MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Baens, Mathijs ^a,b   Bonsignore, Luca ^c   Somers, Riet ^a,b   Vanderheydt, Charlotte ^a,b   Weeks, Stephen D ^d   Gunnarsson, Jenny ^e   Nilsson, Ewa ^e   Roth, Robert G ^e   Thome, Margot ^c   Marynen, Peter ^b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^e ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELL PROTEIN; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 2; I KAPPA B ALPHA; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; MUCOSA ASSOCIATED LYMPHOID TISSUE 1 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTOME; UNCLASSIFIED DRUG; BCL10 PROTEIN, HUMAN; CASPASE; LYMPHOCYTE ANTIGEN RECEPTOR; MALT1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOACCUMULATION; CELL METABOLISM; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MOLECULAR DYNAMICS; NUCLEAR FACTOR KAPPA B GENE; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REPORTER GENE; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; CELL MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION PROFILING; GENETICS; HEK293 CELL LINE; JURKAT CELL LINE; LYMPHOCYTE; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; BLOTTING, WESTERN; CASPASES; CELL MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION PROFILING; HEK293 CELLS; HUMANS; JURKAT CELLS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEOPLASM PROTEINS; NF-KAPPA B; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84905643250     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103774     Document Type: Article

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