Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression

Atherosclerosis

Volumn 213, Issue 1, 2010, Pages 92-101

  Zhou, Zhi ^a   Hu, Chang Ping ^a   Wang, Chen Jing ^a   Li, Ting Ting ^a   Peng, Jun ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Calcitonin gene related peptide; Endothelial progenitor cells; Hypertension; Klotho; Senescence

Indexed keywords

ANGIOTENSIN II; BETA GALACTOSIDASE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAZEPINE; KLOTHO PROTEIN; MESSENGER RNA; MICRORNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUTAECARPINE; TELOMERASE; VANILLOID RECEPTOR 1;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HYPERTENSION; LENTIVIRINAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SENESCENCE; STEM CELL; UMBILICAL CORD BLOOD; WESTERN BLOTTING;

ANGIOTENSIN II; CALCITONIN GENE-RELATED PEPTIDE; CELL AGING; ENDOTHELIAL CELLS; FETAL BLOOD; GENE EXPRESSION REGULATION; GLUCURONIDASE; HUMANS; NADPH OXIDASE; NEUROTRANSMITTER AGENTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; STEM CELLS; UP-REGULATION;

EID: 77958463213     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.08.050     Document Type: Article

References (30)

1. Urbich C., Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004, 95:343-353.
2. Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
3. Imanishi T., Moriwaki C., Hano T., Nishio I. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens 2005, 23:1831-1837.
4. van Z.A.J., Rabelink T.J. Endothelial progenitor cells: biology and therapeutic potential in hypertension. Curr Opin Nephrol Hypertens 2006, 15:167-172.
5. Imanishi T., Hano T., Nishio I. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens 2005, 23:97-104.
6. Bell D., McDermott B.J. Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance. Pharmacol Rev 1996, 48:253-288.
7. Wimalawansa S.J. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev 1996, 17:533-585.
8. Deng P.Y., Li Y.J. Calcitonin gene-related peptide and hypertension. Peptides 2005, 26:1676-1685.
9. Chen Q.Q., Li D., Guo R., et al. Decrease in the synthesis and release of calcitonin gene-related peptide in dorsal root ganglia of spontaneously hypertensive rat: role of nitric oxide synthase inhibitors. Eur J Pharmacol 2008, 596:132-137.
10. Deng P.Y., Ye F., Cai W.J., et al. Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine. J Hypertens 2004, 22:1819-1829.
11. Li D., Peng J., Xin H.Y., et al. Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats. Peptides 2008, 29:1781-1788.
12. Qin X.P., Zeng S.Y., Li D., et al. Calcitonin gene-related peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. J Cardiovasc Pharmacol 2007, 50:654-659.
13. Luo D., Zhang Y.W., Peng W.J., et al. Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide. Regul Pept 2008, 150:66-72.
14. Zhao Q., Liu Z., Wang Z., et al. Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension. Ann Thorac Surg 2007, 84:544-552.
15. Kuro-o M., Matsumura Y., Aizawa H., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
16. Aizawa H., Saito Y., Nakamura T., et al. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem Biophys Res Commun 1998, 249:865-871.
17. Mitani H., Ishizaka N., Aizawa T., et al. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002, 39:838-843.
18. Ikushima M., Rakugi H., Ishikawa K., et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 2006, 339:827-832.
19. Rakugi H., Matsukawa N., Ishikawa K., et al. Anti-oxidative effect of Klotho on endothelial cells through cAMP activation. Endocrine 2007, 31:82-87.
20. Herder C., Tonn T., Oostendorp R., et al. Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2003, 23:2266-2272.
21. Rafii S., Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003, 9:702-712.
22. Hill J.M., Zalos G., Halcox J.P., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600.
23. Kobayashi K., Imanishi T., Akasaka T. Endothelial progenitor cell differentiation and senescence in an angiotensin II-infusion rat model. Hypertens Res 2006, 29:449-455.
24. Tanito M., Nakamura H., Kwon Y.W., et al. Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 2004, 6:89-97.
25. Higashi Y., Sasaki S., Nakagawa K., et al. Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med 2002, 346:1954-1962.
26. Portaluppi F., Trasforini G., Margutti A., et al. Circadian rhythm of calcitonin gene-related peptide in uncomplicated essential hypertension. J Hypertens 1992, 10:1227-1234.
27. Li J., Zhao H., Supowit S.C., DiPette D.J., Wang D.H. Activation of the renin-angiotensin system in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. J Hypertens 2004, 22:1345-1349.
28. Wang H., Xing L., Li W., et al. Production and secretion of calcitonin gene-related peptide from human lymphocytes. J Neuroimmunol 2002, 130:155-162.
29. Shimada T., Takeshita Y., Murohara T., et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004, 110:1148-1155.
30. Liu J.W., Pernod G., Dunoyer-Geindre S., et al. Promoter dependence of transgene expression by lentivirus-transduced human blood-derived endothelial progenitor cells. Stem Cells 2006, 24:199-208.