Magnesium Status in Alzheimer's Disease: A Systematic Review

American Journal of Alzheimer's Disease and other Dementias

Volumn 31, Issue 3, 2016, Pages 208-213

  Veronese, Nicola ^a   Zurlo, Anna ^a   Solmi, Marco ^a   Luchini, Claudio ^b   Trevisan, Caterina ^a   Bano, Giulia ^a   Manzato, Enzo ^a,c   Sergi, Giuseppe ^a   Rylander, Ragnar ^d  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY AND HOSPITAL TRUST OF VERONA   (Italy)

^c CNR   (Italy)

^d BioFact Environmental Health Research Center   (Sweden)

Author keywords

aging; Alzheimer's disease; dementia; healthy controls; magnesium

Indexed keywords

MAGNESIUM;

ALZHEIMER DISEASE; CEREBROSPINAL FLUID LEVEL; HAIR LEVEL; HUMAN; MAGNESIUM BLOOD LEVEL; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; BLOOD; CEREBROSPINAL FLUID; METABOLISM;

ALZHEIMER DISEASE; HUMANS; MAGNESIUM;

EID: 84964336803     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317515602674     Document Type: Review

References (50)

1. Abbott A,. Dementia: a problem of our age. Nature. 2011; 475 (7355): S2-S4.
2. Cummings JL,. Alzheimer's disease. N Engl J Med. 2004; 351 (1): 56-67.
3. Fitzpatrick AL, Kuller LH, Lopez OL, et al. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch Neurol. 2009; 66 (3): 336-342.
4. Raffaitin C, Gin H, Empana JP, et al. Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the three-city study. Diabetes Care. 2009; 32 (1): 169-174.
5. Gudala K, Bansal D, Schifano F, Bhansali A,. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013; 4 (6): 640-650.
6. Lopes da Silva S, Vellas B, Elemans S, et al. Plasma nutrient status of patients with Alzheimer's disease: systematic review and meta-analysis. Alzheimers Dement. 2014; 10 (4): 485-502.
7. Andrási E, Igaz S, Molnár Z, Makó S,. Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease. Magnes Res. 2000; 13 (3): 189-196.
8. Glick JL,. Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease. Med Hypotheses. 1990; 31 (3): 211-225.
9. Sergi G, De Rui M, Coin A, Inelmen EM, Manzato E,. Weight loss and Alzheimer's disease: temporal and aetiologic connections. Proc Nutr Soc. 2013; 72 (1): 160-165.
10. 2+ of NMDA responses in spinal cord neurones. Nature. 1984; 309 (5965): 261-263.
11. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010; 65 (2): 165-177.
12. Ebel H, Günther T,. Magnesium metabolism: a review. J Clin Chem Clin Biochem. 1980; 18 (5): 257-270.
13. 2+ entry through purinergic channels. Brain Res. 2011; 1369: 21-35.
14. Libien J, Sacktor TC, Kass IS,. Magnesium blocks the loss of protein kinase C, leads to a transient translocation of PKC(alpha) and PKC(epsilon), and improves recovery after anoxia in rat hippocampal slices. Brain Res Mol Brain Res. 2005; 136 (1-2): 104-111.
15. Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007; 370 (9596): 1453-1457.
16. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339: b2700.
17. DerSimonian R, Laird N,. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7 (3): 177-188.
18. RevMan 5.3. Informatics & knowledge management department. http://tech.cochrane.org/revman. Accessed May 4, 2015.
19. Higgins JP, Thompson SG,. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21 (11): 1539-1558.
20. Comprehensive Meta-Analysis (CMA) 3.0. http://www.meta-analysis.com/index.php. Accessed May 4, 2015.
21. Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ,. Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease. Magnes Res. 2011; 24 (3): S115-S121.
22. Çilliler AE, Ozturk S, Ozbakir S,. Serum magnesium level and clinical deterioration in Alzheimer's disease. Gerontology. 2007; 53 (6): 419-422.
23. Hozumi I, Hasegawa T, Honda A, et al. Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011; 303 (1-2): 95-99.
24. Lemke MR,. Plasma magnesium decrease and altered calcium/magnesium ratio in severe dementia of the Alzheimer type. Biol Psychiatry. 1993; 37 (5): 341-343.
25. Basun H, Forssell LG, Wetterberg L, Winblad B,. Metals and trace elements in plasma and cerebrospinal fluid in normal ageing and Alzheimer's disease. J Neural Transm Park Dis Dement Sect. 1991; 3 (4): 231-258.
26. Borella P, Giardino A, Neri M, Andermarker E,. Magnesium and potassium status in elderly subjects with and without dementia of Alzheimer type. Magnes Res. 1990; 3 (4): 283-289.
27. Boström F, Hansson O, Blennow K, et al. Cerebrospinal fluid total tau is associated with shorter survival in dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2009; 28 (4): 314-319.
28. Brackenridge JK, Mc Donald C,. The concentrations of magnesium and potassium in erythrocytes and plasma of geriatric patients with psychiatric disorders. Med. J. Aust. 1969; 2 (8): 390-394.
29. Gustaw-Rothenberg K, Kowalczuk K, Stryjecka-Zimmer M,. Lipids' peroxidation markers in Alzheimer's disease and vascular dementia. Geriatr Gerontol Int. 2010; 10 (2): 161-166.
30. Kobayashi S, Fujiwara S, Arimoto S, et al. Hair aluminium in normal aged and senile dementia of Alzheimer type. Prog Clin Biol Res. 1989; 317: 1095-1109.
31. Shore D, Henkin RI, Nelson NR, Agarwal RP, Wyatt RJ,. Hair and serum copper, zinc, calcium, and magnesium concentrations in Alzheimer-type dementia. J. Am Geriatr Soc. 1984; 32 (4): 892-895.
32. Singh NK, Banerjee BD, Bala K, Basu M, Chhillar N,. Polymorphism in cytochrome p450 2d6, glutathione s-transferases pi 1 genes, and organochlorine pesticides in Alzheimer disease: a case-control study in North Indian Population. J Geriatr Psychiatry Neurol. 2014; 27 (2): 119-127.
33. Vural H, Demirin H, Kara Y, Eren I, Delibas N,. Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease. J Trace Elem Med Biol. 2010; 24 (3): 169-173.
34. Francis PT,. Glutamatergic systems in Alzheimer's disease. Int J Geriatr Psychiatry. 2003; 18 (suppl 1): 15-21.
35. Barbagallo M, Belvedere M, Dominguez LJ,. Magnesium homeostasis and aging. Magnes Res. 2009; 22 (4): 235-246.
36. Turlapaty PD, Altura BM,. Magnesium deficiency produces spasms of coronary arteries: relationship to etiology of sudden death ischemic heart disease. Science. 1980; 208 (4440): 198-200.
37. Lemke MR,. Plasma magnesium decrease and altered calcium/magnesium ratio in severe dementia of the Alzheimer type. Biol Psychiatry. 1995; 37 (5): 341-343.
38. Ochi A, Ishimura E, Tsujimoto Y, et al. Hair magnesium, but not serum magnesium, is associated with left ventricular wall thickness in hemodialysis patients. Circ J. 2013; 77 (12): 3029-3036.
39. Kazi TG, Afridi HI, Kazi GH, Jamali MK, Arain MB, Jalbani N,. Evaluation of essential and toxic metals by ultrasound-assisted acid leaching from scalp hair samples of children with macular degeneration patients. Clin Chim Acta. 2006; 369 (1): 52-60.
40. Hac E, Czarnowski W, Gos T, Krechniak J,. Lead and fluoride content in human bone and hair in the Gdansk region. Sci Total Environ. 1997; 206 (2-3): 249-254.
41. Ranade VV, Somberg JC,. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Ther. 2001; 8 (5): 345-357.
42. Dominguez LJ, Barbagallo M, Lauretani F, et al. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr. 2006; 84 (2): 419-426.
43. Veronese N, Berton L, Carraro S, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 2014; 100 (3): 974-981.
44. Zheng J, Mao X, Ling J, He Q, Quan J, Jiang H,. Association between serum level of magnesium and postmenopausal osteoporosis: a meta-analysis. Biol Trace Elem Res. 2014; 159 (1-3): 8-14.
45. Reffelmann T, Ittermann T, Dörr M, et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011; 219 (1): 280-284.
46. Cherbuin N, Kumar R, Sachdev PS, Anstey KJ,. Dietary mineral intake and risk of mild cognitive impairment: the PATH through life project. Front Aging Neurosci. 2014; 6: 4.
47. Li W, Yu J, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverse cognitive deficits in Alzheimer's disease mouse model. Mol Brain. 2014; 7: 65-98.
48. Atwood CS, Moir RD, Huang X, et al. Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physical acidosis. J Biol Chem. 1998; 273 (21): 12817-12826.
49. Rylander R, Remer T, Berkemeyer S, Vormann J,. Acid-base status affects renal magnesium losses in healthy, elderly persons. J Nutr. 2006; 136 (9): 2374-2377.
50. 2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats. Brain Res. 1984; 322 (1): 167-171.