Unraveling the molecular pathways of DNA-methylation inhibitors: Human endogenous retroviruses induce the innate immune response in tumors

OncoImmunology

Volumn 5, Issue 5, 2016, Pages

  Strick, Reiner ^a   Strissel, Pamela L ^a   Baylin, Stephen B ^b   Chiappinelli, Katherine B ^b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

DNA methylation; dsRNA; Endogeneous retrovirus (ERV); Epigenetic therapy; IFN signalling; Immune checkpoints; Innate immunity; TLR

Indexed keywords

DECITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; TOLL LIKE RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CYTOKINE PRODUCTION; DNA METHYLATION; HUMAN; INNATE IMMUNITY; NONHUMAN; RETROVIRIDAE; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; TUMOR VOLUME;

EID: 84964653327     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2015.1122160     Document Type: Article

References (10)

1. M.A.Postow, M.K.Callahan, J.D.Wolchok. Immune Checkpoint Blockade in Cancer Therapy. J Clin Oncol 2015; 33:1974-82; PMID:25605845; http://dx.doi.org/10.1200/JCO.2014.59.4358
2. H.Li, K.B.Chiappinelli, A.A.Guzzetta, H.Easwaran, R.W.Yen, R.Vatapalli, M.J.Topper, J.Luo, R.M.Connolly, N.S.Azad et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 2014; 5:587-98; PMID:24583822; http://dx.doi.org/10.18632/oncotarget.1782
3. K.B.Chiappinelli, P.L.Strissel, A.Desrichard, H.Li, C.Henke, B.Akman, A.Hein, N.S.Rote, L.M.Cope, A.Snyder et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell 2015; 162:974-86; PMID:26317466; http://dx.doi.org/10.1016/j.cell.2015.07.011
4. D.Roulois, H.Loo Yau, R.Singhania, Y.Wang, A.Danesh, S.Y.Shen, H.Han, G.Liang, P.A.Jones, T.J.Pugh et al. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell 2015; 162:961-73; PMID:26317465; http://dx.doi.org/10.1016/j.cell.2015.07.056
5. L.A.J.O'Neill, D.Golenbock, A.G.Bowie. The history of Toll-like receptors — redefining innate immunity. Nat Rev Immunol 2013; 13:453-60; PMID:23681101; http://dx.doi.org/10.1038/nri3446
6. D.De Nardo. Toll-like receptors: Activation, signalling and transcriptional modulation. Cytokine 2015; 74:181-9; PMID:25846205; http://dx.doi.org/10.1016/j.cyto.2015.02.025
7. M.Caskey, F.Lefebvre, A.Filali-Mouhim, M.J.Cameron, J.P.Goulet, E.K.Haddad, G.Breton, C.Trumpfheller, S.Pollak, I.Shimeliovich et al. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J Exp Med 2011; 208:2357-66; PMID:22065672; http://dx.doi.org/10.1084/jem.20111171
8. P.Yu, W.Lübben, H.Slomka, J.Gebler, M.Konert, C.Cai, L.Neubrandt, O.Prazeres da Costa, S.Paul et al. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity 2012; 37:867-79; PMID:23142781; http://dx.doi.org/10.1016/j.immuni.2012.07.018
9. S.Reikine, J.B.Nguyen, Y.Modis. Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5. Front Immunol 2014; 5:342; PMID:25101084; http:10.3389/fimmu.2014.00342.
10. A.M.Bruns, G.P.Leser, R.A.Lamb, C.M.Horvath. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell 2014; 55:771-81; PMID:25127512; http://dx.doi.org/10.1016/j.molcel.2014.07.003