Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: Implications for anthracycline cardiomyopathy

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Chen, Billy ^a   Zhong, Lin ^b   Roush, Sarah F ^b   Pentassuglia, Laura ^b   Peng, Xuyang ^b   Samaras, Susan ^b   Davidson, Jeffrey M ^b,c   Sawyer, Douglas B ^b   Lim, Chee Chew ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANKYRIN; CARDIAC ANKYRIN REPEAT PROTEIN; DOXORUBICIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; ANKRD1 PROTEIN, RAT; ANTINEOPLASTIC ANTIBIOTIC; GATA4 PROTEIN, RAT; MUSCLE PROTEIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ADVERSE OUTCOME; ANIMAL CELL; ARTICLE; CARDIOMYOPATHY; CARDIOTOXICITY; CELL DAMAGE; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HEART CELL CULTURE; HEART MUSCLE CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; RAT; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; SARCOMERE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARDIOMYOPATHIES; DOXORUBICIN; GATA4 TRANSCRIPTION FACTOR; MALE; MUSCLE PROTEINS; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; SARCOMERES; SIGNAL TRANSDUCTION;

EID: 84859970435     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035743     Document Type: Article

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