Primaquine or other 8-aminoquinoline for reducing P. falciparum transmission

Cochrane Database of Systematic Reviews

Volumn 2014, Issue 6, 2014, Pages

  Graves, Patricia M ^a,b   Gelband, Hellen ^c   Garner, Paul ^d  

^a EpiVec Consulting   (United States)

^b JAMES COOK UNIVERSITY   (Australia)

^c Center for Disease Dynamics Economics and Policy   (United States)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 AMINOQUINOLINE DERIVATIVE; ARTEMISININ DERIVATIVE; BULAQUINE; PRIMAQUINE; ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE; CHLOROQUINE; DRUG COMBINATION; FANASIL, PYRIMETHAMINE DRUG COMBINATION; MEFLOQUINE; PYRIMETHAMINE; QUININE; SULFADOXINE;

ADULT; ADVERSE EVENT; ASEXUAL REPRODUCTION; BLOOD TOXICITY; CHILD; COMMUNITY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; EVIDENCE BASED MEDICINE; GAMETOCYTE; HUMAN; INCIDENCE; LOW DRUG DOSE; MALARIA FALCIPARUM; META ANALYSIS; MOSQUITO; PARASITE CLEARANCE; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; QUASI EXPERIMENTAL STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; DRUG COMBINATION; DRUG EFFECTS; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; MALARIA, FALCIPARUM; TRANSMISSION;

ANTIMALARIALS; ARTEMISININS; CHLOROQUINE; DRUG COMBINATIONS; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HUMANS; MALARIA, FALCIPARUM; MEFLOQUINE; PLASMODIUM FALCIPARUM; PRIMAQUINE; PYRIMETHAMINE; QUININE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SULFADOXINE;

EID: 84964313856     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD008152.pub3     Document Type: Review

References (123)

1. Arango EA, Upegui UA, Carmona-Fonseca J. Efficacy of different primaquine-based antimalarial regimens againstPlasmodium falciparum gametocytemia. Acta Tropica 2012;122(2012):177-82.
2. Chen PQ, Li GQ, Guo XB, Fu YX, He KR, Fu LC, et al.A double blind study on the infectivity of gametocytes of P. falciparum in patients treated with mefloquine and Fansimef. Journal of Guangzhou College of Traditional Chinese Medicine 1993;10(1):1-5.
3. Chen PQ, Li GQ, Guo XB. The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin. Chinese Medical Journal 1994;74(4):209-10, 253-4.
4. Chen PQ, Li GQ, Guo XB, He KR, Fu YX, Fu LC, et al.The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin. Chinese Medical Journal 1994;107(9):709-11.
5. El-Sayed B, El-Zaki SE, Babiker H, Gadalla N, Ageep T, Mansour F, et al.A randomized open-label trial of artesunate-sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. PLoS ONE 2007;2(12):e1311.
6. Eziefula AC, Bousema T, Yeung S, Kamya M, Owaraganise A, Gabagaya G, et al.Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial. Lancet Infectious Diseases 2013;14(2):130-9.
7. Eziefula AC, Staedke SG, Yeung S, Webb E, Kamya M, White NJ, et al.Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda. BMJ Open 2013;3(3):e002759.
8. Gogtay NJ, Kamtekar KD, Dalvi SS, Chogle AR, Aigal U, Kshirsagar N. Preliminary report of the evaluation of the gametocytocidal action of bulaquine, in adult patients with acute, Plasmodium falciparum malaria. Annals of Tropical Medicine and Parasitology 2004;98(5):525-8.
9. Gogtay NJ, Kamtekar KD, Dalvi SS, Mehta SS, Chogle AR, Aigal U, et al.A randomized, parallel study of the safety and efficacy of 45 mg primaquine versus 75 mg bulaquine as gametocytocidal agents in adults with blood schizonticide-responsive uncomplicated falciparum malaria [ISCRTN50134587]. BMC Infectious Diseases 2006;6:16.
10. Kamtekar KD, Gogtay NJ, Dalvi SS, Karnad DR, Chogle AR, Aigal U, et al.A prospective study evaluating the efficacy of a single, 45-mg dose of primaquine, as a gametocytocidal agent, in patients with Plasmodium falciparum malaria in Mumbai, India. Annals of Tropical Medicine and Parasitology 2004;98(5):453-8.
11. Khoo KK. The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah. Annals of Tropical Medicine and Parasitology 1981;75(6):591-5.
12. Kolaczinski K, Leslie T, Ali I, Durrani N, Lee S, Barends M, et al.Defining Plasmodium falciparum treatment in South West Asia: a randomized trial comparing artesunate or primaquine combined with chloroquine or SP. PLoS One 2012;7(1):e28957.
13. Lederman ER, Maguire JD, Sumawinata IW, Chand K, Elyazar I, Estiana L, et al.Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia. Malaria Journal 2006;5:108.
14. Pukrittayakamee S, Chotivanich K, Chantra A, Clemens R, Looareesuwan S, White NJ. Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria. Antimicrobial Agents and Chemotherapy 2004;48(4):1329-34.
15. Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, et al.Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs. Malaria Journal 2010;9:136.
16. Shekalaghe S, Drakeley C, Gosling R, Ndaro A, van Meegeren M, Enevold A, et al.Primaquine clears submicroscopicPlasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. PLoS ONE 2007;2(10):e1023.
17. Singhasivanon V, Chongsuphajaisiddhi T, Sabchareon A, Attanath P, Webster HK, Edstein MD, et al.Pharmacokinetic study of mefloquine in Thai children aged 5-12 years suffering from uncomplicated falciparum malaria treated with MSP or MSP plus primaquine. European Journal of Drug Metabolism and Pharmacokinetics 1994;19(1):27-32.
18. Smithuis F, Kyaw MK, Phe O, Win T, Aung PP, Oo AP, et al.Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial. Lancet Infectious Diseases 2010;10(10):673-81.
19. Sutanto I, Suprijanto S, Kosasih A, Dahlan MS, Syafruddin D, Kusriastuti R, et al.The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South Sumatra, Western Indonesia: an open-label, randomized, controlled trial. Clinical Infectious Diseases 2013;56(5):685-93.
20. Vásquez AM, Sanín F, Alvarez LG, Tobón A, Ríos A, Blair S. Therapeutic efficacy of a regimen of artesunate-mefloquine-primaquine treatment for Plasmodium falciparum malaria and treatment effects on gametocytic development [Estudio piloto de la eficacia y de los efectos sobre los gametocitos del esquema artesunato-mefloquina-primaquina para la malaria por Plasmodium falciparum]. Biomedica 2009;29(2):307-19.
21. Wang YS, Brown PP. Clinical study on artemether combined with Primaquine for Pf cases treatment [Chinese]. Tianjin Medical Journal 2006;34(8):538.
22. Baird JK, Wiady I, Sutanihardja A, Suradi, Purnomo, Basri H, et al.Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia. American Journal of Tropical Medicine and Hygiene 2002; Vol. 66, issue 6:659-60.
23. Barber MA, Komp WHW, Newman BM. The effect of small doses of plasmochin on the viability of gametocytes of malaria as measured by mosquito infection experiments. Public Health Reports 1929;44(24):1409-20.
24. Barber MA, Rice JB, Brown JY. Malaria studies on the Firestone Rubber Plantation in Liberia, West Africa. American Journal of Hygiene 1932;15(3):601-33.
25. Brueckner RP, Lasseter KC, Lin ET, Schuster BG. First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial. American Journal of Tropical Medicine & Hygiene 1998;58(5):645-9.
26. Bunnag D, Harinasuta T, Pinichpongse D, Suntharasamai P. Effect of primaquine on gametocytes of Plasmodium falciparum in Thailand. Lancet 1980;2(8185):91.
27. Burgess RW, Bray RS. The effect of a single dose of primaquine upon the gametocytes, gametogony and sporogony of Laverania (=Plasmodium) falciparum. World Health Organization WHO/MAL/271 1960:1-10.
28. Burgess RW, Bray RS. The effect of a single dose of primaquine upon the gametocytes, gametogony and sporogony of Laverania falciparum. Bulletin of the World Health Organization 1961;24:451-6.
29. Cai X, Yang X, He X, Zhan W, Zhan X, Ye B. The combined use of artemether, SP & PQ in the treatment of CQ-resistant Pf [Chinese]. Chinese Journal of Parasitology and Parasitic Diseases 1985;3(2):81-4.
30. Carter N, Pamba A, Duparc S, Waitumbi JN. Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials. Malaria Journal 2011;10:241.
31. Che LG, Huang KG, Yang HL, Yu L, Lin ZL, Huang R. Combined use of pyronaridine, sulfadoxine and primaquine in areas with chloroquine-resistant falciparum malaria. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (Chinese Journal of Parasitology and Parasitic Diseases) 1987;5(3):194-6.
32. Che L, Huang K, Dong Y, Yang H, Yang P. Efficacy of two combined therapies for treatment of chloroquine-resistant P. falciparum [Chinese]. Chinese Journal of Parasitic Disease Control 1990;3(1):24-6.
33. Chevalley S, Coste A, Lopez A, Pipy B, Valentin A. Flow cytometry for the evaluation of anti-plasmodial activity of drugs on Plasmodium falciparum gametocytes. Malaria Journal 2010;9:49.
34. Clyde DF. Mass administration of an antimalarial drug containing 4-aminoquinoline and 8-aminoquinoline in Tanganyika. Bulletin of the World Health Organization 1962;27:203-12.
35. Clyde DF, DuPont HL, Miller RM, McCarthy VC. Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya. Transactions of the Royal Society of Tropical Medicine and Hygiene 1970;64(6):834-8.
36. Clyde DF, Miller RM, Music SI, McCarthy VC. Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam. American Journal of Tropical Medicine and Hygiene 1971;20(1):1-5.
37. da Silva AR, Carneiro EW, dos Santos HJ. Response of human Plasmodium to antimalarials on the island of Saint Louis, State of Maranhão, Brazil. Revista do Instituto de Medecina Tropical de São Paulo 1984;26(3):139-46.
38. Degowin RL, Eppes RB, Powell RD, Carson PE. The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency. Bulletin of the World Health Organization 1966;35(2):165-79.
39. Doi H, Kaneko A, Panjaitan W, Ishii A. Chemotherapeutic malaria control operation by single dose of Fansidar plus primaquine in North Sumatra, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 1989;20(3):341-9.
40. Giao PT, de Vries PJ, Hung le Q, Binh TQ, Nam NV, Kager PA. CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam. Tropical Medicine and International Health 2004;9(2):209-16.
41. Gogtay NJ, Chogle AR, Sorabjee JS, Marathe SN, Kshirsagar NA. Poor gametocytocidal activity of 45 mg primaquine in chloroquine-treated patients with acute, uncomplicated, Plasmodium falciparum malaria in Mumbai (Bombay): an issue of public-health importance. Annals of Tropical Medicine and Parasitology 1999;93(8):813-6.
42. Gunders AE. The effect of a single dose of pyrimethamine and primaquine in combination upon gametocytes and sporogony of Laverania falciparum; Plasmodium falciparum in Liberia. Bulletin of the World Health Organization 1961;24:650-3.
43. Hii JL, Vun YS, Chin KF, Chua R, Tambakau S, Binisol ES, et al.The influence of permethrin-impregnated bednets and mass drug administration on the incidence of Plasmodium falciparum malaria in children in Sabah, Malaysia. Medical and Veterinary Entomology 1987;1(4):397-407.
44. Huang ZS, Fu SG, Cai XZh. Combined use of pyronaridine/SP with primaquine for P. falciparum treatment [Chinese]. Journal of Hainan Medicine 1993;4(1):10-2.
45. Huang Z, Meng F, Fu S. Comparative studies on the treatment of drug-resistant P. falciparum with pyronaridine/SP and primaquine [Chinese]. Chinese Journal Parasitology and Parasitic Disease 1996;14(4):314-7.
46. Huang JR, Gao YQ, Elie N. A study of artemether combined with primaquine in the treatment of falciparum malaria [Chinese]. Chinese Journal of Parasitology and Parasitic Diseases 2001;19(5):308-9.
47. Jeffery GM, Young MD, Eyles DE. The treatment of Plasmodium falciparum infection with chloroquine, with a note on infectivity to mosquitoes of primaquine- and pyrimethamine- treated cases. American Journal of Hygiene 1956;64(1):1-11.
48. Jeffery GM, Collins WE, Skinner JC. Antimalarial drug trials on a multiresistant strain of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene 1963;12:844-50.
49. Jerace F, Giovannola A. The sterilizing action of plasmochina on gametocytes of malaria parasites and its prophylactic importance [L'azzione sterilizzante della plasmochina sui gametociti di parassiti malarigeni e sua importanza profilattica]. Rivista di Malariaologia 1933;12:475.
50. Kaneko A, Kamei K, Suzuki T, Ishii A, Siagian R, Panjaitan W. Gametocytocidal effect of primaquine in a chemotherapeutic malaria control trial in North Sumatra, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 1989;20(3):351-9.
51. Karbwang J, Molunto P, Bunnag D, Harinasuta T. Plasma quinine levels in patients with falciparum malaria when given alone or in combination with tetracycline with or without primaquine. Southeast Asian Journal of Tropical Medicine and Public Health 1991;22(1):72-6.
52. Karbwang J, Na Bangchang K, Thanavibul A, Back DJ, Bunnag D. Pharmacokinetics of mefloquine in the presence of primaquine. European Journal of Clinical Pharmacology 1992;42(5):559-60.
53. Myat-Phone-Kyaw, Myint-Oo, Aung-Naing, Aye-Lwin-Htwe. The use of primaquine in malaria infected patients with red cell glucose phosphate (G6PD) deficiency in Myanmar. Southeast Asian Journal of Tropical Medicine and Public Health 1994;25(4):170-13.
54. Li J, Xiao H, Wang W, Ma W, Rao B. Artemether combined with primaquine for P.falciparum cases treatment [Chinese]. Clinical Medical Journal of China 2007;14(5):736-7.
55. Li WJ, Li XL. Observation of curative effect of falciparum malaria treatment with artemether/lumefantrine and primaquine [Chinese]. Journal of Modern Preventive Medicine 2010;37(5):973-5.
56. Lin L, Wang D-L, Liu B, Hu G. Artemether combined with primaquine for treatment of malaria cases from UN peace force [Chinese]. Chinese Journal of Parasitic Disease Control 2004;17(5):5-6.
57. Mackerras MJ, Ercole QN. Observations on the action of quinine, atebrine and plasmoquine on the gametocytes of Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene 1949;42(5):455-63.
58. Rieckmann KH, McNamara JV, Frischer H, Stockert TA, Carson PE, Powell RD. Gametocytocidal and sporontocidal effects of primaquine and of sulfadiazine with pyrimethamine in a chloroquine-resistant strain of Plasmodium falciparum. Bulletin of the World Health Organization 1968;38(4):625-32.
59. Rieckmann KH, McNamara JV, Kass L, Powell RD. Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum. Military Medicine 1969;134(10):802-19.
60. Santana MS, da Rocha MA, Arcanjo AR, Sardinha JF, Alecrim WD, Alecrim Md. Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine [Associação de metemoglobinemia e deficiência de glicose-6-fosfato desidrogenase em pacientes com malária tratados com primaquina]. Revista da Sociedade de Brasileira de Medicina Tropical 2007;40(5):533-6.
61. Shah NK, Schapira A, Juliano JJ, Srivastava B, MacDonald PD, Poole C, et al.Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of Plasmodium falciparum gametocytes. Antimicrobial Agents and Chemotherapy 2013;57(7):2948-54.
62. Shekalaghe SA, ter Braak R, Daou M, Kavishe R, van den Bijllaardt W, van den Bosch S, et al.In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals. Antimicrobial Agents and Chemotherapy 2010;54(5):1762-8.
63. Skekalaghe SA, Drakeley C, van den Bosch S, ter Braak R, van den Bijllhaardt W, Mwanziva C, et al.A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malaria Journal 2011;10:247.
64. Sun W-H, Traore A. Artesunate combined with primaquine in treatment study on delay or relapse of malaria [Chinese]. Chinese Journal of Clinical Pharmacology and Therapeutics 2011;1:98-100.
65. Suputtamongkol Y, Chindarat S, Silpasakorn S, Chaikachonpatd S, Lim K, Chanthapakajee K, et al.The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia. American Journal of Tropical Medicine and Hygiene 2003;68(5):620-3.
66. Tangpukdee N, Krudsood S, Srivilairit S, Phophak N, Chonsawat P, Yanpanich W, et al.Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 2008;46(2):65-70.
67. Yang H, Che L, Huang K, Yang P, Dong Y, Lin Z, et al.The effect of combinations of pyronaridine, sufadoxine and primaquine on chloroquine-resistant P. falciparum. Chinese Journal of Parasitic Disease Control 1989;2(1):7-10.
68. Yeramian P, Meshnick SR, Krudsood S, Chalermrut, K, Silachamroon U, Tangpukdee N, et al.Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections. Journal of Infectious Diseases 2005;192(2):319-22.
69. Young MD. The effect of small doses of primaquine upon malaria infections. Indian Journal of Malariology 1959;13:69-74.
70. Chen L. Efficacy of artemether/primaquine against drug resistant P. falciparum [Chinese]. Journal of Applied Medicine 1993;1(1):31-3.
71. Ishii A, Ohta N, Owhashi M, Kawabata M, Chung D, Bobogare A, et al.Trials of transmission blocking of P. falciparum with single dose primaquine in villages of Solomon Islands. MIM conference October 2009 MIM 16723361.
72. Li J, et al.Artemether combined with primaquine for treatment of 50 Pf cases [Chinese]. Journal of Applied Medicine 2006;22(19):2299-300.
73. Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers Treated With Dihydroartemisinin-piperaquine in The Gambia. Ongoing study August 2013; December 2014 (final data collection date for primary outcome measure).
74. Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia. Ongoing study September 2014 (final data collection date for primary outcome measure).
75. Surveillance and Treatment With Dihydroartemisinin-piperaquine Plus Primaquine (MTC Belu)Sub-title: Impact of Mass Screening and Selective Treatment With Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in High Endemic Area, Belu Regency, Nusa Tenggara Timur Province, Indonesia: a Randomized Cluster Trial. Ongoing study June 2013.
76. Active Surveillance for P. falciparum Drug Resistance With Assessment of Transmission Blocking Activity of Single Dose Primaquine in Cambodia. Ongoing study December 2012; December 2014 (final data collection date for primary outcome measure).
77. The Optimal Timing of Primaquine to Prevent Malaria Transmission After Artemisinin-Combination Therapy. Ongoing study May 2013; October 2013 (final data collection date for primary outcome measure).
78. Pharmacokinetic Study of Primaquine and Dihydroartemisinin-Piperaquine in Healthy Subjects. Ongoing study February 2012.
79. Low Dose Primaquine for Clearance of Gametocytes: LOPRIM-1. Ongoing study September 2013.
80. Abay SM. Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta-analysis. Parasites and Vectors 2013;6(1):278.
81. Arnold J, Alving AS, Hockwald RS, Clayman CB, Dern RJ, Beutler E, et al.The antimalarial action of primaquine against the blood and tissue stages of falciparum malaria (Panama, P-F-6 strain). Journal of Laboratory and Clinical Medicine 1955;46(3):391-7.
82. Barnes, KI, Little F, Mabuza A, Mngomezulu N, Govere J, Durrheim D, et al.Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria. Journal of Infectious Diseases 2008;197(11):1605-13.
83. Bhasin VK, Trager W. Chapter XI: Gametocytocidal effects in vitro of primaquine and related compounds on Plasmodium falciparum. In: Wernsdorfer WH, Trigg PI editor(s). Primaquine: pharmacokinetics, metabolism, toxicity and activity. UNDP/World Bank/WHO, 1984.
84. Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, et al.Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs. Malaria Journal 2010;9:136.
85. Bousema T, Drakeley C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eradication. Clinical Microbiology Reviews 2011;24(2):377-410.
86. Bousema T, Dinglasan RR, Morlais I, Gouagna LC, van Warmerdam T, Awono-Ambene PH, et al.Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers. PLoS One 2012;7(8):e42821.
87. Breman JG. Resistance to artemisinin based combination therapy. Lancet Infectious Diseases 2012;12(11):820-2.
88. Carter R, Graves PM. Gametocytes. In: Wernsdorfer, MacGregror editor(s). Malaria: principles and practice of malariology. Edinburgh: Churchill Livingstone, 1988.
89. Chotivanich K, Sattabongkot J, Udomsangpetch U, Looareesuwan S, Day NP, Coleman RE, et al.Transmission-blocking activities of quinine, primaquine, and artesunate. Antimicrobial Agents and Chemotherapy 2006;50(6):1927-30.
90. Churcher TS, Bousema T, Walker M, Drakeley C, Schneider P, Ouédraogo AL, et al.Predicting mosquito infection from Plasmodium falciparum gametocye density and estimating the reservoir of infection. eLife 2013;2:e00626.
91. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16(1):31-41.
92. Drakeley, Sutherland C, Bousema JT, Sauerwein RW, Targett GA. The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion. Trends in Parasitology 2006;22(9):424-30.
93. Dunyo S, Milligan P, Edwards T, Sutherland C, Targett G, Pinder M. Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. PLoS Clinical Trials 2006;1(4):e20.
94. Eichner M, Diebner HH, Molineaux L, Collins WE, Jeffery GM, Dietz K. Genesis, sequestration and survival of Plasmodium falciparum gametocytes: parameter estimates from fitting a model to malaria therapy data. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(5):497-501.
95. Eziefula A, Gosling R, Hwang J, Hsiang M, Bousema T, von Seidlein L, et al.Rationale for short course primaquine in Africa to interrupt malaria transmission. Malaria Journal 2012;11:360.
96. Roll Back Malaria Partnership. Global Malaria Action Plan. Geneva: RBM/WHO, 2008.
97. Graves PM, Burkot TR, Carter R, Cattani JA, Lagog M, Parker J, et al.Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua New Guinea. Parasitology 1988;96(Pt 2):251-63.
98. Graves PM, Burkot TR, Saul AJ, Hayes RJ, Carter R. Estimation of anopheline survival rate, vectorial capacity and mosquito infection probability from malaria infection rates in villages near Madang, Papua New Guinea. Journal of Applied Ecology 1990;27:134-47.
99. Higgins JPT, Altman DH, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
100. Howes RE, Battle KE, Satyagraha AW, Baird JK, Hay SI. G6PD deficiency: global distribution, genetic variants and primaquine therapy. Adv Parasitol 2013;81:133-201. [DOI: 10.1016/B978-0-12-407826-0.00004-7]
101. Johnston GL, Gething PW, Hay SI, Smith DL, Fidock DA. Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination. PLoS Computational Biology 2014;10(1):e1003434.
102. Kaneko A, Taleo G, Kalkoa M, Yamar S, Kobayakawa T, Björkman A. Malaria eradication on islands. Lancet 2000;356(9241):1560-4.
103. Killeen GF, Ross A, Smith T. Infectiousness of malaria-endemic human populations to vectors. American Journal of Tropical Medicine and Hygiene 2006;75(2 Suppl):38-45.
104. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors) editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. Chichester: John Wiley & Sons, 2011.
105. Lines JD, Wilkes TJ, Lyimo EO. Human malaria infectiousness measured by age-specific sporozoite rates in Anopheles gambiae in Tanzania. Parasitology 1991;102(2):167-77.
106. Méndez F, Muñoz A, Plowe CV. Use of area under the curve to characterize transmission potential after antimalarial treatment. American Journal of Tropical Medicine and Hygiene 2006;75(4):640-4.
107. Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer W. From malaria control to eradication: the WHO perspective. Tropical Medicine and International Health 2009;14(7):802-9.
108. Okell LC, Drakeley CJ, Ghani AC, Bousema T, Sutherland CJ. Reduction of transmission from malaria patients by artemisinin therapies: a pooled analysis of six randomized trials. Malaria Journal 2008;7:125.
109. Okell LC, Drakeley CJ, Bousema T, Whitty CJ, Ghani AC. Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity. PLoS Medicine 2008;5(11):e226.
110. Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database of Systematic Reviews 2013, Issue 12. [DOI: 10.1002/14651858.CD008846.pub2]
111. Price R, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, Chongsuphajaisiddhi T, et al.The effects of artemisinin derivatives on malaria transmissibility. Lancet 1996;347(9016):1654-8.
112. The Nordic Cochrane Centre. The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre. The Cochrane Collaboration, 2011.
113. Smalley ME, Sinden RE. Plasmodium falciparum gametocytes: their longevity and infectivity. Parasitology 1977;74(1):1-8.
114. Sturrock HJW, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, et al.Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Medicine 2013;10(6):e1001467.
115. Von Seidlein L, Greenwood BM. Mass administrations of antimalarial drugs. Trends in Parasitology 2003;19(10):452-60.
116. White NJ. Antimalarial pharmacokinetics and treatment regimens. British Journal of Clinical Pharmacology 1992;34(1):1-10.
117. White NJ. The role of antimalarial drugs in eliminating malaria. Malaria Journal 2008;7(Suppl 1):S8.
118. White NJ, Guo Qiao LG, Qi G, Luzzatto L. Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malaria Journal 2012;11:418.
119. White NJ. Primaquine to prevent transmission of falciparum malaria. Lancet Infectious Diseases 2013;13(2):175-81.
120. World Health Organization. Guidelines for the treatment of malaria, second edition. Guidelines for the treatment of malaria. 2nd Edition. Geneva: WHO, 2010.
121. World Health Organization. WHO Evidence Review Group: The safety and effectiveness of single dose primaquine as a P. falciparium gametoctyocide. Meeting Report. Geneva: World Health Organization, 2012.
122. World Health Organization. Single dose primaquine as a gametocytocide in Plasmodium falciparum malaria. Updated WHO Policy Recommendation. Geneva: Global Malaria Programme. World Health Organization, October 2012.
123. Graves PM, Gelband H, Garner P. Primaquine for reducing Plasmodium falciparum transmission. Cochrane Database of Systematic Reviews 2012, Issue 9. [DOI: 10.1002/14651858.CD008152.pub2]