Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Johnson, Abbie Chapman ^a   Tremble, Sarah M ^a   Chan, Siu Lung ^a   Moseley, Janae ^b   LaMarca, Babbette ^b   Nagle, Keith J ^a   Cipolla, Marilyn J ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM SULFATE; CONVULSANT AGENT; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN WATER; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; FEMALE; HYPERTENSION; IN VIVO STUDY; INTRAUTERINE GROWTH RETARDATION; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PLACENTA PERFUSION; PREECLAMPSIA; PREGNANCY; RAT; SEIZURE; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; ANIMAL; BRAIN; COMPLICATION; DISEASE MODEL; DISEASE PREDISPOSITION; DRUG EFFECTS; ECLAMPSIA; INFLAMMATION; LIPID DIET; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; PHYSIOLOGY; SEIZURES; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN EDEMA; CONVULSANTS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ECLAMPSIA; FEMALE; INFLAMMATION; MAGNESIUM SULFATE; MICROGLIA; OXIDATIVE STRESS; PENTYLENETETRAZOLE; PERMEABILITY; PRE-ECLAMPSIA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SEVERITY OF ILLNESS INDEX;

EID: 84915749427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113670     Document Type: Article

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