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Volumn 61, Issue 2, 2016, Pages 244-248

Recent advancements in diagnostic tools in mitochondrial energy metabolism diseases

Author keywords

Aging; Mitochondria; Monogenic; Pathology; Therapy

Indexed keywords

DIAGNOSTIC PROCEDURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MEDICAL PRACTICE; MEDICAL TECHNOLOGY; METABOLOMICS; MITOCHONDRIAL GENOME; MOLECULAR GENETICS; REVIEW; METABOLISM; MITOCHONDRIAL DISEASES; MITOCHONDRION;

EID: 84964344641     PISSN: 18961126     EISSN: 18984002     Source Type: Journal    
DOI: 10.1016/j.advms.2016.02.002     Document Type: Review
Times cited : (3)

References (55)
  • 1
    • 78651126508 scopus 로고
    • A case of severe hyper metabolism of non-thyroid origin with a defect in the maintenance of mitochondrial respiratory control: A correlated clinical, biochemical, and morphological study
    • R. Luft, D. Ikkos, G. Palmieri, L. Ernster, and B. Afzelius A case of severe hyper metabolism of non-thyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study J Clin Investig 41 1962 1776 1804
    • (1962) J Clin Investig , vol.41 , pp. 1776-1804
    • Luft, R.1    Ikkos, D.2    Palmieri, G.3    Ernster, L.4    Afzelius, B.5
  • 2
    • 77956255442 scopus 로고    scopus 로고
    • A history of mitochondrial diseases
    • S.J. DiMauro A history of mitochondrial diseases J Inherit Metab Dis 34 2011 261 276
    • (2011) J Inherit Metab Dis , vol.34 , pp. 261-276
    • DiMauro, S.J.1
  • 4
    • 0042266280 scopus 로고    scopus 로고
    • Minimum birth prevalence of mitochondrial respiratory chain disorders in children
    • D. Skladal, J. Halliday, and D.R. Thorburn Minimum birth prevalence of mitochondrial respiratory chain disorders in children Brain 126 2003 1905 1912
    • (2003) Brain , vol.126 , pp. 1905-1912
    • Skladal, D.1    Halliday, J.2    Thorburn, D.R.3
  • 5
    • 78651128209 scopus 로고
    • Intramitochondrial fibers with DNA characteristics. I. Fixation and electron staining reactions
    • M.M. Nass, and S. Nass Intramitochondrial fibers with DNA characteristics. I. Fixation and electron staining reactions J Cell Biol 19 1963 593 611
    • (1963) J Cell Biol , vol.19 , pp. 593-611
    • Nass, M.M.1    Nass, S.2
  • 6
    • 66249136027 scopus 로고    scopus 로고
    • Mapping gene associations in human mitochondria using clinical disease phenotypes
    • C. Scharfe, H. Lu, J. Neuenburg, E. Allen, G. Li, T. Klopstock, and et al. Mapping gene associations in human mitochondria using clinical disease phenotypes PLoS Comput Biol 5 4 2009 e1000374
    • (2009) PLoS Comput Biol , vol.5 , Issue.4
    • Scharfe, C.1    Lu, H.2    Neuenburg, J.3    Allen, E.4    Li, G.5    Klopstock, T.6
  • 7
    • 23644433329 scopus 로고    scopus 로고
    • The mitochondrial genome in human adaptive radiation and disease: On the road to therapeutics and performance enhancement
    • D.C. Wallace The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement Gene 354 2005 169 180
    • (2005) Gene , vol.354 , pp. 169-180
    • Wallace, D.C.1
  • 8
    • 0037073677 scopus 로고    scopus 로고
    • NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II
    • H. Cai, Z. Li, S. Dikalov, S.M. Holland, J. Hwang, H. Jo, and et al. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II J Biol Chem 277 2002 48311 48317
    • (2002) J Biol Chem , vol.277 , pp. 48311-48317
    • Cai, H.1    Li, Z.2    Dikalov, S.3    Holland, S.M.4    Hwang, J.5    Jo, H.6
  • 9
    • 0028466383 scopus 로고
    • Oxygen and the control of gene expression
    • H.L. Pahl, and P.A. Baeuerle Oxygen and the control of gene expression Bioessays 16 1994 497 502
    • (1994) Bioessays , vol.16 , pp. 497-502
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 10
    • 1642305344 scopus 로고    scopus 로고
    • Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts
    • F.S. Wang, C.J. Wang, Y.J. Chen, P.R. Chang, Y.T. Huang, Y.C. Sun, and et al. Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts J Biol Chem 279 2004 10331 10337
    • (2004) J Biol Chem , vol.279 , pp. 10331-10337
    • Wang, F.S.1    Wang, C.J.2    Chen, Y.J.3    Chang, P.R.4    Huang, Y.T.5    Sun, Y.C.6
  • 11
    • 0037131391 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes
    • G.B. Waypa, J.D. Marks, M.M. Mack, C. Boriboun, P.T. Mungai, and P.T. Schumacker Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes Circ Res 91 2002 719 726
    • (2002) Circ Res , vol.91 , pp. 719-726
    • Waypa, G.B.1    Marks, J.D.2    Mack, M.M.3    Boriboun, C.4    Mungai, P.T.5    Schumacker, P.T.6
  • 12
    • 84928978368 scopus 로고    scopus 로고
    • Energy metabolism disorders in rare and common diseases. Toward bioenergetic modulation therapy and the training of a new generation of European scientists
    • R. Rossignol Energy metabolism disorders in rare and common diseases. Toward bioenergetic modulation therapy and the training of a new generation of European scientists Int J Biochem Cell Biol 63 2015 2 9
    • (2015) Int J Biochem Cell Biol , vol.63 , pp. 2-9
    • Rossignol, R.1
  • 13
    • 84900542451 scopus 로고    scopus 로고
    • Metabolic features of the cell danger response
    • R.K. Naviaux Metabolic features of the cell danger response Mitochondrion 16 2014 7 17
    • (2014) Mitochondrion , vol.16 , pp. 7-17
    • Naviaux, R.K.1
  • 14
    • 0000238410 scopus 로고
    • Diffuse progressive degeneration of gray matter of cerebrum
    • B.J. Alpers Diffuse progressive degeneration of gray matter of cerebrum Arch Neurol Psychiatry 25 1931 469 505
    • (1931) Arch Neurol Psychiatry , vol.25 , pp. 469-505
    • Alpers, B.J.1
  • 15
    • 2142705756 scopus 로고    scopus 로고
    • POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion
    • R.K. Naviaux, and K.V. Nguyen POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion Ann Neurol 55 2004 706 712
    • (2004) Ann Neurol , vol.55 , pp. 706-712
    • Naviaux, R.K.1    Nguyen, K.V.2
  • 16
    • 84857030799 scopus 로고    scopus 로고
    • Neurodegeneration as a consequence of failed mitochondrial maintenance
    • M. Karbowski, and A. Neutzner Neurodegeneration as a consequence of failed mitochondrial maintenance Acta Neuropathol 123 2012 157 171
    • (2012) Acta Neuropathol , vol.123 , pp. 157-171
    • Karbowski, M.1    Neutzner, A.2
  • 17
    • 77954169092 scopus 로고    scopus 로고
    • A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy
    • H. Ashrafian, L. Docherty, V. Leo, C. Towlson, M. Neilan, V. Steeples, and et al. A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy PLoS Genet 6 6 2010 e1001000
    • (2010) PLoS Genet , vol.6 , Issue.6
    • Ashrafian, H.1    Docherty, L.2    Leo, V.3    Towlson, C.4    Neilan, M.5    Steeples, V.6
  • 18
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • K.F. Petersen, S. Dufour, D. Befroy, R. Garcia, and G.I. Shulman Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 2004 664 671
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 19
    • 0024242545 scopus 로고
    • Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
    • D.C. Wallace, G. Singh, M.T. Lott, J.A. Hodge, T.G. Schurr, A.M. Lezza, and et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy Science 242 1988 1427 1430
    • (1988) Science , vol.242 , pp. 1427-1430
    • Wallace, D.C.1    Singh, G.2    Lott, M.T.3    Hodge, J.A.4    Schurr, T.G.5    Lezza, A.M.6
  • 20
    • 33746466098 scopus 로고    scopus 로고
    • Mitochondrial mutations in cancer
    • M. Brandon, P. Baldi, and D.C. Wallace Mitochondrial mutations in cancer Oncogene 25 2006 4647 4662
    • (2006) Oncogene , vol.25 , pp. 4647-4662
    • Brandon, M.1    Baldi, P.2    Wallace, D.C.3
  • 21
    • 0038046118 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA in HIV-1-infected patients and its amelioration by antiretroviral therapy
    • T. Miura, M. Goto, N. Hosoya, T. Odawara, Y. Kitamura, T. Nakamura, and et al. Depletion of mitochondrial DNA in HIV-1-infected patients and its amelioration by antiretroviral therapy J Med Virol 70 2003 497 505
    • (2003) J Med Virol , vol.70 , pp. 497-505
    • Miura, T.1    Goto, M.2    Hosoya, N.3    Odawara, T.4    Kitamura, Y.5    Nakamura, T.6
  • 22
    • 84874591240 scopus 로고    scopus 로고
    • The role of mitochondria in aging
    • A. Bratic, and N.G. Larsson The role of mitochondria in aging J Clin Investig 123 3 2013 951 957
    • (2013) J Clin Investig , vol.123 , Issue.3 , pp. 951-957
    • Bratic, A.1    Larsson, N.G.2
  • 23
    • 84870348705 scopus 로고    scopus 로고
    • Air pollution and type 2 diabetes: Mechanistic insights
    • S. Rajagopalan, and R.D. Brook Air pollution and type 2 diabetes: mechanistic insights Diabetes 61 12 2012 3037 3045
    • (2012) Diabetes , vol.61 , Issue.12 , pp. 3037-3045
    • Rajagopalan, S.1    Brook, R.D.2
  • 24
    • 0142043300 scopus 로고    scopus 로고
    • Mitochondrial encephalopathy
    • N. Longo Mitochondrial encephalopathy Neurol Clin 21 4 2003 817 831
    • (2003) Neurol Clin , vol.21 , Issue.4 , pp. 817-831
    • Longo, N.1
  • 25
    • 0030011347 scopus 로고    scopus 로고
    • Non neutral mitochondrial DNA variation in humans and chimpanzees
    • M.W. Nachman, W.M. Brown, M. Stoneking, and C.F. Aquadro Non neutral mitochondrial DNA variation in humans and chimpanzees Genetics 142 3 1996 953 963
    • (1996) Genetics , vol.142 , Issue.3 , pp. 953-963
    • Nachman, M.W.1    Brown, W.M.2    Stoneking, M.3    Aquadro, C.F.4
  • 26
    • 17744393686 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • R.W. Taylor, and D.M. Turnbull Mitochondrial DNA mutations in human disease Nat Rev Genet 6 5 2005 389 402
    • (2005) Nat Rev Genet , vol.6 , Issue.5 , pp. 389-402
    • Taylor, R.W.1    Turnbull, D.M.2
  • 27
    • 0242417495 scopus 로고    scopus 로고
    • Assessment of precision and concordance of quantitative mitochondrial DNA assays: A collaborative international quality assurance study
    • E.L. Hammond, D. Sayer, D. Nolan, U.A. Walker, A. de Ronde, J.S. Montaner, and et al. Assessment of precision and concordance of quantitative mitochondrial DNA assays: a collaborative international quality assurance study J Clin Virol 27 1 2003 97 110
    • (2003) J Clin Virol , vol.27 , Issue.1 , pp. 97-110
    • Hammond, E.L.1    Sayer, D.2    Nolan, D.3    Walker, U.A.4    De Ronde, A.5    Montaner, J.S.6
  • 28
    • 10644246729 scopus 로고    scopus 로고
    • Molecular analysis for mitochondrial DNA disorders
    • S. Shanske, and L.J. Wong Molecular analysis for mitochondrial DNA disorders Mitochondrion 4 5-6 2004 403 415
    • (2004) Mitochondrion , vol.4 , Issue.5-6 , pp. 403-415
    • Shanske, S.1    Wong, L.J.2
  • 29
    • 0026712954 scopus 로고
    • Use of single strand conformation polymorphism analysis to detect point mutations in human mitochondrial DNA
    • A. Suomalainen, E. Ciafaloni, Y. Koga, L. Peltonen, S. DiMauro, and E.A. Schon Use of single strand conformation polymorphism analysis to detect point mutations in human mitochondrial DNA J Neurol Sci 11 1992 222 226
    • (1992) J Neurol Sci , vol.11 , pp. 222-226
    • Suomalainen, A.1    Ciafaloni, E.2    Koga, Y.3    Peltonen, L.4    DiMauro, S.5    Schon, E.A.6
  • 30
    • 0032880563 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA mutations by temporal temperature gradient gel electrophoresis
    • T.J. Chen, R.G. Boles, and L.J. Wong Detection of mitochondrial DNA mutations by temporal temperature gradient gel electrophoresis Clin Chem 45 1999 1162 1167
    • (1999) Clin Chem , vol.45 , pp. 1162-1167
    • Chen, T.J.1    Boles, R.G.2    Wong, L.J.3
  • 31
    • 0030873290 scopus 로고    scopus 로고
    • Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes
    • Y. Michikawa, G. Ho fhaus, L.S. Lerman, and G. Attardi Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes Nucleic Acids Res 25 1997 2455 2463
    • (1997) Nucleic Acids Res , vol.25 , pp. 2455-2463
    • Michikawa, Y.1    Ho Fhaus, G.2    Lerman, L.S.3    Attardi, G.4
  • 32
    • 0025269309 scopus 로고
    • Detecting base pair substitutions in DNA fragments by temperature-gradient gel electrophoresis
    • R.M. Wartell, S.H. Hosseini, and C.P. Moran Detecting base pair substitutions in DNA fragments by temperature-gradient gel electrophoresis Nucleic Acids Res 18 1990 2699 2705
    • (1990) Nucleic Acids Res , vol.18 , pp. 2699-2705
    • Wartell, R.M.1    Hosseini, S.H.2    Moran, C.P.3
  • 33
    • 84863012272 scopus 로고    scopus 로고
    • Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing
    • S.E. Calvo, A.G. Compton, S.G. Hershman, S.C. Lim, D.S. Lieber, E.J. Tucker, and et al. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing Sci Transl Med 4 118 2012
    • (2012) Sci Transl Med , vol.4 , Issue.118
    • Calvo, S.E.1    Compton, A.G.2    Hershman, S.G.3    Lim, S.C.4    Lieber, D.S.5    Tucker, E.J.6
  • 35
    • 0034921209 scopus 로고    scopus 로고
    • Congenital disorders of glycosylation (CDG) may be underdiagnosed when mimicking mitochondrial disease
    • P. Briones, M.A. Vilaseca, M.T. Garcia-Silva, M. Pineda, J. Colomer, I. Ferrer, and et al. Congenital disorders of glycosylation (CDG) may be underdiagnosed when mimicking mitochondrial disease Eur J Paediatr Neurol 5 3 2001 127 131
    • (2001) Eur J Paediatr Neurol , vol.5 , Issue.3 , pp. 127-131
    • Briones, P.1    Vilaseca, M.A.2    Garcia-Silva, M.T.3    Pineda, M.4    Colomer, J.5    Ferrer, I.6
  • 36
    • 84867487186 scopus 로고    scopus 로고
    • Fidelity of capture-enrichment for mtDNA genome sequencing: Influence of NUMTs
    • M. Li, R. Schroeder, A. Ko, and M. Stoneking Fidelity of capture-enrichment for mtDNA genome sequencing: influence of NUMTs Nucleic Acids Res 40 18 2012 e137
    • (2012) Nucleic Acids Res , vol.40 , Issue.18 , pp. e137
    • Li, M.1    Schroeder, R.2    Ko, A.3    Stoneking, M.4
  • 37
    • 1042299965 scopus 로고    scopus 로고
    • Mitochondrial DNA-like sequences in the nucleus (NUMTs): Insights into our African origins and the mechanism of foreign DNA integration
    • D. Mishmar, E. Ruiz-Pesini, M. Brandon, and D.C. Wallace Mitochondrial DNA-like sequences in the nucleus (NUMTs): insights into our African origins and the mechanism of foreign DNA integration Hum Mutat 23 2004 125 133
    • (2004) Hum Mutat , vol.23 , pp. 125-133
    • Mishmar, D.1    Ruiz-Pesini, E.2    Brandon, M.3    Wallace, D.C.4
  • 38
    • 30344440795 scopus 로고    scopus 로고
    • Molecular research technologies in mitochondrial diseases: The microarray approach
    • M. Crimi, S.F. O'Hearn, D.C. Wallace, and G.P. Comi Molecular research technologies in mitochondrial diseases: the microarray approach IUBMB Life 57 2005 811 818
    • (2005) IUBMB Life , vol.57 , pp. 811-818
    • Crimi, M.1    O'Hearn, S.F.2    Wallace, D.C.3    Comi, G.P.4
  • 40
    • 77955562856 scopus 로고    scopus 로고
    • Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes
    • M. Li, A. Schonberg, M. Schaefer, R. Schroeder, I. Nasidze, and M. Stoneking Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes Am J Hum Genet 87 2010 237 249
    • (2010) Am J Hum Genet , vol.87 , pp. 237-249
    • Li, M.1    Schonberg, A.2    Schaefer, M.3    Schroeder, R.4    Nasidze, I.5    Stoneking, M.6
  • 41
    • 79953203261 scopus 로고    scopus 로고
    • Analysis of mitochondrial DNA point mutation heteroplasmy by ARMS quantitative PCR
    • Chapter 19
    • J. Wang, V. Venegas, F. Li, and L.J. Wong Analysis of mitochondrial DNA point mutation heteroplasmy by ARMS quantitative PCR Curr Protoc Hum Genet 2011 [Chapter 19]
    • (2011) Curr Protoc Hum Genet
    • Wang, J.1    Venegas, V.2    Li, F.3    Wong, L.J.4
  • 42
    • 77956255221 scopus 로고    scopus 로고
    • Molecular genetics of mitochondrial disorders
    • L.J. Wong Molecular genetics of mitochondrial disorders Dev Disabil Res Rev 16 2010 154 162
    • (2010) Dev Disabil Res Rev , vol.16 , pp. 154-162
    • Wong, L.J.1
  • 43
    • 84905116272 scopus 로고    scopus 로고
    • The Bioenergetic Health Index: A new concept in mitochondrial translational research
    • B.K. Chacko, P.A. Kramer, S. Ravi, G.A. Benavides, T. Mitchell, B.P. Dranka, and et al. The Bioenergetic Health Index: a new concept in mitochondrial translational research Clin Sci 127 2014 367 373
    • (2014) Clin Sci , vol.127 , pp. 367-373
    • Chacko, B.K.1    Kramer, P.A.2    Ravi, S.3    Benavides, G.A.4    Mitchell, T.5    Dranka, B.P.6
  • 44
    • 84860251058 scopus 로고    scopus 로고
    • Platelet mitochondrial dysfunction is evident in type 2 diabetes in association with modifications of mitochondrial anti-oxidant stress proteins. Experimental and clinical endocrinology
    • C. Avila, R.J. Huang, M.V. Stevens, A.M. Aponte, D. Tripodi, K.Y. Kim, and et al. Platelet mitochondrial dysfunction is evident in type 2 diabetes in association with modifications of mitochondrial anti-oxidant stress proteins. Experimental and clinical endocrinology Diabetes 120 4 2012 248 251
    • (2012) Diabetes , vol.120 , Issue.4 , pp. 248-251
    • Avila, C.1    Huang, R.J.2    Stevens, M.V.3    Aponte, A.M.4    Tripodi, D.5    Kim, K.Y.6
  • 45
    • 43649092320 scopus 로고    scopus 로고
    • Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets
    • C. Shi, K. Guo, D.T. Yew, Z. Yao, E.L. Forster, H. Wang, and et al. Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets Exp Gerontol 43 2008 589 594
    • (2008) Exp Gerontol , vol.43 , pp. 589-594
    • Shi, C.1    Guo, K.2    Yew, D.T.3    Yao, Z.4    Forster, E.L.5    Wang, H.6
  • 46
    • 79955476448 scopus 로고    scopus 로고
    • Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5′-triphosphate synthase activity
    • A.M. Japiassu, A.P. Santiago, J.C. d'Avila, L.F. Garcia-Souza, A. Galina, H.C. Castro Faria-Neto, and et al. Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5′-triphosphate synthase activity Crit Care Med 39 5 2011 1056 1063
    • (2011) Crit Care Med , vol.39 , Issue.5 , pp. 1056-1063
    • Japiassu, A.M.1    Santiago, A.P.2    D'Avila, J.C.3    Garcia-Souza, L.F.4    Galina, A.5    Castro Faria-Neto, H.C.6
  • 47
    • 77649282583 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: Implications in the pathogenesis of the disease
    • M.D. Cordero, M. De Miguel, A.M. Moreno Fernández, I.M. Carmona López, J. Garrido Maraver, D. Cotán, and et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease Arthritis Res Ther 12 2010 R17
    • (2010) Arthritis Res Ther , vol.12 , pp. R17
    • Cordero, M.D.1    De Miguel, M.2    Moreno Fernández, A.M.3    Carmona López, I.M.4    Garrido Maraver, J.5    Cotán, D.6
  • 48
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • D. Altshuler, M.J. Daly, and E.S. Lander Genetic mapping in human disease Science 322 2008 881 888
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 50
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • L.A. Hindorff, P. Sethupathy, H.A. Junkins, E.M. Ramos, and J.P. Mehta Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci USA 106 2009 9362 9367
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5
  • 51
    • 84860440529 scopus 로고    scopus 로고
    • Genome-wide association studies with metabolomics
    • J. Adamski Genome-wide association studies with metabolomics Genome Med 4 4 2012
    • (2012) Genome Med , vol.4 , Issue.4
    • Adamski, J.1
  • 54
    • 84155172490 scopus 로고    scopus 로고
    • Applications of mass spectrometry to metabolomics and metabolomics: Detection of biomarkers of aging and of age-related diseases
    • R.J. Mishur, and S.L. Rea Applications of mass spectrometry to metabolomics and metabolomics: detection of biomarkers of aging and of age-related diseases Mass Spectrom Rev 31 1 2012 70 95
    • (2012) Mass Spectrom Rev , vol.31 , Issue.1 , pp. 70-95
    • Mishur, R.J.1    Rea, S.L.2
  • 55
    • 72149119731 scopus 로고    scopus 로고
    • Mitochondrial proteome evolution and genetic disease
    • M.A. Huynen, M. de Hollander, and R. Szklarczyk Mitochondrial proteome evolution and genetic disease Biochim Biophys Acta 1792 12 2009 1122 1129
    • (2009) Biochim Biophys Acta , vol.1792 , Issue.12 , pp. 1122-1129
    • Huynen, M.A.1    De Hollander, M.2    Szklarczyk, R.3


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