Impact of age and sex on the composition and abundance of the intestinal microbiota in individuals with and without enteric infections

Annals of Epidemiology

Volumn 26, Issue 5, 2016, Pages 380-385

  Singh, Pallavi ^a   Manning, Shannon D ^a  

^a Michigan State University ^*  (United States)

Author keywords

16S rRNA; Diarrhea; Microbiota

Indexed keywords

DNA; RNA 16S;

ADOLESCENT; ADULT; ARTICLE; BACTEROIDES; CHILD; CONTROLLED STUDY; ESCHERICHIA; FECES; FEMALE; GENE SEQUENCE; GROUPS BY AGE; HUMAN; INTESTINE FLORA; INTESTINE INFECTION; MAJOR CLINICAL STUDY; MALE; MICROBIAL COMMUNITY; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; ACUTE DISEASE; AGE; BIODIVERSITY; CASE CONTROL STUDY; COMPARATIVE STUDY; ENTERITIS; GENETICS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFANT; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; REFERENCE VALUE; SEX FACTOR; YOUNG ADULT;

ACUTE DISEASE; ADULT; AGE FACTORS; BIODIVERSITY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; ENTERITIS; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; INFANT; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; REFERENCE VALUES; RNA, RIBOSOMAL, 16S; SEX FACTORS; YOUNG ADULT;

EID: 84964374838     PISSN: 10472797     EISSN: 18732585     Source Type: Journal    
DOI: 10.1016/j.annepidem.2016.03.007     Document Type: Article

References (19)

1. [1] Cummings, J.H., Macfarlane, G.T., Role of intestinal bacteria in nutrient metabolism. JPEN J Parenter Enteral Nutr 21:6 (1997), 357–365.
2. [2] Sonnenburg, J.L., Angenent, L.T., Gordon, J.I., Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?. Nat Immunol 5:6 (2004), 569–573.
3. [3] Lovat, L.B., Age related changes in gut physiology and nutritional status. Gut 38:3 (1996), 306–309.
4. [4] Hopkins, M.J., Sharp, R., Macfarlane, G.T., Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48:2 (2001), 198–205.
5. [5] Freire, A.C., Basit, A.W., Choudhary, R., Piong, C.W., Merchant, H.A., Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery. Int J Pharm 415:1-2 (2011), 15–28.
6. [6] Bolnick, D.I., Snowberg, L.K., Hirsch, P.E., Lauber, C.L., Org, E., Parks, B., et al. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nat Commun, 5, 2014, 4500.
7. [7] Markle, J.G., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M., Rolle-Kampczyk, U., et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 339:6123 (2013), 1084–1088.
8. [8] Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72:2 (2006), 1027–1033.
9. [9] Collado, M.C., Derrien, M., Isolauri, E., de Vos, W.M., Salminen, S., Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly. Appl Environ Microbiol 73:23 (2007), 7767–7770.
10. [10] Zwielehner, J., Liszt, K., Handschur, M., Lassl, C., Lapin, A., Haslberger, A.G., Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, Bifidobacteria and Clostridium cluster IV in institutionalized elderly. Exp Gerontol 44:6-7 (2009), 440–446.
11. [11] Singh, P., Teal, T.K., Marsh, T.L., Tiedje, J.M., Mosci, R., Jernigan, K., et al. Intestinal microbial communities associated with acute enteric infections and disease recovery. Microbiome, 3(1), 2015, 45.
12. [12] Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7:5 (2010), 335–336.
13. [13] Edgar, R.C., Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26:19 (2010), 2460–2461.
14. [14] Hammer, O., Harper, D.A.T., Ryan, P.D., PAST: Paleontological Statistics Software Package for Education and Data Analysis. Palaeontol Electron, 4(1), 2001, 9.
15. [15] Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W.S., et al. Metagenomic biomarker discovery and explanation. Genome Biol, 12(6), 2011, R60.
16. [16] Backhed, F., Fraser, C.M., Ringel, Y., Sanders, M.E., Sartor, R.B., Sherman, P.M., et al. Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe 12:5 (2012), 611–622.
17. [17] Pedron, T., Mulet, C., Dauga, C., Frangeul, L., Chervaux, C., Grompone, G., et al. A crypt-specific core microbiota resides in the mouse colon. mBio, 3(3), 2012 e00116-12.
18. [18] Herbel, S.R., Vahjen, W., Wieler, L.H., Guenther, S., Timely approaches to identify probiotic species of the genus Lactobacillus. Gut Pathog, 5(1), 2013, 27.
19. [19] Winter, S.E., Winter, M.G., Xavier, M.N., Thiennimitr, P., Poon, V., Keestra, A.M., et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339:6120 (2013), 708–711.