-
1
-
-
79960304808
-
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
-
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE (2011) Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10, 686-698.
-
(2011)
Aging Cell
, vol.10
, pp. 686-698
-
-
Deelen, J.1
Beekman, M.2
Uh, H.W.3
Helmer, Q.4
Kuningas, M.5
Christiansen, L.6
Kremer, D.7
van der Breggen, R.8
Suchiman, H.E.9
Lakenberg, N.10
van den Akker, E.B.11
Passtoors, W.M.12
Tiemeier, H.13
van Heemst, D.14
de Craen, A.J.15
Rivadeneira, F.16
de Geus, E.J.17
Perola, M.18
van der Ouderaa, F.J.19
Gunn, D.A.20
Boomsma, D.I.21
Uitterlinden, A.G.22
Christensen, K.23
van Duijn, C.M.24
Heijmans, B.T.25
Houwing-Duistermaat, J.J.26
Westendorp, R.G.27
Slagboom, P.E.28
more..
-
2
-
-
84874963173
-
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges
-
Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE (2013) Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. BioEssays 35, 386-396.
-
(2013)
BioEssays
, vol.35
, pp. 386-396
-
-
Deelen, J.1
Beekman, M.2
Capri, M.3
Franceschi, C.4
Slagboom, P.E.5
-
3
-
-
84904741764
-
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
-
Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guethbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Bohringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, McNerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefansson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sorensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefansson K, Metspalu A, Magnusson P, Blanche H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duistermaat JJ, Slagboom PE (2014) Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum. Mol. Genet. 23, 4420-4432.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 4420-4432
-
-
Deelen, J.1
Beekman, M.2
Uh, H.W.3
Broer, L.4
Ayers, K.L.5
Tan, Q.6
Kamatani, Y.7
Bennet, A.M.8
Tamm, R.9
Trompet, S.10
Guethbjartsson, D.F.11
Flachsbart, F.12
Rose, G.13
Viktorin, A.14
Fischer, K.15
Nygaard, M.16
Cordell, H.J.17
Crocco, P.18
van den Akker, E.B.19
Bohringer, S.20
Helmer, Q.21
Nelson, C.P.22
Saunders, G.I.23
Alver, M.24
Andersen-Ranberg, K.25
Breen, M.E.26
van der Breggen, R.27
Caliebe, A.28
Capri, M.29
Cevenini, E.30
Collerton, J.C.31
Dato, S.32
Davies, K.33
Ford, I.34
Gampe, J.35
Garagnani, P.36
de Geus, E.J.37
Harrow, J.38
van Heemst, D.39
Heijmans, B.T.40
Heinsen, F.A.41
Hottenga, J.J.42
Hofman, A.43
Jeune, B.44
Jonsson, P.V.45
Lathrop, M.46
Lechner, D.47
Martin-Ruiz, C.48
McNerlan, S.E.49
Mihailov, E.50
Montesanto, A.51
Mooijaart, S.P.52
Murphy, A.53
Nohr, E.A.54
Paternoster, L.55
Postmus, I.56
Rivadeneira, F.57
Ross, O.A.58
Salvioli, S.59
Sattar, N.60
Schreiber, S.61
Stefansson, H.62
Stott, D.J.63
Tiemeier, H.64
Uitterlinden, A.G.65
Westendorp, R.G.66
Willemsen, G.67
Samani, N.J.68
Galan, P.69
Sorensen, T.I.70
Boomsma, D.I.71
Jukema, J.W.72
Rea, I.M.73
Passarino, G.74
de Craen, A.J.75
Christensen, K.76
Nebel, A.77
Stefansson, K.78
Metspalu, A.79
Magnusson, P.80
Blanche, H.81
Christiansen, L.82
Kirkwood, T.B.83
van Duijn, C.M.84
Franceschi, C.85
Houwing-Duistermaat, J.J.86
Slagboom, P.E.87
more..
-
4
-
-
62449083712
-
Association of FOXO3A variation with human longevity confirmed in German centenarians
-
Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl Acad. Sci. USA 106, 2700-2705.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2700-2705
-
-
Flachsbart, F.1
Caliebe, A.2
Kleindorp, R.3
Blanche, H.4
von Eller-Eberstein, H.5
Nikolaus, S.6
Schreiber, S.7
Nebel, A.8
-
5
-
-
33846111415
-
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
-
Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128, 92-105.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 92-105
-
-
Franceschi, C.1
Capri, M.2
Monti, D.3
Giunta, S.4
Olivieri, F.5
Sevini, F.6
Panourgia, M.P.7
Invidia, L.8
Celani, L.9
Scurti, M.10
Cevenini, E.11
Castellani, G.C.12
Salvioli, S.13
-
6
-
-
0034665338
-
Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns
-
Kelly BL, Locksley RM (2000) Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J. Immunol. 165, 2982-2986.
-
(2000)
J. Immunol.
, vol.165
, pp. 2982-2986
-
-
Kelly, B.L.1
Locksley, R.M.2
-
7
-
-
84927761261
-
Human RAD50 makes a functional DNA-binding complex
-
Kinoshita E, van Rossum-Fikkert S, Sanchez H, Kertokalio A, Wyman C (2015) Human RAD50 makes a functional DNA-binding complex. Biochimie 113, 47-53.
-
(2015)
Biochimie
, vol.113
, pp. 47-53
-
-
Kinoshita, E.1
van Rossum-Fikkert, S.2
Sanchez, H.3
Kertokalio, A.4
Wyman, C.5
-
8
-
-
0037963472
-
Regulation of the Th2 cytokine locus by a locus control region
-
Lee GR, Fields PE, Griffin TJ, Flavell RA (2003) Regulation of the Th2 cytokine locus by a locus control region. Immunity 19, 145-153.
-
(2003)
Immunity
, vol.19
, pp. 145-153
-
-
Lee, G.R.1
Fields, P.E.2
Griffin, T.J.3
Flavell, R.A.4
-
9
-
-
52949124119
-
The 5q31 variants associated with psoriasis and Crohn's disease are distinct
-
Li Y, Chang M, Schrodi SJ, Callis-Duffin KP, Matsunami N, Civello D, Bui N, Catanese JJ, Leppert MF, Krueger GG, Begovich AB (2008) The 5q31 variants associated with psoriasis and Crohn's disease are distinct. Hum. Mol. Genet. 17, 2978-2985.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2978-2985
-
-
Li, Y.1
Chang, M.2
Schrodi, S.J.3
Callis-Duffin, K.P.4
Matsunami, N.5
Civello, D.6
Bui, N.7
Catanese, J.J.8
Leppert, M.F.9
Krueger, G.G.10
Begovich, A.B.11
-
10
-
-
75849162175
-
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
-
e311.
-
Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER (2010) Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J. Allergy Clin. Immunol. 125, 328-335 e311.
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 328-335
-
-
Li, X.1
Howard, T.D.2
Zheng, S.L.3
Haselkorn, T.4
Peters, S.P.5
Meyers, D.A.6
Bleecker, E.R.7
-
11
-
-
79961208019
-
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
-
Nebel A, Kleindorp R, Caliebe A, Nothnagel M, Blanche H, Junge O, Wittig M, Ellinghaus D, Flachsbart F, Wichmann HE, Meitinger T, Nikolaus S, Franke A, Krawczak M, Lathrop M, Schreiber S (2011) A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech. Ageing Dev. 132, 324-330.
-
(2011)
Mech. Ageing Dev.
, vol.132
, pp. 324-330
-
-
Nebel, A.1
Kleindorp, R.2
Caliebe, A.3
Nothnagel, M.4
Blanche, H.5
Junge, O.6
Wittig, M.7
Ellinghaus, D.8
Flachsbart, F.9
Wichmann, H.E.10
Meitinger, T.11
Nikolaus, S.12
Franke, A.13
Krawczak, M.14
Lathrop, M.15
Schreiber, S.16
-
12
-
-
84856283235
-
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
-
Paternoster L, Standl M, Chen CM, Ramasamy A, Bonnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H, Feenstra B, Sleiman PM, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA, Groen-Blokhuis MM, Kerkhof M, Saaf A, Franke A, Ellinghaus D, Folster-Holst R, Dermitzakis E, Montgomery SB, Prokisch H, Heim K, Hartikainen AL, Pouta A, Pekkanen J, Blakemore AI, Buxton JL, Kaakinen M, Duffy DL, Madden PA, Heath AC, Montgomery GW, Thompson PJ, Matheson MC, Le Souef P, Pourcain BS, Smith GD, Henderson J, Kemp JP, Timpson NJ, Deloukas P, Ring SM, Wichmann HE, Muller-Nurasyid M, Novak N, Klopp N, Rodriguez E, McArdle W, Linneberg A, Menne T, Nohr EA, Hofman A, Uitterlinden AG, van Duijn CM, Rivadeneira F, de Jongste JC, van der Valk RJ, Wjst M, Jogi R, Geller F, Boyd HA, Murray JC, Kim C, Mentch F, March M, Mangino M, Spector TD, Bataille V, Pennell CE, Holt PG, Sly P, Tiesler CM, Thiering E, Illig T, Imboden M, Nystad W, Simpson A, Hottenga JJ, Postma D, Koppelman GH, Smit HA, Soderhall C, Chawes B, Kreiner-Moller E, Bisgaard H, Melen E, Boomsma DI, Custovic A, Jacobsson B, Probst-Hensch NM, Palmer LJ, Glass D, Hakonarson H, Melbye M, Jarvis DL, Jaddoe VW, Gieger C, Strachan DP, Martin NG, Jarvelin MR, Heinrich J, Evans DM, Weidinger S (2011) Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat. Genet. 44, 187-192.
-
(2011)
Nat. Genet.
, vol.44
, pp. 187-192
-
-
Paternoster, L.1
Standl, M.2
Chen, C.M.3
Ramasamy, A.4
Bonnelykke, K.5
Duijts, L.6
Ferreira, M.A.7
Alves, A.C.8
Thyssen, J.P.9
Albrecht, E.10
Baurecht, H.11
Feenstra, B.12
Sleiman, P.M.13
Hysi, P.14
Warrington, N.M.15
Curjuric, I.16
Myhre, R.17
Curtin, J.A.18
Groen-Blokhuis, M.M.19
Kerkhof, M.20
Saaf, A.21
Franke, A.22
Ellinghaus, D.23
Folster-Holst, R.24
Dermitzakis, E.25
Montgomery, S.B.26
Prokisch, H.27
Heim, K.28
Hartikainen, A.L.29
Pouta, A.30
Pekkanen, J.31
Blakemore, A.I.32
Buxton, J.L.33
Kaakinen, M.34
Duffy, D.L.35
Madden, P.A.36
Heath, A.C.37
Montgomery, G.W.38
Thompson, P.J.39
Matheson, M.C.40
Le Souef, P.41
Pourcain, B.S.42
Smith, G.D.43
Henderson, J.44
Kemp, J.P.45
Timpson, N.J.46
Deloukas, P.47
Ring, S.M.48
Wichmann, H.E.49
Muller-Nurasyid, M.50
Novak, N.51
Klopp, N.52
Rodriguez, E.53
McArdle, W.54
Linneberg, A.55
Menne, T.56
Nohr, E.A.57
Hofman, A.58
Uitterlinden, A.G.59
van Duijn, C.M.60
Rivadeneira, F.61
de Jongste, J.C.62
van der Valk, R.J.63
Wjst, M.64
Jogi, R.65
Geller, F.66
Boyd, H.A.67
Murray, J.C.68
Kim, C.69
Mentch, F.70
March, M.71
Mangino, M.72
Spector, T.D.73
Bataille, V.74
Pennell, C.E.75
Holt, P.G.76
Sly, P.77
Tiesler, C.M.78
Thiering, E.79
Illig, T.80
Imboden, M.81
Nystad, W.82
Simpson, A.83
Hottenga, J.J.84
Postma, D.85
Koppelman, G.H.86
Smit, H.A.87
Soderhall, C.88
Chawes, B.89
Kreiner-Moller, E.90
Bisgaard, H.91
Melen, E.92
Boomsma, D.I.93
Custovic, A.94
Jacobsson, B.95
Probst-Hensch, N.M.96
Palmer, L.J.97
Glass, D.98
Hakonarson, H.99
more..
-
13
-
-
77956586071
-
LocusZoom: regional visualization of genome-wide association scan results
-
Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP, Boehnke M, Abecasis GR, Willer CJ (2010) LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336-2337.
-
(2010)
Bioinformatics
, vol.26
, pp. 2336-2337
-
-
Pruim, R.J.1
Welch, R.P.2
Sanna, S.3
Teslovich, T.M.4
Chines, P.S.5
Gliedt, T.P.6
Boehnke, M.7
Abecasis, G.R.8
Willer, C.J.9
-
14
-
-
0033910870
-
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
-
Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA (2000) Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am. J. Hum. Genet. 66, 1863-1870.
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1863-1870
-
-
Rioux, J.D.1
Silverberg, M.S.2
Daly, M.J.3
Steinhart, A.H.4
McLeod, R.S.5
Griffiths, A.M.6
Green, T.7
Brettin, T.S.8
Stone, V.9
Bull, S.B.10
Bitton, A.11
Williams, C.N.12
Greenberg, G.R.13
Cohen, Z.14
Lander, E.S.15
Hudson, T.J.16
Siminovitch, K.A.17
-
15
-
-
84901038448
-
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production
-
Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J (2014) Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production. Nat. Immunol. 15, 538-545.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 538-545
-
-
Roth, S.1
Rottach, A.2
Lotz-Havla, A.S.3
Laux, V.4
Muschaweckh, A.5
Gersting, S.W.6
Muntau, A.C.7
Hopfner, K.P.8
Jin, L.9
Vanness, K.10
Petrini, J.H.11
Drexler, I.12
Leonhardt, H.13
Ruland, J.14
-
16
-
-
0028359655
-
Genetic associations with human longevity at the APOE and ACE loci
-
Schächter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D (1994) Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 29-32.
-
(1994)
Nat. Genet.
, vol.6
, pp. 29-32
-
-
Schächter, F.1
Faure-Delanef, L.2
Guenot, F.3
Rouger, H.4
Froguel, P.5
Lesueur-Ginot, L.6
Cohen, D.7
-
17
-
-
78249280592
-
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
-
Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L (2010) Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9, 1010-1017.
-
(2010)
Aging Cell
, vol.9
, pp. 1010-1017
-
-
Soerensen, M.1
Dato, S.2
Christensen, K.3
McGue, M.4
Stevnsner, T.5
Bohr, V.A.6
Christiansen, L.7
-
18
-
-
0032555480
-
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
-
Trujillo KM, Yuan SS, Lee EY, Sung P (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273, 21447-21450.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21447-21450
-
-
Trujillo, K.M.1
Yuan, S.S.2
Lee, E.Y.3
Sung, P.4
-
19
-
-
82255192188
-
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
-
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-Rosun L, Castillejo G, de la Concha EG, de Almeida RC, Dias KR, van Diemen CC, Dubois PC, Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GA, Hrdlickova B, Hunt S, Plaza Izurieta L, Izzo V, Joosten LA, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, Nunez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes-Koninckx C, Ricano-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Troncone R, Varade J, Wallace C, Wolters VM, Zhernakova A, Thelma BK, Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA (2011) Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat. Genet. 43, 1193-1201.
-
(2011)
Nat. Genet.
, vol.43
, pp. 1193-1201
-
-
Trynka, G.1
Hunt, K.A.2
Bockett, N.A.3
Romanos, J.4
Mistry, V.5
Szperl, A.6
Bakker, S.F.7
Bardella, M.T.8
Bhaw-Rosun, L.9
Castillejo, G.10
de la Concha, E.G.11
de Almeida, R.C.12
Dias, K.R.13
van Diemen, C.C.14
Dubois, P.C.15
Duerr, R.H.16
Edkins, S.17
Franke, L.18
Fransen, K.19
Gutierrez, J.20
Heap, G.A.21
Hrdlickova, B.22
Hunt, S.23
Plaza Izurieta, L.24
Izzo, V.25
Joosten, L.A.26
Langford, C.27
Mazzilli, M.C.28
Mein, C.A.29
Midah, V.30
Mitrovic, M.31
Mora, B.32
Morelli, M.33
Nutland, S.34
Nunez, C.35
Onengut-Gumuscu, S.36
Pearce, K.37
Platteel, M.38
Polanco, I.39
Potter, S.40
Ribes-Koninckx, C.41
Ricano-Ponce, I.42
Rich, S.S.43
Rybak, A.44
Santiago, J.L.45
Senapati, S.46
Sood, A.47
Szajewska, H.48
Troncone, R.49
Varade, J.50
Wallace, C.51
Wolters, V.M.52
Zhernakova, A.53
Thelma, B.K.54
Cukrowska, B.55
Urcelay, E.56
Bilbao, J.R.57
Mearin, M.L.58
Barisani, D.59
Barrett, J.C.60
Plagnol, V.61
Deloukas, P.62
Wijmenga, C.63
van Heel, D.A.64
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FOXO3A genotype is strongly associated with human longevity
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Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD (2008) FOXO3A genotype is strongly associated with human longevity. Proc. Natl Acad. Sci. USA 105, 13987-13992.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 13987-13992
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-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
Chen, R.4
Grove, J.S.5
Yano, K.6
Masaki, K.H.7
Willcox, D.C.8
Rodriguez, B.9
Curb, J.D.10
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