A new cyclic dipeptide penicimutide: the activated production of cyclic dipeptides by introduction of neomycin-resistance in the marine-derived fungus Penicillium purpurogenum G59

Archives of Pharmacal Research

Volumn 39, Issue 6, 2016, Pages 762-770

  Wang, Nan ^a   Cui, Cheng Bin ^a   Li, Chang Wei ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Cyclic dipeptide; Fungal metabolite; Marine derived Penicillium purpurogenum; Neomycin resistant mutant; Penicimutide; Structure determination

Indexed keywords

4,5 DIDEHYDRO LEVO LEUCINE; AMINO ACID; ANTINEOPLASTIC AGENT; CYCLO(ISOLEUCYLPROLINE); CYCLO(LEUCYLPROLINE); CYCLO(PHENYLALANYLPROLINE); CYCLO(VALYLPROLIENE); DIMETHYL SULFOXIDE; DIPEPTIDE DERIVATIVE; FLUOROURACIL; NEOMYCIN; PENICIMUTIDE; UNCLASSIFIED DRUG; CYCLOPEPTIDE;

ANTIBIOTIC RESISTANCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CANCER INHIBITION; CHEMICAL ANALYSIS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIUM PURPUROGENUM; ANTIFUNGAL RESISTANCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; GENETICS; ISOLATION AND PURIFICATION; K-562 CELL LINE; MCF-7 CELL LINE; MICROBIOLOGY; PENICILLIUM; PROCEDURES; SEDIMENT;

ANTINEOPLASTIC AGENTS; DRUG DISCOVERY; DRUG RESISTANCE, FUNGAL; GEOLOGIC SEDIMENTS; HELA CELLS; HUMANS; K562 CELLS; MCF-7 CELLS; MOLECULAR STRUCTURE; NEOMYCIN; PENICILLIUM; PEPTIDES, CYCLIC;

EID: 84964661471     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-016-0751-7     Document Type: Article

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