Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho

Kidney International

Volumn 89, Issue 3, 2016, Pages 586-600

  Chang, Jin Rui ^a,b,c,d   Guo, Jun ^a,b   Wang, Yue ^e   Hou, Yue Long ^a,b,c   Lu, Wei Wei ^a,b,c   Zhang, Jin Sheng ^a,b,c   Yu, Yan Rong ^c   Xu, Ming Jiang ^c   Liu, Xiu Ying ^f   Wang, Xiu Jie ^f   Guan, You Fei ^c   Zhu, Yi ^c   Du, Jie ^a,b   Tang, Chao Shu ^a,b,c   Qi, Yong Fen ^a,b,c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d XI'AN MEDICAL UNIVERSITY   (China)

^e PEKING UNIVERSITY THIRD HOSPITAL   (China)

^f INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

Author keywords

calcitonin receptor like receptor; chronic kidney disease; intermedin1 53; vascular calcification; Klotho

Indexed keywords

ALPHA KLOTHO PROTEIN; CALCITONIN RECEPTOR LIKE RECEPTOR; COLECALCIFEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; INTERMEDIN 1-53; INTERMEDIN DERIVATIVE; KLOTHO PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; UNCLASSIFIED DRUG; ADM2 PROTEIN, HUMAN; BETA GLUCURONIDASE; CALCITONIN RECEPTOR; CYCLIC AMP; PEPTIDE HORMONE; RAMP3 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISEASE; ARTICLE; BLOOD VESSEL CALCIFICATION; CELL TRANSFORMATION; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; ENZYME LOCALIZATION; HORMONE ACTION; IN VITRO STUDY; MALE; NEPHRECTOMY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; CELL CULTURE; CELL TRANSDIFFERENTIATION; DISEASE MODEL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHENOTYPE; RENAL INSUFFICIENCY, CHRONIC; RNA INTERFERENCE; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; THORACIC AORTA; UPREGULATION; VASCULAR CALCIFICATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; CHOLECALCIFEROL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; GLUCURONIDASE; HUMANS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEPHRECTOMY; OSTEOBLASTS; PEPTIDE HORMONES; PHENOTYPE; RATS, SPRAGUE-DAWLEY; RECEPTOR ACTIVITY-MODIFYING PROTEIN 3; RECEPTORS, CALCITONIN; RENAL INSUFFICIENCY, CHRONIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION; VASCULAR CALCIFICATION;

EID: 84964412220     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2015.12.029     Document Type: Article

References (55)

1. M. Wu, C. Rementer, and C.M. Giachelli Vascular calcification: an update on mechanisms and challenges in treatment Calcif Tissue Int 93 2013 365 373
2. R. Shroff, D.A. Long, and C. Shanahan Mechanistic insights into vascular calcification in CKD J Am Soc Nephrol 24 2013 179 189
3. C.M. Shanahan, M.H. Crouthamel, A. Kapustin, and C.M. Giachelli Arterial calcification in chronic kidney disease: key roles for calcium and phosphate Circ Res 109 2011 697 711
4. J.S. Shao, J. Cai, and D.A. Towler Molecular mechanisms of vascular calcification: lessons learned from the aorta Arterioscler Thromb Vasc Biol 26 2006 1423 1430
5. M. Kuro-o, Y. Matsumura, H. Aizawa, and et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing Nature 390 1997 45 51
6. Y. Matsumura, H. Aizawa, T. Shiraki-Iida, and et al. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein Biochem Biophys Res Commun 242 1998 626 630
7. T. Shiraki-Iida, H. Aizawa, Y. Matsumura, and et al. Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein FEBS Lett 424 1998 6 10
8. I. Urakawa, Y. Yamazaki, T. Shimada, and et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23 Nature 444 2006 770 774
9. Y. Maekawa, M. Ohishi, M. Ikushima, and et al. Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway Geriatr Gerontol Int 11 2011 510 516
10. M.C. Hu, M. Shi, J. Zhang, and et al. Klotho deficiency causes vascular calcification in chronic kidney disease J Am Soc Nephrol 22 2011 124 136
11. J. Xie, J. Yoon, S.W. An, and et al. Soluble Klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate J Am Soc Nephrol 26 2015 1150 1160
12. Y.B. Zhou, Q. Gao, P. Li, and et al. Adrenomedullin attenuates vascular calcification in fructose-induced insulin resistance rats Acta Physiol (Oxf) 207 2013 437 446
13. Q.H. Liang, Y. Jiang, X. Zhu, and et al. Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway PLoS One 7 2012 e33126
14. Z. Huang, J. Li, Z. Jiang, and et al. Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells J Cardiovasc Pharmacol 42 2003 89 97
15. 1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway Exp Biol Med (Maywood) 238 2013 1136 1146
16. J. Roh, C.L. Chang, A. Bhalla, and et al. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes J Biol Chem 279 2004 7264 7274
17. Y. Takei, K. Inoue, M. Ogoshi, and et al. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator FEBS Lett 556 2004 53 58
18. J.H. Yang, Y.X. Jia, C.S. Pan, and et al. Effects of intermedin (1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts Biochem Biophys Res Commun 327 2005 713 719
19. L.M. McLatchie, N.J. Fraser, M.J. Main, and et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor Nature 393 1998 333 339
20. D. Bell, and B.J. McDermott Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems Br J Pharmacol 153 suppl 1 2008 S247 S262
21. X. Teng, Y. Bian, Y. Cai, and et al. Downregulation of endogenous intermedin augmented myocardial injury in rats ischemic/reperfusion Horm Metab Res 45 2013 206 212
22. Y. Cai, M.J. Xu, X. Teng, and et al. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein Cardiovasc Res 85 2010 864 873
23. Y. Hong, D.L. Hay, R. Quirion, and D.R. Poyner The pharmacology of adrenomedullin 2/intermedin Br J Pharmacol 166 2012 110 120
24. 1-53 on angiotensin II-induced hypertrophy in neonatal rat ventricular myocytes J Cardiovasc Pharmacol 56 2010 45 52
25. X.Y. Dai, Y. Cai, D.D. Mao, and et al. Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice J Mol Cell Cardiol 53 2012 509 520
26. Z. Zhou, C.P. Hu, C.J. Wang, and et al. Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression Atherosclerosis 213 2010 92 101
27. J.R. Wu-Wong, W. Noonan, J. Ma, and et al. Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification J Pharmacol Exp Ther 318 2006 90 98
28. K. Lim, T.S. Lu, G. Molostvov, and et al. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23 Circulation 125 2012 2243 2255
29. K. Tamura, Y. Suzuki, M. Matsushita, and et al. Prevention of aortic calcification by etidronate in the renal failure rat model Eur J Pharmacol 558 2007 159 166
30. N. Shobeiri, M.A. Adams, and R.M. Holden Vascular calcification in animal models of CKD: a review Am J Nephrol 31 2010 471 481
31. A. Cardús, S. Panizo, E. Parisi, and et al. Differential effects of vitamin D analogs on vascular calcification J Bone Miner Res 22 2007 860 866
32. A. Gauthier-Bastien, R.V. Ung, R. Larivière, and et al. Vascular remodeling and media calcification increases arterial stiffness in chronic kidney disease Clin Exp Hypertens 36 2014 173 180
33. V. Shalhoub, E.M. Shatzen, S.C. Ward, and et al. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality J Clin Invest 122 2012 2543 2553
34. F.J. Mendoza, I. Lopez, A. Montes de Oca, and et al. Metabolic acidosis inhibits soft tissue calcification in uremic rats Kidney Int 73 2008 407 414
35. M.G. Vervloet, A.Y. Adema, T.E. Larsson, and Z.A. Massy The role of klotho on vascular calcification and endothelial function in chronic kidney disease Semin Nephrol 34 2014 578 585
36. A. Callegari, M.L. Coons, J.L. Ricks, and et al. Bone marrow- or vessel wall-derived osteoprotegerin is sufficient to reduce atherosclerotic lesion size and vascular calcification Arterioscler Thromb Vasc Biol 33 2013 2491 2500
37. A. Bashir, W.E. Moody, N.C. Edwards, and et al. Coronary artery calcium assessment in CKD: utility in cardiovascular disease risk assessment and treatment? Am J Kidney Dis 65 2015 937 948
38. C. Vlachopoulos, K. Aznaouridis, and C. Stefanadis Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis J Am Coll Cardiol 55 2010 1318 1327
39. M. Krog, S. Ejerblad, I. Eriksson, and H. Johansson Arterial calcifications in uraemic rats treated with 1-alpha-hydroxycholecalciferol and parathyroidectomy Scand J Urol Nephrol 18 1984 227 239
40. Y. Shimamura, K. Hamada, K. Inoue, and et al. Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis Clin Exp Nephrol 16 2012 722 729
41. R.D. Thurston, C.B. Larmonier, P.M. Majewski, and et al. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis Gastroenterology 138 2010 1384 1394 1394.e1-2
42. M. Mitobe, T. Yoshida, H. Sugiura, and et al. Oxidative stress decreases klotho expression in a mouse kidney cell line Nephron Exp Nephrol 101 2005 e67 e74
43. H.E. Yoon, J.Y. Ghee, S. Piao, and et al. Angiotensin II blockade upregulates the expression of Klotho the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy Nephrol Dial Transplant 26 2011 800 813
44. W.G. van Rijt, G.J. Nieuwenhuijs-Moeke, H. van Goor, and et al. ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury J Transl Med 11 2013 9
45. L. Xiao, T. Naganawa, J. Lorenzo, and et al. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and Klotho J Biol Chem 285 2010 2834 2846
46. H. Galitzer, I.Z. Ben-Dov, J. Silver, and T. Naveh-Many Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease Kidney Int 77 2010 211 218
47. C.S. Pan, Y.F. Qi, S.H. Wang, and et al. Alterations of adrenomedullin and its receptor system components in calcified vascular smooth muscle cells Regul Pept 120 2004 77 83
48. J.A. Fischer, R. Muff, and W. Born Functional relevance of G-protein-coupled-receptor- associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs) Biochem Soc Trans 30 2002 455 460
49. S. Mittra, and J.P. Bourreau Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes Am J Physiol Heart Circ Physiol 290 2006 H1842 H1847
50. B.L. Riser, F.C. Barreto, R. Rezg, and et al. Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia Nephrol Dial Transplant 26 2011 3349 3357
51. X.H. Wang, X. Zhang, C.J. Mu, and et al. Effects of lanthanum carbonate on vascular calcification in elderly maintenance hemodialysis patients J Huazhong Univ Sci Technolog Med Sci 35 2015 508 513
52. M. Li, P. Wu, J. Shao, and et al. Losartan inhibits vascular calcification by suppressing the BMP2 and Runx2 expression in rats in vivo [e-pub ahead of print] Cardiovasc Toxicol 2015 Apr 21 Available at: http://www.ncbi.nlm.nih.gov/pubmed/?term=Losartan+inhibits+vascular+calcification+by+suppressing+the+BMP2+and+Runx2+expression+in+rats+in+vivo. Accessed January 20, 2016
53. Y. Yuan, X. Wang, Q. Zeng, and et al. Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats J Geriatr Cardiol 9 2012 17 27
54. F. Dong, M.M. Taylor, W.K. Samson, and J. Ren Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes J Appl Physiol (1985) 101 2006 778 784
55. Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Sciences, National Research Council of the National Academies Guide for the Care and Use of Laboratory Animals 8th edition 2011 The National Academies Press Washington, D.C.