메뉴 건너뛰기




Volumn 96, Issue 1, 2015, Pages 156-166

First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis

Author keywords

Bevacizumab; Cetuximab; Colorectal cancer; Overall survival; Panitumumab; Randomized clinical trials

Indexed keywords

BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; MONOCLONAL ANTIBODY; OXALIPLATIN; PANITUMUMAB; RAS PROTEIN;

EID: 84942198699     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2015.05.016     Document Type: Review
Times cited : (72)

References (47)
  • 2
    • 84861198824 scopus 로고    scopus 로고
    • Biologic therapies in the metastatic colorectal cancer treatment continuum: applying current evidence to clinical practice
    • Peeters M., Price T. Biologic therapies in the metastatic colorectal cancer treatment continuum: applying current evidence to clinical practice. Cancer Treat Rev 2012, 38:397-406.
    • (2012) Cancer Treat Rev , vol.38 , pp. 397-406
    • Peeters, M.1    Price, T.2
  • 3
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 4
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
    • Douillard J.Y., Siena S., Cassidy J., et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010, 28:4697-4705.
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 5
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials
    • Bokemeyer C., Van Cutsem E., Rougier P., et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer 2012, 48:1466-1475.
    • (2012) Eur J Cancer , vol.48 , pp. 1466-1475
    • Bokemeyer, C.1    Van Cutsem, E.2    Rougier, P.3
  • 6
    • 84857993465 scopus 로고    scopus 로고
    • Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer: meta-analytical estimation and implications for therapeutic strategies
    • Loupakis F., Cremolini C., Salvatore L., et al. Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer: meta-analytical estimation and implications for therapeutic strategies. Cancer 2012, 118:1523-1532.
    • (2012) Cancer , vol.118 , pp. 1523-1532
    • Loupakis, F.1    Cremolini, C.2    Salvatore, L.3
  • 7
    • 21244450758 scopus 로고    scopus 로고
    • Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab
    • Ince W.L., Jubb A.M., Holden S.N., et al. Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab. J Natl Cancer Inst 2005, 97:981-989.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 981-989
    • Ince, W.L.1    Jubb, A.M.2    Holden, S.N.3
  • 8
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker D.J., O'Callaghan C.J., Karapetis C.S., et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007, 357:2040-2048.
    • (2007) N Engl J Med , vol.357 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 9
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26:5705-5712.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 10
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F., Lampis A., Orsenigo M., et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol 2009, 20:84-90.
    • (2009) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3
  • 11
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • De Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11:753-762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 12
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard J.Y., Oliner K.S., Siena S., et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013, 369:1023-1034.
    • (2013) N Engl J Med , vol.369 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 13
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
    • Schwartzberg L.S., Rivera F., Karthaus M., et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol 2014, 32:2240-2247.
    • (2014) J Clin Oncol , vol.32 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3
  • 14
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial
    • Heinemann V., von Weikersthal L.F., Decker T., et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 2014, 15:1065-1075.
    • (2014) Lancet Oncol , vol.15 , pp. 1065-1075
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3
  • 15
    • 84879786289 scopus 로고    scopus 로고
    • Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
    • Seymour M.T., Brown S.R., Middleton G., et al. Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial. Lancet Oncol 2013, 14:749-759.
    • (2013) Lancet Oncol , vol.14 , pp. 749-759
    • Seymour, M.T.1    Brown, S.R.2    Middleton, G.3
  • 16
    • 84877087305 scopus 로고    scopus 로고
    • Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer
    • Peeters M., Oliner K.S., Parker A., et al. Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer. Clin Cancer Res 2013, 19:1902-1912.
    • (2013) Clin Cancer Res , vol.19 , pp. 1902-1912
    • Peeters, M.1    Oliner, K.S.2    Parker, A.3
  • 17
    • 84907023716 scopus 로고    scopus 로고
    • Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab
    • suppl
    • Ciardiello F., Lenz H.J., Kohne C.H., et al. Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab. J Clin Oncol 2014, 32(5s). (suppl; abstr 3506).
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Ciardiello, F.1    Lenz, H.J.2    Kohne, C.H.3
  • 18
    • 84901777464 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS mutations in phase 3 study 20050181 of panitumumab (pmab) plus FOLFIRI versus FOLFIRI for second-line treatment (tx) of metastatic colorectal cancer (mCRC)
    • suppl
    • Peeters M., Oliner K.S., Price T.J., et al. Analysis of KRAS/NRAS mutations in phase 3 study 20050181 of panitumumab (pmab) plus FOLFIRI versus FOLFIRI for second-line treatment (tx) of metastatic colorectal cancer (mCRC). J Clin Oncol 2014, 32(5s). (suppl; abstr LBA387).
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Peeters, M.1    Oliner, K.S.2    Price, T.J.3
  • 19
    • 84942203693 scopus 로고    scopus 로고
    • The summary for product characteristics for cetuximab
    • The summary for product characteristics for cetuximab available at: 〈http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000558/human_med_000769.jsp&mid=WC0b01ac058001d124〉.
  • 20
    • 84942203694 scopus 로고    scopus 로고
    • The summary for product characteristics for panitumumab
    • The summary for product characteristics for panitumumab available at: 〈http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000741/human_med_001128.jsp&mid=WC0b01ac058001d124〉.
  • 21
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: is blinding necessary?
    • Jadad A.R., Moore R.A., Carroll D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 1996, 17:1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 22
    • 69449100622 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009, 339:b2535. PRISMA Group.
    • (2009) BMJ , vol.339 , pp. b2535
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 23
    • 0023886868 scopus 로고
    • Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates
    • Morris J.A., Gardner M.J. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. Br Med J (Clin Res Ed) 1988, 296:313-1316.
    • (1988) Br Med J (Clin Res Ed) , vol.296 , pp. 313-1316
    • Morris, J.A.1    Gardner, M.J.2
  • 24
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins J.P., Thompson S.G., Deeks J.J., et al. Measuring inconsistency in meta-analyses. BMJ 2003, 327:557-560.
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3
  • 26
    • 84888358440 scopus 로고    scopus 로고
    • The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen
    • Review Manager (RevMan) [Computer program]. Version 5.2 2012, The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen, Available at: 〈http://ims.cochrane.org/revman/download〉.
    • (2012) [Computer program]. Version 5.2
  • 27
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
    • Maughan T.S., Adams R.A., Smith C.G., et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011, 377:2103-2114.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 28
    • 84907023716 scopus 로고    scopus 로고
    • Treatment outcome according to tumor RAS mutation status in OPUS study patients with metastatic colorectal cancer (mCRC) randomized to FOLFOX4 with/without cetuximab
    • suppl
    • Bokemeyer C., Kohne C.H., Ciardiello F., et al. Treatment outcome according to tumor RAS mutation status in OPUS study patients with metastatic colorectal cancer (mCRC) randomized to FOLFOX4 with/without cetuximab. J Clin Oncol 2014, 32(5s). (suppl; abstr 3505).
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Bokemeyer, C.1    Kohne, C.H.2    Ciardiello, F.3
  • 29
    • 84937204003 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: PHASE III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
    • suppl
    • Lenz H., Niedzwiecki D., Innocenti F., et al. CALGB/SWOG 80405: PHASE III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (MCRC). Ann Oncol 2014, 25(4s). (suppl; abstr 501O).
    • (2014) Ann Oncol , vol.25 , Issue.4 S
    • Lenz, H.1    Niedzwiecki, D.2    Innocenti, F.3
  • 30
    • 84923199426 scopus 로고    scopus 로고
    • Independent radiological evaluation of objective response rate, early tumor shrinkage, and depth of response in FIRE-3 (AIO KRK-0306) in the final RAS evaluable population
    • suppl
    • Stintzing F., Modest D.P., Fischer von Weikersthal L., et al. Independent radiological evaluation of objective response rate, early tumor shrinkage, and depth of response in FIRE-3 (AIO KRK-0306) in the final RAS evaluable population. Ann Oncol 2014, 25(4s). (suppl; abstr LBA11).
    • (2014) Ann Oncol , vol.25 , Issue.4 S
    • Stintzing, F.1    Modest, D.P.2    Fischer von Weikersthal, L.3
  • 31
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344:783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 32
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J., Cortés J., Kim S.B., et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012, 366:109-119.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 33
    • 84857414572 scopus 로고    scopus 로고
    • Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials
    • Petrelli F., Borgonovo K., Cabiddu M., et al. Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials. Clin Lung Cancer 2012, 13:107-114.
    • (2012) Clin Lung Cancer , vol.13 , pp. 107-114
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3
  • 34
    • 84906221716 scopus 로고    scopus 로고
    • First-line crizotinib versus pemetrexed-cisplatin or pemetrexed-carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014)
    • suppl
    • Mok T., Kim D.W., Wu Y.L., et al. First-line crizotinib versus pemetrexed-cisplatin or pemetrexed-carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014). J Clin Oncol 2014, 32(5s). (suppl; abstr 8002).
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Mok, T.1    Kim, D.W.2    Wu, Y.L.3
  • 35
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman P.B., Hauschild A., Robert C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364:2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 36
    • 84929141867 scopus 로고    scopus 로고
    • Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials
    • Sorich M.J., Wiese M.D., Rowland A., et al. Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials. Ann Oncol. 2015, 26:13-21.
    • (2015) Ann Oncol. , vol.26 , pp. 13-21
    • Sorich, M.J.1    Wiese, M.D.2    Rowland, A.3
  • 37
    • 58749087713 scopus 로고    scopus 로고
    • Toxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience
    • Adams R.A., Meade A.M., Madi A., et al. Toxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience. Br J Cancer 2009, 100:251-258.
    • (2009) Br J Cancer , vol.100 , pp. 251-258
    • Adams, R.A.1    Meade, A.M.2    Madi, A.3
  • 38
    • 84861656612 scopus 로고    scopus 로고
    • Does anti-EGFR therapy improve outcome in advanced colorectal cancer?. A systematic review and meta-analysis
    • Vale C.L., Tierney J.F., Fisher D., et al. Does anti-EGFR therapy improve outcome in advanced colorectal cancer?. A systematic review and meta-analysis. Cancer Treat Rev 2012, 38:618-625.
    • (2012) Cancer Treat Rev , vol.38 , pp. 618-625
    • Vale, C.L.1    Tierney, J.F.2    Fisher, D.3
  • 39
    • 84911474269 scopus 로고    scopus 로고
    • Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Van Cutsem E., Cervantes A., Nordlinger B., et al. Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014, 25(3s suppl.).
    • (2014) Ann Oncol , vol.25 , Issue.3 S SUPPL.
    • Van Cutsem, E.1    Cervantes, A.2    Nordlinger, B.3
  • 40
    • 84884700039 scopus 로고    scopus 로고
    • Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial
    • Cunningham D., Lang I., Marcuello E., et al. Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncol 2013, 14:1077-1085.
    • (2013) Lancet Oncol , vol.14 , pp. 1077-1085
    • Cunningham, D.1    Lang, I.2    Marcuello, E.3
  • 41
    • 84908139591 scopus 로고    scopus 로고
    • Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
    • Loupakis F., Cremolini C., Masi G., et al. Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med 2014, 371:1609-1618.
    • (2014) N Engl J Med , vol.371 , pp. 1609-1618
    • Loupakis, F.1    Cremolini, C.2    Masi, G.3
  • 42
    • 84861199721 scopus 로고    scopus 로고
    • Recommendations on management of EGFR inhibitor-induced skin toxicity: a systematic review
    • Baas J.M., Krens L.L., Guchelaar H.J., et al. Recommendations on management of EGFR inhibitor-induced skin toxicity: a systematic review. Cancer Treat Rev 2012, 38:505-514.
    • (2012) Cancer Treat Rev , vol.38 , pp. 505-514
    • Baas, J.M.1    Krens, L.L.2    Guchelaar, H.J.3
  • 43
    • 0034729931 scopus 로고    scopus 로고
    • Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis-Meta-Analysis Group in Cancer
    • Buyse M., Thirion P., Carlson R.W., et al. Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis-Meta-Analysis Group in Cancer. Lancet 2000, 356:373-378.
    • (2000) Lancet , vol.356 , pp. 373-378
    • Buyse, M.1    Thirion, P.2    Carlson, R.W.3
  • 44
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
    • Mao C., Yang Z.Y., Hu X.F., et al. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012, 23:1518-1525.
    • (2012) Ann Oncol , vol.23 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3
  • 45
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • Bardelli A., Corso S., Bertotti A., et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov 2013, 3:658-673.
    • (2013) Cancer Discov , vol.3 , pp. 658-673
    • Bardelli, A.1    Corso, S.2    Bertotti, A.3
  • 46
    • 84862772839 scopus 로고    scopus 로고
    • A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
    • Bertotti A., Migliardi G., Galimi F., et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov 2011, 1:508-523.
    • (2011) Cancer Discov , vol.1 , pp. 508-523
    • Bertotti, A.1    Migliardi, G.2    Galimi, F.3
  • 47
    • 84898875151 scopus 로고    scopus 로고
    • Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status
    • Pietrantonio F., Maggi C., Di Bartolomeo M., et al. Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status. PLoS ONE 2014, 9:e92147.
    • (2014) PLoS ONE , vol.9 , pp. e92147
    • Pietrantonio, F.1    Maggi, C.2    Di Bartolomeo, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.