Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease

Digestive and Liver Disease

Volumn 48, Issue 7, 2016, Pages 745-752

  Di Sabatino, Antonio ^a   Giuffrida, Paolo ^a   Fornasa, Giulia ^b   Salvatore, Chiara ^a   Vanoli, Alessandro ^a   Naviglio, Samuele ^c   De Leo, Luigina ^d   Pasini, Alessandra ^a   De Amici, Mara ^a   Alvisi, Costanza ^a   Not, Tarcisio ^c,d   Rescigno, Maria ^b   Corazza, Gino Roberto ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

Chemokine; Cytokine; Duodenal mucosa; Tissue transglutaminase

Indexed keywords

ALPHA INTERFERON; CCL1 CHEMOKINE; CHEMOKINE; CXCL1 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUTEN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 32ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; RANTES; THYMIC STROMAL LYMPHOPOIETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ADULT; AGED; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DUODENUM BIOPSY; EOSINOPHIL; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOLOGY; INNATE IMMUNITY; LAMINA PROPRIA; LYMPHOCYTE; MALE; MIDDLE AGED; NONCELIAC GLUTEN SENSITIVITY; NUTRITIONAL INTOLERANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SYMPTOM; YOUNG ADULT; ADOLESCENT; CASE CONTROL STUDY; COMPARATIVE STUDY; DIET THERAPY; DUODENUM; GLUTEN FREE DIET; IMMUNOLOGY; ITALY; MUCOSAL IMMUNITY; PATHOLOGY; SELF REPORT;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CELIAC DISEASE; CYTOKINES; DIET, GLUTEN-FREE; DUODENUM; FEMALE; GLUTENS; HUMANS; IMMUNITY, INNATE; IMMUNITY, MUCOSAL; ITALY; MALE; MIDDLE AGED; SELF REPORT; YOUNG ADULT;

EID: 84964607666     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2016.03.024     Document Type: Article

References (42)

1. Sapone A., Bai J.C., Ciacci C., et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Medicine 2012, 10:13.
2. Catassi C., Bai J.C., Bonaz B., et al. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients 2013, 5:3839-3853.
3. Ludvigsson J.F., Leffler D.A., Bai J.C., et al. The Oslo definitions for coeliac disease and related terms. Gut 2013, 62:43-52.
4. Monteleone I., Monteleone G., Del Vecchio Blanco G., et al. Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa. Gut 2004, 53:1090-1095.
5. Monteleone I., Sarra M., Del Vecchio Blanco G., et al. Characterization of IL-17A-producing cells in celiac disease mucosa. Journal of Immunology 2010, 184:2211-2218.
6. Di Sabatino A., Ciccocioppo R., Cupelli F., et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 2006, 55:469-477.
7. Maiuri L., Ciacci C., Ricciardelli I., et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003, 362:30-37.
8. Fasano A., Sapone A., Zevallos V., et al. Nonceliac gluten sensitivity. Gastroenterology 2015, 148:1195-1204.
9. Aziz I., Hadjivassiliou M., Sanders D.S. Self-reported gluten sensitivity: an international concept in need of consensus?. American Journal of Gastroenterology 2014, 109:1498-1499.
10. Brottveit M., Beitnes A.C., Tollefsen S., et al. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. American Journal of Gastroenterology 2013, 108:842-850.
11. Volta U., Bardella M.T., Calabrò A., et al. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Medicine 2014, 12:85.
12. Aziz I., Lewis N.R., Hadjivassiliou M., et al. A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. European Journal of Gastroenterology and Hepatology 2014, 26:33-39.
13. Di Sabatino A., Corazza G.R. Coeliac disease. Lancet 2009, 379:1480-1493.
14. Corazza G.R., Villanacci V. Coeliac disease. Journal of Clinical Pathology 2005, 58:573-574.
15. Di Sabatino A., Volta U., Salvatore C., et al. Small amounts of gluten in subjects with suspected nonceliac gluten sensitivity: a randomized, double-blind, placebo-controlled, cross-over trial. Clinical Gastroenterology and Hepatology 2015, 13:1604-1612.
16. Salmi T.T., Collin P., Korponay-Szabó I.R., et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006, 55:1746-1753.
17. Di Sabatino A., Jackson C.L., Pickard K.M., et al. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009, 58:777-789.
18. Rimoldi M., Chieppa M., Salucci V., et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nature Immunology 2005, 6:507-514.
19. Monteleone G., Pender S.L., Alstead E., et al. Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut 2001, 48:425-429.
20. Biancheri P., Di Sabatino A., Rescigno M., et al. Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut 2015, 10.1136/gutjnl-2014-308876.
21. Biesiekierski J.R., Newnham E.D., Irving P.M., et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. American Journal of Gastroenterology 2011, 106:508-514.
22. Sapone A., Lammers K.M., Casolaro V., et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Medicine 2011, 9:23.
23. Vazquez-Roque M.I., Camilleri M., Smyrk T., et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013, 144:903-911.
24. Sapone A., Lammers K.M., Mazzarella G., et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. International Archives of Allergy and Immunology 2010, 152:75-80.
25. Bucci C., Zingone F., Russo I., et al. Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity. Clinical Gastroenterology and Hepatology 2013, 11:1294-1299.
26. Atreya R., Neurath M.F. Chemokines in inflammatory bowel diseases. Digestive Diseases 2010, 28:386-394.
27. Hamilton J.A. Colony-stimulating factors in inflammation and autoimmunity. Nature Reviews Immunology 2008, 8:533-544.
28. Desreumaux P., Delaporte E., Colombel J.F., et al. Similar IL-5, IL-3, and GM-CSF syntheses by eosinophils in the jejunal mucosa of patients with celiac disease and dermatitis herpetiformis. Clinical Immunology and Immunopathology 1998, 88:14-21.
29. Di Sabatino A., Rovedatti L., Rosado M.M., et al. Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood. Human Pathology 2009, 40:699-704.
30. Carroccio A., Mansueto P., Iacono G., et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. American Journal of Gastroenterology 2012, 107:1898-1906.
31. Zanini B., Baschè R., Ferraresi A., et al. Randomised clinical study: gluten challenge induces symptom recurrence in only a minority of patients who meet clinical criteria for non-coeliac gluten sensitivity. Alimentary Pharmacology and Therapeutics 2015, 42:968-976.
32. Not T., Ziberna F., Vatta S., et al. Cryptic genetic gluten intolerance revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut 2011, 60:1487-1493.
33. Suarez F.L., Savaiano D.A., Levitt M.D. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. New England Journal of Medicine 1995, 333:1-4.
34. Jewett D.L., Fein G., Greenberg M.H. A double-blind study of symptom provocation to determine food sensitivity. New England Journal of Medicine 1990, 323:429-433.
35. Di Sabatino A., Corazza G.R. Nonceliac gluten sensitivity: sense or sensibility?. Annals of Internal Medicine 2012, 156:309-311.
36. Junker Y., Zeissig S., Kim S.J., et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. Journal of Experimental Medicine 2012, 209:2395-2408.
37. Lister J., Fletcher P.J., Nobrega J.N., et al. Behavioral effects of food-derived opioid-like peptides in rodents: implications for schizophrenia?. Pharmacology Biochemistry and Behavior 2015, 134:70-78.
38. Gibson P.R., Muir J.G., Newnham E.D. Other Dietary Confounders: FODMAPS et al. Digestive Diseases 2015, 33:269-276.
39. Corazza G.R., Frazzoni M., Strocchi A., et al. Alimentary exorphin actions on motility and hormonal secretion of gastrointestinal tract. Opioid peptides in periphery 1984, 243-247. Elsevier Science Publisher, Amsterdam. F. Fraioli, A. Isidori, M. Mazzetti (Eds.).
40. Levitt M.D., Hirsh P., Fetzer C.A., et al. H2 excretion after ingestion of complex carbohydrates. Gastroenterology 1987, 92:383-389.
41. Di Stefano M., Carnevale Maffè G., Bergonzi M., et al. The effect of gluten on intestinal fermentation, gastric and gallbladder emptying in healthy volunteers. Digestive and Liver Disease 2015, 47:751-756.
42. Biesiekierski J.R., Peters S.L., Newnham E.D., et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013, 145:320-328.