Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity

Psychological Medicine

Volumn 46, Issue 10, 2016, Pages 2215-2226

  Wolf, E J ^a,b   Bovin, M J ^a,b   Green, J D ^a,b   Mitchell, K S ^a,b   Stoop, T B ^c   Barretto, K M ^a   Jackson, C E ^a,b   Lee, L O ^a,b   Fang, S C ^d   Trachtenberg, F ^d   Rosen, R C ^d   Keane, T M ^a,b   Marx, B P ^a,b  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA Boston   (United States)

^d NEW ENGLAND RESEARCH INSTITUTES   (United States)

Author keywords

Accelerated aging; cross lagged design; longitudinal; metabolic syndrome; PTSD; veterans

Indexed keywords

ADULT; AGED; COMORBIDITY; FEMALE; HUMAN; LONGITUDINAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA; VETERAN; WAR; YOUNG ADULT;

ADULT; AFGHAN CAMPAIGN 2001-; AGED; COMORBIDITY; FEMALE; HUMANS; IRAQ WAR, 2003-2011; LONGITUDINAL STUDIES; MALE; METABOLIC SYNDROME; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; STRESS DISORDERS, POST-TRAUMATIC; VETERANS; YOUNG ADULT;

EID: 84964336933     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291716000817     Document Type: Article

References (65)

1. Ahmadi N, Hajsadeghi F, Mirshkarlo HB, Budoff M, Yehuda R, Ebrahimi R (2011). Post-traumatic stress disorders, coronary atherosclerosis, and mortality. American Journal of Cardiology 208, 29-33
2. Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group (2005). The metabolic syndrome-A new world definition. Lancet 366, 1059-1062
3. Atli A, Bulut M, Bez Y, Kaplan I, Özdemir PG, Uysal C, Selçuk H, Sir A (in press). Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors. European Archives of Psychiatry and Clinical Neuroscience
4. Bartoli F, Carrà G, Crocamo C, Caretta D, Clerici M (2013). Metabolic syndrome in people suffering from posttraumatic stress disorder a systematic review and meta-analysis. Metabolic Syndrome and Related Disorders 11, 301-308
5. Bartoli F, Crocamo C, Alamia A, Amidani F, Paggi E, Pini E, Clerici M, Carrà G (2015). Posttraumatic stress disorder and risk of obesity: systematic review and meta-analysis. Journal of Clinical Psychiatry 76, e1253-e1261
6. Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE (2015). Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences USA 112, E4104-E4110
7. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM (1995). The development of a clinician-administered PTSD scale. Journal of Traumatic Stress 8, 75-90
8. Bovin MJ, Marx BP, Weathers FW, Gallagher MW, Rodriguez P, Schnurr PP, Keane TM (in press). Psychometric properties of the PTSD Checklist for DSM-5 (PCL-5) in Veterans. Psychological Assessment
9. Bovin MJ, Weathers FW (2012). Assessing PTSD Symptoms. In The Oxford Handbook of Traumatic Stress Disorders (ed. J. G. Beck and D. M. Sloan), pp. 235-249 Oxford University Press: New York
10. Brudey C, Park J, Wiaderkiewicz J, Kobayashi I, Mellman T, Marvar P (2015). Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 309, R315-R321
11. Dennis PA, Watkins LL, Calhoun PS, Oddone A, Sherwood A, Dennis MF, Rissling MB, Beckham JC (2014). Posttraumatic stress, heart rate variability, and the mediating role of behavioral health risks. Psychosomatic Medicine 76, 629-637
12. Epel ES (2009). Psychological and metabolic stress a recipe for accelerated cellular aging? Hormones (Athens) 8, 7-22
13. Eraly SA, Nievergelt CM, Maihofer AX, Barkauskas DA, Biswas N, Agorastos A, O'Connor DT, Baker DG, Marine Resiliency Study Team (2014). Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry 71, 423-431
14. Ervin RB (2009). Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006. National Health Statistics Report 13, 1-7
15. Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D (2012). Metabolic syndrome and risk of cancer a systematic review and meta-analysis. Diabetes Care 35, 2402-2411
16. Farr OM, Ko BJ, Joung KE, Zaichenko L, Usher N, Tsoukas M, Thakkar B, Davis CR, Crowell JA, Mantzoros CS (2015). Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk. Nutrition, Metabolism, and Cardiovascular Diseases 25, 479-488
17. Francis MM, Nikulina V, Widom CS (2015). A prospective examination of the mechanisms linking childhood physical abuse to body mass index in adulthood. Child Maltreatment 20, 203-213
18. First M, Spitzer R, Williams J, Gibbon M (2000). Structured clinical interview for DSM-IV Axis 1 disorders (SCID-I), pp. 49-53 In Handbook of Psychiatric Measures. American Psychiatric Association: Washington, DC
19. First MB, Williams JBW, Karg RS, Spitzer RL (2015). Structured Clinical Interview for DSM-5-Research Version (SCID-5 for DSM-5, Research Version; SCID-5-RV). American Psychiatric Association: Arlington, VA
20. Gautam A, D'Arpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M (2015). Acute and chronic plasma metabolomics and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder. PLoS ONE 10, e0117092
21. Gavrieli A, Farr OM, Davis CR, Crowell JA, Mantzoros CS (2015). Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population a cross-sectional and prospective study. Metabolism 64, 1597-1610
22. Georgiades A, Sherwood A, Gullette EC, Babyak MA, Hinderliter A, Waugh R, Tweedy D, Craighead L, Bloomer R, Blumenthal JA (2000). Effects of exercise and weight loss on mental stress-induced cardiovascular responses in individuals with high blood pressure. Hypertension 36, 171-176
23. Grattagliano I, Palmieri VO, Portincasa P, Moschetta A, Palasciano G (2008). Oxidative stress-induced risk factors associated with metabolic syndrome a unifying hypothesis. Journal of Nutritional Biochemistry 19, 491-504
24. Gray MJ, Litz BT, Hsu JL, Lombardo TW (2004). Psychometric Properties of the Life Events Checklist. Assessment 11, 330-341
25. Green E, Fairchild JK, Kinoshita LM, Noda A, Yesavage J (2016). Effects of posttraumatic stress disorder and metabolic syndrome on cognitive aging in veterans. Gerontologist 56, 72-81
26. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr. SC, Spertus JA, Costa F (2005). Diagnosis and management of the metabolic syndrome an American Heart Association/ National Heart, Lung, and Blood Institute scientific statement: executive summary. Critical Pathways in Cardiology 4, 198-203
27. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr. SC, Spertus JA, Costa F (2006). Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Current Opinion in Cardiology 21, 1-6
28. Hall KS, Hoerster KD, Yancy Jr. WS (2015). Post-traumatic stress disorder, physical activity, and eating behaviors. Epidemiologic Review 37, 103-115
29. Heppner PS, Lohr JB, Kash TP, Jin H, Wang H, Baker DG (2012). Metabolic syndrome: relative risk associated with post-traumatic stress disorder (PTSD) severity and antipsychotic medication use. Psychosomatics 53, 550-558
30. Hu L, Bentler PM (1999). Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling 6, 1-55
31. Kibler JL, Tursich M, Ma M, Malcolm L, Greenbarg R (2014). Metabolic, autonomic and immune markers for cardiovascular disease in posttraumatic stress disorder. World Journal of Cardiology 6, 455-461
32. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT (2002). The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Journal of the American Medical Association 288, 2709-2716
33. Levine AB, Levine LM, Levine TB (2014). Posttraumatic stress disorder and cardiometabolic disease. Cardiology 127, 1-19
34. Liu P, Ma F, Lou H, Liu Y (2013). The utility of fat mass index vs. body mass index and percentage of body fat in the screening of metabolic syndrome. BMC Public Health 13, 629
35. Lohr JB, Palmer BW, Eidt CA, Aailaboyina S, Mausbach BT, Wolkowitz OM, Thorp SR, Jeste DV (2015). Is posttraumatic stress disorder associated with premature senescence? A review of the literature. American Journal of Geriatric Psychiatry 23, 709-725
36. Miller MW, Fogler JM, Wolf EJ, Kaloupek DG, Keane TM (2008). The internalizing and externalizing structure of psychiatric comorbidity in combat veterans. Journal of Traumatic Stress 21, 58-65
37. MillerMW, Sadeh N (2014). Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Molecular Psychiatry 19, 1156-1162
38. Miller MW, Wolf EJ, Kilpatrick D, Resnick H, Marx BP, Holowka DW, Keane TM, Rosen RC, Friedman MJ (2013). The prevalence and latent structure of proposed DSM-5 posttraumatic stress disorder symptoms in US national and veteran samples. Psychological Trauma 5, 501-512
39. Muthén LK, Muthén BO (2012). Mplus User's Guide. Muthén &Muthén: Los Angeles, CA
40. NCEP (2001). Executive summary of the third report of the National Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Journal of the American Medical Association 285, 2486-2497
41. O'Donovan A, Cohen BE, Seal KH, Bertenthal D, Margaretten M, Nishimi K, Neylan TC (2015). Elevated risk for autoimmune disorders in Iraq and Afghanistan veterans with posttraumatic stress disorder. Biological Psychiatry 77, 365-374
42. Pietrzak RH, Goldstein RB, Southwick SM, Grant BF (2012). Psychiatric comorbidity of full and partial posttraumatic stress disorder among older adults in the United States: results from wave 2 of the National Epidemiologic Survey of Alcohol and Related Conditions. American Journal of Geriatric Psychiatry 20, 380-390
43. Pulkki-Råback L, Elovainio M, Kivimäki M, Mattsson N, Raitakari OT, Puttonen S, Marniemi J, Viikari JS, Keltikangas-Järvinen L (2009). Depressive symptoms and the metabolic syndrome in childhood and adulthood a prospective cohort study. Health Psychology 28, 108-116
44. Regier DA, Narrow WE, Clarke DE, Kraemer HC, Kuramoto SJ, Kuhl EA, Kupfer DJ (2013). DSM-5 field trials in the United States and Canada, part II: test-retest reliability of selected categorical diagnoses. American Journal of Psychiatry 170, 59-70
45. Roberts AL, Agnew-Blais JC, Spiegelman D, Kubzansky LD, Mason SM, Galea S, Hu FB, Rich-Edwards JW, Koenen KC (2015). Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women a 22-year longitudinal study. JAMA Psychiatry 72, 203-210
46. Rosen RC, Marx BP, Maserejian NN, Holowka DW, Gates MA, Sleeper LA, Vasterling JJ, Kang HK, Keane TM (2012). Project VALOR: design and methods of a longitudinal registry of post-traumatic stress disorder (PTSD) in combat-exposed veterans in the Afghanistan and Iraqi military theaters of operations. International Journal of Methods in Psychiatric Research 21, 5-16
47. Rosenbaum S, Sherrington C, Tiedemann A (2015a). Exercise augmentation compared with usual care for post-traumatic stress disorder a randomized controlled trial. Acta Psychiatrica Scandinavica 131, 350-359
48. Rosenbaum S, Stubbs B, Ward PB, Steel Z, Lederman O, Vancampfort D (2015b). The prevalence and risk of metabolic syndrome and its components among people with posttraumatic stress disorder a systematic review and meta-analysis. Metabolism 64, 926-933
49. Rosenbaum S, Vancampfort D, Steel Z, Newby J, Ward PB, Stubbs B (2015c). Physical activity in the treatment of post-traumatic stress disorder a systematic review and meta-analysis. Psychiatry Research 230, 130-136
50. Rosenthal R, Rosnow RL (1991). Essentials of Behavioral Research: Methods and Data Analysis, 2nd edn. McGraw-Hill: Boston, MA
51. Roy SS, Foraker RE, Girton RA, Mansfield AJ (2015). Posttraumatic stress disorder and incident heart failure among a community-based sample of US veterans. American Journal of Public Health 105, 757-763
52. Schnurr PP, Spiro A, Paris AH (2000). Physician-diagnosed medical disorders in relations to PTSD symptoms in older male military veterans. Health Psychology 19, 91-97
53. Sullivan PW, Ghushchyan V, Wyatt HR, Hill JO (2007). The medical cost of cardiometabolic risk factor clusters in the United States. Obesity (Silver Spring) 15, 3150-3158
54. Sumner JA, Kubzansky LD, Elkind MS, Roberts AL, Agnew-Blais J, Chen Q, Cerdá M, Rexrode KM, Rich-Edwards JW, Spiegelman D, Suglia SF, Rimm EB, Koenen KC (2015). Trauma exposure and posttraumatic stress disorder symptoms predict onset of cardiovascular events in women. Circulation 132, 251-259
55. Talbot LS, Rao MN, Cohen BE, Richards A, Inslicht SS, O'Donovan A, Maguen S, Metzler TJ, Neylan TC (2015). Metabolic risk factors and posttraumatic stress disorder: the role of sleep in young, healthy adults. Psychosomatic Medicine 77, 383-391
56. Tyrka AR, Parade SH, Price LH, Kao HT, Porton B, Philip NS, Welch ES, Carpenter LL (2016). Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology. Biological Psychiatry 79, 78-86
57. Vancampfort D, Stubbs B, Mitchell AJ, De Hert M, Wampers M, Ward PB, Rosenbaum S, Correll CU (2015). Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder a systematic review and meta-analysis. World Psychiatry 14, 339-347
58. Vitaliano PP, Scanlan JM, Zhang J, Savage MV, Hirsch IB, Siegler IC (2002). A path model of chronic stress, the metabolic syndrome, and coronary heart disease. Psychosomatic Medicine 64, 418-435
59. Wentworth BA, Stein MB, Redwine LS, Xue Y, Taub PR, Clopton P, Nayak KR, Maisel AS (2013). Post-traumatic stress disorder a fast track to premature cardiovascular disease? Cardiology in Review 21, 16-22
60. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB (2005). Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 112, 3066-3072
61. Wolf EJ, LogueMW,Hayes JP, Sadeh N, Schichman SA, Stone A, Salat DH,MilbergW, McGlinchey R, MillerMW(2016). Accelerated DNA methylation age associations with PTSD and neural integrity. Psychoneuroendocrinology 63, 155-162
62. Wolf EJ, Sadeh N, Leritz EC, Logue MW, Stoop T, McGlinchey R, Milberg W, Miller MW (in press). PTSD as a catalyst for the association between Metabolic Syndrome and reduced cortical thickness. Biological Psychiatry
63. World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic; Report of a WHO Consultation (WHO Technical Report Series). World Health Organization: Geneva
64. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB (2004). The metabolic syndrome, inflammation, and risk of cognitive decline. Journal of the American Medical Association 292, 2237-2242
65. Zandieh A, Esteghamati A, Morteza A, Noshad S, Khalilzadeh O, Gouya MM, Nakhiavani M (2012). Appropriate BMI cut-off values for identification of metabolic risk factors: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Annals of Human Biology 39, 484-489