubenberger J.K., Katze M.G., and Tumpey T.M. Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J. Virol. 78 (2004) 9499-9511
47. Kash J.C., Goodman A.G., Korth M.J., and Katze M.G. Hijacking of the host-cell response and translational control during influenza virus infection. Virus Res. 119 (2006) 111-120
48. Kash J.C., Muhlberger E., Carter V., Grosch M., Perwitasari O., Proll S.C., Thomas M.J., Weber F., Klenk H.D., and Katze M.G. Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. J. Virol. 80 (2006) 3009-3020
49. Kash J.C., Tumpey T.M., Proll S.C., Carter V., Perwitasari O., Thomas M.J., Basler C.F., Palese P., Taubenberger J.K., Garcia-Sastre A., Swayne D.E., and Katze M.G. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443 (2006) 578-581
50. Kobasa D., Jones S.M., Shinya K., Kash J.C., Copps J., Ebihara H., Hatta Y., Kim J.H., Halfmann P., Hatta M., Feldmann F., Alimonti J.B., Fernando L., Li Y., Katze M.G., Feldmann H., and Kawaoka Y. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445 (2007) 319-323
51. Korth M.J., Kash J.C., Furlong J.C., and Katze M.G. Virus infection and the interferon response: a global view through functional genomics. Methods Mol. Med. 116 (2005) 37-55
52. Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., and Donnelly R.P. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat. Immunol. 4 (2003) 69-77
53. Liu M., Popper S.J., Rubins K.H., and Relman D.A. Early days: genomics and human responses to infection. Curr. Opin. Microbiol. 9 (2006) 312-319
54. Loo Y.M., and Gale Jr. M. Viral regulation and evasion of the host response. Curr. Top. Microbiol. Immunol. 316 (2007) 295-313
55. Lu X., Tumpey T.M., Morken T., Zaki S.R., Cox N.J., and Katz J.M. A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans. J. Virol. 73 (1999) 5903-5911
56. Mendrick D.L. Genomic and genetic biomarkers of toxicity. Toxicology 245 (2008) 175-181
57. Mizukami T., Imai J., Hamaguchi I., Kawamura M., Momose H., Naito S., Maeyama J., Masumi A., Kuramitsu M., Takizawa K., Nomura N., Watanabe S., and Yamaguchi K. Application of DNA microarray technology to influenza A/Vietnam/1194/2004 (H5N1) vaccine safety evaluation. Vaccine 26 (2008) 2270-2283
58. Mohamadzadeh M., Chen L., Olinger G.G., Pratt W.D., and Schmaljohn A.L. Filoviruses and the balance of innate, adaptive, and inflammatory responses. Viral Immunol. 19 (2006) 602-612
59. Mordstein M., Kochs G., Dumoutier L., Renauld J.C., Paludan S.R., Klucher K., and Staeheli P. Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog. 4 (2008) e1000151
60. Morens D.M., Taubenberger J.K., and Fauci A.S. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J. Infect. Dis. 198 (2008) 962-970
61. Morikawa S., Saijo M., and Kurane I. Current knowledge on lower virulence of Reston Ebola virus (in French: Connaissances actuelles sur la moindre virulence du virus Ebola Reston). Comp. Immunol. Microbiol. Infect. Dis. 30 (2007) 391-398
62. Mosca F., Tritto E., Muzzi A., Monaci E., Bagnoli F., Iavarone C., O'Hagan D., Rappuoli R., and De Gregorio E. Molecular and cellular signatures of human vaccine adjuvants. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 10501-10506
63. Nuwaysir E.F., Bittner M., Trent J., Barrett J.C., and Afshari C.A. Microarrays and toxicology: the advent of toxicogenomics. Mol. Carcinog. 24 (1999) 153-159
64. Onoguchi K., Yoneyama M., Takemura A., Akira S., Taniguchi T., Namiki H., and Fujita T. Viral infections activate types I and III interferon genes through a common mechanism. J. Biol. Chem. 282 (2007) 7576-7581
65. Osterlund P.I., Pietila T.E., Veckman V., Kotenko S.V., and Julkunen I. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J. Immunol. 179 (2007) 3434-3442
66. Pacenti M., Barzon L., Favaretto F., Fincati K., Romano S., Milan G., Vettor R., and Palu G. Microarray analysis during adipogenesis identifies new genes altered by antiretroviral drugs. Aids 20 (2006) 1691-1705
67. Pan-Hammarstrom Q., Wen S., and Hammarstrom L. Cytokine gene expression profiles in human lymphocytes induced by a formula of traditional Chinese medicine, vigconic VI-28. J. Interferon Cytokine Res. 26 (2006) 628-636
68. Perrone L.A., Plowden J.K., Garcia-Sastre A., Katz J.M., and Tumpey T.M. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog. 4 (2008) e1000115
69. Pestka S., Krause C.D., and Walter M.R. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202 (2004) 8-32
70. Randall R.E., and Goodbourn S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89 (2008) 1-47
71. Reghunathan R., Jayapal M., Hsu L.Y., Chng H.H., Tai D., Leung B.P., and Melendez A.J. Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome. BMC Immunol. 6 (2005) 2
72. Reid A.H., Fanning T.G., Hultin J.V., and Taubenberger J.K. Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 1651-1656
73. Reid A.H., Fanning T.G., Janczewski T.A., Lourens R.M., and Taubenberger J.K. Novel origin of the 1918 pandemic influenza virus nucleoprotein gene. J. Virol. 78 (2004) 12462-12470
74. Reid A.H., Fanning T.G., Janczewski T.A., McCall S., and Taubenberger J.K. Characterization of the 1918 "Spanish" influenza virus matrix gene segment. J. Virol. 76 (2002) 10717-10723
75. Reid A.H., Janczewski T.A., Lourens R.M., Elliot A.J., Daniels R.S., Berry C.L., Oxford J.S., and Taubenberger J.K. 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants. Emerg. Infect. Dis. 9 (2003) 1249-1253
76. Reid S.P., Leung L.W., Hartman A.L., Martinez O., Shaw M.L., Carbonnelle C., Volchkov V.E., Nichol S.T., and Basler C.F. Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. J. Virol. 80 (2006) 5156-5167
77. Rubins K.H., Hensley L.E., Wahl-Jensen V., Daddario DiCaprio K.M., Young H.A., Reed D.S., Jahrling P.B., Brown P.O., Relman D.A., and Geisbert T.W. The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome Biol. 8 (2007) R174
78. Sadler A.J., and Williams B.R. Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 8 (2008) 559-568
79. Saito T., and Gale Jr. M. Principles of intracellular viral recognition. Curr. Opin. Immunol. 19 (2007) 17-23
80. Sanchez A., Ksiazek T.G., Rollin P.E., Miranda M.E., Trappier S.G., Khan A.S., Peters C.J., and Nichol S.T. Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates. J. Infect. Dis. 179 Suppl. 1 (1999) S164-S169
81. Sen G.C., and Sarkar S.N. The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses. Curr. Top. Microbiol. Immunol. 316 (2007) 233-250
82. Sommereyns C., Paul S., Staeheli P., and Michiels T. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog. 4 (2008) e1000017
83. Suarez D.L., Perdue M.L., Cox N., Rowe T., Bender C., Huang J., and Swayne D.E. Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong. J. Virol. 72 (1998) 6678-6688
84. Subbarao K., Klimov A., Katz J., Regnery H., Lim W., Hall H., Perdue M., Swayne D., Bender C., Huang J., Hemphill M., Rowe T., Shaw M., Xu X., Fukuda K., and Cox N. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279 (1998) 393-396
85. Takeuchi O., and Akira S. MDA5/RIG-I and virus recognition. Curr. Opin. Immunol. 20 (2008) 17-22
86. Taubenberger J.K. The origin and virulence of the 1918 "Spanish" influenza virus. Proc. Am. Philos. Soc. 150 (2006) 86-112
87. Taubenberger J.K., Hultin J.V., and Morens D.M. Discovery and characterization of the 1918 pandemic influenza virus in historical context. Antivir. Ther. 12 (2007) 581-591
88. Taubenberger J.K., and Morens D.M. The pathology of influenza virus infections. Annu. Rev. Pathol. 3 (2008) 499-522
89. Taubenberger J.K., Reid A.H., Krafft A.E., Bijwaard K.E., and Fanning T.G. Initial genetic characterization of the 1918 "Spanish" influenza virus. Science 275 (1997) 1793-1796
90. Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., and Fanning T.G. Characterization of the 1918 influenza virus polymerase genes. Nature 437 (2005) 889-893
91. Thompson W.W., Shay D.K., Weintraub E., Brammer L., Cox N., Anderson L.J., and Fukuda K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289 (2003) 179-186
92. Tumpey T.M., Basler C.F., Aguilar P.V., Zeng H., Solorzano A., Swayne D.E., Cox N.J., Katz J.M., Taubenberger J.K., Palese P., and Garcia-Sastre A. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310 (2005) 77-80
93. Ubol S., Masrinoul P., Chaijaruwanich J., Kalayanarooj S., Charoensirisuthikul T., and Kasisith J. Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever. J. Infect. Dis. 197 (2008) 1459-1467
94. Van Campen H., Easterday B.C., and Hinshaw V.S. Virulent avian influenza A viruses: their effect on avian lymphocytes and macrophages in vivo and in vitro. J. Gen. Virol. 70 Pt 11 (1989) 2887-2895
95. Venter M., Myers T.G., Wilson M.A., Kindt T.J., Paweska J.T., Burt F.J., Leman P.A., and Swanepoel R. Gene expression in mice infected with West Nile virus strains of different neurovirulence. Virology 342 (2005) 119-140
96. Villinger F., Rollin P.E., Brar S.S., Chikkala N.F., Winter J., Sundstrom J.B., Zaki S.R., Swanepoel R., Ansari A.A., and Peters C.J. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J. Infect. Dis. 179 Suppl. 1 (1999) S188-S191
97. Walters K.A., and Katze M.G. Using high-throughput genomics to study hepatitis C: what determines the outcome of infection?. Antiviral Res. 81 (2009) 198-208
98. Warke R.V., Xhaja K., Martin K.J., Fournier M.F., Shaw S.K., Brizuela N., de Bosch N., Lapointe D., Ennis F.A., Rothman A.L., and Bosch I. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J. Virol. 77 (2003) 11822-11832
99. Wu J.Q., Dwyer D.E., Dyer W.B., Yang Y.H., Wang B., and Saksena N.K. Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses. Virology 380 (2008) 124-135