A practical strategy to discover new antitumor compounds by activating silent metabolite production in fungi by diethyl sulphate mutagenesis

Marine Drugs

Volumn 12, Issue 4, 2014, Pages 1788-1814

  Fang, Shi Ming ^a,b   Wu, Chang Jing ^a,b   Li, Chang Wei ^b   Cui, Cheng Bin ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Alkaloids; DES mutagenesis; Natural products; Silent fungal metabolite production; Structure elucidation

Indexed keywords

ANTINEOPLASTIC AGENT; DIETHYL SULFATE; FLUOROURACIL; FRUCTIGENINE A; NATURAL PRODUCT; PENICIMUTANIN A; PENICIMUTANIN B; PENICIMUTANOLONE; PENICIMUTATIN; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; SULFATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; FUNGAL METABOLISM; FUNGUS MUTANT; HUMAN; HUMAN CELL; IC 50; METABOLITE; NONHUMAN; PENICILLIUM PURPUROGENUM; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC50; METABOLISM; MUTAGENESIS; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PENICILLIUM; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MUTAGENESIS; NEOPLASMS; PENICILLIUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFURIC ACID ESTERS;

EID: 84897050888     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12041788     Document Type: Article

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