Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

Nature Medicine

Volumn 22, Issue 5, 2016, Pages 547-556

  Burridge, Paul W ^a,b   Li, Yong Fuga ^a   Matsa, Elena ^a   Wu, Haodi ^a   Ong, Sang Ging ^a   Sharma, Arun ^a   Holmström, Alexandra ^a   Chang, Alex C ^a   Coronado, Michael J ^a   Ebert, Antje D ^a   Knowles, Joshua W ^a   Telli, Melinda L ^a   Witteles, Ronald M ^a   Blau, Helen M ^a   Bernstein, Daniel ^a   Altman, Russ B ^a   Wu, Joseph C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CALCIUM; DOXORUBICIN; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC ANTIBIOTIC; TRANSCRIPTOME;

ARTICLE; BREAST CANCER; CANCER PATIENT; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; ADULT; AGED; APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; CHEMICALLY INDUCED; DISEASE PREDISPOSITION; DNA DAMAGE; DRUG EFFECTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HEART FAILURE; HEART MITOCHONDRION; METABOLISM; MIDDLE AGED; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BREAST NEOPLASMS; CALCIUM; CARDIOTOXICITY; CELL SURVIVAL; DISEASE SUSCEPTIBILITY; DNA DAMAGE; DOXORUBICIN; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEART FAILURE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 84964409142     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4087     Document Type: Article

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