Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice

Brain

Volumn 139, Issue 3, 2016, Pages 856-870

  Helwig, Michael ^a   Klinkenberg, Michael ^a   Rusconi, Raffaella ^a   Musgrove, Ruth E ^a   Majbour, Nour K ^b   El Agnaf, Omar M A ^c   Ulusoy, Ayse ^a   Di Monte, Donato A ^a  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c HAMAD BIN KHALIFA UNIVERSITY   (Qatar)

Author keywords

Adeno associated virus; Fibrils; Oligomers; Parkinson's disease; Vagus nerve

Indexed keywords

ALPHA SYNUCLEIN; ANTIBODY; MONOMER; NONFIBRILLAR PROTEIN; OLIGOMER; PROTEIN; PROTEIN AGGREGATE; UNCLASSIFIED DRUG; VIRUS VECTOR; SNCA PROTEIN, HUMAN;

AMYGDALA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXON; BRAIN; BRAIN REGION; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FEMALE; FOREBRAIN; GENETIC TRANSDUCTION; HUMAN; IMMUNOREACTIVITY; LOCUS CERULEUS; MEDULLA OBLONGATA; MESENCEPHALON; MOUSE; NERVE CELL; NERVE CELL LESION; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SYNAPSE; TISSUE SECTION; VAGUS NERVE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ALPHA-SYNUCLEIN; ANIMALS; BRAIN; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 84964689099     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv376     Document Type: Article

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