Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts

Biochemical Journal

Volumn 458, Issue 2, 2014, Pages 281-289

  Kan, Shih Hsin ^a   Troitskaya, Larisa A ^a   Sinow, Carolyn S ^a   Haitz, Karyn ^a   Todd, Amanda K ^a   Di Stefano, Ariana ^a   Le, Steven Q ^a   Dickson, Patricia I ^a   Tippin, Brigette L ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Enzyme replacement therapy; Insulin like growth factor (IGF); Lysosomal storage disease; Mucopolysaccharidosis; Sanfilippo

Indexed keywords

ACETYLGLUCOSAMINIDASE; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; ENDOCYTOSIS; FIBROBLASTS; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LYSOSOMES; MUCOPOLYSACCHARIDOSIS III; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; UP-REGULATION;

EID: 84894274289     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130845     Document Type: Article

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