Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5′-triphosphate synthase activity

Critical Care Medicine

Volumn 39, Issue 5, 2011, Pages 1056-1063

  Japiassú, André M ^a,b,c   Santiago, Ana Paula S A ^c   D'Avila, Joana Da Costa P ^c   Garcia Souza, Luiz F ^c   Galina, Antonio ^c   Castro Faria Neto, Hugo C ^d   Bozza, Fernando A ^a,c   Oliveira, Marcus F ^c  

^a Funda??o Oswaldo Cruz   (Brazil)

^b Intensive Care Unit   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

immune system; metabolism; mitochondria; organ dysfunction; oxygen consumption; sepsis

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ADULT; AGED; CELL STIMULATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; INTENSIVE CARE UNIT; MALE; MITOCHONDRIAL RESPIRATION; MULTIPLE ORGAN FAILURE; OXYGEN CONSUMPTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RESPIROMETRY; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 79955476448     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31820eda5c     Document Type: Conference Paper

References (43)

1. Crouser ED: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004; 4:729-741 (Pubitemid 39646818)
2. Exline MC, Crouser ED: Mitochondrial mechanisms of sepsis-induced organ failure. Front Biosci 2008; 13:5030-5041 (Pubitemid 351599656)
3. Carré JE, Singer M: Cellular energetic me-tabolism in sepsis: The need for a systems approach. Biochim Biophys Acta 2008; 1777: 763-771
4. Singer M: Mitochondrial function in sepsis: Acute phase versus multiple organ failure. Crit Care Med 2007; 35:S441-S448 (Pubitemid 47312177)
5. Crouser ED, Julian MW, Blaho DV, et al: Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med 2002; 30:276-284 (Pubitemid 34158107)
6. Callahan LA, Supinski GS: Sepsis induces diaphragm electron transport chain dysfunc-tion and protein depletion. Am J Respir Crit Care Med 2005; 172:861-868 (Pubitemid 41369070)
7. Belikova I, Lukaszewicz AC, Faivre V, et al: Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med 2007; 35:2702-2708 (Pubitemid 350175764)
8. d'Avila JCP, Santiago APSA, Amâncio RT, et al: Sepsis induces brain mitochondrial dys-function. Crit Care Med 2008; 36:1925-1932
9. Crouser ED, Julian MW, Joshi MS, et al: Cyclosporin A ameliorates mitochondrial ul-trastructural injury in the ileum during acute endotoxemia. Crit Care Med 2002; 30: 2722-2728 (Pubitemid 36870575)
10. Brealey D, Brand M, Hargreaves I, et al: As-sociation between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223 (Pubitemid 34804650)
11. Adrie C, Bachelet M, Vayssier-Taussat M, et al: Mitochondrial membrane potential and apoptosis peripheral blood monocytes in se-vere human sepsis. Am J Respir Crit Care Med 2001; 164:389-395 (Pubitemid 32778204)
12. Bone RC, Balk RA, Cerra FB, et al: Defini-tions for sepsis and organ failure and guide-lines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Confer-ence Committee American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
13. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multi-center study. JAMA 1993; 270:2957-2963 (Pubitemid 24000804)
14. Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict out-come in critically ill patients. JAMA 2001; 286:1754-1758 (Pubitemid 33010262)
15. Dellinger RP, Carlet JM, Masur H, et al: Sur-viving Sepsis Campaign guidelines for man-agement of severe sepsis and septic shock. Intensive Care Med 2004; 30:536-555 (Pubitemid 38541501)
16. Sims NR, Blass JP: Expression of classical mitochondrial respiratory responses in homogenates of rat forebrain. J Neurochem 1986; 47:496-505 (Pubitemid 16052868)
17. Nicholls DG, Ferguson SJ: Bioenergetics 3. Third Edition. London, Academic Press, 2002, pp. 82-83
18. Trzcionka M, Withers KW, Klingenspor M, et al: The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an am-phibian, the cane toad Bufo marinus. J Exp Biol 2008; 211:1911-1918 (Pubitemid 352026183)
19. Dyson A, Stidwill R, Taylor V, et al: Tissue oxygen monitoring in rodent models of shock. Am JPhysiolHeart Circ Physiol 2007; 293:526-533
20. Rosser DM, Manji M, Cooksley H, et al: Endo-toxin reduces maximal oxygen consumption in hepatocytes independent of any hypoxic insult. Intensive Care Med 1998; 24:725-729 (Pubitemid 28393406)
21. Rosser DM, Stidwill RP, Jacobson D, et al: Cardiorespiratory and tissue oxygen dose re-sponse to rat endotoxemia. Am J Physiol 1996; 271:891-895
22. VanderMeer TJ, Wang H, Fink MP: Endotox-emia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normody-namic porcine model of septic shock. Crit Care Med 1995; 23:1217-1226
23. Boekstegers P, Weidenhöfer S, Pilz G, et al: Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: Compari-son to limited infection and cardiogenic shock. Infection 1991; 19:317-323
24. Sair M, Etherington PJ, Winlove PC, et al: Tissue oxygenation and perfusion in patients with systemic sepsis. Crit Care Med 2001; 29:1343-1349 (Pubitemid 32641795)
25. Hodgin UG, Sanford JP: Gram-negative rod bacteremia. An analysis of 100 patients. Am J Med 1965; 39:952-960
26. Gattinoni L, Brazzi L, Pelosi P, et al: A trial of goal-oriented hemodynamic therapy in crit-ically ill patients. SvO2 Collaborative Group. N Engl J Med 1995; 333:1025-1032
27. Hayes MA, Timmins AC, Yau EH, et al: Ele-vation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994; 330:1717-1722 (Pubitemid 24171030)
28. Fink MP: Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 2001; 17:219-237 (Pubitemid 32163188)
29. Distelmaier F, Koopman WJ, van den Heuvel LP, et al: Mitochondrial complex I deficiency: From organelle dysfunction to clinical dis-ease. Brain 2009; 132:833-842
30. Banerjee R, Starkov AA, Beal MF, et al: Mi-tochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta 2009; 1792:651-663
31. Comim CM, Rezin GT, Scaini G, et al: Mito-chondrial respiratory chain and creatine ki-nase activities in rat brain after sepsis in-duced by cecal ligation and perforation. Mitochondrion 2008; 8:313-318
32. Calvano SE, Xiao W, Richards DR, et al: A network-based analysis of systemic inflam-mation in humans. Nature 2005; 437: 1032-1037 (Pubitemid 41486985)
33. Haynes V, Traaseth NJ, Elfering S, et al: Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging. Am J Physiol Endocrinol Metab 2010; 298: 978-987
34. 2 is mediated by iron ions not tightly bound in the protein. Biochem Biophys Res Commun 1991; 181:764-770
35. Kantrow SP, Tatro LG, Piantadosi CA: Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. Free Radic Biol Med 2000; 28:251-260 (Pubitemid 30084017)
36. Yan LJ, Sohal RS: Mitochondrial adenine nu-cleotide translocase is modified oxidatively during aging. Proc Nat Acad Sci USA 1998; 95:12896-12901 (Pubitemid 28509494)
37. Echtay KS, Esteves TC, Pakay JL, et al: A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBOJ2003; 22:4103-4110 (Pubitemid 37021739)
38. Reynolds CM, Suliman HB, Hollingsworth JW, et al: Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radic Biol Med 2009; 46:564-572
39. Lunemann JD, Buttgereit F, Tripmacher R, et al: Norepinephrine inhibits energy metab-olism of human peripheral blood mononu-clear cells via adrenergic receptors. Biosci-ence Report 2001; 21:627-635 (Pubitemid 34816192)
40. Regueira T, Bänziger B, Djafarzadeh S, et al: Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with im-proved hepatic mitochondrial respiration. Crit Care 2008; 12:R88
41. Allan EH, Chisholm AB, Titheradge MA: The stimulation of hepatic oxidative phosphory-lation following dexamethasone treatment of rats. Biochim Biophys Acta 1983; 725:71-76 (Pubitemid 14247032)
42. Simon N, Jolliet P, Morin C, et al: Glucocor-ticoids decrease cytochrome c oxidase activ-ity of isolated rat kidney mitochondria. FEBS Lett 1998; 435:25-28 (Pubitemid 28432008)
43. Fujita C, Ichikawa F, Teratani T, et al: Direct effects of corticosterone on ATP production by mitochondria from immortalized hypo-thalamic GT1-7 neurons. J Steroid Biochem MolBiol2009; 117:50-55