Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Zeng, Min ^a   Kikuchi, Hirotoshi ^a   Pino, Maria S ^a   Chung, Daniel C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; MESSENGER RNA; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; VASCULOTROPIN;

APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL STRAIN CACO 2; CELL STRAIN HT29; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTO ONCOGENE; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION; WILD TYPE;

APOPTOSIS; CELL HYPOXIA; COLONIC NEOPLASMS; GENES, RAS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; RNA, SMALL INTERFERING; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77955179588     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010966     Document Type: Article

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