Regulation of interferon-inducible proteins by doxorubicin via interferon γ-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells

Molecular Pharmacology

Volumn 81, Issue 5, 2012, Pages 679-688

  Hussner, J ^a   Ameling, S ^a   Hammer, E ^a   Herzog, S ^a   Steil, L ^a   Schwebe, M ^a   Niessen, J ^a   Schroeder, H W S ^a   Kroemer, H K ^a   Ritter, C A ^a   Volker U ^a   Bien, Sandra ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AURINTRICARBOXYLIC ACID; CYTOSTATIC AGENT; DOXORUBICIN; GAMMA INTERFERON; INTERLEUKIN 1BETA CONVERTING ENZYME; JANUS KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN INHIBITOR OF ACTIVATED STAT; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXICITY; DESENSITIZATION; DRUG EXPOSURE; GENETIC REGULATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MICROARRAY ANALYSIS; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DOXORUBICIN; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-GAMMA; JANUS KINASE 1; KILLER CELLS, NATURAL; NEOPLASMS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 84859990216     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.075994     Document Type: Article

References (37)

1. Arinaga S, Akiyoshi T, and Tsuji H (1986) Augmentation of the generation of cell-mediated cytotoxicity after a single dose of adriamycin in cancer patients. Cancer Res 46:4213-4216. (Pubitemid 16075934)
2. Bhardwaj N (2007) Harnessing the immune system to treat cancer. J Clin Invest 117:1130-1136.
3. Bromberg J and Darnell JE Jr (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19:2468-2473. (Pubitemid 30339202)
4. Chen CW, Chao Y, Chang YH, Hsu MJ, and Lin WW (2002) Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid. Br J Pharmacol 137:1011-1020. (Pubitemid 35440741)
5. Cho H, Lee DY, Shrestha S, Shim YS, Kim KC, Kim MK, Lee KH, Won J, and Kang JS (2004) Aurintricarboxylic acid translocates across the plasma membrane, inhibits protein tyrosine phosphatase and prevents apoptosis in PC12 cells. Mol Cells 18:46-52. (Pubitemid 39386654)
6. Darnell JE Jr (1997) STATs and gene regulation. Science 277:1630-1635.
7. Darnell JE Jr (1998) Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. J Interferon Cytokine Res 18:549-554.
8. Der SD, Zhou A, Williams BR, and Silverman RH (1998) Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 95:15623-15628. (Pubitemid 29018750)
9. Di Marco A, Gaetani M, and Scarpinato B (1969) Adriamycin (NSC-123,127): a new antibiotic with antitumor activity. Cancer Chemother Rep 53:33-37.
10. Ehrke MJ, Ryoyama K, and Cohen SA (1984) Cellular basis for adriamycin-induced augmentation of cell-mediated cytotoxicity in culture. Cancer Res 44:2497-2504. (Pubitemid 14108333)
11. Eppstein DA, van der Pas MA, Marsh YV, Bruno NA, and Kurahara CG (1988) Enhanced antitumor efficacy of adriamycin in combination with interferongamma: effects on macrophages. J Interferon Res 8:263-273.
12. Fillmore RA, Mitra A, Xi Y, Ju J, Scammell J, Shevde LA, and Samant RS (2009) Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth. Int J Cancer 125:556-564.
13. Gamen S, Anel A, Lasierra P, Alava MA, Martinez-Lorenzo MJ, Piñeiro A, and Naval J (1997) Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS Lett 417:360-364. (Pubitemid 27511623)
14. Gupta S, Radha V, Furukawa Y, and Swarup G (2001) Direct transcriptional activation of human caspase-1 by tumor suppressor P53. J Biol Chem 276:10585-10588. (Pubitemid 38089225)
15. Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, and Finbloom DS (1994) Interferon-gamma induces tyrosine phosphorylation of interferon- gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 269:14333-14336.
16. Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, Aridome K, Hokita S, and Aikou T (2000) Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 88:577-583. (Pubitemid 30056932)
17. Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, and Schreiber RD (1998) Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 95:7556-7561. (Pubitemid 28293291)
18. Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, et al. (2009) STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. PLoS One 4:e5821.
19. Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, and Lee ZH (2008) AG490, a Jak2- specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathway. Mol Cells 26.
20. Lamkanfi M, Kanneganti TD, Franchi L, and Núñez G (2007) Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol 82:220-225. (Pubitemid 47230630)
21. Leonard WJ and O'Shea JJ (1998) Jaks and STATs: biological implications. Annu Rev Immunol 16:293-322. (Pubitemid 28183367)
22. Levy DE and Gilliland DG (2000) Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19:2505-2510. (Pubitemid 30339206)
23. Maccubbin DL, Wing KR, Mace KF, Ho RL, Ehrke MJ, and Mihich E (1992) Adriamycin- induced modulation of host defenses in tumor-bearing mice. Cancer Res 52:3572-3576.
24. Matsukawa A (2007) STAT proteins in innate immunity during sepsis: lessons from gene knockout mice. Acta Med Okayama 61:239-245.
25. Minotti G, Menna P, Salvatorelli E, Cairo G, and Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229. (Pubitemid 38720829)
26. Salup RR, Back TC, and Wiltrout RH (1987) Successful treatment of advanced murine renal cell cancer by bicompartmental adoptive chemoimmunotherapy. J Immunol 138:641-647. (Pubitemid 17002233)
27. Schwartz HS and Grindey GB (1973) Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression. Cancer Res 33:1837-1844.
28. Thomas M, Finnegan CE, Rogers KM, Purcell JW, Trimble A, Johnston PG, and Boland MP (2004) STAT1: a modulator of chemotherapy-induced apoptosis. Cancer Res 64:8357-8364. (Pubitemid 39491775)
29. Tsi CJ, Chao Y, Chen CW, and Lin WW (2002) Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition. Mol Pharmacol 62:90-101. (Pubitemid 34680520)
30. Ujhazy P, Zaleskis G, Mihich E, Ehrke MJ, and Berleth ES (2003) Doxorubicin induces specific immune functions and cytokine expression in peritoneal cells. Cancer Immunol Immunother 52:463-472. (Pubitemid 36831368)
31. Wadler S and Schwartz EL (1990) Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review. Cancer Res 50:3473-3486. (Pubitemid 20194083)
32. Wang LH, Kirken RA, Erwin RA, Yu CR, and Farrar WL (1999) JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol 162:3897-3904. (Pubitemid 29314768)
33. Wu MH, Chen XY, and Cai KR (2009) Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z. Ai Zheng 28:24-28.
34. Zhao LY, Huang C, Li ZF, Liu L, Ni L, and Song TS (2009) STAT1/2 is involved in the inhibition of cell growth induced by U0126 in HeLa cells. Cell Mol Biol (Noisy-legrand) 55 (Suppl):OL1168-OL1174.
35. Zhou X, Liao J, Meyerdierks A, Feng L, Naumovski L, Bottger EC, and Omary MB (2000) Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. J Biol Chem 275:21364-21371. (Pubitemid 30481836)
36. Zhu M, John S, Berg M, and Leonard WJ (1999) Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell 96:121-130.
37. Zhu S, Waguespack M, Barker SA, and Li S (2007) Doxorubicin directs the accumulation of interleukin-12 induced IFN gamma into tumors for enhancing STAT1 dependent antitumor effect. Clin Cancer Res 13:4252-4260. (Pubitemid 47105990)