Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Journal of Pharmaceutical Sciences

Volumn 105, Issue 2, 2016, Pages 1017-1021

  Simoff, Ivailo ^a   Karlgren, Maria ^a   Backlund, Maria ^a   Lindström, Anne Christine ^a   Gaugaz, Fabienne Z ^a   Matsson, Pär ^a   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

ABC transporters; CRISPR Cas9; drug transport; efflux pumps; genomics; MDCK cells; membrane transporter; P glycoprotein; permeability; proteomics

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; DIGOXIN; GUIDE RNA; LABETALOL; LOPERAMIDE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 1; PRAZOSIN; QUINIDINE; RITONAVIR; SAQUINAVIR; VINBLASTINE; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL CELL; ARTICLE; CELL CLONE; CONTROLLED STUDY; CRISPR CAS SYSTEM; GENE FREQUENCY; GENE INACTIVATION; GENETIC PROCEDURES; GENOTYPE; HOMOZYGOSITY; MDCK CELL LINE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; ANIMAL; DEFICIENCY; DOG; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROCEDURES;

ANIMALS; BASE SEQUENCE; CRISPR-CAS SYSTEMS; DOGS; GENE KNOCKOUT TECHNIQUES; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN;

EID: 84964522884     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/S0022-3549(15)00171-9     Document Type: Article

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