Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts

Molecular Pharmaceutics

Volumn 13, Issue 4, 2016, Pages 1385-1392

  Boado, Ruben J ^a   Lu, Jeff Zhiqiang ^a   Hui, Eric Ka Wai ^a   Lin, Huilan ^a   Pardridge, William M ^a  

^a ArmaGen Inc   (United States)

Author keywords

blood brain barrier; IgG fusion protein; insulin receptor; lysosomal enzyme; Rhesus monkey; Sanfilippo syndrome

Indexed keywords

ALPHA N ACETYLGLUCOSAMINIDASE; BOLTON HUNTER REAGENT I 125; GLYCOSAMINOGLYCAN; HEAVY CHAIN INSULIN RECEPTOR MONOCLONAL ANTIBODY ALPHA N ACETYLGLUCOSAMINIDASE FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G3 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ACETYLGLUCOSAMINIDASE; ALPHA-N-ACETYL-D-GLUCOSAMINIDASE; INSULIN RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CENTRAL VOLUME OF DISTRIBUTION; CONCENTRATION AT STEADY-STATE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME ENGINEERING; FEMALE; FIBROBLAST; HINGE REGION; IMMUNOREACTIVITY; LYSOSOME; MEAN RESIDENCE TIME; MEMBRANE PERMEABILITY; NONHUMAN; PLASMA CLEARANCE; PLASMA HALF LIFE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RHESUS MONKEY; SANFILIPPO SYNDROME; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ACETYLGLUCOSAMINIDASE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; FIBROBLASTS; GLYCOSAMINOGLYCANS; HUMANS; MACACA MULATTA; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS;

EID: 84964389639     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00037     Document Type: Article

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