Impact of multicellular tumor spheroids as an in vivo-like tumor model on anticancer drug response

International Journal of Oncology

Volumn 48, Issue 6, 2016, Pages 2295-2302

  Galateanu, Bianca ^a   Hudita, Ariana ^a   Negrei, Carolina ^b   Ion, Rodica Mariana ^c,d   Costache, Marieta ^a   Stan, Miriana ^b   Nikitovic, Dragana ^e   Hayes, A Wallace ^f   Spandidos, Demetrios A ^g   Tsatsakis, Aristidis M ^e   Ginghina, Octav ^b  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c NATIONAL RESEARCH AND DEVELOPMENT INSTITUTE FOR CHEMISTRY AND PETROCHEMISTRY ICECHIM   (Romania)

^d VALAHIA UNIVERSITY OF TARGOVISTE   (Romania)

^e UNIVERSITY OF CRETE   (Greece)

^f MICHIGAN STATE UNIVERSITY   (United States)

^g UNIVERSITY OF CRETE   (Greece)

Author keywords

5 fluorouracil; Colorectal cancer; Liposomes; Multicellular tumor spheroids; Oxaliplatin; Therapy

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LIPOSOME; MESO TETRA(4 SULFONATOPHENYL)PORPHYRIN; OXALIPLATIN; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FOLIC ACID; PLATINUM COMPLEX;

ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR SPHEROID; ADENOCARCINOMA; COLONIC NEOPLASMS; DRUG SCREENING; HT-29 CELL LINE; PATHOLOGY; PROCEDURES; SPECTROPHOTOMETRY;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; FOLIC ACID; HT29 CELLS; HUMANS; LIPOSOMES; ORGANOPLATINUM COMPOUNDS; SPECTROPHOTOMETRY; SPHEROIDS, CELLULAR;

EID: 84964687244     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3467     Document Type: Article

References (46)

1. Zavoral M, Suchanek S, Zavada F, Dusek L, Muzik J, Seifert B and Fric P: Colorectal cancer screening in Europe. World J Gastroenterol 15: 5907-5915, 2009.
2. Jemal A, Clegg LX, Ward E, Ries LA, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN and Edwards BK: Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 101: 3-27, 2004.
3. Boyle P and Langman JS: ABC of colorectal cancer: Epidemiology. BMJ 321: 805-808, 2000.
4. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
5. Jackson-Thompson J, Ahmed F, German RR, Lai SM and Friedman C: Descriptive epidemiology of colorectal cancer in the United States, 1998-2001. Cancer 107 (Suppl 5): 1103-1111, 2006.
6. Mayer RJ: Moving beyond fluorouracil for colorectal cancer. N Engl J Med 343: 963-964, 2000.
7. Saltz LB, Cox J V, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, Maroun JA, Ackland SP, Locker PK, Pirotta N, et al; Irinotecan Study Group: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343: 905-914, 2000.
8. De Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18: 2938-2947, 2000.
9. Giacchetti S, Perpoint B, Zidani R, Le Bail N, Faggiuolo R, Focan C, Chollet P, Llory J F, Letourneau Y, Coudert B, et al: Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18: 136-147, 2000.
10. Scheithauer W, Rosen H, Kornek GV, Sebesta C and Depisch D: Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with meta-static colorectal cancer. BMJ 306: 752-755, 1993.
11. Mimeault M, Hauke R and Batra SK: Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther 83: 673-691, 2008.
12. Flaten GE, Dhanikula AB, Luthman K and Brandl M: Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion. Eur J Pharm Sci 27: 80-90, 2006.
13. Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC and Alberts SR: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22: 23-30, 2004.
14. Dinu-Pîrvu C, Ferdes M, Buţu A, Orţan A and Ghica MV: Physicochemical investigation of low soluble biocompounds entrapped in lipid carriers. Farmacia 61: 182-192, 2013.
15. House MG, Ito H, Gönen M, Fong Y, Allen PJ, DeMatteo RP, Brennan MF, Blumgart LH, Jarnagin WR, D'Angelica MI: Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1, 600 patients during two decades at a single institution. J Am Coll Surg 210: 744-752, 752-755 2010.
16. Abbott A: Cell culture: Biology's new dimension. Nature 424: 870-872, 2003.
17. Mazzoleni G, Di Lorenzo D and Steimberg N: Modelling tissues in 3D: The next future of pharmaco-toxicology and food research? Genes Nutr 4: 13-22, 2009.
18. Pampaloni F, Reynaud EG and Stelzer EH: The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8: 839-845, 2007.
19. Ghosh S, Spagnoli GC, Martin I, Ploegert S, Demougin P, Heberer M and Reschner A: Three-dimensional culture of melanoma cells profoundly affects gene expression profile: A high density oligonucleotide array study. J Cell Physiol 204: 522-531, 2005.
20. Ernst A, Hofmann S, Ahmadi R, Becker N, Korshunov A, Engel F, Hartmann C, Felsberg J, Sabel M, Peterziel H, et al: Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Clin Cancer Res 15: 6541-6550, 2009.
21. Haycock JW: 3D cell culture: A review of current approaches and techniques. Methods Mol Biol 695: 1-15, 2011.
22. Sutherland RM, Sordat B, Bamat J, Gabbert H, Bourrat B and Mueller-Klieser W: Oxygenation and differentiation in multi-cellular spheroids of human colon carcinoma. Cancer Res 46: 5320-5329, 1986.
23. Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W and Kunz-Schughart LA: Multicellular tumor spheroids: An underestimated tool is catching up again. J Biotechnol 148: 3-15, 2010.
24. Spencer VA, Xu R and Bissell MJ: Gene expression in the third dimension: The ECM-nucleus connection. J Mammary Gland Biol Neoplasia 15: 65-71, 2010.
25. Jacks T and Weinberg RA: Taking the study of cancer cell survival to a new dimension. Cell 111: 923-925, 2002.
26. Sutherland RM, McCredie JA and Inch WR: Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. J Natl Cancer Inst 46: 113-120, 1971.
27. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J and Dirks PB: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003.
28. Deisboeck TS, Berens ME, Kansal AR, Torquato S, Stemmer-Rachamimov AO and Chiocca EA: Pattern of self-organization in tumour systems: Complex growth dynamics in a novel brain tumour spheroid model. Cell Prolif 34: 115-134, 2001.
29. Wartenberg M, Dönmez F, Ling FC, Acker H, Hescheler J and Sauer H: Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J 15: 995-1005, 2001.
30. Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D and Ho M: The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PLoS One 6: e14640, 2011.
31. Del Duca D, Werbowetski T and Del Maestro. RF: Spheroid preparation from hanging drops: Characterization of a model of brain tumor invasion. J Neurooncol 67: 295-303, 2004.
32. Friedrich J, Seidel C, Ebner R and Kunz-Schughart LA: Spheroid-based drug screen: Considerations and practical approach. Nat Protoc 4: 309-324, 2009.
33. Weiswald LB, Guinebretière JM, Richon S, Bellet D, Saubaméa B and Dangles-Marie V: In situ protein expression in tumour spheres: Development of an immunostaining protocol for confocal microscopy. BMC Cancer 10: 106, 2010.
34. Li Q, Chen C, Kapadia A, Zhou Q, Harper MK, Schaack J and LaBarbera DV: 3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen. J Biomol Screen 16: 141-154, 2011.
35. Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV and Varticovski L: Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics. Breast Cancer Res 10: R10, 2008.
36. Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y and Wang TC: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27: 1006-1020, 2009.
37. Lee GY, Kenny PA, Lee EH and Bissell MJ: Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 4: 359-365, 2007.
38. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ and Mooney DJ: Engineering tumors with 3D scaffolds. Nat Methods 4: 855-860, 2007.
39. Kim JB, Stein R and O'Hare MJ: Three-dimensional in vitro tissue culture models of breast cancer - a review. Breast Cancer Res Treat 85: 281-291, 2004.
40. Derycke AS and De Witte. PA: Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes. Int J Oncol 20: 181-187, 2002.
41. Ion RM and Apostol S: Photochemical study of porphyrin aggregates. Rev Chem 56: 607-620, 2005.
42. Mueller-Klieser W: Multicellular spheroids: A review on cellular aggregates in cancer research. J Cancer Res Clin Oncol 113: 101-122, 1987.
43. Wibe E, Berg J P, Tveit KM, Nesland JM and Lunde S: Multicellular spheroids grown directly from human tumour material. Int J Cancer 34: 21-26, 1984.
44. Boothby CD, Daniel J, Adam S and Dyson JE: Use of a laser diffraction particle sizer for the measurement of mean diameter of multicellular tumour spheroids. in Vitro Cell Dev Biology 25: 946-950, 1989.
45. Olive PL and Durand RE: Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Rev 13: 121-138, 1994.
46. Inoue T, Inoue T, Teshima T, Murayama S, Shimizutani K, Fuchihata H and Furukawa S: Phase III trial of high and low dose rate interstitial radiotherapy for early oral tongue cancer. Int J Radiat Oncol Biol Phys 36: 1201-1204, 1996.