Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor

Brain Research

Volumn 1642, Issue , 2016, Pages 487-496

  Li, Xiaolan ^a,b   Han, Xinjia ^a,b   Bao, Junjie ^b   Liu, Yuanyuan ^a,b   Ye, Aihua ^a,b   Thakur, Mukesh ^c   Liu, Huishu ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Guangzhou Women and Children's Medical Center   (China)

^c AMITY UNIVERSITY   (India)

Author keywords

Eclampsia; Hippocampal neuron; Inflammatory cytokines; Microglia; Nicotine

Indexed keywords

ALPHA BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; CYTOKINE; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NICOTINE; PENTETRAZOLE; TUMOR NECROSIS FACTOR ALPHA; NICOTINIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL ACTIVATION; DISEASE SEVERITY; DRUG EFFECT; ECLAMPSIA; EXPERIMENTAL BEHAVIORAL TEST; FEMALE; FETUS OUTCOME; GESTATION PERIOD; HIPPOCAMPAL CA1 REGION; IMMUNOFLUORESCENCE; MATERNAL SERUM; MICROGLIA; NEUROPROTECTION; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SYSTOLIC BLOOD PRESSURE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD PRESSURE; DISEASE MODEL; DRUG EFFECTS; IMMUNOMODULATION; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; PREGNANCY; PREGNANCY OUTCOME; RANDOMIZATION; SEIZURES; SPRAGUE DAWLEY RAT;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ASTROCYTES; BLOOD PRESSURE; CA1 REGION, HIPPOCAMPAL; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ECLAMPSIA; FEMALE; LIPOPOLYSACCHARIDES; MICROGLIA; NEUROIMMUNOMODULATION; NEURONS; NICOTINE; NICOTINIC AGONISTS; PENTYLENETETRAZOLE; PREGNANCY; PREGNANCY OUTCOME; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 84964600721     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2016.04.043     Document Type: Article

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