Titin and diaphragm dysfunction in mechanically ventilated rats

Intensive Care Medicine

Volumn 38, Issue 4, 2012, Pages 702-709

  Hees, Hieronymus W H Van ^a   Schellekens, Willem Jan M ^a   Acuña, Gilberto L Andrade ^a   Linkels, Marianne ^a   Hafmans, Theo ^b   Ottenheijm, Coen A C ^a   Granzier, Henk L ^a   Scheffer, Gert Jan ^a   Hoeven, Johannes G Van Der ^a   Dekhuijzen, P N Richard ^a   Heunks, Leo M A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b University of Arizona   (United States)

Author keywords

Diaphragm; Force; Mechanical ventilation; Myosin Titin; Single fiber

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; CONNECTIN; MYOSIN; MYOSIN HEAVY CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DIAPHRAGM DISEASE; DIAPHRAGM MUSCLE; IN VITRO STUDY; MALE; MEAN ARTERIAL PRESSURE; MUSCLE FORCE; MUSCLE STRETCHING; NONHUMAN; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; SOLEUS MUSCLE;

ANIMALS; DIAPHRAGM; DISEASE MODELS, ANIMAL; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOSINS; PROTEIN KINASES; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; VENTILATOR WEANING;

EID: 84862533035     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2504-5     Document Type: Article

References (40)

1. Vassilakopoulos T (2008) Ventilatorinduced diaphragm dysfunction: the clinical relevance of animal models. Intensive Care Med 34:7-16
2. Vassilakopoulos T, Petrof BJ (2004) Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 169:336-341
3. Vassilakopoulos T, Zakynthinos S, Roussos C (1998) The tension-time index and the frequency/tidal volume ratio are the major pathophysiologic determinants of weaning failure and success. Am J Respir Crit Care Med 158:378-385
4. Harikumar G, Egberongbe Y, Nadel S, Wheatley E, Moxham J, Greenough A et al (2009) Tension-time index as a predictor of extubation outcome in ventilated children. Am J Respir Crit Care Med 180:982-988
5. Heunks LM, van der Hoeven JG (2010) Clinical review: the ABC of weaning failure-a structured approach. Crit Care 14:245
6. Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, Zhu J, Sachdeva R, Sonnad S, Kaiser LR, Rubinstein NA, Powers SK, Shrager JB (2008) Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 358:1327-1335
7. Shanely RA, Zergeroglu MA, Lennon SL, Sugiura T, Yimlamai T, Enns D, Belcastro A, Powers SK (2002) Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med 166:1369-1374
8. Jaber S, Petrof BJ, Jung B, Chanques G, Berthet JP, Rabuel C, Bouyabrine H, Courouble P, Koechlin-Ramonatxo C, Sebbane M, Similowski T, Scheuermann V, Mebazaa A, Capdevila X, Mornet D, Mercier J, Lacampagne A, Philips A, Matecki S (2011) Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 183:364-371
9. Sassoon CS, Caiozzo VJ, Manka A, Sieck GC (2002) Altered diaphragm contractile properties with controlled mechanical ventilation. J Appl Physiol 92:2585-2595
10. Le Bourdelles G, Viires N, Boczkowski J, Seta N, Pavlovic D, Aubier M (1994) Effects of mechanical ventilation on diaphragmatic contractile properties in rats. Am J Respir Crit Care Med 149:1539-1544
11. Powers SK, Shanely RA, Coombes JS, Koesterer TJ, McKenzie M, Van Gammeren D, Cicale M, Dodd SL (2002) Mechanical ventilation results in progressive contractile dysfunction in the diaphragm. J Appl Physiol 92:1851-1858
12. Maes K, Testelmans D, Powers S, Decramer M, Gayan-Ramirez G (2007) Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Am J Respir Crit Care Med 175:1134-1138
13. Brenner B (1998) Muscle mechanics II skinned muscle fibers. In: Sugi H (ed) Current methods in muscle physiology. Oxford University Press, New York, pp 33-69
14. Geiger PC, Cody MJ, Macken RL, Sieck GC (2000) Maximum specific force depends on myosin heavy chain content in rat diaphragm muscle fibers. J Appl Physiol 89:695-703
15. Bernard N, Matecki S, Py G, Lopez S, Mercier J, Capdevila X (2003) Effects of prolonged mechanical ventilation on respiratory muscle ultrastructure and mitochondrial respiration in rabbits. Intensive Care Med 29:111-118
16. Horwich TB, Patel J, Maclellan WR, Fonarow GC (2003) Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 108:833-838
17. Horowits R, Kempner ES, Bisher ME, Podolsky RJ (1986) A physiological role for titin and nebulin in skeletal muscle. Nature 323:160-164
18. Granzier H, Labeit S (2007) Structurefunction relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle Nerve 36:740-755
19. Udaka J, Ohmori S, Terui T, Ohtsuki I, Ishiwata S, Kurihara S, Fukuda N (2008) Disuse-induced preferential loss of the giant protein titin depresses muscle performance via abnormal sarcomeric organization. J Gen Physiol 131:33-41
20. Ottenheijm CA, Granzier H (2010) Role of titin in skeletal muscle function and disease. Adv Exp Med Biol 682:105-122
21. Ottenheijm CA, Heunks LM, Hafmans T, van der Ven PF, Benoist C, Zhou H, Labeit S, Granzier HL, Dekhuijzen PN (2006) Titin and diaphragm dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 173:527-534
22. van Hees HW, Ottenheijm CA, Granzier HL, Dekhuijzen PN, Heunks LM (2010) Heart failure decreases passive tension generation of rat diaphragm fibers. Int J Cardiol 141:275-283
23. Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H (2009) PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res 105(631-8):17
24. van Hees HW, van der Heijden HF, Ottenheijm CA, Heunks LM, Pigmans CJ, Verheugt FW, Brouwer RM, Dekhuijzen PN (2007) Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats. Am J Physiol Heart Circ Physiol 293:H819-H828
25. Ochala J, Radell PJ, Eriksson LI, Larsson L (2010) EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation. Pflugers Arch 459:475-483
26. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT (2011) Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 183:483-490
27. Ottenheijm CA, Heunks LM, Sieck GC, Zhan WZ, Jansen SM, Degens H, de Boo T, Dekhuijzen PN (2005) Diaphragm dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 172:200-205
28. van Hees HW, Dekhuijzen PN, Heunks LM (2009) Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 179:41-47
29. Shanely RA, Van Gammeren D, Deruisseau KC, Zergeroglu AM, McKenzie MJ, Yarasheski KE, Powers SK (2004) Mechanical ventilation depresses protein synthesis in the rat diaphragm. Am J Respir Crit Care Med 170:994-999
30. Hussain SN, Mofarrahi M, Sigala I, Kim HC, Vassilakopoulos T, Maltais F, Bellenis I, Chaturvedi R, Gottfried SB, Metrakos P, Danialou G, Matecki S, Jaber S, Petrof BJ, Goldberg P (2010) Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med 182:1377-1386
31. McClung JM, Kavazis AN, DeRuisseau KC, Falk DJ, Deering MA, Lee Y, Sugiura T, Powers SK (2007) Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilationinduced atrophy. Am J Respir Crit Care Med 175:150-159
32. LeWinter MM, Granzier H (2010) Cardiac titin: a multifunctional giant. Circulation 121:2137-2145
33. Labeit D, Watanabe K, Witt C, Fujita H, Wu Y, Lahmers S, Funck T, Labeit S, Granzier H (2003) Calciumdependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A 100:13716-13721
34. Pierno S, Desaphy JF, Liantonio A, De Luca A, Zarrilli A, Mastrofrancesco L, Procino G, Valenti G, Conte Camerino D (2007) Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance. J Physiol 584:983-995
35. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M (2005) The kinase domain of titin controls muscle gene expression and protein turnover. Science 308:1599-1603
36. Puchner EM, Alexandrovich A, Kho AL, Hensen U, Schäfer LV, Brandmeier B, Gräter F, Grubmüller H, Gaub HE, Gautel M (2008) Mechanoenzymatics of titin kinase. Proc Natl Acad Sci U S A 105:13385-13390
37. Ottenheijm CA, van Hees HW, Heunks LM, Granzier H (2011) Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? Am J Physiol Lung Cell Mol Physiol 300:L161-L166
38. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T (2007) Weaning from mechanical ventilation. Eur Respir J 29:1033-1056
39. Sassoon CS, Zhu E, Caiozzo VJ (2004) Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 170:626-632
40. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guérin C, Prat G, Morange S, Roch A, ACURASYS Study Investigators (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363:1107-1116