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Volumn 105, Issue 1, 2016, Pages 276-283

Novel Antitransferrin Receptor Antibodies Improve the Blood-Brain Barrier Crossing Efficacy of Immunoliposomes

Author keywords

blood brain barrier; cancer; drug delivery systems; liposomes; mAb

Indexed keywords

DOXORUBICIN; EPITOPE; IMMUNOGLOBULIN G; IMMUNOLIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CB MIEL 1; MONOCLONAL ANTIBODY CB MIEL 2; MONOCLONAL ANTIBODY CB26; MONOCLONAL ANTIBODY MYBE 4C1; MONOCLONAL ANTIBODY MYBE 4G3; MONOCLONAL ANTIBODY MYBE 5F5; NANOCARRIER; NANOPARTICLE; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BLOCKING ANTIBODY; LIPOSOME;

EID: 84964691736     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2015.11.009     Document Type: Article
Times cited : (24)

References (48)
  • 2
    • 51249091226 scopus 로고    scopus 로고
    • Recent advances in blood-brain barrier disruption as a CNS delivery strategy
    • M.A. Bellavance, M. Blanchette, and D. Fortin Recent advances in blood-brain barrier disruption as a CNS delivery strategy AAPS J 10 1 2008 166 177
    • (2008) AAPS J , vol.10 , Issue.1 , pp. 166-177
    • Bellavance, M.A.1    Blanchette, M.2    Fortin, D.3
  • 3
    • 84879347670 scopus 로고    scopus 로고
    • Ultrasound-mediated strategies in opening brain barriers for drug brain delivery
    • Y.Z. Zhao, C.T. Lu, X.K. Li, and J. Cai Ultrasound-mediated strategies in opening brain barriers for drug brain delivery Expert Opin Drug Deliv 10 7 2013 987 1001
    • (2013) Expert Opin Drug Deliv , vol.10 , Issue.7 , pp. 987-1001
    • Zhao, Y.Z.1    Lu, C.T.2    Li, X.K.3    Cai, J.4
  • 4
    • 57449121882 scopus 로고    scopus 로고
    • Getting into the brain: Approaches to enhance brain drug delivery
    • M.M. Patel, B.R. Goyal, S.V. Bhadada, J.S. Bhatt, and A.F. Amin Getting into the brain: approaches to enhance brain drug delivery CNS Drugs 23 1 2009 35 58
    • (2009) CNS Drugs , vol.23 , Issue.1 , pp. 35-58
    • Patel, M.M.1    Goyal, B.R.2    Bhadada, S.V.3    Bhatt, J.S.4    Amin, A.F.5
  • 5
    • 84929121133 scopus 로고    scopus 로고
    • Accessing targeted nanoparticles to the brain: The vascular route
    • A. Burkhart, M. Azizi, M.S. Thomsen, L.B. Thomsen, and T. Moos Accessing targeted nanoparticles to the brain: the vascular route Curr Med Chem 21 36 2014 4092 4099
    • (2014) Curr Med Chem , vol.21 , Issue.36 , pp. 4092-4099
    • Burkhart, A.1    Azizi, M.2    Thomsen, M.S.3    Thomsen, L.B.4    Moos, T.5
  • 6
    • 84859996647 scopus 로고    scopus 로고
    • Modern methods for delivery of drugs across the blood-brain barrier
    • Y. Chen, and L. Liu Modern methods for delivery of drugs across the blood-brain barrier Adv Drug Deliv Rev 64 7 2012 640 665
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.7 , pp. 640-665
    • Chen, Y.1    Liu, L.2
  • 7
    • 0024367249 scopus 로고
    • Microplate selection technique (MPST). A new method for selecting mouse transfectants expressing human gene products
    • L. Peruzzi, G. Melioli, L.B. De Monte, and et al. Microplate selection technique (MPST). A new method for selecting mouse transfectants expressing human gene products J Immunol Methods 123 1 1989 113 121
    • (1989) J Immunol Methods , vol.123 , Issue.1 , pp. 113-121
    • Peruzzi, L.1    Melioli, G.2    De Monte, L.B.3
  • 8
    • 0037111572 scopus 로고    scopus 로고
    • Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
    • S. Deaglio, A. Capobianco, A. Calì, and et al. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum Blood 100 10 2002 3782 3789
    • (2002) Blood , vol.100 , Issue.10 , pp. 3782-3789
    • Deaglio, S.1    Capobianco, A.2    Calì, A.3
  • 9
    • 24344482904 scopus 로고    scopus 로고
    • Purification of clinical-grade monoclonal antibodies by chromatographic methods
    • A.L. Horenstein, I. Durelli, and F. Malavasi Purification of clinical-grade monoclonal antibodies by chromatographic methods Methods Mol Biol 308 2005 191 208
    • (2005) Methods Mol Biol , vol.308 , pp. 191-208
    • Horenstein, A.L.1    Durelli, I.2    Malavasi, F.3
  • 10
    • 84877288426 scopus 로고    scopus 로고
    • Liposomes functionalized to overcome the blood-brain barrier and to target amyloid-β peptide: The chemical design affects the permeability across an in vitro model
    • E. Salvati, F. Re, S. Sesana, and et al. Liposomes functionalized to overcome the blood-brain barrier and to target amyloid-β peptide: the chemical design affects the permeability across an in vitro model Int J Nanomedicine 8 2013 1749 1758
    • (2013) Int J Nanomedicine , vol.8 , pp. 1749-1758
    • Salvati, E.1    Re, F.2    Sesana, S.3
  • 11
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 12
    • 0019304939 scopus 로고
    • Colorimetric determination of phospholipids with ammonium ferrothiocyanate
    • J.C. Stewart Colorimetric determination of phospholipids with ammonium ferrothiocyanate Anal Biochem 104 1 1980 10 14
    • (1980) Anal Biochem , vol.104 , Issue.1 , pp. 10-14
    • Stewart, J.C.1
  • 13
    • 0029741953 scopus 로고    scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes is superior to free drug or drug-containing conventional liposomes at suppressing growth and metastases of human lung tumor xenografts
    • T. Sakakibara, F.A. Chen, H. Kida, and et al. Doxorubicin encapsulated in sterically stabilized liposomes is superior to free drug or drug-containing conventional liposomes at suppressing growth and metastases of human lung tumor xenografts Cancer Res 56 16 1996 3743 3746
    • (1996) Cancer Res , vol.56 , Issue.16 , pp. 3743-3746
    • Sakakibara, T.1    Chen, F.A.2    Kida, H.3
  • 14
    • 33749073801 scopus 로고    scopus 로고
    • Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient
    • A. Fritze, F. Hens, A. Kimpfler, R. Schubert, and R. Peschka-Süss Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient Biochim Biophys Acta 1758 10 2006 1633 1640
    • (2006) Biochim Biophys Acta , vol.1758 , Issue.10 , pp. 1633-1640
    • Fritze, A.1    Hens, F.2    Kimpfler, A.3    Schubert, R.4    Peschka-Süss, R.5
  • 15
    • 77953962852 scopus 로고    scopus 로고
    • Lipid-based nanoparticles with high binding affinity for amyloid-β 1-42 peptide
    • M. Gobbi, F. Re, M. Canovi, and et al. Lipid-based nanoparticles with high binding affinity for amyloid-β 1-42 peptide Biomaterials 31 25 2010 6519 6529
    • (2010) Biomaterials , vol.31 , Issue.25 , pp. 6519-6529
    • Gobbi, M.1    Re, F.2    Canovi, M.3
  • 16
    • 82955195917 scopus 로고    scopus 로고
    • Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide
    • F. Re, I. Cambianica, S. Sesana, and et al. Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide J Biotechnol 156 4 2010 341 346
    • (2010) J Biotechnol , vol.156 , Issue.4 , pp. 341-346
    • Re, F.1    Cambianica, I.2    Sesana, S.3
  • 17
    • 0033526177 scopus 로고    scopus 로고
    • In vitro model for evaluating drug transport across the blood-brain barrier
    • R. Cecchelli, B. Dehouck, L. Descamps, and et al. In vitro model for evaluating drug transport across the blood-brain barrier Adv Drug Deliv Rev 36 2-3 1999 165 178
    • (1999) Adv Drug Deliv Rev , vol.36 , Issue.2-3 , pp. 165-178
    • Cecchelli, R.1    Dehouck, B.2    Descamps, L.3
  • 18
    • 84876225395 scopus 로고    scopus 로고
    • Effect of nanoparticles binding β-amyloid peptide on nitric oxide production by cultured endothelial cells and macrophages
    • A. Orlando, F. Re, S. Sesana, and et al. Effect of nanoparticles binding β-amyloid peptide on nitric oxide production by cultured endothelial cells and macrophages Int J Nanomedicine 8 2013 1335 1347
    • (2013) Int J Nanomedicine , vol.8 , pp. 1335-1347
    • Orlando, A.1    Re, F.2    Sesana, S.3
  • 19
    • 84940508465 scopus 로고    scopus 로고
    • Iron oxide nanoparticles surface coating and cell uptake affect biocompatibility and inflammatory responses of endothelial cells and macrophages
    • A. Orlando, M. Colombo, D. Prosperi, and et al. Iron oxide nanoparticles surface coating and cell uptake affect biocompatibility and inflammatory responses of endothelial cells and macrophages J Nanopart Res 17 2015 351
    • (2015) J Nanopart Res , vol.17 , pp. 351
    • Orlando, A.1    Colombo, M.2    Prosperi, D.3
  • 20
    • 0028884966 scopus 로고
    • Attachment of antibodies to sterically stabilized liposomes: Evaluation, comparison and optimization of coupling procedures
    • C.B. Hansen, G.Y. Kao, E.H. Moase, S. Zalipsky, and T.M. Allen Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures Biochim Biophys Acta 1239 2 1995 133 144
    • (1995) Biochim Biophys Acta , vol.1239 , Issue.2 , pp. 133-144
    • Hansen, C.B.1    Kao, G.Y.2    Moase, E.H.3    Zalipsky, S.4    Allen, T.M.5
  • 21
    • 55849128943 scopus 로고    scopus 로고
    • The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies
    • B. Poller, H. Gutmann, S. Krähenbühl, and et al. The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies J Neurochem 107 5 2008 1358 1368
    • (2008) J Neurochem , vol.107 , Issue.5 , pp. 1358-1368
    • Poller, B.1    Gutmann, H.2    Krähenbühl, S.3
  • 22
    • 77953397089 scopus 로고    scopus 로고
    • Receptor-mediated therapeutic transport across the blood-brain barrier
    • Y.Y. Wang, P.C. Lui, and J.Y. Li Receptor-mediated therapeutic transport across the blood-brain barrier Immunotherapy 1 6 2009 983 993
    • (2009) Immunotherapy , vol.1 , Issue.6 , pp. 983-993
    • Wang, Y.Y.1    Lui, P.C.2    Li, J.Y.3
  • 23
    • 84929083605 scopus 로고    scopus 로고
    • Nanomedicine for the treatment of Alzheimer's disease
    • M. Gregori, M. Masserini, and S. Mancini Nanomedicine for the treatment of Alzheimer's disease Nanomedicine (Lond) 10 7 2015 1203 1218
    • (2015) Nanomedicine (Lond) , vol.10 , Issue.7 , pp. 1203-1218
    • Gregori, M.1    Masserini, M.2    Mancini, S.3
  • 24
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptor-mediation
    • A. Jones, and E. Shusta Blood-brain barrier transport of therapeutics via receptor-mediation Pharm Res 24 2007 1759 1771
    • (2007) Pharm Res , vol.24 , pp. 1759-1771
    • Jones, A.1    Shusta, E.2
  • 25
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • J. Huwyler, D. Wu, and W.M. Pardridge Brain drug delivery of small molecules using immunoliposomes Proc Natl Acad Sci U S A 93 24 1996 14164 14169
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.24 , pp. 14164-14169
    • Huwyler, J.1    Wu, D.2    Pardridge, W.M.3
  • 26
    • 84924971966 scopus 로고    scopus 로고
    • Preparation and evaluation of Baicalin-loaded cationic solid lipid nanoparticles conjugated with OX26 for improved delivery across the BBB
    • Z. Liu, H. Zhao, L. Shu, and et al. Preparation and evaluation of Baicalin-loaded cationic solid lipid nanoparticles conjugated with OX26 for improved delivery across the BBB Drug Dev Ind Pharm 41 3 2015 353 356
    • (2015) Drug Dev Ind Pharm , vol.41 , Issue.3 , pp. 353-356
    • Liu, Z.1    Zhao, H.2    Shu, L.3
  • 27
    • 79951955199 scopus 로고    scopus 로고
    • Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain
    • I. van Rooy, E. Mastrobattista, G. Storm, W.E. Hennink, and R.M. Schiffelers Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain J Control Release 150 1 2011 30 36
    • (2011) J Control Release , vol.150 , Issue.1 , pp. 30-36
    • Van Rooy, I.1    Mastrobattista, E.2    Storm, G.3    Hennink, W.E.4    Schiffelers, R.M.5
  • 28
    • 84899523576 scopus 로고    scopus 로고
    • Mono and dually decorated nanoliposomes for brain targeting, in vitro and in vivo studies
    • E. Markoutsa, K. Papadia, A.D. Giannou, and et al. Mono and dually decorated nanoliposomes for brain targeting, in vitro and in vivo studies Pharm Res 31 5 2014 1275 1289
    • (2014) Pharm Res , vol.31 , Issue.5 , pp. 1275-1289
    • Markoutsa, E.1    Papadia, K.2    Giannou, A.D.3
  • 29
    • 84864933593 scopus 로고    scopus 로고
    • OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: Synthesis, characterization and evaluation of its brain delivery ability
    • H. Bao, X. Jin, L. Li, F. Lv, and T. Liu OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: synthesis, characterization and evaluation of its brain delivery ability J Mater Sci Mater Med 23 8 2012 1891 1901
    • (2012) J Mater Sci Mater Med , vol.23 , Issue.8 , pp. 1891-1901
    • Bao, H.1    Jin, X.2    Li, L.3    Lv, F.4    Liu, T.5
  • 30
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    • K. Ulbrich, T. Hekmatara, E. Herbert, and J. Kreuter Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur J Pharm Biopharm 71 2 2009 251 256
    • (2009) Eur J Pharm Biopharm , vol.71 , Issue.2 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 31
    • 77955562994 scopus 로고    scopus 로고
    • The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies
    • J. Wang, S. Tian, R.A. Petros, M.E. Napier, and J.M. Desimone The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies J Am Chem Soc 132 32 2010 11306 11313
    • (2010) J Am Chem Soc , vol.132 , Issue.32 , pp. 11306-11313
    • Wang, J.1    Tian, S.2    Petros, R.A.3    Napier, M.E.4    Desimone, J.M.5
  • 32
    • 0026410275 scopus 로고
    • Analysis and isolation of human transferrin receptor using the OKT-9 monoclonal antibody covalently crosslinked to magnetic beads
    • G.B. Karlsson, and F.M. Platt Analysis and isolation of human transferrin receptor using the OKT-9 monoclonal antibody covalently crosslinked to magnetic beads Anal Biochem 199 2 1991 219 222
    • (1991) Anal Biochem , vol.199 , Issue.2 , pp. 219-222
    • Karlsson, G.B.1    Platt, F.M.2
  • 33
    • 16844367179 scopus 로고    scopus 로고
    • Detection of channel proximity by nanoparticle-assisted delaying of toxin binding; A combined patch-clamp and flow cytometric energy transfer study
    • B. Rubovszky, P. Hajdú, Z. Krasznai, and et al. Detection of channel proximity by nanoparticle-assisted delaying of toxin binding; a combined patch-clamp and flow cytometric energy transfer study Eur Biophys J 34 2 2005 127 143
    • (2005) Eur Biophys J , vol.34 , Issue.2 , pp. 127-143
    • Rubovszky, B.1    Hajdú, P.2    Krasznai, Z.3
  • 34
    • 54549092412 scopus 로고    scopus 로고
    • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells
    • E. Wang, N. Obeng-Adjei, Q. Ying, and et al. Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells Virology 381 2 2008 230 240
    • (2008) Virology , vol.381 , Issue.2 , pp. 230-240
    • Wang, E.1    Obeng-Adjei, N.2    Ying, Q.3
  • 35
    • 84873252557 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: From concept to clinical applications
    • T.M. Allen, and P.R. Cullis Liposomal drug delivery systems: from concept to clinical applications Adv Drug Deliv Rev 65 1 2013 36 48
    • (2013) Adv Drug Deliv Rev , vol.65 , Issue.1 , pp. 36-48
    • Allen, T.M.1    Cullis, P.R.2
  • 36
    • 84856638259 scopus 로고    scopus 로고
    • Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy
    • H.I. Chang, and M.K. Yeh Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy Int J Nanomedicine 7 2012 49 60
    • (2012) Int J Nanomedicine , vol.7 , pp. 49-60
    • Chang, H.I.1    Yeh, M.K.2
  • 37
    • 0028855939 scopus 로고
    • Sphingomyelincholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models
    • M.S. Webb, T.O. Harasym, D. Masin, M.B. Bally, and L.D. Mayer Sphingomyelincholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models Br J Cancer 72 1995 896 904
    • (1995) Br J Cancer , vol.72 , pp. 896-904
    • Webb, M.S.1    Harasym, T.O.2    Masin, D.3    Bally, M.B.4    Mayer, L.D.5
  • 38
    • 84865820981 scopus 로고    scopus 로고
    • A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue
    • E.A. Nance, G.F. Woodworth, K.A. Sailor, and et al. A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue Sci Transl Med 4 149 2012 149ra119
    • (2012) Sci Transl Med , vol.4 , Issue.149 , pp. 149ra119
    • Nance, E.A.1    Woodworth, G.F.2    Sailor, K.A.3
  • 39
    • 11944265265 scopus 로고    scopus 로고
    • Nanoparticle surface charges alter blood-brain barrier integrity and permeability
    • P.R. Lockman, J.M. Koziara, R.J. Mumper, and D.D. Allen Nanoparticle surface charges alter blood-brain barrier integrity and permeability J Drug Target 12 9-10 2004 635 641
    • (2004) J Drug Target , vol.12 , Issue.9-10 , pp. 635-641
    • Lockman, P.R.1    Koziara, J.M.2    Mumper, R.J.3    Allen, D.D.4
  • 40
    • 84868660382 scopus 로고    scopus 로고
    • The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells
    • M. Pinzón-Daza, R. Garzón, P. Couraud, and et al. The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells Br J Pharmacol 167 7 2012 1431 1447
    • (2012) Br J Pharmacol , vol.167 , Issue.7 , pp. 1431-1447
    • Pinzón-Daza, M.1    Garzón, R.2    Couraud, P.3
  • 41
    • 0029585915 scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: Biodistribution and therapeutic efficacy
    • T. Siegal, A. Horowitz, and A. Gabizon Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy J Neurosurg 83 6 1995 1029 1037
    • (1995) J Neurosurg , vol.83 , Issue.6 , pp. 1029-1037
    • Siegal, T.1    Horowitz, A.2    Gabizon, A.3
  • 42
    • 12144288634 scopus 로고    scopus 로고
    • Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles
    • S.C. Steiniger, J. Kreuter, A.S. Khalansky, and et al. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles Int J Cancer 109 5 2004 759 767
    • (2004) Int J Cancer , vol.109 , Issue.5 , pp. 759-767
    • Steiniger, S.C.1    Kreuter, J.2    Khalansky, A.S.3
  • 43
    • 84904968815 scopus 로고    scopus 로고
    • Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model
    • J. Lin, S. Shigdar, D.Z. Fang, and et al. Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model PLoS One 9 7 2014 e103736
    • (2014) PLoS One , vol.9 , Issue.7
    • Lin, J.1    Shigdar, S.2    Fang, D.Z.3
  • 44
    • 84884264215 scopus 로고    scopus 로고
    • Tumor-penetrating peptide functionalization enhances the anti-glioblastoma effect of doxorubicin liposomes
    • Y. Yang, Z. Yan, D. Wei, and et al. Tumor-penetrating peptide functionalization enhances the anti-glioblastoma effect of doxorubicin liposomes Nanotechnology 24 40 2013 405101
    • (2013) Nanotechnology , vol.24 , Issue.40 , pp. 405101
    • Yang, Y.1    Yan, Z.2    Wei, D.3
  • 45
    • 79955801224 scopus 로고    scopus 로고
    • Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers
    • S. Wohlfart, A.S. Khalansky, S. Gelperina, and et al. Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers PLoS One 6 5 2011 e19121
    • (2011) PLoS One , vol.6 , Issue.5
    • Wohlfart, S.1    Khalansky, A.S.2    Gelperina, S.3
  • 46
    • 0029056457 scopus 로고
    • In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier
    • T. Ohnishi, I. Tamai, K. Sakanaka, and et al. In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier Biochem Pharmacol 49 10 1995 1541 1544
    • (1995) Biochem Pharmacol , vol.49 , Issue.10 , pp. 1541-1544
    • Ohnishi, T.1    Tamai, I.2    Sakanaka, K.3
  • 47
    • 0018560916 scopus 로고
    • Adriamycin (doxorubicin) cardiotoxicity: A review
    • R.T. Chlebowski Adriamycin (doxorubicin) cardiotoxicity: a review West J Med 131 5 1979 364 368
    • (1979) West J Med , vol.131 , Issue.5 , pp. 364-368
    • Chlebowski, R.T.1
  • 48
    • 84858241851 scopus 로고    scopus 로고
    • PEGylated liposomal doxorubicin targeted to α5β1-expressing MDA-MB-231 breast cancer cells
    • K. Shroff, and E. Kokkoli PEGylated liposomal doxorubicin targeted to α5β1-expressing MDA-MB-231 breast cancer cells Langmuir 28 10 2012 4729 4736
    • (2012) Langmuir , vol.28 , Issue.10 , pp. 4729-4736
    • Shroff, K.1    Kokkoli, E.2


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