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Volumn 78, Issue 2, 2016, Pages 233-244

The Best. First. Anti-EGFR before anti-VEGF, in the first-line treatment of RAS wild-type metastatic colorectal cancer: from bench to bedside

Author keywords

Anti EGFR therapy; Bevacizumab; Cetuximab; Colon cancer; Panitumumab; Sequential treatment

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BIOLOGICAL PRODUCT; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; IRINOTECAN; PANITUMUMAB; RAMUCIRUMAB; RAS PROTEIN; VASCULOTROPIN; VASCULOTROPIN A;

EID: 84964335444     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-016-3032-8     Document Type: Review
Times cited : (32)

References (51)
  • 1
    • 84882937605 scopus 로고    scopus 로고
    • Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRASwildtype metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3)
    • Heinemann V, von Weikersthal LF, Decker T et al (2013) Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRASwildtype metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3). Proc Am Soc Clin Oncol 31:LBA3506
    • (2013) Proc Am Soc Clin Oncol , vol.31 , pp. 3506
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3
  • 2
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BC2cXhsFKntLnJ, PID: 24687833
    • Schwartzberg LS, Rivera F, Karthaus M et al (2014) PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol 32:2240–2247
    • (2014) J Clin Oncol , vol.32 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3
  • 3
    • 84907027361 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5- FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
    • Venook AP, Niedzwiecki D, Lenz HJ et al (2014) CALGB/SWOG 80405: phase III trial of irinotecan/5- FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC). Proc Am Soc Clin Oncol 32(suppl):LBA3
    • (2014) Proc Am Soc Clin Oncol , vol.32 , pp. 3
    • Venook, A.P.1    Niedzwiecki, D.2    Lenz, H.J.3
  • 4
    • 77955179588 scopus 로고    scopus 로고
    • Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells
    • PID: 20532039
    • Zeng M, Kikuchi H, Pino MS, Chung DC (2010) Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One 5(6):e10966
    • (2010) PLoS One , vol.5 , Issue.6 , pp. 10966
    • Zeng, M.1    Kikuchi, H.2    Pino, M.S.3    Chung, D.C.4
  • 5
    • 78649952814 scopus 로고    scopus 로고
    • Mac Gabhann F, Popel AS. Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    • COI: 1:CAS:528:DC%2BC3cXhsFamurjI, PID: 21118974
    • Stefanini MO, Wu FT (2010) Mac Gabhann F, Popel AS. Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model. Cancer Res 70(23):9886–9894
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9886-9894
    • Stefanini, M.O.1    Wu, F.T.2
  • 6
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • COI: 1:CAS:528:DC%2BC3cXivFartLY%3D, PID: 20008624
    • Kopetz S, Hoff PM, Morris JS et al (2010) Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 28(3):453–459
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 7
    • 84961672293 scopus 로고    scopus 로고
    • Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer? Oncotarget. doi:10.18632/oncotarget.7008
    • Derangère V, Fumet JD, Boidot R et al (2016) Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer? Oncotarget. doi:10.18632/oncotarget.7008. [Epub ahead of print]
    • (2016) [Epub ahead of print]
    • Derangère, V.1    Fumet, J.D.2    Boidot, R.3
  • 8
    • 84873160542 scopus 로고    scopus 로고
    • Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
    • COI: 1:CAS:528:DC%2BC3sXjvVOktb0%3D, PID: 23301832
    • Mimeault M, Batra SK (2013) Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells. J Cell Mol Med 17(1):30–54
    • (2013) J Cell Mol Med , vol.17 , Issue.1 , pp. 30-54
    • Mimeault, M.1    Batra, S.K.2
  • 9
    • 84953403252 scopus 로고    scopus 로고
    • Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer. Oncotarget. doi:10.18632/oncotarget.6293
    • Zhou J, Wang J, Zeng Y et al (2015) Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer. Oncotarget. doi:10.18632/oncotarget.6293. [Epub ahead of print]
    • (2015) [Epub ahead of print]
    • Zhou, J.1    Wang, J.2    Zeng, Y.3
  • 10
    • 84936748494 scopus 로고    scopus 로고
    • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
    • COI: 1:CAS:528:DC%2BC2MXhtFeisrrI, PID: 26030179
    • Siravegna G, Mussolin B, Buscarino M et al (2015) Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat Med 21(7):795–801
    • (2015) Nat Med , vol.21 , Issue.7 , pp. 795-801
    • Siravegna, G.1    Mussolin, B.2    Buscarino, M.3
  • 11
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    • COI: 1:CAS:528:DC%2BD3MXmt12kt7g%3D, PID: 11507052
    • Zhang X, Gaspard JP, Chung DC (2001) Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61(16):6050–6054
    • (2001) Cancer Res , vol.61 , Issue.16 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 12
    • 52649143725 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    • COI: 1:CAS:528:DC%2BD1cXpslKgt7s%3D, PID: 18694994
    • Bianco R, Rosa R, Damiano V et al (2008) Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. Clin Cancer Res 14(16):5069–5080
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5069-5080
    • Bianco, R.1    Rosa, R.2    Damiano, V.3
  • 13
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    • COI: 1:CAS:528:DC%2BD2cXovVKitw%3D%3D, PID: 14760102
    • Ciardiello F, Bianco R, Caputo R et al (2004) Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 10(2):784–793
    • (2004) Clin Cancer Res , vol.10 , Issue.2 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3
  • 14
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD3MXltVequ70%3D, PID: 11431346
    • Viloria-Petit A, Crombet T, Jothy S et al (2001) Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 61(13):5090–6101
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5090-6101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3
  • 15
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhtlahs7nK, PID: 25088940
    • Heinemann V, von Weikersthal LF, Decker T et al (2014) FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 15(10):1065–1075
    • (2014) Lancet Oncol. , vol.15 , Issue.10 , pp. 1065-1075
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3
  • 16
    • 84923199426 scopus 로고    scopus 로고
    • Lba11:independent radiological evaluation of objective response, early tumor shrinkage, and depth of response in fire-3 (aio krk-0306) in the final ras evaluable population
    • PID: 25411415
    • Stintzing S, Modest DP, von Weikersthal LF et al (2014) Lba11:independent radiological evaluation of objective response, early tumor shrinkage, and depth of response in fire-3 (aio krk-0306) in the final ras evaluable population. Ann Oncol. doi:10.1093/annonc/mdu438.9
    • (2014) Ann Oncol
    • Stintzing, S.1    Modest, D.P.2    von Weikersthal, L.F.3
  • 17
    • 84979915331 scopus 로고    scopus 로고
    • PD-014. First-line treatment with modified FOLFOX6 (mFOLFOX6) + panitumumab or bevacizumab in patients with RAS/BRAF wild-type (WT) metastatic colorectal carcinoma (mCRC)
    • Rivera F, Koukakis R, Karthaus M, Hecht et al (2015) PD-014. First-line treatment with modified FOLFOX6 (mFOLFOX6) + panitumumab or bevacizumab in patients with RAS/BRAF wild-type (WT) metastatic colorectal carcinoma (mCRC). Ann Oncol 26(suppl 4):101–107
    • (2015) Ann Oncol , vol.26 , pp. 101-107
    • Rivera, F.1    Koukakis, R.2    Karthaus, M.3    Hecht4
  • 18
    • 84939475603 scopus 로고    scopus 로고
    • Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC)
    • PID: 26188850
    • Heinemann V, Stintzing S, Modest DP et al (2015) Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC). Eur J Cancer 51(14):1927–1936
    • (2015) Eur J Cancer , vol.51 , Issue.14 , pp. 1927-1936
    • Heinemann, V.1    Stintzing, S.2    Modest, D.P.3
  • 19
    • 84947436561 scopus 로고    scopus 로고
    • Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial: first-line therapy with FOLFIRI plus Cetuximab or Bevacizumab in patients with KRAS wild-type tumors in metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BC28XhtVSntbzP, PID: 26261259
    • Modest DP, Stintzing S, von Weikersthal LF et al (2015) Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial: first-line therapy with FOLFIRI plus Cetuximab or Bevacizumab in patients with KRAS wild-type tumors in metastatic colorectal cancer. J Clin Oncol 33(32):3718–3726
    • (2015) J Clin Oncol , vol.33 , Issue.32 , pp. 3718-3726
    • Modest, D.P.1    Stintzing, S.2    von Weikersthal, L.F.3
  • 20
    • 84937204003 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5-fu/leucovorin (FOLFIRI) or oxaliplatin/5-fu/leucovorin (mFOLFOX6) with bevacizumab (bv) or cetuximab (cet) for patients (pts) with kras wild-type (wt) untreated metastatic adenocarcinoma of the colon
    • Venook A, Niedzwiecki D, Lenz HJ et al (2015) CALGB/SWOG 80405: phase III trial of irinotecan/5-fu/leucovorin (FOLFIRI) or oxaliplatin/5-fu/leucovorin (mFOLFOX6) with bevacizumab (bv) or cetuximab (cet) for patients (pts) with kras wild-type (wt) untreated metastatic adenocarcinoma of the colon. Ann Oncol 25(suppl 2):ii112–ii113
    • (2015) Ann Oncol , vol.25 , pp. ii112-ii113
    • Venook, A.1    Niedzwiecki, D.2    Lenz, H.J.3
  • 21
    • 84929519878 scopus 로고    scopus 로고
    • Role of first-line anti-epidermal growth factor receptor therapy compared with anti-vascular endothelial growth factor therapy in advanced colorectal cancer: a meta-analysis of randomized clinical trials
    • PID: 25666296
    • Khattak MA, Martin H, Davidson A, Phillips M (2015) Role of first-line anti-epidermal growth factor receptor therapy compared with anti-vascular endothelial growth factor therapy in advanced colorectal cancer: a meta-analysis of randomized clinical trials. Clin Colorectal Cancer 14(2):81–90
    • (2015) Clin Colorectal Cancer , vol.14 , Issue.2 , pp. 81-90
    • Khattak, M.A.1    Martin, H.2    Davidson, A.3    Phillips, M.4
  • 22
    • 84942198699 scopus 로고    scopus 로고
    • First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
    • PID: 26088456
    • Pietrantonio F, Cremolini C, Petrelli F et al (2015) First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Crit Rev Oncol Hematol 96(1):156–166
    • (2015) Crit Rev Oncol Hematol , vol.96 , Issue.1 , pp. 156-166
    • Pietrantonio, F.1    Cremolini, C.2    Petrelli, F.3
  • 23
    • 85020159604 scopus 로고    scopus 로고
    • Anti-EGFR or Bevacizumab in first line treatment of RAS wild type metastatic colorectal neoplasm (RwtMCRC): meta-analysis of randomized clincal trials
    • Tamburini E, Rudnas B, Gianni L et al (2015) Anti-EGFR or Bevacizumab in first line treatment of RAS wild type metastatic colorectal neoplasm (RwtMCRC): meta-analysis of randomized clincal trials. Ann Oncol 26(suppl 6):vi36–vi52
    • (2015) Ann Oncol , vol.26 , pp. vi36-vi52
    • Tamburini, E.1    Rudnas, B.2    Gianni, L.3
  • 24
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BD1cXntVOltrk%3D, PID: 18390971
    • Sobrero AF, Maurel J, Fehrenbacher L et al (2008) EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 26(14):2311–2319
    • (2008) J Clin Oncol , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 25
    • 77149166461 scopus 로고    scopus 로고
    • Analysis of k-ras mutations in patients with metastatic colorectal cancer receiving cetuximab in combination with irinotecan: results from the epic trial
    • Langer C, Kopit J, Awad M et al (2008) Analysis of k-ras mutations in patients with metastatic colorectal cancer receiving cetuximab in combination with irinotecan: results from the epic trial. Ann Oncol 19(Supplement):8. doi:10.1093/annonc/mdn507.viii.133
    • (2008) Ann Oncol , vol.19 , pp. 8
    • Langer, C.1    Kopit, J.2    Awad, M.3
  • 26
    • 84879786289 scopus 로고    scopus 로고
    • Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
    • COI: 1:CAS:528:DC%2BC3sXosVOntr4%3D, PID: 23725851
    • Seymour MT, Brown SR, Middleton G et al (2013) Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial. Lancet Oncol. 14(8):749–759
    • (2013) Lancet Oncol. , vol.14 , Issue.8 , pp. 749-759
    • Seymour, M.T.1    Brown, S.R.2    Middleton, G.3
  • 27
    • 84899940235 scopus 로고    scopus 로고
    • Final results from a randomized phase 3 study of FOLFIRI ± panitumumab for second-line treatment of metastatic colorectal cancer
    • COI: 1:STN:280:DC%2BC2c3ovFGiuw%3D%3D, PID: 24356622
    • Peeters M, Price TJ, Cervantes A et al (2014) Final results from a randomized phase 3 study of FOLFIRI ± panitumumab for second-line treatment of metastatic colorectal cancer. Ann Oncol 25(1):107–116
    • (2014) Ann Oncol , vol.25 , Issue.1 , pp. 107-116
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 28
    • 84954163383 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BC2MXitVKjs7vF, PID: 26341920
    • Peeters M, Oliner KS, Price TJ et al (2015) Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer. Clin Cancer Res 21(24):5469–5479
    • (2015) Clin Cancer Res , vol.21 , Issue.24 , pp. 5469-5479
    • Peeters, M.1    Oliner, K.S.2    Price, T.J.3
  • 29
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the eastern cooperative oncology group study E3200
    • COI: 1:CAS:528:DC%2BD2sXlsVyntbc%3D, PID: 17442997
    • Giantonio BJ, Catalano PJ, Meropol NJ et al (2007) Bevacizumab in combination with oxaliplatin fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the eastern cooperative oncology group study E3200. J Clin Oncol 25(12):1539–1544
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 30
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • PID: 22949147
    • Van Cutsem E, Tabernero J, Lakomy R et al (2012) Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 30(28):3499–3506
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 31
    • 84891831211 scopus 로고    scopus 로고
    • Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial
    • COI: 1:CAS:528:DC%2BC3sXhs1Ojs7vM, PID: 24140268
    • Tabernero J, Van Cutsem E, Lakomý R et al (2014) Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial. Eur J Cancer 50(2):320–331
    • (2014) Eur J Cancer , vol.50 , Issue.2 , pp. 320-331
    • Tabernero, J.1    Van Cutsem, E.2    Lakomý, R.3
  • 32
    • 84871720057 scopus 로고    scopus 로고
    • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC3sXhsV2gug%3D%3D, PID: 23168366
    • Bennouna J, Sastre J, Arnold D et al (2013) Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 14(1):29–37
    • (2013) Lancet Oncol. , vol.14 , Issue.1 , pp. 29-37
    • Bennouna, J.1    Sastre, J.2    Arnold, D.3
  • 33
    • 84933673498 scopus 로고    scopus 로고
    • Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study
    • COI: 1:CAS:528:DC%2BC2MXmsFSgu7w%3D, PID: 25877855
    • Tabernero J, Yoshino T, Cohn AL et al (2015) Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study. Lancet Oncol. 16(5):499–508
    • (2015) Lancet Oncol. , vol.16 , Issue.5 , pp. 499-508
    • Tabernero, J.1    Yoshino, T.2    Cohn, A.L.3
  • 34
    • 85053263302 scopus 로고    scopus 로고
    • A phase III multicenter trial comparing two different sequences of second/third line therapy (cetuximab/irinotecan followed by FOLFOX versus FOLFOX followed by cetuximab/irinotecan) in metastatic K-RAS wt colorectal cancer (mCC) patients, refractory to FOLFIRI/Bevacizumab)
    • Cascinu S, Lonardi S, Rosati G et al (2015) A phase III multicenter trial comparing two different sequences of second/third line therapy (cetuximab/irinotecan followed by FOLFOX versus FOLFOX followed by cetuximab/irinotecan) in metastatic K-RAS wt colorectal cancer (mCC) patients, refractory to FOLFIRI/Bevacizumab. Eur J Cancer 51(suppl 3):S329
    • (2015) Eur J Cancer , vol.51 , pp. 329
    • Cascinu, S.1    Lonardi, S.2    Rosati, G.3
  • 35
    • 84929331013 scopus 로고    scopus 로고
    • SPIRITT: a randomized, multicenter, phase II study of panitumumab with FOLFIRI and bevacizumab with FOLFIRI as second-line treatment in patients with unresectable wild type KRAS metastatic colorectal cancer
    • PID: 25982297
    • Hecht JR, Cohn A, Dakhil S et al (2015) SPIRITT: a randomized, multicenter, phase II study of panitumumab with FOLFIRI and bevacizumab with FOLFIRI as second-line treatment in patients with unresectable wild type KRAS metastatic colorectal cancer. Clin Colorectal Cancer. 14(2):72–80
    • (2015) Clin Colorectal Cancer. , vol.14 , Issue.2 , pp. 72-80
    • Hecht, J.R.1    Cohn, A.2    Dakhil, S.3
  • 36
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • COI: 1:CAS:528:DC%2BD1cXht12nu77J, PID: 18946061
    • Karapetis CS, Khambata-Ford S, Jonker DJ et al (2008) K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359(17):1757–1765
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 37
    • 79952419581 scopus 로고    scopus 로고
    • Systemic therapy for metastatic colorectal cancer: patterns of chemotherapy and biologic therapy use in US medical oncology practice
    • PID: 21358960
    • Hess GP, Wang PF, Quach D et al (2010) Systemic therapy for metastatic colorectal cancer: patterns of chemotherapy and biologic therapy use in US medical oncology practice. J Oncol Pract. 6(6):301–307
    • (2010) J Oncol Pract. , vol.6 , Issue.6 , pp. 301-307
    • Hess, G.P.1    Wang, P.F.2    Quach, D.3
  • 38
    • 84893877419 scopus 로고    scopus 로고
    • Chemotherapy usage patterns in a US-wide cohort of patients with metastatic colorectal cancer
    • PID: 24511107
    • Abrams TA, Meyer G, Schrag D et al (2014) Chemotherapy usage patterns in a US-wide cohort of patients with metastatic colorectal cancer. J Natl Cancer Inst 106(2):djt371
    • (2014) J Natl Cancer Inst , vol.106 , Issue.2 , pp. 371
    • Abrams, T.A.1    Meyer, G.2    Schrag, D.3
  • 39
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fl uorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • COI: 1:CAS:528:DC%2BD2cXpsVGktLo%3D, PID: 15051767
    • Grothey A, Sargent D, Goldberg RM, Schmoll HJ (2004) Survival of patients with advanced colorectal cancer improves with the availability of fl uorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 22:1209–1214
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.J.4
  • 40
    • 84908139591 scopus 로고    scopus 로고
    • Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
    • PID: 25337750
    • Loupakis F, Cremolini C, Masi G et al (2014) Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med 371(17):1609–1618
    • (2014) N Engl J Med , vol.371 , Issue.17 , pp. 1609-1618
    • Loupakis, F.1    Cremolini, C.2    Masi, G.3
  • 41
    • 84953856186 scopus 로고    scopus 로고
    • FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study
    • COI: 1:CAS:528:DC%2BC2MXhsVOntL3F, PID: 26338525
    • Cremolini C, Loupakis F, Antoniotti C et al (2015) FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study. Lancet Oncol. 16(13):1306–1315
    • (2015) Lancet Oncol. , vol.16 , Issue.13 , pp. 1306-1315
    • Cremolini, C.1    Loupakis, F.2    Antoniotti, C.3
  • 42
    • 84938086499 scopus 로고    scopus 로고
    • Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord Ovest
    • COI: 1:STN:280:DC%2BC2MrosVGjsQ%3D%3D, PID: 25712456
    • Cremolini C, Loupakis F, Antoniotti C et al (2015) Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord Ovest. Ann Oncol 26(6):1188–1194
    • (2015) Ann Oncol , vol.26 , Issue.6 , pp. 1188-1194
    • Cremolini, C.1    Loupakis, F.2    Antoniotti, C.3
  • 43
    • 84926460438 scopus 로고    scopus 로고
    • Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomised phase II trial
    • COI: 1:STN:280:DC%2BC2MvhvVWhsw%3D%3D, PID: 25538173
    • Gruenberger T, Bridgewater J, Chau I et al (2015) Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomised phase II trial. Ann Oncol 26(4):702–708
    • (2015) Ann Oncol , vol.26 , Issue.4 , pp. 702-708
    • Gruenberger, T.1    Bridgewater, J.2    Chau, I.3
  • 44
    • 79551520348 scopus 로고    scopus 로고
    • Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3MXhs1Chsbs%3D, PID: 21285426
    • Ranpura V, Hapani S, Wu S (2011) Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 305(5):487–494
    • (2011) JAMA , vol.305 , Issue.5 , pp. 487-494
    • Ranpura, V.1    Hapani, S.2    Wu, S.3
  • 45
    • 77950495095 scopus 로고    scopus 로고
    • Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BC3cXksFSqtbc%3D, PID: 20142600
    • Lacouture ME, Mitchell EP, Piperdi B et al (2010) Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol 28(8):1351–1357
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1351-1357
    • Lacouture, M.E.1    Mitchell, E.P.2    Piperdi, B.3
  • 46
    • 84923094904 scopus 로고    scopus 로고
    • Randomized controlled trial on the skin toxicity of panitumumab in Japanese patients with metastatic colorectal cancer: hGCSG1001 study
    • COI: 1:CAS:528:DC%2BC2MXislGhsbw%3D, PID: 25686117
    • Kobayashi Y, Komatsu Y, Yuki S et al (2015) Randomized controlled trial on the skin toxicity of panitumumab in Japanese patients with metastatic colorectal cancer: hGCSG1001 study. J-STEPP. Future Oncol. 11(4):617–627
    • (2015) J-STEPP. Future Oncol. , vol.11 , Issue.4 , pp. 617-627
    • Kobayashi, Y.1    Komatsu, Y.2    Yuki, S.3
  • 47
    • 84961173961 scopus 로고    scopus 로고
    • Pan canadian rash trial: a randomized phase III trial evaluating the impact of a prophylactic skin treatment regimen on epidermal growth factor receptor-tyrosine kinase inhibitor-induced skin toxicities in patients with metastatic lung cancer
    • Melosky B, Anderson H, Burkes RL et al (2015) Pan canadian rash trial: a randomized phase III trial evaluating the impact of a prophylactic skin treatment regimen on epidermal growth factor receptor-tyrosine kinase inhibitor-induced skin toxicities in patients with metastatic lung cancer. J Clin Oncol. pii: JCO.2015.62.3918. [Epub ahead of print]
    • (2015) J Clin Oncol. pii: JCO.2015 , vol.3918 , Issue.[Epub ahead of print] , pp. 62
    • Melosky, B.1    Anderson, H.2    Burkes, R.L.3
  • 48
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • PID: 19339720
    • Van Cutsem E, Köhne CH, Hitre E et al (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360(14):1408–1417
    • (2009) N Engl J Med , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 49
    • 84872115684 scopus 로고    scopus 로고
    • Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorin
    • PID: 23116683
    • Láng I, Köhne CH, Folprecht G et al (2013) Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorin. Eur J Cancer 49(2):439–448
    • (2013) Eur J Cancer , vol.49 , Issue.2 , pp. 439-448
    • Láng, I.1    Köhne, C.H.2    Folprecht, G.3
  • 50
    • 84930872726 scopus 로고    scopus 로고
    • Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BC2MXht1elsr3N, PID: 25989278
    • Rowland A, Dias MM, Wiese MD, Kichenadasse G, McKinnon RA, Karapetis CS, Sorich MJ (2015) Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer. Br J Cancer 112(12):1888–1894
    • (2015) Br J Cancer , vol.112 , Issue.12 , pp. 1888-1894
    • Rowland, A.1    Dias, M.M.2    Wiese, M.D.3    Kichenadasse, G.4    McKinnon, R.A.5    Karapetis, C.S.6    Sorich, M.J.7
  • 51
    • 84979929813 scopus 로고    scopus 로고
    • PARADIGM study: A multicenter, randomized, phase III study of 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab or bevacizumab as first-line treatment in patients with RAS (KRAS/NRAS) wild-type metastatic colorectal cancer
    • Yoshino T, Uetake H, Tsuchihara K et al. (2016) PARADIGM study: A multicenter, randomized, phase III study of 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab or bevacizumab as first-line treatment in patients with RAS (KRAS/NRAS) wild-type metastatic colorectal cancer. J Clin Oncol 34, (suppl 4S; abstr TPS776)
    • (2016) J Clin Oncol , vol.34
    • Yoshino, T.1    Uetake, H.2    Tsuchihara, K.3


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